PE20011212A1 - Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica - Google Patents
Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronicaInfo
- Publication number
- PE20011212A1 PE20011212A1 PE2001000357A PE2001000357A PE20011212A1 PE 20011212 A1 PE20011212 A1 PE 20011212A1 PE 2001000357 A PE2001000357 A PE 2001000357A PE 2001000357 A PE2001000357 A PE 2001000357A PE 20011212 A1 PE20011212 A1 PE 20011212A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- halogen
- treatment
- compounds
- chronic fatigue
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 3
- 206010008874 Chronic Fatigue Syndrome Diseases 0.000 title abstract 2
- 208000001640 Fibromyalgia Diseases 0.000 title abstract 2
- 208000029766 myalgic encephalomeyelitis/chronic fatigue syndrome Diseases 0.000 title abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 4
- -1 CYANE Chemical class 0.000 abstract 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 abstract 2
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical group [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical compound C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Proteins 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 1
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical class [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000003857 carboxamides Chemical class 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/48—Ergoline derivatives, e.g. lysergic acid, ergotamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Heterocyclic Compounds Containing Sulfur Atoms (AREA)
Abstract
SE REFIERE AL USO DE COMPUESTOS TIPO a)AMINA HETEROCICLICA DE FORMULA A; R1, R2, R3 SON H, ALQUILO C1-C6, ALQUENILO C3-C5, ENTRE OTROS; X ES H, ALQUILO C1-C6, HALOGENO, CIANO, CARBOXAMIDA, CARBOXILO, ENTRE OTROS; A ES CH, CH2, CH- HALOGENO, CHCH3, CO, CS, ENTRE OTROS; B ES CH2, CH, CH-HALOGENO, CO, ENTRE OTROS; n ES 0-1; D ES CH, CH2, CH-HALOGENO, ENTRE OTROS. b)FENILAZACICLOALCANO DE FORMULA B; n ES 0-3; R1 Y R2 SON H, OH, CN, CH2CN, 4-CF3, ENTRE OTROS; R3 ES H, CF3, CH2CF3, ENTRE OTROS; R4 ES H, CF3, CH2CF3, ALQUILO C1-C8, ENTRE OTROS; R5 ES FENILO, 2-TIOFENILO, ENTRE OTROS; R6 Y R7 SON H, ALQUILO C1-C8, CICLOALQUILO C3-C8, ENTRE OTROS; c)CABERGOLINA DE FORMULA C; PARA LA PREPARACION DE UN MEDICAMENTO PARA EL TRATAMIENTO DE SINTOMAS DE SINDROME DE FIBROMIALGIA, SINDROME DE FATIGA CRONICA. SON COMPUESTOS PREFERIDOS (Z)-2-BUTENDIOATO DE (R)-5,6-DIHIDRO-5-(METILAMINO)-4H-IMIDAZOL[4,5,1-ij]-QUINOLIN-2(1H)ONA, CLORHIDRATO DE (3S)-3-[3-(METILSULFONIL)FENIL]-1-PROPILPIPERIDINA, 1-((6-ALILERGOLIN-8ß-IL)-CARBONIL)-1-[3-(DIMETILAMINO)PROPIL)-3-ETILUREA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19895900P | 2000-04-21 | 2000-04-21 | |
| US20056900P | 2000-04-28 | 2000-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20011212A1 true PE20011212A1 (es) | 2001-11-21 |
Family
ID=26894316
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2001000357A PE20011212A1 (es) | 2000-04-21 | 2001-04-19 | Compuestos para el tratamiento de la fibromialgia y el sindrome de fatiga cronica |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US6448258B2 (es) |
| EP (1) | EP1274430B1 (es) |
| JP (1) | JP2004502650A (es) |
| KR (1) | KR20040007215A (es) |
| CN (3) | CN1450898A (es) |
| AR (3) | AR028355A1 (es) |
| AT (1) | ATE312608T1 (es) |
| AU (2) | AU5311401A (es) |
| BR (1) | BR0110210A (es) |
| CA (1) | CA2405565A1 (es) |
| DE (1) | DE60115872T2 (es) |
| DK (1) | DK1274430T3 (es) |
| ES (1) | ES2253370T3 (es) |
| NZ (3) | NZ531172A (es) |
| PE (1) | PE20011212A1 (es) |
| WO (1) | WO2001081343A2 (es) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE46117E1 (en) | 1999-12-22 | 2016-08-23 | Teva Pharmaceuticals International Gmbh | Modulators of dopamine neurotransmission |
| AU5522301A (en) * | 2000-04-21 | 2001-11-26 | Upjohn Co | Treatment of fibromyalgia and chronic fatigue syndrome |
| AR033520A1 (es) * | 2000-04-27 | 2003-12-26 | Upjohn Co | (5r)-(metilamino) -5,6-dihidro-4h-imidazo[4,5,1-ij] quinolin-2(1h)-tiona |
| PL363365A1 (en) * | 2000-08-16 | 2004-11-15 | Pharmacia & Upjohn Company | Compounds for the treatment of addictive disorders |
| DE10041478A1 (de) | 2000-08-24 | 2002-03-14 | Sanol Arznei Schwarz Gmbh | Neue pharmazeutische Zusammensetzung |
| AR031152A1 (es) | 2000-10-31 | 2003-09-10 | Upjohn Co | Tratamientos nuevos para el sindrome de piernas inquietas |
| JP2006506360A (ja) * | 2002-10-04 | 2006-02-23 | ファルマシア・コーポレーション | パーキンソン病の治療のための医薬組成物 |
| MXPA05003512A (es) * | 2002-10-04 | 2005-06-03 | Pharmacia Corp | Composiciones y metodos para el tratamiento de la disfuncion sexual. |
| JP2009501184A (ja) | 2005-07-13 | 2009-01-15 | エフ．ホフマン−ラ ロシュ アーゲー | ５−ｈｔ６、５−ｈｔ２４としてのベンゾイミダゾール誘導体 |
| TWI392670B (zh) * | 2006-06-22 | 2013-04-11 | Ucb Pharma Gmbh | 經取代的２-胺基萘滿之於製造用於預防、減緩及／或治療各種類型疼痛之藥物上的用途 |
| ES2332645B1 (es) * | 2009-06-30 | 2010-10-18 | Grifols, S.A. | Utilizacion de alfa-1-antitripsina para la preparacion de medicamentos para el tratamiento del sindrome de fatiga cronica. |
| WO2012039660A1 (en) * | 2010-09-20 | 2012-03-29 | A. Carlsson Research Ab | Phenylpiperidine compounds for the treatment of neurological and psychiatric disorders |
| ES2755827T3 (es) | 2013-03-15 | 2020-04-23 | Incyte Holdings Corp | Heterciclos tricíclicos como inhibidores de proteína BET |
| ES2635560T3 (es) | 2013-07-08 | 2017-10-04 | Incyte Holdings Corporation | Heterociclos tricíclicos como inhibidores de la proteína NET |
| WO2015081203A1 (en) | 2013-11-26 | 2015-06-04 | Incyte Corporation | Bicyclic heterocycles as bet protein inhibitors |
| US9315501B2 (en) | 2013-11-26 | 2016-04-19 | Incyte Corporation | Bicyclic heterocycles as BET protein inhibitors |
| WO2015095492A1 (en) | 2013-12-19 | 2015-06-25 | Incyte Corporation | Tricyclic heterocycles as bet protein inhibitors |
| EP3674302B1 (en) | 2014-04-23 | 2023-03-01 | Incyte Holdings Corporation | 1h-pyrrolo[2,3-c]pyridin-7(6h)-ones and pyrazolo[3,4-c]pyridin-7(6h)-ones as inhibitors of bet proteins |
| DE102014008742A1 (de) * | 2014-06-12 | 2015-12-17 | Daimler Ag | Separator für einen elektrochemischen Speicher, Verfahren zur Herstellung eines Elektrodenmaterials sowie elektrochemischer Energiespeicher |
| US9527864B2 (en) | 2014-09-15 | 2016-12-27 | Incyte Corporation | Tricyclic heterocycles as BET protein inhibitors |
| EP3294337B1 (en) * | 2015-05-13 | 2024-12-18 | Arvid Carlsson Research AB | Treatment of debilitating fatigue by combined use of 3(s)-3-[3-(methylsulfonyl)phenyl]-1- propylpiperidine and an anti-depressive agent |
| AR106520A1 (es) | 2015-10-29 | 2018-01-24 | Incyte Corp | Forma sólida amorfa de un inhibidor de proteína bet |
| CN114366748A (zh) | 2016-06-20 | 2022-04-19 | 因赛特公司 | Bet抑制剂的结晶固体形式 |
| US11833155B2 (en) | 2020-06-03 | 2023-12-05 | Incyte Corporation | Combination therapy for treatment of myeloproliferative neoplasms |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4526892A (en) * | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
| US5273975A (en) | 1989-06-09 | 1993-12-28 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
| DE69016430T2 (de) | 1989-06-09 | 1995-06-01 | Upjohn Co | Heterozyklische amine mit zns-wirksamkeit. |
| ES2157204T3 (es) | 1991-04-17 | 2001-08-16 | Upjohn Co | Derivados de (s)-3-fenilpiperidina sustituidos, su preparacion y uso como antagonistas de autorreceptores de dopamina. |
| WO1995004056A1 (en) | 1993-07-27 | 1995-02-09 | The Upjohn Company | Heterocyclic amines having central nervous system activity |
| JPH1053525A (ja) * | 1996-06-06 | 1998-02-24 | Bitakain Seiyaku Kk | 疼痛治療剤 |
| US6455564B1 (en) | 1999-01-06 | 2002-09-24 | Pharmacia & Upjohn Company | Method of treating sexual disturbances |
| AU3490300A (en) * | 1999-03-12 | 2000-10-04 | Nitromed, Inc. | Dopamine agonists in combination with nitric oxide donors, compositions and methods of use |
| ATE319453T1 (de) | 1999-07-01 | 2006-03-15 | Pharmacia & Upjohn Co Llc | Reboxetin zur behandlung von fibromyalgie und anderen somatoformen störungen |
| DE19938823A1 (de) * | 1999-08-19 | 2001-02-22 | Boehringer Ingelheim Pharma | Medikamentöse Behandlung des Restless Leg Syndroms |
| WO2001015677A2 (en) * | 1999-08-31 | 2001-03-08 | Alcon Laboratories, Inc. | Use of 5-ht1b/1d agonists to treat otic pain |
-
2001
- 2001-04-17 NZ NZ531172A patent/NZ531172A/en unknown
- 2001-04-17 NZ NZ531171A patent/NZ531171A/en unknown
- 2001-04-17 DE DE60115872T patent/DE60115872T2/de not_active Expired - Fee Related
- 2001-04-17 CN CN01806849A patent/CN1450898A/zh active Pending
- 2001-04-17 AU AU5311401A patent/AU5311401A/xx active Pending
- 2001-04-17 AU AU2001253114A patent/AU2001253114B2/en not_active Ceased
- 2001-04-17 KR KR1020027014072A patent/KR20040007215A/ko not_active Withdrawn
- 2001-04-17 BR BR0110210-9A patent/BR0110210A/pt not_active IP Right Cessation
- 2001-04-17 WO PCT/US2001/010807 patent/WO2001081343A2/en not_active Ceased
- 2001-04-17 CA CA002405565A patent/CA2405565A1/en not_active Abandoned
- 2001-04-17 ES ES01926590T patent/ES2253370T3/es not_active Expired - Lifetime
- 2001-04-17 DK DK01926590T patent/DK1274430T3/da active
- 2001-04-17 AT AT01926590T patent/ATE312608T1/de not_active IP Right Cessation
- 2001-04-17 NZ NZ522112A patent/NZ522112A/en unknown
- 2001-04-17 EP EP01926590A patent/EP1274430B1/en not_active Expired - Lifetime
- 2001-04-17 CN CNA2004100476391A patent/CN1554341A/zh active Pending
- 2001-04-17 JP JP2001578433A patent/JP2004502650A/ja active Pending
- 2001-04-17 CN CNA2004100476387A patent/CN1554343A/zh active Pending
- 2001-04-17 US US09/836,660 patent/US6448258B2/en not_active Expired - Fee Related
- 2001-04-19 PE PE2001000357A patent/PE20011212A1/es not_active Application Discontinuation
- 2001-04-20 AR ARP010101861A patent/AR028355A1/es unknown
-
2002
- 2002-05-30 US US10/159,913 patent/US6555548B2/en not_active Expired - Fee Related
-
2003
- 2003-03-07 US US10/383,467 patent/US20030191149A1/en not_active Abandoned
- 2003-04-10 AR ARP030101258A patent/AR039632A2/es unknown
- 2003-04-10 AR ARP030101259A patent/AR039633A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CN1554343A (zh) | 2004-12-15 |
| NZ522112A (en) | 2004-10-29 |
| NZ531172A (en) | 2005-07-29 |
| ES2253370T3 (es) | 2006-06-01 |
| KR20040007215A (ko) | 2004-01-24 |
| DK1274430T3 (da) | 2006-02-13 |
| CN1554341A (zh) | 2004-12-15 |
| DE60115872T2 (de) | 2006-07-13 |
| US20030191149A1 (en) | 2003-10-09 |
| EP1274430B1 (en) | 2005-12-14 |
| ATE312608T1 (de) | 2005-12-15 |
| NZ531171A (en) | 2005-03-24 |
| BR0110210A (pt) | 2003-01-28 |
| AR039633A2 (es) | 2005-03-02 |
| DE60115872D1 (de) | 2006-01-19 |
| CN1450898A (zh) | 2003-10-22 |
| AU2001253114B2 (en) | 2005-08-25 |
| US6555548B2 (en) | 2003-04-29 |
| AU5311401A (en) | 2001-11-07 |
| EP1274430A2 (en) | 2003-01-15 |
| WO2001081343A3 (en) | 2002-02-28 |
| WO2001081343A2 (en) | 2001-11-01 |
| AR028355A1 (es) | 2003-05-07 |
| JP2004502650A (ja) | 2004-01-29 |
| CA2405565A1 (en) | 2001-11-01 |
| US20020143010A1 (en) | 2002-10-03 |
| US6448258B2 (en) | 2002-09-10 |
| US20020004510A1 (en) | 2002-01-10 |
| AR039632A2 (es) | 2005-03-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FC | Refusal |