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PE20080364A1 - Acido bifenilcarboxilicos substituidos y sus derivados como moduladores de la actividad de la gamma-secretasa - Google Patents

Acido bifenilcarboxilicos substituidos y sus derivados como moduladores de la actividad de la gamma-secretasa

Info

Publication number
PE20080364A1
PE20080364A1 PE2007000496A PE2007000496A PE20080364A1 PE 20080364 A1 PE20080364 A1 PE 20080364A1 PE 2007000496 A PE2007000496 A PE 2007000496A PE 2007000496 A PE2007000496 A PE 2007000496A PE 20080364 A1 PE20080364 A1 PE 20080364A1
Authority
PE
Peru
Prior art keywords
substituted
modulators
gamma
acid
secretase
Prior art date
Application number
PE2007000496A
Other languages
English (en)
Inventor
Francis Wilson
Alison Reid
Valerie Reader
Richard John Harrison
Mihiro Sunose
Remedios Hernandez-Perni
Jeremy Major
Cyrille Boussard
Kathryn Smelt
Jess Taylor
Adeline Leformal
Andrew Cansfield
Chih Yung Ho
Yan Zhang
Svenja Burckhardt
Original Assignee
Cellzome Ltd
Ortho Mcneil Janssen Pharm
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Ltd, Ortho Mcneil Janssen Pharm filed Critical Cellzome Ltd
Publication of PE20080364A1 publication Critical patent/PE20080364A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

SE REFIERE A COMPUESTOS ACIDO BIFENILCARBOXILICOS SUBSTITUIDOS DE FORMULA (I), EN DONDE A ES O, NH U S; X ES -CR5R6, DONDE R5 Y R6 SON INDEPENDIENTEMENTE H, ALQUILO SELECCIONADO DE CH3, C2H5, i-C4H9, ENTRE OTROS; R1, R2, R3 Y R4 SON INDEPENDIENTEMENTE H, HALOGENO, OH, ALQUILO OPCIONALMENTE SUSTITUIDO, ENTRE OTROS; R9 Y R10 SON INDEPENDIENTEMENTE H, F O CF3; Y ES UN GRUPO CARBOXI-C(O)OH O UN TETRAZOL SUSTITUIDO O NO. SON SELECCIONADOS: ACIDO 2-(5-(4-FLUOROFENOXI)-4'-TRIFLUOROMETILBIFENIL-3-IL)-PENTANOICO, ACIDO 2-(5-(FENOXI)-4'-TRIFLUOROMETILBIFENIL-3-IL)-PENTANOICO, ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA Y UN PROCEDIMIENTO DE PREPARACION. ESTOS COMPUESTOS SON MODULADORES DE LA ACTIVIDAD DE LA GAMMA-SECRETASA POR LO QUE SON UTILES EN EL TRATAMIENTO DE LA ENFERMEDAD DE ALZHEIMER (EA)
PE2007000496A 2006-04-21 2007-04-20 Acido bifenilcarboxilicos substituidos y sus derivados como moduladores de la actividad de la gamma-secretasa PE20080364A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
PE20080364A1 true PE20080364A1 (es) 2008-05-16

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007000496A PE20080364A1 (es) 2006-04-21 2007-04-20 Acido bifenilcarboxilicos substituidos y sus derivados como moduladores de la actividad de la gamma-secretasa

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194790A (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004318A (es) * 2007-10-19 2010-04-30 Janssen Pharmaceutica Nv Moduladores de la gamma-secretasa con enlaces de amina.
AU2008312612B2 (en) 2007-10-19 2013-11-28 Janssen Pharmaceutica, N.V. Piperidinyl and piperazinyl modulators of gamma-secretase
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Ｇｓｍ 중간체
MX2010004310A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de gamma-secretasa con enlaces de carbono.
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
US20140187556A1 (en) * 2011-03-03 2014-07-03 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
WO2001078721A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research Aβ42 LOWERING AGENTS
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
EP1546086A2 (en) * 2002-06-27 2005-06-29 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
TW200621227A (en) * 2004-08-24 2006-07-01 Kissei Pharmaceutical Medicament for preventing or treating fatty liver
WO2007039736A1 (en) * 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
TNSN08413A1 (en) 2010-04-14
GT200900120A (es) 2009-11-16
MX2008013445A (es) 2009-03-10
CY1109399T1 (el) 2014-07-02
TWI399362B (zh) 2013-06-21
US20070293567A1 (en) 2007-12-20
DK1849762T3 (da) 2009-10-12
DE602006007810D1 (de) 2009-08-27
EP1849762A1 (en) 2007-10-31
CR10451A (es) 2009-03-31
EP1849762B1 (en) 2009-07-15
JP2009544573A (ja) 2009-12-17
IL194790A0 (en) 2009-08-03
AP2008004656A0 (en) 2008-10-31
EA016129B1 (ru) 2012-02-28
KR20090024679A (ko) 2009-03-09
GEP20115269B (en) 2011-08-25
CA2650006A1 (en) 2007-11-01
UY30301A1 (es) 2007-08-31
CR10375A (es) 2009-02-26
PL1849762T3 (pl) 2009-12-31
ZA200809856B (en) 2009-06-24
CA2650006C (en) 2016-08-23
TW200815320A (en) 2008-04-01
IL194852A0 (en) 2009-08-03
EP2021314A1 (en) 2009-02-11
ES2328616T3 (es) 2009-11-16
MY148953A (en) 2013-06-14
AR060568A1 (es) 2008-06-25
CN101687758A (zh) 2010-03-31
SI1849762T1 (sl) 2009-12-31
KR101542255B1 (ko) 2015-08-06
IL194790A (en) 2012-12-31
EA016129B9 (ru) 2012-06-29
BRPI0710656A2 (pt) 2011-08-16
UA95952C2 (ru) 2011-09-26
JP5479088B2 (ja) 2014-04-23
AU2007240335B2 (en) 2013-05-02
AU2007240335A1 (en) 2007-11-01
CN101687758B (zh) 2014-05-14
WO2007124394A1 (en) 2007-11-01
EP2021314B1 (en) 2013-01-23
EA200802172A1 (ru) 2009-06-30
SMAP200800061A (it) 2008-11-19
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
NZ573000A (en) 2011-11-25
MA30475B1 (fr) 2009-06-01
SMP200800061B (it) 2009-07-14
PT1849762E (pt) 2009-09-16
ES2400530T3 (es) 2013-04-10

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