PE20001318A1 - Derivados de 3-azabiciclo [3.1.0] hexano como moduladores de receptores opiaceos - Google Patents
Derivados de 3-azabiciclo [3.1.0] hexano como moduladores de receptores opiaceosInfo
- Publication number
- PE20001318A1 PE20001318A1 PE1999001310A PE00131099A PE20001318A1 PE 20001318 A1 PE20001318 A1 PE 20001318A1 PE 1999001310 A PE1999001310 A PE 1999001310A PE 00131099 A PE00131099 A PE 00131099A PE 20001318 A1 PE20001318 A1 PE 20001318A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- heterocycle
- alkylene
- halogen
- rings
- Prior art date
Links
- 150000005228 3‐azabicyclo[3.1.0]hexanes Chemical class 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 208000002551 irritable bowel syndrome Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical class CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/36—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
- C07D233/61—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms with hydrocarbon radicals, substituted by nitrogen atoms not forming part of a nitro radical, attached to ring nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/04—1,2,3-Triazoles; Hydrogenated 1,2,3-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/12—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
SE REFIERE A UN DERIVADO DE 3-AZABICICLO[3.1.0]HEXANO DE FORMULA I, DONDE: Ar ES FENILO OPCIONALMENTE BENZOCONDENSADO, HETEROARILO DE 5-6 MIEMBROS; R1 ES H, HALOGENO, NO2, NH2, NY2WY1, HET1, AD, ENTRE OTROS; Y2 ES H, ALQUILO C1-C6, ALQUENILO C3-C6; W ES SO2, CO, COO, P(Y1)=O, P(Y1)=S; Y1 ES ALQUILO C1-C10; HET ES UN HETEROCICLO CON 4 HETEROATOMOS CON HASTA 3 ANILLOS; A ES ALQUILENO C1-C4, ALQUENILENO C2-C4, ALQUINILENO C2-C4; D ES H, OH, CN, ENTRE OTROS; AD ES CN, NR25R26; R25 Y R26 SON H, ALQUILO C1-C3; JUNTO CON N FORMAN UN HETEROCICLO DE 4-7 MIEMBROS; R2 ES H, HALOGENO; R1 Y R2 JUNTO A C FORMAN UN HET1a; HET1a ES UN HETEROCICLO DE HASTA 3 ANILLOS; R3 ES H, CN, HALOGENO, ALCOXI C1-C6, ALCOXICARBONILO C1-C6, ENTRE OTROS; R4 ES ALQUILO C1-C10, ALQUENILO C3-C10, ALQUINILO C3-C10, UNIDO A UN CARBONO SP3; R5 Y R8 SON H, ALQUILO C1-C6, O JUNTO A C FORMAN UN ANILLO CICLOALQUILO C3-C8; R6, R7, R9, R10 SON H; R5, R6, R7 SON CICLOALQUILO C3-C8; n ES 0-2; q ES 0-1; Y2 ES H, ALQUILO C1-C6, ALQUENILO C3-C6; W ES SO2, CO-COO, P(Y1)=O, P(Y1)=S; Y1 ES ALQUILO C1-C10, HET ES UN HETEROCICLO CON 4 N, O, S CON 3 ANILLOS. TAMBIEN SE REFIERE A PROCEDIMIENTOS PARA LA PREPARACION Y A COMPUESTOS INTERMEDIOS. EL COMPUESTO I SE UNE A RECEPTORES OPIACEOS Y PUEDE SER UTIL PARA EL TRATAMIENTO DEL SINDROME DEL INTESTINO IRRITABLE, ESTRENIMIENTO, NAUSEAS
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9828485.4A GB9828485D0 (en) | 1998-12-23 | 1998-12-23 | Compounds useful in therapy |
| GBGB9912425.7A GB9912425D0 (en) | 1999-05-27 | 1999-05-27 | Compounds useful in therapy |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20001318A1 true PE20001318A1 (es) | 2000-12-01 |
Family
ID=40257194
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE1999001310A PE20001318A1 (es) | 1998-12-23 | 1999-12-22 | Derivados de 3-azabiciclo [3.1.0] hexano como moduladores de receptores opiaceos |
Country Status (10)
| Country | Link |
|---|---|
| KR (1) | KR100504647B1 (es) |
| AR (1) | AR035157A1 (es) |
| CO (1) | CO5261495A1 (es) |
| IL (1) | IL142697A (es) |
| MY (1) | MY130771A (es) |
| PA (1) | PA8488001A1 (es) |
| PE (1) | PE20001318A1 (es) |
| PT (1) | PT1140828E (es) |
| RS (1) | RS50051B (es) |
| TN (1) | TNSN99235A1 (es) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2007267183B2 (en) | 2006-05-31 | 2011-10-20 | F. Hoffmann-La Roche Ag | Aryl-4-ethynyl-isoxazole derivatives |
-
1999
- 1999-11-19 RS YUP-415/01A patent/RS50051B/sr unknown
- 1999-11-19 KR KR10-2001-7008062A patent/KR100504647B1/ko not_active Expired - Fee Related
- 1999-11-19 MY MYPI99005067A patent/MY130771A/en unknown
- 1999-11-19 PT PT99954290T patent/PT1140828E/pt unknown
- 1999-12-08 TN TNTNSN99235A patent/TNSN99235A1/fr unknown
- 1999-12-22 PE PE1999001310A patent/PE20001318A1/es not_active Application Discontinuation
- 1999-12-23 AR ARP990106728A patent/AR035157A1/es unknown
- 1999-12-23 PA PA19998488001A patent/PA8488001A1/es unknown
- 1999-12-23 CO CO99080388A patent/CO5261495A1/es not_active Application Discontinuation
-
2001
- 2001-04-19 IL IL142697A patent/IL142697A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU41501A (sh) | 2004-03-12 |
| PT1140828E (pt) | 2006-12-29 |
| AR035157A1 (es) | 2004-05-05 |
| KR100504647B1 (ko) | 2005-07-29 |
| KR20010086462A (ko) | 2001-09-12 |
| TNSN99235A1 (fr) | 2005-11-10 |
| MY130771A (en) | 2007-07-31 |
| RS50051B (sr) | 2008-11-28 |
| CO5261495A1 (es) | 2003-03-31 |
| PA8488001A1 (es) | 2002-10-28 |
| IL142697A (en) | 2009-05-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PE20070189A1 (es) | COMPUESTO DE AMINO-5-HETEROARILO (5 MIEMBROS) IMIDAZOLONA Y SU USO PARA MODULACION DE LA ß-SECRETASA | |
| PE20010741A1 (es) | Derivados de piperazina como antagonistas de taquicininas | |
| PE20080067A1 (es) | DERIVADOS DE TRIAZOLOPIRAZINA COMO MODULADORES DEL RECEPTOR DEL FACTOR DE CRECIMIENTO DE HEPATOCITO (c-MET O HGFR) | |
| PE20010219A1 (es) | AGONISTAS ß-ADRENORRECEPTORES | |
| PE20020253A1 (es) | Derivados de 3-azabiciclo[3.1.0]hexano como ligandos de receptores opiaceos | |
| PE20010964A1 (es) | Derivados de tiazolilamida | |
| DE60228406D1 (de) | PYRAZOLOÄ3,4-dÜPYRIMIDINDERIVATE UND IHRE VERWENDUNG ALS ANTAGONISTEN DES PURINERGEN REZEPTORS | |
| CY1105688T1 (el) | Κυανοπυρρολες ως αγωνιστες υποδοχεων προγεστερονης | |
| PE20090276A1 (es) | Compuestos derivados de imidazoquinolina como moduladores de tlr7 | |
| PE20050482A1 (es) | Derivados de dihidrobenzofuranilo alcanamida | |
| PE20011310A1 (es) | Alquinil fenil amidas heteroaromaticas como activadores de la glucokinasa | |
| PE20061297A1 (es) | Compuestos derivados de cromano y cromeno moduladores del receptor de serotonina 5-ht2c | |
| CO5280079A1 (es) | Nuevos compuestos | |
| PE20070218A1 (es) | COMPUESTOS DE CICLOALQUILO AMINO-HIDANTOINA Y USO DE ESTOS PARA LA MODULACION DE ß-SECRETASA | |
| PE20020753A1 (es) | Heteroaromaticos fusionados como activadores de la glucoquinasa | |
| PE20011047A1 (es) | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas | |
| AR040477A1 (es) | Benzoilureas heterociclicamente sustituidas, procedimiento para su preparacion y su uso como farmacos | |
| PE20070528A1 (es) | Compuestos heterociclicos como ligandos del receptor vaniloide del subtipo 1 | |
| PE20040772A1 (es) | Composicion y actividad antiviral de derivados de piperazina azaindoloxoaceticos | |
| PE20020589A1 (es) | 5-espiropirimidin-2,4,6-triona como inhibidores de metaloproteinasas | |
| AR058562A1 (es) | Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 | |
| CO5590960A2 (es) | Derivados de azaindolilalquilamina como ligandos de 5- hidroxitriptamina-6 | |
| CO5680438A2 (es) | Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas | |
| PE20050420A1 (es) | Fenacilo 2-hidroxi-3-diaminoalcanos | |
| PE20011212A1 (es) | Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant, registration | ||
| FD | Application declared void or lapsed |