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UY30301A1 - Ácidos bifenilcarboxílicos substituidos y sus derivados - Google Patents

Ácidos bifenilcarboxílicos substituidos y sus derivados

Info

Publication number
UY30301A1
UY30301A1 UY30301A UY30301A UY30301A1 UY 30301 A1 UY30301 A1 UY 30301A1 UY 30301 A UY30301 A UY 30301A UY 30301 A UY30301 A UY 30301A UY 30301 A1 UY30301 A1 UY 30301A1
Authority
UY
Uruguay
Prior art keywords
bifenyl
derivatives
substituted
carboxylic acids
compounds
Prior art date
Application number
UY30301A
Other languages
English (en)
Inventor
Yan Zhang
Ching Yu Ho
Svenja Burckhardt
Andrew Cansfield
Adeline Leformal
Kathryn Smelt
Jees Taylor
Cyrille Boussard
Jeremy Major
Hernandez-Perni
Mihiro Sunose
Richard John Harrison
Valerie Reader
Alison Reid
Francis Wilson
Original Assignee
Ortho Mcneil Pharm Inc
Cellzome Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ortho Mcneil Pharm Inc, Cellzome Uk Ltd filed Critical Ortho Mcneil Pharm Inc
Publication of UY30301A1 publication Critical patent/UY30301A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente invención se relaciona con compuestos que tienen la Fórmula general I con las definiciones de X, Y, R1, R2, R3, R4, R9 y R10 dadas a continuación y/o una sal o éster del mismo. Más aún, la invención se relaciona con el uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y con su uso para la modulación de la actividad gama-secretasa
UY30301A 2006-04-21 2007-04-20 Ácidos bifenilcarboxílicos substituidos y sus derivados UY30301A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
UY30301A1 true UY30301A1 (es) 2007-08-31

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
UY30301A UY30301A1 (es) 2006-04-21 2007-04-20 Ácidos bifenilcarboxílicos substituidos y sus derivados

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194790A (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010004318A (es) * 2007-10-19 2010-04-30 Janssen Pharmaceutica Nv Moduladores de la gamma-secretasa con enlaces de amina.
AU2008312612B2 (en) 2007-10-19 2013-11-28 Janssen Pharmaceutica, N.V. Piperidinyl and piperazinyl modulators of gamma-secretase
KR20100081350A (ko) * 2007-10-19 2010-07-14 얀센 파마슈티카 엔.브이. Ｇｓｍ 중간체
MX2010004310A (es) 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Moduladores de gamma-secretasa con enlaces de carbono.
US20110092554A1 (en) * 2007-11-19 2011-04-21 Richard Chesworth 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
AU2008345573B2 (en) 2007-12-20 2013-12-19 Envivo Pharmaceuticals, Inc. Tetrasubstituted benzenes
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
US20140187556A1 (en) * 2011-03-03 2014-07-03 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
WO2016201168A1 (en) 2015-06-10 2016-12-15 Forum Pharmceuticals Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
WO2001078721A1 (en) 2000-04-13 2001-10-25 Mayo Foundation For Medical Education And Research Aβ42 LOWERING AGENTS
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
EP1546086A2 (en) * 2002-06-27 2005-06-29 Fujisawa Pharmaceutical Co., Ltd. Aminoalcohol derivatives
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
TW200621227A (en) * 2004-08-24 2006-07-01 Kissei Pharmaceutical Medicament for preventing or treating fatty liver
WO2007039736A1 (en) * 2005-10-06 2007-04-12 Astrazeneca Ab Novel compounds

Also Published As

Publication number Publication date
TNSN08413A1 (en) 2010-04-14
GT200900120A (es) 2009-11-16
MX2008013445A (es) 2009-03-10
CY1109399T1 (el) 2014-07-02
TWI399362B (zh) 2013-06-21
US20070293567A1 (en) 2007-12-20
DK1849762T3 (da) 2009-10-12
DE602006007810D1 (de) 2009-08-27
EP1849762A1 (en) 2007-10-31
CR10451A (es) 2009-03-31
EP1849762B1 (en) 2009-07-15
JP2009544573A (ja) 2009-12-17
IL194790A0 (en) 2009-08-03
AP2008004656A0 (en) 2008-10-31
EA016129B1 (ru) 2012-02-28
KR20090024679A (ko) 2009-03-09
GEP20115269B (en) 2011-08-25
CA2650006A1 (en) 2007-11-01
CR10375A (es) 2009-02-26
PL1849762T3 (pl) 2009-12-31
ZA200809856B (en) 2009-06-24
CA2650006C (en) 2016-08-23
TW200815320A (en) 2008-04-01
IL194852A0 (en) 2009-08-03
EP2021314A1 (en) 2009-02-11
ES2328616T3 (es) 2009-11-16
MY148953A (en) 2013-06-14
AR060568A1 (es) 2008-06-25
CN101687758A (zh) 2010-03-31
SI1849762T1 (sl) 2009-12-31
KR101542255B1 (ko) 2015-08-06
IL194790A (en) 2012-12-31
EA016129B9 (ru) 2012-06-29
BRPI0710656A2 (pt) 2011-08-16
UA95952C2 (ru) 2011-09-26
JP5479088B2 (ja) 2014-04-23
AU2007240335B2 (en) 2013-05-02
AU2007240335A1 (en) 2007-11-01
CN101687758B (zh) 2014-05-14
WO2007124394A1 (en) 2007-11-01
EP2021314B1 (en) 2013-01-23
EA200802172A1 (ru) 2009-06-30
PE20080364A1 (es) 2008-05-16
SMAP200800061A (it) 2008-11-19
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
NZ573000A (en) 2011-11-25
MA30475B1 (fr) 2009-06-01
SMP200800061B (it) 2009-07-14
PT1849762E (pt) 2009-09-16
ES2400530T3 (es) 2013-04-10

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