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CR20170110A - Derivados estabilizados de adrenomedulina y uso de los mismos - Google Patents

Derivados estabilizados de adrenomedulina y uso de los mismos

Info

Publication number
CR20170110A
CR20170110A CR20170110A CR20170110A CR20170110A CR 20170110 A CR20170110 A CR 20170110A CR 20170110 A CR20170110 A CR 20170110A CR 20170110 A CR20170110 A CR 20170110A CR 20170110 A CR20170110 A CR 20170110A
Authority
CR
Costa Rica
Prior art keywords
adrenomeduline
same
compounds
stabilized derivatives
relates
Prior art date
Application number
CR20170110A
Other languages
English (en)
Inventor
Dr Ingo Flamme
Dr Bernd Riedl
Prof Dra Annette Beck-Sickinger
Jan-Patrick Fischer
Dr Johannes Köbberling
Dr Donald Bierer
Ria Schoenauer
Original Assignee
Bayer Pharma AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Pharma AG filed Critical Bayer Pharma AG
Publication of CR20170110A publication Critical patent/CR20170110A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/001—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof by chemical synthesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Diabetes (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Communicable Diseases (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)

Abstract

La invención se refiere acompuestos de Adrenomedulina (ADM) estabilizados, biológicamente activos, novedosos. La invención se refiere además a los compuestos para utilizar en un método para el tratamiento y/o prevención de enfermedades, especialmente de trastornos cardiovasculares, edematosos y/o inflamatorios, y se refiere a medicamentos que comprenden los compuestos para el tratamiento y/o prevención de trastornos cardiovasculares, edematosos y/o inflamatorios.
CR20170110A 2014-09-26 2015-09-24 Derivados estabilizados de adrenomedulina y uso de los mismos CR20170110A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP14186572 2014-09-26
PCT/EP2015/071941 WO2016046301A1 (en) 2014-09-26 2015-09-24 Stabilized adrenomedullin derivatives and use thereof

Publications (1)

Publication Number Publication Date
CR20170110A true CR20170110A (es) 2017-05-08

Family

ID=51610047

Family Applications (1)

Application Number Title Priority Date Filing Date
CR20170110A CR20170110A (es) 2014-09-26 2015-09-24 Derivados estabilizados de adrenomedulina y uso de los mismos

Country Status (24)

Country Link
US (1) US20180022780A1 (es)
EP (1) EP3197481A1 (es)
JP (1) JP2018500272A (es)
KR (1) KR20170062490A (es)
CN (1) CN107001440A (es)
AP (1) AP2017009826A0 (es)
AU (1) AU2015323769A1 (es)
CA (1) CA2962486A1 (es)
CO (1) CO2017002813A2 (es)
CR (1) CR20170110A (es)
CU (1) CU20170038A7 (es)
DO (1) DOP2017000085A (es)
EA (1) EA201790699A1 (es)
EC (1) ECSP17018513A (es)
IL (1) IL250927A0 (es)
MA (1) MA40524A (es)
MX (1) MX2017003897A (es)
NI (1) NI201700036A (es)
PE (1) PE20170702A1 (es)
PH (1) PH12017500563A1 (es)
SG (1) SG11201701803XA (es)
TN (1) TN2017000109A1 (es)
WO (1) WO2016046301A1 (es)
ZA (1) ZA201702901B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7001285B2 (ja) * 2017-03-29 2022-01-19 国立大学法人 宮崎大学 長時間作用型アドレノメデュリン誘導体
NL2020518B1 (en) * 2018-03-02 2019-09-12 Mimetas B V Device and method for performing electrical measurements
CA3143584A1 (en) * 2019-06-18 2020-12-24 Bayer Aktiengesellschaft Adrenomedullin-analogues for long-term stabilization and their use
JP2023520543A (ja) * 2020-04-03 2023-05-17 バイエル アクチェンゲゼルシャフト 医薬製剤であるアドレノメデュリンのポリエチレングリコールベースのプロドラッグおよび使用
KR20220163412A (ko) * 2020-04-03 2022-12-09 바이엘 악티엔게젤샤프트 액체 제약 제제 아드레노메둘린의 폴리에틸렌 글리콜계 전구약물 및 용도
WO2022177018A1 (ja) * 2021-02-22 2022-08-25 国立大学法人宮崎大学 長時間作用型アドレノメデュリン誘導体の製造方法

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Also Published As

Publication number Publication date
AP2017009826A0 (en) 2017-03-31
CO2017002813A2 (es) 2017-06-30
MA40524A (fr) 2021-03-17
TN2017000109A1 (en) 2018-07-04
EP3197481A1 (en) 2017-08-02
IL250927A0 (en) 2017-04-30
ZA201702901B (en) 2019-06-26
MX2017003897A (es) 2017-06-28
WO2016046301A1 (en) 2016-03-31
CA2962486A1 (en) 2016-03-31
US20180022780A1 (en) 2018-01-25
EA201790699A1 (ru) 2017-10-31
AU2015323769A1 (en) 2017-04-13
PE20170702A1 (es) 2017-06-24
SG11201701803XA (en) 2017-04-27
JP2018500272A (ja) 2018-01-11
ECSP17018513A (es) 2017-05-31
DOP2017000085A (es) 2017-04-30
CU20170038A7 (es) 2017-10-05
KR20170062490A (ko) 2017-06-07
PH12017500563A1 (en) 2017-08-30
NI201700036A (es) 2017-06-16
CN107001440A (zh) 2017-08-01

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