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PE20021003A1 - Fenil-heterociclil-eteres como inhibidores selectivos de la recaptacion de serotonina (ssri) - Google Patents

Fenil-heterociclil-eteres como inhibidores selectivos de la recaptacion de serotonina (ssri)

Info

Publication number
PE20021003A1
PE20021003A1 PE2002000290A PE2002000290A PE20021003A1 PE 20021003 A1 PE20021003 A1 PE 20021003A1 PE 2002000290 A PE2002000290 A PE 2002000290A PE 2002000290 A PE2002000290 A PE 2002000290A PE 20021003 A1 PE20021003 A1 PE 20021003A1
Authority
PE
Peru
Prior art keywords
heterocyclyl
phenyl
recaptation
etheres
ssri
Prior art date
Application number
PE2002000290A
Other languages
English (en)
Inventor
Mavis Diane Adam
Mark David Andrews
David Hepworth
Donald Stuart Middleton
Alan Stobie
Harry Ralph Howard Jr
Geoffrey Edward Gymer
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PE20021003A1 publication Critical patent/PE20021003A1/es

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    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/79—Acids; Esters
    • C07D213/80—Acids; Esters in position 3
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Addiction (AREA)
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  • Endocrinology (AREA)
  • Psychology (AREA)
  • Reproductive Health (AREA)
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  • Hematology (AREA)
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  • Rheumatology (AREA)
  • Urology & Nephrology (AREA)
  • Obesity (AREA)
  • Anesthesiology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Child & Adolescent Psychology (AREA)
  • Nutrition Science (AREA)
  • Hospice & Palliative Care (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A FENIL-HETEROCICLIL-ETERES DE FORMULA I DONDE L Y U SON -N-, -N(O)-, -CH-; M Y Q SON -N-, -N(O)-, -CR4- DONDE EL ANILLO A CONTIENE 1-2 ATOMOS DE N; R1 Y R2 SON H, ALQUILO C1-C6, (CH2)m(CICLOALQUILO C3-C6) DONDE m ES 0-3; R1 Y R2 JUNTO A N FORMAN UN ANILLO DE AZETIDINA; W, Y, Z SON H, HALOGENO, ALQUILO C1-C6, CF3, OCF3, ENTRE OTROS; R4 ES A-X DONDE A ES -(CH2)p- DONDE p ES 0-2; X ES H, CONR6R7, SO2NR6R7, ENTRE OTROS. SON COMPUESTOS PREFERIDOS N-METIL-N-({4-[4-(METILSULFANIL)FENOXI]-3-PIRIDINIL}METIL)AMINA, N-({4-[3-CLORO-4-(METILSULFANIL)FENOXI]-3-PIRIDINIL}METIL)-N-METILAMINA, ENTRE OTROS. LOS COMPUESTOS MENCIONADOS SON UTILES PARA EL TRATAMIENTO HIPERTENSION, ANSIEDAD, FOBIAS
PE2002000290A 2001-04-11 2002-04-10 Fenil-heterociclil-eteres como inhibidores selectivos de la recaptacion de serotonina (ssri) PE20021003A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0109103.2A GB0109103D0 (en) 2001-04-11 2001-04-11 Novel compounds

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PE20021003A1 true PE20021003A1 (es) 2002-11-12

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EP (1) EP1377550B9 (es)
JP (1) JP2005504728A (es)
KR (1) KR100570376B1 (es)
CN (1) CN1656072A (es)
AP (1) AP1543A (es)
AR (1) AR035818A1 (es)
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AU (1) AU2002244898B2 (es)
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JP3916871B2 (ja) * 1999-02-23 2007-05-23 ファイザー・プロダクツ・インク Ｃｎｓ障害の治療のためのモノアミン再吸収阻害剤
MXPA01011905A (es) * 1999-05-21 2004-03-19 Biovitrum Ab Compuestos novedosos, su uso y preparacion.
NZ517696A (en) * 1999-10-13 2004-12-24 Pfizer Prod Inc Biaryl ether derivatives useful as monoamine reuptake inhibitors

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AR035818A1 (es) 2004-07-14
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CN1656072A (zh) 2005-08-17
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ATE281435T1 (de) 2004-11-15
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