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CO5680438A2 - Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas - Google Patents

Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas

Info

Publication number
CO5680438A2
CO5680438A2 CO05004450A CO05004450A CO5680438A2 CO 5680438 A2 CO5680438 A2 CO 5680438A2 CO 05004450 A CO05004450 A CO 05004450A CO 05004450 A CO05004450 A CO 05004450A CO 5680438 A2 CO5680438 A2 CO 5680438A2
Authority
CO
Colombia
Prior art keywords
substituted
alkyl
group
aryl
carbon
Prior art date
Application number
CO05004450A
Other languages
English (en)
Inventor
Kern Jeffrey Curtis
Original Assignee
Wyeth Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp filed Critical Wyeth Corp
Publication of CO5680438A2 publication Critical patent/CO5680438A2/es

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425Thiazoles
    • A61K31/4261,3-Thiazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/536Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with carbocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18Feminine contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28Antiandrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30Oestrogens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1.- El uso del compuesto de la fórmula I o la fórmula II, o un tautómero del mismo, en la preparación de un medicamento para el uso en la inducción de la contracepción, dicho medicamento usado en combinación con al menos un modulador del receptor de estrógeno selectivo, caracterizado porque:la fórmula I tiene la estructura: en donde:R1 y R2 son sustituyentes independientes seleccionados del grupo que consiste de H, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C2 a C6, alquenilo C2 a C6 sustituido, alquinilo C2 a C6, alquinilo C2 a C6 sustituido, cicloalquilo C3 a C8, cicloalquilo C3 a C8 sustituido, arilo, arilo sustituido, anillo heterocíclico basado en carbono que tiene en su esqueleto 1 a 3 heteroátomos, anillo heterocíclico basado en carbono sustituido que tiene en su esqueleto 1 a 3 heteroátomos, CORA, y NRBCORA;ó R1 y R2 están fusionados para formar un anillo seleccionado del grupo que consiste de a), b) y c), en donde dicho anillo es opcionalmente sustituido por 1 a 3 sustituyentes seleccionados del grupo que consiste de H y alquilo C1 a C3;a) un anillo espirocíclico saturado de 3 a 8 miembros basado en carbono;b) un anillo espirocíclico de 3 a 8 miembros basado en carbono que tiene uno o más dobles enlaces carbono carbono; y c) un anillo espirocíclico de 3 a 8 miembros que tiene en su esqueleto uno a tres heteroátomos seleccionados del grupo que consiste de O, S y N;RA es seleccionado del grupo que consiste de H, alquilo C1 a C3, alquilo C1 a C3 sustituido, arilo, arilo sustituido, alcoxilo C1 a C3, alcoxilo C1 a C3 sustituido, amino, aminoalquilo C1 a C3, y aminoalquilo C1 a C3 sustituido;RB es seleccionado del grupo que consiste de H, alquilo C1 a C3, y alquilo C1 a C3 sustituido;R3 es seleccionado del grupo que consiste de H, OH, NH2, alquilo C1 a C6, alquilo C1 a C6 sustituido, alquenilo C3 a C6, alquenilo C3 a C6 sustituido, alquinilo, alquinilo sustituido, y CORC;RC es seleccionado del grupo que consiste de H, alquilo C1 a C4, alquilo C1 a C4 sustituido, arilo, arilo sustituido, ...
CO05004450A 2002-06-25 2005-01-20 Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas CO5680438A2 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39187102P 2002-06-25 2002-06-25

Publications (1)

Publication Number Publication Date
CO5680438A2 true CO5680438A2 (es) 2006-09-29

Family

ID=30000766

Family Applications (1)

Application Number Title Priority Date Filing Date
CO05004450A CO5680438A2 (es) 2002-06-25 2005-01-20 Uso de derivados de ciclotiocarbamato en tratamiento de condiciones relacionadas con hormonas

Country Status (19)

Country Link
US (1) US7192956B2 (es)
EP (1) EP1515725A4 (es)
JP (1) JP2005535624A (es)
KR (1) KR20050013247A (es)
CN (1) CN1662241A (es)
AR (1) AR040333A1 (es)
AU (1) AU2003247608A1 (es)
BR (1) BR0312024A (es)
CA (1) CA2489847A1 (es)
CO (1) CO5680438A2 (es)
CR (1) CR7611A (es)
EC (1) ECSP055576A (es)
IL (1) IL165396A0 (es)
MX (1) MXPA04012421A (es)
NO (1) NO20045216L (es)
RU (1) RU2005101638A (es)
TW (1) TW200404548A (es)
WO (1) WO2004000801A2 (es)
ZA (1) ZA200410411B (es)

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US6391907B1 (en) * 1999-05-04 2002-05-21 American Home Products Corporation Indoline derivatives
US6509334B1 (en) 1999-05-04 2003-01-21 American Home Products Corporation Cyclocarbamate derivatives as progesterone receptor modulators
US6407101B1 (en) * 1999-05-04 2002-06-18 American Home Products Corporation Cyanopyrroles
US6355648B1 (en) * 1999-05-04 2002-03-12 American Home Products Corporation Thio-oxindole derivatives
UA73119C2 (en) * 2000-04-19 2005-06-15 American Home Products Corpoir Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors
CA2489813A1 (en) * 2002-06-25 2003-12-31 Wyeth Use of thio-oxindole derivatives in treatment of hormone-related conditions
US20040248989A1 (en) 2003-06-05 2004-12-09 Risto Santti Method for the treatment or prevention of lower urinary tract symptoms
ES2313334T3 (es) * 2004-04-08 2009-03-01 Wyeth Procedimientos para mimimizar las impurezas de tiomida.
MXPA06011696A (es) * 2004-04-08 2006-12-14 Wyeth Corp Derivados de tioamida como moduladores del receptor de progesterona.
WO2005105739A2 (en) * 2004-04-27 2005-11-10 Wyeth Cyanopyrrole containing cyclic carbamate and thiocarbamate biaryls and methods for preparing the same
EP1778710B1 (en) * 2004-08-13 2012-01-18 Wyeth LLC Tanaproget derivatives, metabolites, and uses thereof
US7399766B2 (en) * 2004-08-18 2008-07-15 Parion Sciences, Inc. Soluble amide & ester pyrazinoylguanidine sodium channel blockers
US7496489B2 (en) 2004-08-20 2009-02-24 Wyeth Design of progesterone receptor ligands
US20060246128A1 (en) * 2005-04-28 2006-11-02 Wyeth Micronized tanaproget and compositions containing same
AU2011226814B2 (en) * 2005-04-28 2013-06-13 Wyeth Llc Micronized tanaproget, compositions, and methods of preparing the same
GT200600173A (es) * 2005-04-28 2006-11-22 Forma purificada de tranaproget
MX2007013465A (es) 2005-04-28 2008-01-21 Wyeth Corp Tanaproget micronizado, composiciones y metodos para preparar las mismas.
DK1874278T3 (da) * 2005-04-28 2009-09-28 Wyeth Corp Sammensætninger indeholdende mikroniseret tanaproget
CN101166736B (zh) * 2005-04-28 2013-02-06 惠氏公司 他那普戈特的多晶型ⅱ
AU2011203520B2 (en) * 2005-04-28 2012-06-14 Wyeth Micronized tanaproget and compostions containing same
US20060280800A1 (en) * 2005-06-09 2006-12-14 Wyeth Tanaproget compositions containing ethinyl estradiol
EP2097401A1 (en) * 2006-12-22 2009-09-09 F. Hoffmann-Roche AG Processes for the preparation of (3r, 4r) -n- (4 -chlorophenyl) -1- (2, 2-difluoroethyl) -n' - [2-fluoro-4- (2-oxo-1 (2h) -pyridinyl) phenyl]-3, 4-pyrrolidinedicarboxamide
EA201070715A1 (ru) 2007-12-20 2011-02-28 Тева Вимен'С Хелс, Инк. Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции
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JP2013504531A (ja) * 2009-09-11 2013-02-07 バイエル・ファルマ・アクチェンゲゼルシャフト 抗癌薬としての置換(ヘテロアリールメチル)チオヒダントイン
ES2627692T3 (es) 2010-06-10 2017-07-31 Aragon Pharmaceuticals, Inc. Moduladores de receptores de estrógenos y usos de los mismos
EA029559B1 (ru) 2011-12-14 2018-04-30 Серагон Фармасьютикалс, Инк. Фторированные модуляторы рецепторов эстрогенов и их применение
US20170014174A1 (en) * 2015-07-17 2017-01-19 Candela Corporation Cryogenic Cylinder

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Also Published As

Publication number Publication date
WO2004000801A2 (en) 2003-12-31
EP1515725A2 (en) 2005-03-23
ECSP055576A (es) 2005-04-18
WO2004000801A3 (en) 2004-03-25
CN1662241A (zh) 2005-08-31
CR7611A (es) 2006-05-30
RU2005101638A (ru) 2006-01-20
MXPA04012421A (es) 2005-04-19
US7192956B2 (en) 2007-03-20
NO20045216L (no) 2005-01-24
CA2489847A1 (en) 2003-12-31
AR040333A1 (es) 2005-03-30
IL165396A0 (en) 2006-01-15
US20040006060A1 (en) 2004-01-08
TW200404548A (en) 2004-04-01
JP2005535624A (ja) 2005-11-24
EP1515725A4 (en) 2005-09-21
BR0312024A (pt) 2005-03-22
ZA200410411B (en) 2007-06-27
AU2003247608A1 (en) 2004-01-06
KR20050013247A (ko) 2005-02-03

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