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AR058562A1 - Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 - Google Patents

Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1

Info

Publication number
AR058562A1
AR058562A1 ARP060105620A ARP060105620A AR058562A1 AR 058562 A1 AR058562 A1 AR 058562A1 AR P060105620 A ARP060105620 A AR P060105620A AR P060105620 A ARP060105620 A AR P060105620A AR 058562 A1 AR058562 A1 AR 058562A1
Authority
AR
Argentina
Prior art keywords
dgat
inhibitors
pirimido
acetil
oxazines
Prior art date
Application number
ARP060105620A
Other languages
English (en)
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37806230&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR058562(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of AR058562A1 publication Critical patent/AR058562A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Los compuestos de la presente, son inhibidores de DGAT-1 y son por ende utiles en el tratamiento de, por ejemplo, la obesidad. También se dscriben procesos para preparar los compuestos. Reivindicacion 1: Un compuesto de la formula (1) o su sal, donde: R1 se selecciona entre H, metilo y trifluormetilo; R2 es H, Cl o F; el anillo A es bicicloalcanodiilo C7-10 o tricicloalcanodiilo C8-12; R3 es carboxi o un mímico de ácido carboxílico o bioisotero; R4 y R5 son cada uno independientemente H metilo; n es 0 o 1.
ARP060105620A 2005-12-22 2006-12-19 Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1 AR058562A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US75331205P 2005-12-22 2005-12-22

Publications (1)

Publication Number Publication Date
AR058562A1 true AR058562A1 (es) 2008-02-13

Family

ID=37806230

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP060105620A AR058562A1 (es) 2005-12-22 2006-12-19 Derivados de pirimido [4,5 b] (1,4) oxazinas , procedimientos de obtencion y su uso como inhibidores de acetil coa y dgat 1

Country Status (9)

Country Link
US (2) US7749997B2 (es)
EP (1) EP1966221A1 (es)
JP (1) JP2009520786A (es)
CN (1) CN101346387A (es)
AR (1) AR058562A1 (es)
CL (1) CL2006003672A1 (es)
TW (1) TW200732341A (es)
UY (1) UY30050A1 (es)
WO (1) WO2007071966A1 (es)

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EP2301923B1 (en) 2006-03-31 2016-06-08 Novartis AG Pyridine derivatives as dgat inhibitors
EP2041099A1 (en) 2006-05-30 2009-04-01 AstraZeneca AB 1, 3, 4 -oxadiazole derivatives as dgat1 inhibitors
MX2008015228A (es) 2006-05-30 2008-12-12 Astrazeneca Ab Acido 5-fenilamino-1,3,4-oxadiazol-2-ilcarbonilamino-4-fenoxi-cicl ohexanocarboxilico sustituido como inhibidor de diacilglicerol aciltransferasa de acetil coenzima a.
DE602007012875D1 (de) * 2006-06-08 2011-04-14 Astrazeneca Ab Benzimidazole und ihre verwendung zur behandlung von diabetes
RU2470017C2 (ru) 2007-06-08 2012-12-20 Янссен Фармацевтика Н.В. Производные пиперидина/пиперазина
CA2687912C (en) 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687918C (en) 2007-06-08 2016-11-08 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
US20090036425A1 (en) * 2007-08-02 2009-02-05 Pfizer Inc Substituted bicyclolactam compounds
BRPI0815490A2 (pt) * 2007-08-17 2017-03-21 Astrazeneca Ab composto, composição faramcêutica, método para tratar diabetes mellitus e/ou obesidade em um animal de sangue quente, e, processo para preparar um composto
AR066169A1 (es) 2007-09-28 2009-07-29 Novartis Ag Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat
WO2009081195A1 (en) 2007-12-20 2009-07-02 Astrazeneca Ab Carbamoyl compounds as dgat1 inhibitors 190
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CA2747306A1 (en) * 2008-12-19 2010-06-24 Astrazeneca Ab 1,3,4-oxadiazole derivatives and their uses to treat diabetes
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WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
WO2013068328A1 (en) * 2011-11-07 2013-05-16 Intervet International B.V. Bicyclo [2.2.2] octan-1-ylcarboxylic acid compounds as dgat-1 inhibitors
JP2016516708A (ja) 2013-03-14 2016-06-09 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ ビシクロ［２．２．２］酸のｇｐｒ１２０モジュレーター
CN112552158B (zh) * 2020-12-09 2023-05-19 南京工业大学 一种含酮羧酸结构的高吸收铬鞣助剂的制备及应用
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Also Published As

Publication number Publication date
CL2006003672A1 (es) 2008-02-08
EP1966221A1 (en) 2008-09-10
JP2009520786A (ja) 2009-05-28
US20080306059A1 (en) 2008-12-11
CN101346387A (zh) 2009-01-14
WO2007071966A1 (en) 2007-06-28
UY30050A1 (es) 2007-07-31
US8017603B2 (en) 2011-09-13
TW200732341A (en) 2007-09-01
US20100311737A1 (en) 2010-12-09
US7749997B2 (en) 2010-07-06

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