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DK1315750T3 - Cykliske peptider med melanocortin-4-receptoragonistaktivitet - Google Patents

Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Info

Publication number
DK1315750T3
DK1315750T3 DK01962958T DK01962958T DK1315750T3 DK 1315750 T3 DK1315750 T3 DK 1315750T3 DK 01962958 T DK01962958 T DK 01962958T DK 01962958 T DK01962958 T DK 01962958T DK 1315750 T3 DK1315750 T3 DK 1315750T3
Authority
DK
Denmark
Prior art keywords
melanocortin
receptor agonist
agonist activity
cyclic peptides
peptides
Prior art date
Application number
DK01962958T
Other languages
Danish (da)
English (en)
Inventor
Li Chen
Adrian Wai-Hing Cheung
Xin-Jie Chu
Waleed Danho
Joseph Swistok
Yao Wang
Keith Alan Yagaloff
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK1315750T3 publication Critical patent/DK1315750T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64—Cyclic peptides containing only normal peptide links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/68—Melanocyte-stimulating hormone [MSH]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK01962958T 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet DK1315750T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22918400P 2000-08-30 2000-08-30
PCT/EP2001/009630 WO2002018437A2 (en) 2000-08-30 2001-08-21 Cyclic peptides having melanocortin-4 receptor agonist activity

Publications (1)

Publication Number Publication Date
DK1315750T3 true DK1315750T3 (da) 2007-06-11

Family

ID=22860145

Family Applications (1)

Application Number Title Priority Date Filing Date
DK01962958T DK1315750T3 (da) 2000-08-30 2001-08-21 Cykliske peptider med melanocortin-4-receptoragonistaktivitet

Country Status (35)

Country Link
US (1) US7045591B2 (es)
EP (1) EP1315750B1 (es)
JP (1) JP4217069B2 (es)
KR (1) KR100483300B1 (es)
CN (1) CN100491396C (es)
AR (2) AR030504A1 (es)
AT (1) ATE353918T1 (es)
AU (2) AU8402601A (es)
BR (1) BR0113637A (es)
CA (1) CA2420058C (es)
CY (1) CY1106562T1 (es)
CZ (1) CZ2003584A3 (es)
DE (1) DE60126624T2 (es)
DK (1) DK1315750T3 (es)
EC (1) ECSP034503A (es)
ES (1) ES2280393T3 (es)
HR (1) HRP20030126B1 (es)
HU (1) HUP0303078A3 (es)
IL (2) IL154575A0 (es)
JO (1) JO2454B1 (es)
MA (1) MA27681A1 (es)
MX (1) MXPA03001721A (es)
MY (1) MY137457A (es)
NO (1) NO20030916L (es)
NZ (1) NZ523989A (es)
PA (1) PA8527201A1 (es)
PE (1) PE20020483A1 (es)
PL (1) PL366630A1 (es)
PT (1) PT1315750E (es)
RU (1) RU2239642C1 (es)
SI (1) SI1315750T1 (es)
TW (1) TWI248941B (es)
WO (1) WO2002018437A2 (es)
YU (1) YU15603A (es)
ZA (1) ZA200301015B (es)

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WO2003006604A2 (en) * 2001-07-12 2003-01-23 Merck & Co., Inc. Cyclic peptides as potent and selective melanocortin-4 receptor agonists
US7718802B2 (en) 2001-08-10 2010-05-18 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US7456184B2 (en) 2003-05-01 2008-11-25 Palatin Technologies Inc. Melanocortin receptor-specific compounds
JP2005504043A (ja) 2001-08-10 2005-02-10 パラチン テクノロジーズ インク． 生物学的に活性な金属ペプチド類のペプチド模倣体類
US7354923B2 (en) 2001-08-10 2008-04-08 Palatin Technologies, Inc. Piperazine melanocortin-specific compounds
US7732451B2 (en) 2001-08-10 2010-06-08 Palatin Technologies, Inc. Naphthalene-containing melanocortin receptor-specific small molecule
US7655658B2 (en) 2001-08-10 2010-02-02 Palatin Technologies, Inc. Thieno [2,3-D]pyrimidine-2,4-dione melanocortin-specific compounds
WO2004005324A2 (en) 2002-07-09 2004-01-15 Palatin Technologies, Inc. Peptide composition for treatment of sexual dysfunction
US7727990B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine and keto-piperazine compounds
US7727991B2 (en) 2003-05-01 2010-06-01 Palatin Technologies, Inc. Substituted melanocortin receptor-specific single acyl piperazine compounds
US7968548B2 (en) 2003-05-01 2011-06-28 Palatin Technologies, Inc. Melanocortin receptor-specific piperazine compounds with diamine groups
MXPA05011830A (es) 2003-05-09 2006-01-26 Novo Nordisk As Peptidos para uso en el tratamiento de la obesidad.
EP1625158A2 (en) * 2003-05-09 2006-02-15 Novo Nordisk A/S Peptides for use in treating obesity
US20070105759A1 (en) * 2003-06-19 2007-05-10 Eli Lilly And Company Melanocortin receptor 4 (mc4) agonists and their uses
US20060293223A1 (en) * 2003-06-19 2006-12-28 Eli Lilly And Company Patent Division Uses of melanocortin-3 receptor (mc3r) agonist peptides
US7084111B2 (en) 2003-06-23 2006-08-01 University Of Florida Research Foundation, Inc. Melanocortin receptor templates, peptides, and use thereof
CN100482682C (zh) * 2003-09-30 2009-04-29 诺沃挪第克公司 黑皮素受体激动剂
US7550602B1 (en) 2004-01-14 2009-06-23 Palatin Technologies, Inc. Small molecule compositions for sexual dysfunction
US6974187B2 (en) * 2004-01-28 2005-12-13 Tachi-S Co., Ltd. Vehicle seat structure
EP1732586A1 (en) * 2004-03-29 2006-12-20 Eli Lilly And Company Uses of melanocortin-4 receptor (mc4r) agonist peptides administered by continunous infusion
WO2005097973A1 (en) * 2004-04-08 2005-10-20 Astellas Pharma Inc. Compound ws 727713
US7709484B1 (en) 2004-04-19 2010-05-04 Palatin Technologies, Inc. Substituted melanocortin receptor-specific piperazine compounds
US20080280820A1 (en) * 2004-11-04 2008-11-13 Ulrich Sensfuss Novel Peptides for Use in the Treatment of Obesity
EP1809667A1 (en) * 2004-11-04 2007-07-25 Novo Nordisk A/S Peptides for use in the treatment of obesity
JP2008519007A (ja) * 2004-11-04 2008-06-05 ノボ ノルディスク アクティーゼルスカブ 肥満症の治療に使用するためのペプチド
WO2006048449A2 (en) * 2004-11-04 2006-05-11 Novo Nordisk A/S Mc4r selective peptides and their use in the treatment of obesity
EP1885743A1 (en) * 2005-05-31 2008-02-13 Yissum Research Development Company, of The Hebrew University of Jerusalem BACKBONE CYCLIZED MELANOCORTIN STIMULATING HORMONE ( alpha S ) ANALOGS
EP1893240A2 (en) * 2005-06-13 2008-03-05 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives
US20080015304A1 (en) 2006-07-13 2008-01-17 Klaus Hintzer Aqueous emulsion polymerization process for producing fluoropolymers
US20070015937A1 (en) * 2005-07-15 2007-01-18 3M Innovative Properties Company Process for recovery of fluorinated carboxylic acid surfactants from exhaust gas
GB2430437A (en) * 2005-09-27 2007-03-28 3M Innovative Properties Co Method of making a fluoropolymer
US7834017B2 (en) 2006-08-11 2010-11-16 Palatin Technologies, Inc. Diamine-containing, tetra-substituted piperazine compounds having identical 1- and 4-substituents
WO2008080845A1 (en) * 2006-12-29 2008-07-10 F. Hoffmann-La Roche Ag Methods for the synthesis of cyclic peptides
BRPI0807109A2 (pt) * 2007-02-16 2014-05-06 3M Innovative Properties Co Sistema e processo para a remoção de fluoroquiímicos da água
US20080264864A1 (en) * 2007-04-27 2008-10-30 3M Innovative Properties Company PROCESS FOR REMOVING FLUORINATED EMULSIFIER FROM FLUOROPOLMER DISPERSIONS USING AN ANION-EXCHANGE RESIN AND A pH-DEPENDENT SURFACTANT AND FLUOROPOLYMER DISPERSIONS CONTAINING A pH-DEPENDENT SURFACTANT
US8563000B2 (en) 2007-05-25 2013-10-22 Ipsen Pharma S.A.S. Melanocortin receptor ligands modified with hydantoin
US8258313B2 (en) 2007-07-19 2012-09-04 Tokuyama Corporation Compound having hydantoin ring and method of producing the same
EP2502907B1 (de) 2008-03-27 2018-08-29 Grünenthal GmbH Substituierte 4-Aminocyclohexan-Derivate
WO2009118163A1 (de) * 2008-03-27 2009-10-01 Grünenthal GmbH (hetero-)aryl-cyclohexan-derivate
AU2009257631B2 (en) 2008-06-09 2014-07-24 Palatin Technologies, Inc. Melanocortin receptor-specific peptides for treatment of sexual dysfunction
AR072072A1 (es) * 2008-06-09 2010-08-04 Palatin Technologies Inc Peptidos especificos del receptor de melanocortina para el tratamiento de la obesidad / 669
WO2010144341A2 (en) 2009-06-08 2010-12-16 Palatin Technologies, Inc. Lactam-bridged melanocortin receptor-specific peptides
CN105037502A (zh) 2009-06-08 2015-11-11 帕拉丁科技公司 黑皮质素受体特异性肽
UY32690A (es) 2009-06-08 2011-01-31 Astrazeneca Ab Péptidos específicos para receptores de melanocortina
WO2011063366A1 (en) 2009-11-23 2011-05-26 Palatin Technologies, Inc. Melanocortin-1 receptor-specific cyclic peptides
KR20120102716A (ko) 2009-11-23 2012-09-18 팔라틴 테크놀로지스 인코포레이티드 멜라노코르틴-1 수용체 특이적 선형 펩티드
CA2906694A1 (en) 2013-03-15 2014-09-18 Rhythm Metabolic, Inc. Peptide compositions
GB201416352D0 (en) 2014-09-16 2014-10-29 Shire Internat Gmbh Spirocyclic derivatives
GB201416351D0 (en) * 2014-09-16 2014-10-29 Shire Internat Gmbh Heterocyclic derivatives
EP3197481A1 (en) * 2014-09-26 2017-08-02 Bayer Pharma Aktiengesellschaft Stabilized adrenomedullin derivatives and use thereof
US11542302B2 (en) 2015-10-15 2023-01-03 Arizona Board Of Regents On Behalf Of The University Of Arizona Modulators of melanocortin receptors for the treatment of depression and anxiety
WO2017066754A1 (en) 2015-10-15 2017-04-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for the treatment of depression and anxiety
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
US20190255142A1 (en) * 2016-10-17 2019-08-22 Arizona Board Of Regents On Behalf Of The University Of Arizona Novel modulators of melanocortin receptors for the treatment of depression and anxiety
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
CN106496005B (zh) * 2016-10-20 2019-04-09 上海毕得医药科技有限公司 一种4-(4-氯苯基)环己酮的合成方法
CN106496008A (zh) * 2016-10-20 2017-03-15 上海毕得医药科技有限公司 一种合成4‑(4‑氯苯基)环己酮的方法
US10745444B2 (en) * 2017-04-17 2020-08-18 National Tsing Hua University Cyclopeptide, pharmaceutical or cosmetic composition comprising the same and method for preparing the same
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
CN118530294B (zh) * 2024-05-10 2025-02-14 浙江大学 一种芳基二胺固载连接子、其前体以及制备方法和应用

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US5731408A (en) * 1995-04-10 1998-03-24 Arizona Board Of Regents On Behalf Of The University Of Arizona Peptides having potent antagonist and agonist bioactivities at melanocortin receptors
US5858972A (en) 1996-01-11 1999-01-12 La Jolla Cancer Research Foundation Antithrombotic agents and methods of use
SE9700620D0 (sv) * 1997-02-21 1997-02-21 Wapharm Ab Cykliska peptider med selektivitet för MSH-receptor subtyper
TR200102765T2 (tr) 1999-03-29 2002-05-21 The Procter & Gamble Company Melanokortin reseptör ligandları

Also Published As

Publication number Publication date
CN1451017A (zh) 2003-10-22
ECSP034503A (es) 2003-04-25
WO2002018437A2 (en) 2002-03-07
AU2001284026B2 (en) 2007-03-01
EP1315750A2 (en) 2003-06-04
HUP0303078A2 (hu) 2003-12-29
DE60126624T2 (de) 2007-11-22
JP4217069B2 (ja) 2009-01-28
CN100491396C (zh) 2009-05-27
ZA200301015B (en) 2004-05-05
ATE353918T1 (de) 2007-03-15
AR030504A1 (es) 2003-08-20
NZ523989A (en) 2004-08-27
DE60126624D1 (de) 2007-03-29
IL154575A (en) 2008-12-29
HRP20030126A2 (en) 2005-10-31
CY1106562T1 (el) 2012-01-25
NO20030916D0 (no) 2003-02-27
KR20030061788A (ko) 2003-07-22
HUP0303078A3 (en) 2012-02-28
AR061422A2 (es) 2008-08-27
SI1315750T1 (sl) 2007-06-30
IL154575A0 (en) 2003-09-17
EP1315750B1 (en) 2007-02-14
PE20020483A1 (es) 2002-06-06
NO20030916L (no) 2003-02-27
YU15603A (sh) 2006-05-25
CZ2003584A3 (cs) 2003-08-13
MXPA03001721A (es) 2003-05-27
ES2280393T3 (es) 2007-09-16
MA27681A1 (fr) 2006-01-02
US20020143141A1 (en) 2002-10-03
CA2420058C (en) 2009-04-07
TWI248941B (en) 2006-02-11
AU8402601A (en) 2002-03-13
WO2002018437A3 (en) 2002-06-06
PA8527201A1 (es) 2002-04-25
MY137457A (en) 2009-01-30
HRP20030126B1 (en) 2009-01-31
BR0113637A (pt) 2004-02-25
KR100483300B1 (ko) 2005-04-15
CA2420058A1 (en) 2002-03-07
RU2239642C1 (ru) 2004-11-10
JO2454B1 (en) 2008-10-09
PT1315750E (pt) 2007-05-31
PL366630A1 (en) 2005-02-07
JP2004507558A (ja) 2004-03-11
US7045591B2 (en) 2006-05-16

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