PE20040837A1 - Compuestos de amina - Google Patents
Compuestos de aminaInfo
- Publication number
- PE20040837A1 PE20040837A1 PE2003001164A PE2003001164A PE20040837A1 PE 20040837 A1 PE20040837 A1 PE 20040837A1 PE 2003001164 A PE2003001164 A PE 2003001164A PE 2003001164 A PE2003001164 A PE 2003001164A PE 20040837 A1 PE20040837 A1 PE 20040837A1
- Authority
- PE
- Peru
- Prior art keywords
- carbonyl
- group
- dimethylamine
- hydrocarbon
- piperidinocarboxamide
- Prior art date
Links
- -1 AMINE COMPOUNDS Chemical class 0.000 title abstract 6
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 abstract 6
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical class [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 4
- 150000002430 hydrocarbons Chemical class 0.000 abstract 3
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 abstract 2
- OCBFFGCSTGGPSQ-UHFFFAOYSA-N [CH2]CC Chemical class [CH2]CC OCBFFGCSTGGPSQ-UHFFFAOYSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical class [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 2
- 108050001286 Somatostatin Receptor Proteins 0.000 abstract 1
- 102000011096 Somatostatin receptor Human genes 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001721 carbon Chemical group 0.000 abstract 1
- 230000001351 cycling effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Child & Adolescent Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Abstract
SE REFIERE A DERIVADOS DE AMINA DE FORMULA I DONDE A ES UN ANILLO AROMATICO; B, Y E Ya SON UN ENLACE ESPACIADOR QUE TIENE UNA CADENA PRINCIPAL DE 1 A 6 ATOMOS; R1 Y R2 SON H, UN HIDROCARBURO QUE TIENE UN GRUPO HETEROCICLO GRUPO; R1 Y R2 JUNTO AL ATOMO DE N ADYACENTE FORMA UN ANILLO HETEROCICLICO; R3 ES H, GRUPO HIDROCARBURO , GRUPO HETEROCICLICO; R4 Y R5 SON H, HIDROCARBURO O JUNTO AL ATOMO DE CARBONO ADYACENTE FORMAN UN ANILLO; R6 ES UN GRUPO INDOLILO; Z Y Za SON H, HALO, GRUPO CICLICO. SON COMPUESTOS PREFERIDOS N-((1R,2S)-1-(((5-((DIMETILAMINO)METIL)-2-((METILAMINO)CARBONIL)FENIL)AMINO)CARBONIL)-2-(1H-INDOL-3-IL)PROPIL)-4-(2-METILFENIL)-1-PIPERIDINOCARBOXAMIDA; N-((1R,2S)-1-(((2-((DIMETILAMINO)CARBONIL)-5-((DIMETILAMINO)METIL)FENIL)AMINO)CARBONIL)-2-(1H-INDOL-3- IL)PROPIL)-4-(4-FLUOROFENIL)-1- PIPERIDINOCARBOXAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS MENCIONADOS TIENEN ACTIVIDAD INHIBIDORA DEL ENLACE DEL RECEPTOR DE SOMATOSTATINA
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002335661 | 2002-11-19 | ||
| JP2003076435 | 2003-03-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20040837A1 true PE20040837A1 (es) | 2004-12-24 |
Family
ID=32328326
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2003001164A PE20040837A1 (es) | 2002-11-19 | 2003-11-18 | Compuestos de amina |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060223826A1 (es) |
| EP (1) | EP1562898A1 (es) |
| AR (1) | AR042064A1 (es) |
| AU (1) | AU2003280838A1 (es) |
| CA (1) | CA2506735A1 (es) |
| PE (1) | PE20040837A1 (es) |
| TW (1) | TW200420559A (es) |
| WO (1) | WO2004046107A1 (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20070171A1 (es) | 2005-06-30 | 2007-03-08 | Boehringer Ingelheim Int | GLICINAMIDAS SUSTITUIDAS CON EFECTO ANTITROMBOTICO E INHIBIDOR DEL FACTOR Xa |
| CN100391938C (zh) * | 2005-09-02 | 2008-06-04 | 上海奥博生物医药技术有限公司 | (s)-n-乙基-n-甲基-3-[1-(二甲氨基)乙基]-氨基甲酸苯酯(ⅰ)及其酒石酸盐(ⅱ)的制备方法 |
| GB0601031D0 (en) * | 2006-01-18 | 2006-03-01 | Novartis Ag | Organic compounds |
| KR100795462B1 (ko) * | 2006-09-27 | 2008-01-16 | 한국생명공학연구원 | 인돌 유도체, 이의 제조방법 및 이를 유효성분으로함유하는 대사성 질환 예방 및 치료용 약학적 조성물 |
| CN102159545A (zh) * | 2008-06-04 | 2011-08-17 | 阿斯利康(瑞典)有限公司 | 小分子瘦蛋白受体调节剂 |
| RU2013126657A (ru) | 2010-11-15 | 2014-12-27 | Эббви Инк. | Ингибиторы nampt и rock |
| EP2668177B1 (en) | 2011-01-28 | 2014-10-22 | Boehringer Ingelheim International GmbH | Substituted pyridinyl-pyrimidines and their use as medicaments |
| MX2016014878A (es) | 2014-05-14 | 2017-03-08 | Pfizer | Pirazolopiridinas y pirazolopirimidinas. |
| US11078259B2 (en) * | 2015-06-05 | 2021-08-03 | Joslin Diabetes Center, Inc. | Methods and compositions for promoting thermogenic potential |
| KR20190114986A (ko) | 2017-02-08 | 2019-10-10 | 오노 야꾸힝 고교 가부시키가이샤 | 소마토스타틴 수용체 작동 활성을 갖는 화합물 및 그 의약 용도 |
| EP3658560A4 (en) * | 2017-07-25 | 2021-01-06 | Crinetics Pharmaceuticals, Inc. | SOMATOSTAT IN MODULATORS AND USES THEREOF |
| JP7620649B2 (ja) | 2020-06-10 | 2025-01-23 | アリゴス セラピューティクス インコーポレイテッド | コロナウイルス、ピコルナウイルス及びノロウイルス感染を治療するための抗ウイルス化合物 |
| MX2024000299A (es) | 2021-07-09 | 2024-03-14 | Aligos Therapeutics Inc | Compuestos antivirales. |
| US12065428B2 (en) | 2021-09-17 | 2024-08-20 | Aligos Therapeutics, Inc. | Anti-viral compounds |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3268515A (en) * | 1964-04-07 | 1966-08-23 | American Home Prod | Amino-acylamino-acylamino-penicillanic acids |
| JPS5826745B2 (ja) * | 1976-06-01 | 1983-06-04 | 三共株式会社 | Ｎα−アシル−α−Ｌ−アミノ酸アニリド化合物 |
| DK201084A (da) * | 1983-04-28 | 1984-10-29 | Kimberly Clark Co | Fremgangsmaade til bestemmelse af cathepsin b i naervaerelse af andre proteolytiske enzymer, og forbindelser til anvendelse ved fremgangsmaaden |
| WO1997006803A1 (en) * | 1995-08-21 | 1997-02-27 | Eli Lilly And Company | 2-acylaminopropanamides as growth hormone secretagogues |
| US6057338A (en) * | 1997-04-04 | 2000-05-02 | Merck & Co., Inc. | Somatostatin agonists |
| US6025372A (en) * | 1997-04-04 | 2000-02-15 | Merck & Co., Inc. | Somatostatin agonists |
| AU5265599A (en) * | 1998-04-08 | 1999-11-01 | Takeda Chemical Industries Ltd. | Amine compounds, their production and their use as somatostatin receptor antagonists or agonists |
| US6228985B1 (en) * | 1998-05-21 | 2001-05-08 | Schering Corporation | Derivatives of aminobenzoic and aminobiphenylcarboxylic acids useful as anti-cancer agents |
| WO2000026188A1 (de) * | 1998-10-30 | 2000-05-11 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Cycloheximid-derivate, die die regeneration von nervengewebe beeinflussen |
| US6387932B1 (en) * | 1999-06-25 | 2002-05-14 | Merck & Co., Inc. | Somatostatin agonists |
| US20020016298A1 (en) * | 1999-09-01 | 2002-02-07 | Hay Bruce A. | Somatostatin antagonists and agonists that act at the sst subtype 2 receptor |
| US6696418B1 (en) * | 1999-09-01 | 2004-02-24 | Pfizer Inc. | Somatostatin antagonists and agonists that act at the SST subtype 2 receptor |
| WO2001055106A2 (en) * | 2000-01-28 | 2001-08-02 | Melacure Therapeutics Ab | Novel melanocortin receptor agonists and antagonists |
| US6600015B2 (en) * | 2000-04-04 | 2003-07-29 | Hoffmann-La Roche Inc. | Selective linear peptides with melanocortin-4 receptor (MC4-R) agonist activity |
| JP2002050697A (ja) * | 2000-08-07 | 2002-02-15 | Mitsubishi Electric Corp | 半導体装置の製造方法、及び半導体装置 |
| PE20020354A1 (es) * | 2000-09-01 | 2002-06-12 | Novartis Ag | Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda) |
| US20020091090A1 (en) * | 2000-12-28 | 2002-07-11 | Cole Bridget M. | Somatostatin antagonists and agonists |
| AU2003220898A1 (en) * | 2002-04-01 | 2003-10-13 | Nippon Chemiphar Co., Ltd. | N-phenyl-n-(4-piperidinyl)amide derivative |
-
2003
- 2003-11-18 US US10/534,725 patent/US20060223826A1/en not_active Abandoned
- 2003-11-18 TW TW092132231A patent/TW200420559A/zh unknown
- 2003-11-18 PE PE2003001164A patent/PE20040837A1/es not_active Application Discontinuation
- 2003-11-18 CA CA002506735A patent/CA2506735A1/en not_active Abandoned
- 2003-11-18 EP EP03772841A patent/EP1562898A1/en not_active Withdrawn
- 2003-11-18 WO PCT/JP2003/014622 patent/WO2004046107A1/en not_active Ceased
- 2003-11-18 AR ARP030104249A patent/AR042064A1/es unknown
- 2003-11-18 AU AU2003280838A patent/AU2003280838A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TW200420559A (en) | 2004-10-16 |
| US20060223826A1 (en) | 2006-10-05 |
| EP1562898A1 (en) | 2005-08-17 |
| WO2004046107A8 (en) | 2005-06-16 |
| CA2506735A1 (en) | 2004-06-03 |
| AU2003280838A1 (en) | 2004-06-15 |
| AU2003280838A8 (en) | 2004-06-15 |
| AR042064A1 (es) | 2005-06-08 |
| WO2004046107A1 (en) | 2004-06-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |