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PE20001483A1 - Acidos oxamicos y derivados como ligandos de receptores tiroideos - Google Patents

Acidos oxamicos y derivados como ligandos de receptores tiroideos

Info

Publication number
PE20001483A1
PE20001483A1 PE2000000166A PE0001662000A PE20001483A1 PE 20001483 A1 PE20001483 A1 PE 20001483A1 PE 2000000166 A PE2000000166 A PE 2000000166A PE 0001662000 A PE0001662000 A PE 0001662000A PE 20001483 A1 PE20001483 A1 PE 20001483A1
Authority
PE
Peru
Prior art keywords
alkyl
oxamic
heterocycle
phenyl
together form
Prior art date
Application number
PE2000000166A
Other languages
English (en)
Inventor
Robert Lee Dow
Yuan-Ching Phoebe Chiang
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20001483A1 publication Critical patent/PE20001483A1/es

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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
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    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
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    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

SE REFIERE A ACIDOS OXAMICOS DE FORMULA I DONDE R1, R2, R3 SON H, HALOGENO, ALQUILO C1-C6, TRIFLUOROMETILO, CN, OCF3, O-ALQUILO C1-C6; R4 ES H, ALQUILO C1-C12, ENTRE OTROS; CUANDO R5 NO ES F; R4 ES SO2NR9R10, CONR9R10, ENTRE OTROS; O R3 Y R4 FORMAN JUNTOS UN CARBOCICLO A: -(CH2)b-, HETEROCICLO A: Q-(CH2)c; (CH2)j-Q-(CH2)k; Q ES O, S, NR17; R5 ES F, OH, ALCOXI C1-C4, OCOR9; R4 Y R5 JUNTOS FORMAN UN HETEROCICLO B: R9C=CR10NH, N=CR9-NH, R9C=CH-O, ENTRE OTROS; R6 ES H, HALOGENO, ALQUILO C1-C4, TRIFLUOROMETILO; R7 ES H, ALQUILO C1-C6; R8 ES OR9, NR19R20; R9 Y R10 SON H, ALQUILO C1-C12, ALQUENILO C2-C12, CICLOALQUILO C3-C10, ARILO, HET, ENTRE OTROS O R9 Y R10 JUNTOS FORMAN UN HETEROCICLO C, ENTRE OTROS, R11 ES ALQUILO C1-C12; R17 ES H, ALQUILO C1-C6, COR9; W ES O, SOd, CH2, NR9; b ES 3-7; c, j Y k SON 2-6. SON COMPUESTOS PREFERIDOS ACIDO N-[3-CLORO-4-(3-CICLOPROPILSULFAMOIL-4-HIDROXI-FENOXI)-5-METIL-FENIL]OXAMICO, ACIDO-N-[4-(3-CICLOPROPILSULFAMOIL-4-HIDROXI-FENOXI)-3,5-DIMETIL-FENIL]OXAMICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION QUE COMPRENDE ADEMAS A UN AGENTE ANOREXIGENICO O UN INHIBIDOR DE LIPASA. EL COMPUESTO I ES UN LIGANDO DEL RECEPTOR TIROIDEO Y PUEDE SER UTIL PARA EL TRATAMIENTO DE LA OBESIDAD, HIPERLIPIDEMIA, GLAUCOMA, ARRITMIA CARDIACA, TRASTORNOS DE LA PIEL, ENFERMEDAD DE TIROIDES, HIPOTIROIDISMO
PE2000000166A 1999-03-01 2000-02-29 Acidos oxamicos y derivados como ligandos de receptores tiroideos PE20001483A1 (es)

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Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6344481B1 (en) * 1999-03-01 2002-02-05 Pfizer Inc. Thyromimetic antiobesity agents
DE60012700T2 (de) * 1999-03-01 2005-07-28 Pfizer Products Inc., Groton Oxamsäure und deren derivate als liganden der thyroid-rezeptoren
DE60015508T2 (de) 1999-03-05 2005-04-21 Univ Durham C-16 ungesätigte fp-selektive prostaglandin analoge
US6790978B2 (en) 1999-03-29 2004-09-14 Novartis Ag Thyromimetic organic compounds
US6599942B1 (en) 1999-03-29 2003-07-29 Novartis Ag Thyromimetic organic compounds
EP1257526B1 (en) 2000-02-17 2005-05-11 Bristol-Myers Squibb Company Aniline-derived ligands for the thyroid receptor
AU2001262113A1 (en) * 2000-03-23 2001-10-03 Bayer Aktiengesellschaft Indoles for treating diseases that can be treated using thyroid hormones
US6664291B2 (en) 2000-03-31 2003-12-16 Pfizer, Inc. Malonamic acids and derivatives thereof as thyroid receptor ligands
US20020172693A1 (en) 2000-03-31 2002-11-21 Delong Michell Anthony Compositions and methods for treating hair loss using non-naturally occurring prostaglandins
US20020037914A1 (en) 2000-03-31 2002-03-28 Delong Mitchell Anthony Compositions and methods for treating hair loss using C16-C20 aromatic tetrahydro prostaglandins
US20020013294A1 (en) 2000-03-31 2002-01-31 Delong Mitchell Anthony Cosmetic and pharmaceutical compositions and methods using 2-decarboxy-2-phosphinico derivatives
US6395784B1 (en) 2000-06-07 2002-05-28 Bristol-Myers Squibb Company Benzamide ligands for the thyroid receptor
GB0015205D0 (en) * 2000-06-21 2000-08-09 Karobio Ab Bioisosteric thyroid receptor ligands and method
DE10038007A1 (de) 2000-08-04 2002-02-14 Bayer Ag Neue Amino-und Amido-Diphenylether für Arzneimittel
DE10046029A1 (de) 2000-09-18 2002-03-28 Bayer Ag Indazole
AU2002223626A1 (en) * 2000-10-20 2002-04-29 Novartis Ag Combinations of a thyromimetic compound and a statin
EP1347959A1 (de) 2000-12-27 2003-10-01 Bayer Aktiengesellschaft Indol-derivate
DE10110750A1 (de) * 2001-03-07 2002-09-12 Bayer Ag Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften
US6777442B2 (en) 2001-03-12 2004-08-17 Bayer Aktiengesellschaft Diphenyl derivatives
DE10122443A1 (de) * 2001-05-09 2002-11-14 Bayer Ag Amido-Diphenyl-Derivate
DE60214080T2 (de) * 2001-05-31 2007-01-04 Pfizer Products Inc., Groton Medizinische Verwendung thyromimetischer Verbindungen gegen Haarausfall und Zusammensetzungen
AU2002336959B2 (en) * 2001-08-10 2006-07-13 Novartis Ag Peptides that bind to atherosclerotic lesions
DE10142668A1 (de) * 2001-08-31 2003-03-20 Aventis Pharma Gmbh Verwendung von C2-substituierten Indan-1-on-Systemen zur Herstellung von Medikamenten zur Prophylaxe oder Behandlung von Obesitas
ES2253495T3 (es) 2001-09-26 2006-06-01 Pfizer Products Inc. Acidos indol carboxilicos como ligandos de receptores tiroideos.
US20040242594A1 (en) * 2001-11-17 2004-12-02 Dan Peters Prodrugs of antidepressants and their use for treating depressions
WO2003064369A1 (en) 2002-01-30 2003-08-07 Kissei Pharmaceutical Co., Ltd. Novel thyroid hormone receptor ligand, medicinal compositions containing the same and use thereof
EP1556373A1 (en) * 2002-10-18 2005-07-27 Pfizer Products Inc. Cannabinoid receptor ligands and uses thereof
WO2004047827A1 (en) * 2002-11-25 2004-06-10 Pfizer Products Inc. Method for promoting nail growth using thyromimetic compounds
JP2007503453A (ja) * 2003-05-14 2007-02-22 ノボ　ノルディスク　アクティーゼルスカブ 肥満症を治療するための新規化合物
NO319624B1 (no) 2003-09-15 2005-09-05 Trouw Internat Bv Fiskefôr for laksefisk i ferskvann og anvendelse av slikt fôr.
WO2005032484A2 (en) * 2003-10-03 2005-04-14 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
KR20060109926A (ko) 2003-11-19 2006-10-23 메타베이시스 테라퓨틱스, 인크. 새로운 인-함유 갑상선 호르몬 모방약들
WO2005051900A1 (en) * 2003-11-25 2005-06-09 Novo Nordisk A/S Novel compounds for the treatment of obesity
WO2005077903A2 (en) * 2004-02-09 2005-08-25 Neurogen Corporation Melanin concentrating hormone receptor ligands: substituted tetrahydroisoquinoline analogues
CA2603589A1 (en) * 2005-04-01 2006-10-05 Methylgene Inc. Inhibitors of histone deacetylase
AU2006249348B2 (en) * 2005-05-26 2012-05-24 Metabasis Therapeutics, Inc. Novel phosphinic acid-containing thyromimetics
US20090232879A1 (en) 2005-05-26 2009-09-17 Metabasis Therapeutics, Inc. Thyromimetics for the Treatment of Fatty Liver Diseases
CN101291640A (zh) * 2005-06-24 2008-10-22 托马斯·拉文 甲状腺素化合物用于人体烧伤和脂肪沉积的治疗
GB0513692D0 (en) * 2005-07-04 2005-08-10 Karobio Ab Novel pharmaceutical compositions
KR100965006B1 (ko) * 2005-07-21 2010-06-21 에프. 호프만-라 로슈 아게 갑상선 호르몬 수용체 작용제로서 피리다진온 유도체
GB0608724D0 (en) 2006-05-03 2006-06-14 Karobio Ab Novel Pharmaceutical Compositions
GB0610322D0 (en) * 2006-05-24 2006-07-05 Karobio Ab Novel pharmaceutical compositions
CA2655913A1 (en) * 2006-06-28 2008-01-03 Sanwa Kagaku Kenkyusho Co., Ltd. Novel 6-5 system bicyclic heterocyclic derivative and its pharmaceutical utility
US7960567B2 (en) * 2007-05-02 2011-06-14 Amgen Inc. Compounds and methods useful for treating asthma and allergic inflammation
SI2061766T1 (sl) * 2007-06-06 2010-12-31 Torrent Pharmaceuticals Ltd Nove spojine
CN101903338A (zh) 2007-12-19 2010-12-01 安姆根有限公司 用作炎症调节剂的苯基乙酸衍生物
AU2009309229B2 (en) * 2008-10-27 2012-03-15 Cadila Healthcare Limited Thyroid receptor ligands
CN110200955A (zh) * 2010-10-30 2019-09-06 金戴克斯治疗学有限责任公司 四氢异-α酸衍生物、组合物及方法
US20140206667A1 (en) 2012-11-14 2014-07-24 Michela Gallagher Methods and compositions for treating schizophrenia
US9594070B2 (en) * 2013-11-05 2017-03-14 Spectrum Tracer Services, Llc Method using halogenated benzoic acid esters and aldehydes for hydraulic fracturing and for tracing petroleum production
CN104193699B (zh) * 2014-08-14 2016-05-25 嘉兴特科罗生物科技有限公司 一种小分子化合物及其合成方法和应用
US10017684B2 (en) * 2016-04-20 2018-07-10 Spectrum Tracer Services, Llc Method and compositions for hydraulic fracturing and for tracing formation water
EP3541395A4 (en) 2016-11-21 2020-07-01 Viking Therapeutics, Inc. GLYCOGENOSIS TREATMENT METHODS
JP7168660B2 (ja) 2017-06-05 2022-11-09 バイキング・セラピューティクス・インコーポレイテッド 線維症の処置のための組成物
MX2020009843A (es) 2018-03-22 2020-12-11 Viking Therapeutics Inc Formas cristalinas y metodos de produccion de formas cristalinas de un compuesto.
WO2020117962A1 (en) 2018-12-05 2020-06-11 Viking Therapeutics, Inc. Compositions for the treatment of fibrosis and inflammation
WO2022011120A1 (en) * 2020-07-10 2022-01-13 Aligos Therapeutics, Inc. MODULATORS OF THR-β AND METHODS OF USE THEREOF

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4069343A (en) 1973-03-23 1978-01-17 American Home Products Corporation Oxamic acid derivatives for the prevention of immediate type hypersensitivity reactions
US4554290A (en) 1983-06-17 1985-11-19 Ciba-Geigy Corporation Oxamic acid derivatives
US5061798A (en) 1985-01-18 1991-10-29 Smith Kline & French Laboratories, Ltd. Benzyl pyridyl and pyridazinyl compounds
GB8501372D0 (en) 1985-01-18 1985-02-20 Smith Kline French Lab Chemical compounds
US5232947A (en) 1988-07-04 1993-08-03 Meiji Seika Kaisha, Ltd. Oxamic acid compounds and pharmaceutical composition for use in improvement of damaged cerebral functions of brain
US5284971A (en) 1992-07-16 1994-02-08 Syntex (U.S.A.) Inc. 4-(3-cyclohexyl-4-hydroxy or-methoxy phenylsulfonyl) 3,5 dibromo phenyl acetic thyromimetic cholesterol-lowering agents
DE69314718T2 (de) * 1992-07-21 1998-02-26 Ciba Geigy Ag Oxamidsäure-Derivate als hypocholesterämische Mittel
GB9816935D0 (en) * 1998-08-05 1998-09-30 Karobio Ab Novel glucocortoid and thyroid receptor ligands for the treatment of metabolic disorders
DE60012700T2 (de) * 1999-03-01 2005-07-28 Pfizer Products Inc., Groton Oxamsäure und deren derivate als liganden der thyroid-rezeptoren
CO5160290A1 (es) 1999-03-29 2002-05-30 Novartis Ag Derivados de acido fenoxifeniloxamico sustituido .

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