PE20060589A1 - FENILAMINOTIAZOLES SUSTITUIDOS COMO AGONISTAS DE ADENOSINA A1 Y A2b - Google Patents
FENILAMINOTIAZOLES SUSTITUIDOS COMO AGONISTAS DE ADENOSINA A1 Y A2bInfo
- Publication number
- PE20060589A1 PE20060589A1 PE2005001012A PE2005001012A PE20060589A1 PE 20060589 A1 PE20060589 A1 PE 20060589A1 PE 2005001012 A PE2005001012 A PE 2005001012A PE 2005001012 A PE2005001012 A PE 2005001012A PE 20060589 A1 PE20060589 A1 PE 20060589A1
- Authority
- PE
- Peru
- Prior art keywords
- amino
- hydroxy
- substituted
- thiazol
- thio
- Prior art date
Links
- 239000000556 agonist Substances 0.000 title abstract 2
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 title 2
- 239000002126 C01EB10 - Adenosine Substances 0.000 title 1
- 229960005305 adenosine Drugs 0.000 title 1
- -1 MONO Chemical compound 0.000 abstract 7
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical compound C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 3
- SCVJRXQHFJXZFZ-KVQBGUIXSA-N 2-amino-9-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-3h-purine-6-thione Chemical compound C1=2NC(N)=NC(=S)C=2N=CN1[C@H]1C[C@H](O)[C@@H](CO)O1 SCVJRXQHFJXZFZ-KVQBGUIXSA-N 0.000 abstract 2
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical class [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 2
- 108010060263 Adenosine A1 Receptor Proteins 0.000 abstract 1
- 101150078577 Adora2b gene Proteins 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical compound ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 206010020772 Hypertension Diseases 0.000 abstract 1
- JCXJVPUVTGWSNB-UHFFFAOYSA-N Nitrogen dioxide Chemical class O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000009977 dual effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE R1 ES H O ALQUILO C1-C6, SUSTITUIDO O NO CON HIDROXI, AMINO, MONO, PIRROLIDINO, ENTRE OTROS; R2 ES ALQUILO C2-C6 SUSTITUIDO UNA O DOS VECES POR HIDROXI, ALCOXI C1-C4, AMINO, MONO- Y DIALQUIL (C1-C4)AMINO; R3 ES HALOGENO, CIANO, NITRO, ALQUILO C1-C6, HIDROXI, ENTRE OTROS; n ES 0-5. SON COMPUESTOS PREFERIDOS: 2-AMINO-6-[({2-[(3-CLOROFENIL)AMINO]-1,3-TIAZOL-4-IL}METIL)TIO]4-[4-(2,3-DIHIDROXIPROPOXI)FENIL]PIPERIDIN-3,5-DICARBONITRILO; 2-AMINO-6-[({2,4-DIFLUROFENIL)AMINO]-1,3-TIAZOL-4-IL}METIL)TIO]-4-[4-(2-HIDROXI-ETOXI)FENIL]-PIRIDIN-3,5-DICARBNITRILO; ACIDO 4-({4-[({6-AMINO-3,5-DICIANO-4-[4-(2-HIDROXIETOXI)FENIL]PIRIDIN-2-IL}TIO)METIL]-1,3-TIAZOL-2-IL}AMINO)BENZOICO; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y A UNA FORMULACION FARMACEUTICA. DICHOS COMPUESTOS SON AGONISTAS DUALES SELECTIVOS DE RECEPTORES DE ADENOSINA A1 Y A2b, UTILES EN EL TRATAMIENTO HIPERTENSION Y ENFERMEDADES CARDIOVASCULARES
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102004042607A DE102004042607A1 (de) | 2004-09-03 | 2004-09-03 | Substituierte Phenylaminothiazole und ihre Verwendung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20060589A1 true PE20060589A1 (es) | 2006-08-12 |
Family
ID=35852458
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2005001012A PE20060589A1 (es) | 2004-09-03 | 2005-09-02 | FENILAMINOTIAZOLES SUSTITUIDOS COMO AGONISTAS DE ADENOSINA A1 Y A2b |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US8691850B2 (es) |
| EP (1) | EP1812430B1 (es) |
| JP (1) | JP4999691B2 (es) |
| KR (1) | KR20070057235A (es) |
| CN (1) | CN101056875A (es) |
| AR (1) | AR050551A1 (es) |
| AT (1) | ATE428710T1 (es) |
| AU (1) | AU2005281941A1 (es) |
| BR (1) | BRPI0514833A (es) |
| CA (1) | CA2578596C (es) |
| DE (2) | DE102004042607A1 (es) |
| EC (1) | ECSP077296A (es) |
| ES (1) | ES2324049T3 (es) |
| GT (1) | GT200500238A (es) |
| IL (1) | IL181670A0 (es) |
| MA (1) | MA28869B1 (es) |
| MX (1) | MX2007002470A (es) |
| NO (1) | NO20071343L (es) |
| PE (1) | PE20060589A1 (es) |
| SV (1) | SV2006002218A (es) |
| TW (1) | TW200621765A (es) |
| UY (1) | UY29099A1 (es) |
| WO (1) | WO2006027142A1 (es) |
| ZA (1) | ZA200701820B (es) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102006009813A1 (de) * | 2006-03-01 | 2007-09-06 | Bayer Healthcare Ag | Verwendung von A2b/A1 Rezeptor Agonisten zur Modulation der Lipidspiegel |
| DE102006042143A1 (de) * | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006044696A1 (de) | 2006-09-22 | 2008-03-27 | Bayer Healthcare Ag | 3-Cyano-5-thiazaheteroaryl-dihydropyridine und ihre Verwendung |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) * | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102007061764A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Anellierte Cyanopyridine und ihre Verwendung |
| DE102007061763A1 (de) * | 2007-12-20 | 2009-06-25 | Bayer Healthcare Ag | Substituierte azabicyclische Verbindungen und ihre Verwendung |
| DE102008008838A1 (de) * | 2008-02-13 | 2009-08-20 | Bayer Healthcare Ag | Cycloalkoxy-substituierte 4-Phenyl-3,5-dicyanopyridine und ihre Verwendung |
| DE102008013587A1 (de) * | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| EP2297104B1 (de) * | 2008-05-29 | 2013-08-07 | Bayer Intellectual Property GmbH | 2-alkoxy-substituierte dicyanopyridine und ihre verwendung |
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) * | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
| DE102009022894A1 (de) * | 2009-05-27 | 2010-12-02 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Piperidine |
| DE102010030688A1 (de) | 2010-06-30 | 2012-01-05 | Bayer Schering Pharma Aktiengesellschaft | Substituierte Dicyanopyridine und ihre Verwendung |
| KR20220147691A (ko) | 2013-08-09 | 2022-11-03 | 알데릭스, 인코포레이티드 | 인산염 수송을 억제하기 위한 화합물 및 방법 |
| WO2018153897A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit hcn-kanal-hemmern |
| WO2018153899A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit stimulatoren und/oder aktivatoren der löslichen guanylatcyclase (sgc) |
| WO2018153898A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit mineralocorticoid-rezeptor-antagonisten |
| WO2018153895A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Pharma Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit einem inhibitor der neutralen endopeptidase und/oder einem angiotensin ii rezeptor-antagonisten |
| WO2018153900A1 (de) | 2017-02-22 | 2018-08-30 | Bayer Aktiengesellschaft | Selektive partielle adenosin a1 rezeptor-agonisten in kombination mit sglt-2-hemmern |
| JP7323913B2 (ja) * | 2019-04-12 | 2023-08-09 | 国立大学法人 筑波大学 | 睡眠誘導剤である複素環化合物 |
Family Cites Families (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW299333B (es) | 1992-12-29 | 1997-03-01 | Takeda Pharm Industry Co Ltd | |
| DE69510940T2 (de) | 1994-06-16 | 1999-11-11 | Pfizer Inc., New York | Pyrazolo und pyrrolopyridine |
| JPH09132529A (ja) | 1995-11-09 | 1997-05-20 | Ono Pharmaceut Co Ltd | 一酸化窒素合成酵素阻害剤 |
| WO1997026265A1 (en) | 1996-01-17 | 1997-07-24 | Novo Nordisk A/S | Fused 1,2,4-thiadiazine and fused 1,4-thiazine derivatives, their preparation and use |
| JPH10324687A (ja) | 1997-02-19 | 1998-12-08 | Nippon Soda Co Ltd | ピロール化合物、製法および農園芸用殺菌剤 |
| JP2002507197A (ja) | 1997-05-30 | 2002-03-05 | ビーエーエスエフ アクチェンゲゼルシャフト | 置換チオピリジン |
| KR20010021936A (ko) | 1997-07-16 | 2001-03-15 | 한센 핀 베네드, 안네 제헤르, 웨이콥 마리안느 | 융합된 1,2,4-티아디아진 유도체, 그의 제조와 사용 |
| US6632823B1 (en) | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
| DE19834047A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Substituierte Pyrazolderivate |
| DE19834044A1 (de) | 1998-07-29 | 2000-02-03 | Bayer Ag | Neue substituierte Pyrazolderivate |
| DE19943635A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943636A1 (de) | 1999-09-13 | 2001-03-15 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19943634A1 (de) | 1999-09-13 | 2001-04-12 | Bayer Ag | Neuartige Dicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE19947154A1 (de) | 1999-10-01 | 2001-10-04 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE60110391T2 (de) | 2000-02-25 | 2006-01-26 | F. Hoffmann-La Roche Ag | Adenosin-rezeptor modulatoren |
| WO2002006237A1 (en) | 2000-07-18 | 2002-01-24 | Yamanouchi Pharmaceutical Co., Ltd. | Medicine comprising dicyanopyridine derivative |
| AR031176A1 (es) | 2000-11-22 | 2003-09-10 | Bayer Ag | Nuevos derivados de pirazolpiridina sustituidos con piridina |
| WO2002048115A2 (en) | 2000-12-11 | 2002-06-20 | E. I. Du Pont De Nemours And Company | Quinazolinones and pyridinopyrimidinones for controlling invertebrate pests |
| EP1347971B1 (en) | 2000-12-21 | 2006-03-01 | Bristol-Myers Squibb Company | Thiazolyl inhibitors of tec family tyrosine kinases |
| DE10110438A1 (de) | 2001-03-05 | 2002-09-19 | Bayer Ag | Substituierte 2-Oxy-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
| DE10110747A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte 2,6-Diamino-3,5-dicyano-4-aryl-pyridine und ihre Verwendung |
| DE10110754A1 (de) | 2001-03-07 | 2002-09-19 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10110750A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Neuartige Aminodicarbonsäurederivate mit pharmazeutischen Eigenschaften |
| DE10115945A1 (de) | 2001-03-30 | 2002-10-02 | Bayer Ag | Substituierte 2-Carba-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10115922A1 (de) | 2001-03-30 | 2002-10-10 | Bayer Ag | Cyclisch substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10134481A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| DE10238113A1 (de) | 2001-12-11 | 2003-06-18 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| JP2003183254A (ja) | 2001-12-20 | 2003-07-03 | Yamanouchi Pharmaceut Co Ltd | ２−アシルアミノ−３，５−ジシアノピリジン誘導体又はその塩 |
| EP1506189A1 (en) | 2002-04-26 | 2005-02-16 | Vertex Pharmaceuticals Incorporated | Pyrrole derivatives as inhibitors of erk2 and uses thereof |
| DE10220570A1 (de) | 2002-05-08 | 2003-11-20 | Bayer Ag | Carbamat-substituierte Pyrazolopyridine |
| EP1388342A1 (en) | 2002-08-07 | 2004-02-11 | Aventis Pharma Deutschland GmbH | Acylated, heteroaryl-condensed cycloalkenylamines and their use as pharmaceuticals |
| US7186716B2 (en) | 2002-08-12 | 2007-03-06 | Sugen, Inc. | 3-Pyrrol-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors |
| MXPA05006367A (es) | 2002-12-12 | 2005-08-29 | Pharmacia Corp | Metodo de uso de compuestos de aminocianopiridina como inhibidores de cinasa-2 de proteina activada de cinasa de proteina activada por mitogeno. |
| AR042667A1 (es) | 2002-12-26 | 2005-06-29 | Taisho Pharmaceutical Co Ltd | Derivados de pirrolopirimidina y pirrolopiridina sustituidos con un grupo amino ciclico |
| TW200418829A (en) | 2003-02-14 | 2004-10-01 | Avanir Pharmaceutics | Inhibitors of macrophage migration inhibitory factor and methods for identifying the same |
| AR045047A1 (es) | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| EP1667683A4 (en) | 2003-09-23 | 2009-04-29 | Merck & Co Inc | QUINOLINE POTASSIUM CHANNEL INHIBITORS |
| CA2545258A1 (en) | 2003-11-10 | 2005-05-26 | Synta Pharmaceuticals, Corp. | Pyridine compounds |
| US20050182105A1 (en) | 2004-02-04 | 2005-08-18 | Nirschl Alexandra A. | Method of using 3-cyano-4-arylpyridine derivatives as modulators of androgen receptor function |
| JP2007161585A (ja) | 2004-06-25 | 2007-06-28 | Taisho Pharmaceut Co Ltd | 環状アミノ基で置換されているピロロピリミジン及びピロロピリジン誘導体 |
| DE102004032651A1 (de) | 2004-07-06 | 2006-02-16 | Bayer Healthcare Ag | Verwendung von substituierten 2-Thio-3,5-dicyano-4-phenyl-6-aminopyriden bei der Behandlung von Übelkeit und Erbrechen |
| DE102006042143A1 (de) | 2006-09-08 | 2008-03-27 | Bayer Healthcare Aktiengesellschaft | Neue substituierte Bipyridin-Derivate und ihre Verwendung |
| DE102006056740A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Cyclisch substituierte 3,5-Dicyano-2-thiopyridine und ihre Verwendung |
| DE102006056739A1 (de) | 2006-12-01 | 2008-06-05 | Bayer Healthcare Ag | Substituierte 4-Amino-3,5-dicyano-2-thiopyridine und ihre Verwendung |
| DE102007035367A1 (de) | 2007-07-27 | 2009-01-29 | Bayer Healthcare Ag | Substituierte Aryloxazole und ihre Verwendung |
| DE102007036076A1 (de) | 2007-08-01 | 2009-02-05 | Bayer Healthcare Aktiengesellschaft | Dipeptoid-Produgs und ihre Verwendung |
| DE102008013587A1 (de) | 2008-03-11 | 2009-09-17 | Bayer Schering Pharma Aktiengesellschaft | Heteroaryl-substituierte Dicyanopyridine und ihre Verwendung |
| DE102008062567A1 (de) | 2008-12-16 | 2010-06-17 | Bayer Schering Pharma Aktiengesellschaft | Dipeptoid-Prodrugs und ihre Verwendung |
| DE102009006602A1 (de) | 2009-01-29 | 2010-08-05 | Bayer Schering Pharma Aktiengesellschaft | Alkylamino-substituierte Dicyanopyridine und deren Aminosäureester-Prodrugs |
-
2004
- 2004-09-03 DE DE102004042607A patent/DE102004042607A1/de not_active Withdrawn
-
2005
- 2005-08-30 WO PCT/EP2005/009316 patent/WO2006027142A1/de not_active Ceased
- 2005-08-30 JP JP2007529331A patent/JP4999691B2/ja not_active Expired - Fee Related
- 2005-08-30 ES ES05776232T patent/ES2324049T3/es not_active Expired - Lifetime
- 2005-08-30 AT AT05776232T patent/ATE428710T1/de not_active IP Right Cessation
- 2005-08-30 CN CNA2005800381572A patent/CN101056875A/zh active Pending
- 2005-08-30 MX MX2007002470A patent/MX2007002470A/es not_active Application Discontinuation
- 2005-08-30 EP EP05776232A patent/EP1812430B1/de not_active Expired - Lifetime
- 2005-08-30 BR BRPI0514833-2A patent/BRPI0514833A/pt not_active IP Right Cessation
- 2005-08-30 AU AU2005281941A patent/AU2005281941A1/en not_active Abandoned
- 2005-08-30 US US11/661,820 patent/US8691850B2/en not_active Expired - Fee Related
- 2005-08-30 KR KR1020077007526A patent/KR20070057235A/ko not_active Withdrawn
- 2005-08-30 DE DE502005007106T patent/DE502005007106D1/de not_active Expired - Lifetime
- 2005-08-30 CA CA2578596A patent/CA2578596C/en not_active Expired - Fee Related
- 2005-09-01 GT GT200500238A patent/GT200500238A/es unknown
- 2005-09-01 AR ARP050103664A patent/AR050551A1/es not_active Application Discontinuation
- 2005-09-02 PE PE2005001012A patent/PE20060589A1/es not_active Application Discontinuation
- 2005-09-02 TW TW094130123A patent/TW200621765A/zh unknown
- 2005-09-02 SV SV2005002218A patent/SV2006002218A/es not_active Application Discontinuation
- 2005-09-05 UY UY29099A patent/UY29099A1/es not_active Application Discontinuation
-
2007
- 2007-03-01 IL IL181670A patent/IL181670A0/en unknown
- 2007-03-01 ZA ZA200701820A patent/ZA200701820B/xx unknown
- 2007-03-02 EC EC2007007296A patent/ECSP077296A/es unknown
- 2007-03-13 NO NO20071343A patent/NO20071343L/no not_active Application Discontinuation
- 2007-03-23 MA MA29769A patent/MA28869B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE428710T1 (de) | 2009-05-15 |
| DE502005007106D1 (de) | 2009-05-28 |
| EP1812430A1 (de) | 2007-08-01 |
| JP2008511614A (ja) | 2008-04-17 |
| CN101056875A (zh) | 2007-10-17 |
| DE102004042607A1 (de) | 2006-03-09 |
| SV2006002218A (es) | 2006-10-04 |
| ES2324049T3 (es) | 2009-07-29 |
| JP4999691B2 (ja) | 2012-08-15 |
| EP1812430B1 (de) | 2009-04-15 |
| AU2005281941A1 (en) | 2006-03-16 |
| UY29099A1 (es) | 2006-04-28 |
| KR20070057235A (ko) | 2007-06-04 |
| GT200500238A (es) | 2006-04-10 |
| US20080269300A1 (en) | 2008-10-30 |
| MX2007002470A (es) | 2009-02-12 |
| ZA200701820B (en) | 2008-08-27 |
| US8691850B2 (en) | 2014-04-08 |
| IL181670A0 (en) | 2007-07-04 |
| CA2578596C (en) | 2012-10-23 |
| MA28869B1 (fr) | 2007-09-03 |
| AR050551A1 (es) | 2006-11-01 |
| BRPI0514833A (pt) | 2008-06-24 |
| TW200621765A (en) | 2006-07-01 |
| WO2006027142A1 (de) | 2006-03-16 |
| ECSP077296A (es) | 2007-04-26 |
| NO20071343L (no) | 2007-05-30 |
| CA2578596A1 (en) | 2006-03-16 |
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