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CO5280079A1 - Nuevos compuestos - Google Patents

Nuevos compuestos

Info

Publication number
CO5280079A1
CO5280079A1 CO00083137A CO00083137A CO5280079A1 CO 5280079 A1 CO5280079 A1 CO 5280079A1 CO 00083137 A CO00083137 A CO 00083137A CO 00083137 A CO00083137 A CO 00083137A CO 5280079 A1 CO5280079 A1 CO 5280079A1
Authority
CO
Colombia
Prior art keywords
alkyl
hydrogen
independently represent
heteroaryl
aryl
Prior art date
Application number
CO00083137A
Other languages
English (en)
Inventor
David Gurley
James Rosamond
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of CO5280079A1 publication Critical patent/CO5280079A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/22Anxiolytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/30Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34Tobacco-abuse
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/10Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/12Radicals substituted by oxygen atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04Indoles; Hydrogenated indoles
    • C07D209/30Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/42Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyridine Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Un compuesto de la fórmula I <EMI FILE="00083137_1" ID="1" IMF=JPEG >en donde:R1 representa hidrógeno, alquil C1-C4, alquenil C2-C4, alquinil C2-C4, o (CH2)nAr;W representa C(O), C(O)O, C(O)NR6, o un enlace;R2 representa hidrógeno, Ar, o (CH2)pCH[(CH2)qR7](CH2)tR8; o juntos R2 y R6 representan (CH2)jY(CH2)k;R3 y R5 independientemente representan hidrógeno, halógeno, o alquil C1-C4;X representa oxígeno, o NH;R4 representa hidrógeno, alquil C1-C4, (CH2)uAr, R9CO, o R9SO2;R6 representa hidrógeno, alquil C1-C4, aril, o heteroaril; o R2 y R6 juntos representan (CH2)j Y(CH2)k;R7 y R8 independientemente representan hidrógeno, halógeno, CN, -C=CH, N3, CF3, NO2, Ar, OR10, NR10R11, C(O)OR10, OC(O)R10, C(O)NR10R11, NR10C(O)R11, SO2NR10R11, o NR10SO2R11.R9 representa alquil C1-C4, o Ar;Ar representa fenil, naftil, o un anillo heterocíclico de 5- o 6-miembros que contiene 0-3 nitrógenos, 0-1 azufres y 0-1 oxígenos;Ar es opcionalmente substituido con uno o más substituyentes independientemente seleccionados entre: hidrógeno, halógeno, alquil C1-C4, alquenil C2-C4, alquinil C2-C4, (CH2)naril, CN, NO2, CF3 OR12 NR12 R13 y , COOR12;R10, R11, R12 y R13 independientemente representan hidrógeno, alquil C1-C4, aril, o heteroaril; o R10 y R11 juntos y/o R12 y R13 independientemente representan (CH2)jY(CH2)k;Y representa oxígeno, azufre, NR14, o un enlace;j es 2-4;k, m, n, p, q, t, y u son independientemente 0-2;R14 representa hidrógeno, alquil C1-C4, aril o heteroarilo un enantiómero del mismo, y sales farmacéuticamente aceptables del mismo.
CO00083137A 1999-11-03 2000-11-01 Nuevos compuestos CO5280079A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9903998A SE9903998D0 (sv) 1999-11-03 1999-11-03 New compounds

Publications (1)

Publication Number Publication Date
CO5280079A1 true CO5280079A1 (es) 2003-05-30

Family

ID=20417608

Family Applications (1)

Application Number Title Priority Date Filing Date
CO00083137A CO5280079A1 (es) 1999-11-03 2000-11-01 Nuevos compuestos

Country Status (16)

Country Link
US (2) US7064143B1 (es)
EP (1) EP1230218A1 (es)
JP (1) JP2003513073A (es)
KR (1) KR20020063175A (es)
CN (1) CN1216864C (es)
AU (1) AU783602B2 (es)
BR (1) BR0015193A (es)
CA (1) CA2387741A1 (es)
CO (1) CO5280079A1 (es)
IL (1) IL149096A0 (es)
MX (1) MXPA02004240A (es)
NO (1) NO323077B1 (es)
NZ (1) NZ518449A (es)
SE (1) SE9903998D0 (es)
WO (1) WO2001032622A1 (es)
ZA (1) ZA200203181B (es)

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GB0205175D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
GB0205176D0 (en) 2002-03-06 2002-04-17 Astrazeneca Ab Chemical compounds
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SK288115B6 (sk) 2002-09-25 2013-09-03 Memory Pharmaceuticals Corporation Indazoles, pharmaceutical compositions comprising them and their use
GB0222909D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
GB0222912D0 (en) 2002-10-03 2002-11-13 Astrazeneca Ab Novel process and intermediates
US7405210B2 (en) 2003-05-21 2008-07-29 Osi Pharmaceuticals, Inc. Pyrrolopyridine-2-carboxylic acid amide inhibitors of glycogen phosphorylase
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JP4698671B2 (ja) 2004-06-01 2011-06-08 エフ.ホフマン−ラ ロシュ アーゲー モノアミン再取り込み阻害剤としての3−アミノ−1−アリールプロピルインドール
AU2005284908B2 (en) 2004-09-13 2011-12-08 Morningside Venture Investments Limited Biosynchronous transdermal drug delivery
US8252321B2 (en) 2004-09-13 2012-08-28 Chrono Therapeutics, Inc. Biosynchronous transdermal drug delivery for longevity, anti-aging, fatigue management, obesity, weight loss, weight management, delivery of nutraceuticals, and the treatment of hyperglycemia, alzheimer's disease, sleep disorders, parkinson's disease, aids, epilepsy, attention deficit disorder, nicotine addiction, cancer, headache and pain control, asthma, angina, hypertension, depression, cold, flu and the like
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Also Published As

Publication number Publication date
NO20022105L (no) 2002-07-02
NZ518449A (en) 2004-07-30
NO20022105D0 (no) 2002-05-02
MXPA02004240A (es) 2002-10-17
IL149096A0 (en) 2002-11-10
WO2001032622A1 (en) 2001-05-10
US7402604B2 (en) 2008-07-22
BR0015193A (pt) 2002-06-18
JP2003513073A (ja) 2003-04-08
CA2387741A1 (en) 2001-05-10
US20050245595A1 (en) 2005-11-03
NO323077B1 (no) 2006-12-27
US7064143B1 (en) 2006-06-20
SE9903998D0 (sv) 1999-11-03
AU783602B2 (en) 2005-11-10
ZA200203181B (en) 2003-07-22
EP1230218A1 (en) 2002-08-14
KR20020063175A (ko) 2002-08-01
CN1216864C (zh) 2005-08-31
CN1387513A (zh) 2002-12-25
AU1426301A (en) 2001-05-14

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