[go: up one dir, main page]

AR060568A1 - Acidos bifenilcarboxilicos substituidos y sus derivados - Google Patents

Acidos bifenilcarboxilicos substituidos y sus derivados

Info

Publication number
AR060568A1
AR060568A1 ARP070101725A ARP070101725A AR060568A1 AR 060568 A1 AR060568 A1 AR 060568A1 AR P070101725 A ARP070101725 A AR P070101725A AR P070101725 A ARP070101725 A AR P070101725A AR 060568 A1 AR060568 A1 AR 060568A1
Authority
AR
Argentina
Prior art keywords
bifenyl
derivatives
substituted
carboxyl acids
compounds
Prior art date
Application number
ARP070101725A
Other languages
English (en)
Original Assignee
Cellzome Uk Ltd
Ortho Mcneil Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cellzome Uk Ltd, Ortho Mcneil Pharm Inc filed Critical Cellzome Uk Ltd
Publication of AR060568A1 publication Critical patent/AR060568A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/40—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/42—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to carbon atoms of at least one six-membered aromatic ring and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton with carboxyl groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by saturated carbon chains
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
    • C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
    • C07C59/66—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings
    • C07C59/68—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings the non-carboxylic part of the ether containing six-membered aromatic rings the oxygen atom of the ether group being bound to a non-condensed six-membered aromatic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

La presente se relaciona con compuestos que tienen la formula general (1) con las definiciones de X, Y, R1, R2, R3, R4, R9, y R10 dadas a continuacion y/o una sal o éster del mismo. Más aun, la presente se relaciona con el uso de dichos compuestos para el tratamiento de la enfermedad de Alzheimer y con su uso para la modulacion de la actividad ?-secretasa.
ARP070101725A 2006-04-21 2007-04-20 Acidos bifenilcarboxilicos substituidos y sus derivados AR060568A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP06112938A EP1849762B1 (en) 2006-04-21 2006-04-21 Substituted biphenyl carboxylic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
AR060568A1 true AR060568A1 (es) 2008-06-25

Family

ID=36688012

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP070101725A AR060568A1 (es) 2006-04-21 2007-04-20 Acidos bifenilcarboxilicos substituidos y sus derivados

Country Status (35)

Country Link
US (1) US7557244B2 (es)
EP (2) EP1849762B1 (es)
JP (1) JP5479088B2 (es)
KR (1) KR101542255B1 (es)
CN (1) CN101687758B (es)
AP (1) AP2008004656A0 (es)
AR (1) AR060568A1 (es)
AU (1) AU2007240335B2 (es)
BR (1) BRPI0710656A2 (es)
CA (1) CA2650006C (es)
CR (2) CR10375A (es)
CY (1) CY1109399T1 (es)
DE (1) DE602006007810D1 (es)
DK (1) DK1849762T3 (es)
EA (1) EA016129B9 (es)
ES (2) ES2328616T3 (es)
GE (1) GEP20115269B (es)
GT (1) GT200900120A (es)
IL (2) IL194790A (es)
MA (1) MA30475B1 (es)
MX (1) MX2008013445A (es)
MY (1) MY148953A (es)
NO (1) NO20084517L (es)
NZ (1) NZ573000A (es)
PE (1) PE20080364A1 (es)
PL (1) PL1849762T3 (es)
PT (1) PT1849762E (es)
SI (1) SI1849762T1 (es)
SM (1) SMP200800061B (es)
TN (1) TNSN08413A1 (es)
TW (1) TWI399362B (es)
UA (1) UA95952C2 (es)
UY (1) UY30301A1 (es)
WO (1) WO2007124394A1 (es)
ZA (1) ZA200809856B (es)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0817433A2 (pt) 2007-10-19 2015-06-16 Janssen Pharmaceutica Nv Moduladores de gama-secretase piperidinila e piperazinila
MX2010004311A (es) * 2007-10-19 2010-05-03 Janssen Pharmaceutica Nv Productos intermedios de moduladores de gamma-secretasa.
CA2702959C (en) 2007-10-19 2016-07-26 Janssen Pharmaceutica Nv Carbon linked modulators of .gamma.-secretase
WO2009052350A1 (en) * 2007-10-19 2009-04-23 Janssen Pharmaceutica, N.V. Amine linked modulators of y-secretase
WO2009067493A2 (en) * 2007-11-19 2009-05-28 Envivo Pharmaceuticals, Inc. 1,3,5 tri-subtituted benzenes for treatment of alzheimer's disease and other disorders
JP2011507909A (ja) 2007-12-20 2011-03-10 エンビボ ファーマシューティカルズ インコーポレイテッド 四置換ベンゼン
WO2011046774A1 (en) * 2009-10-16 2011-04-21 Merck Sharp & Dohme Corp. Diaryl ether derivatives as notch sparing gamma secretase inhibitors
US8785481B2 (en) 2010-09-29 2014-07-22 Merck Sharp & Dohme Corp. Ether benzotriazole derivatives
WO2012119035A1 (en) * 2011-03-03 2012-09-07 Treventis Corporation Anti-amyloid compounds and methods
WO2015109109A1 (en) 2014-01-15 2015-07-23 Forum Pharmaceuticals Inc. Fused morpholinopyrimidines and methods of use thereof
US9802927B2 (en) 2015-06-10 2017-10-31 Denali Therapeutics, Inc. Oxadiazine compounds and methods of use thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5877399A (en) * 1994-01-27 1999-03-02 Johns Hopkins University Transgenic mice expressing APP-Swedish mutation develop progressive neurologic disease
JP3802581B2 (ja) * 1995-03-01 2006-07-26 富山化学工業株式会社 新規なビフェニル誘導体またはその塩およびそれらを含有する抗炎症剤
AU5702201A (en) * 2000-04-13 2001-10-30 Mayo Foundation Abeta<sub>42</sub> lowering agents
DE10131899A1 (de) 2001-07-04 2003-02-27 Boehringer Ingelheim Pharma In vitro-Screening-Assay für gamma-Secretase
RU2319698C2 (ru) * 2002-06-27 2008-03-20 Астеллас Фарма Инк. АЛЬФА-ФЕНИЛ ИЛИ ПИРИДИЛ-ЭТАНОЛАМИНЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ АГОНИСТОВ β3 АДРЕНЕРГИЧЕСКИХ РЕЦЕПТОРОВ
GB0305918D0 (en) * 2003-03-14 2003-04-23 Glaxo Group Ltd Novel compounds
WO2005110963A1 (en) * 2004-05-19 2005-11-24 Cellzome Ag (biphenyl-3-yl)-carboxylic acids and derivatives thereof and their use in therapy
GB0416508D0 (en) * 2004-07-23 2004-08-25 Merck Sharp & Dohme Therapeutic agents
JPWO2006022237A1 (ja) * 2004-08-24 2008-05-08 キッセイ薬品工業株式会社 脂肪肝の予防または治療剤
JP5155171B2 (ja) * 2005-10-06 2013-02-27 アストラゼネカ・アクチエボラーグ 新規化合物

Also Published As

Publication number Publication date
CN101687758A (zh) 2010-03-31
EP2021314B1 (en) 2013-01-23
SMAP200800061A (it) 2008-11-19
DK1849762T3 (da) 2009-10-12
AP2008004656A0 (en) 2008-10-31
PL1849762T3 (pl) 2009-12-31
KR20090024679A (ko) 2009-03-09
GEP20115269B (en) 2011-08-25
MX2008013445A (es) 2009-03-10
IL194790A (en) 2012-12-31
WO2007124394A1 (en) 2007-11-01
SMP200800061B (it) 2009-07-14
CY1109399T1 (el) 2014-07-02
UY30301A1 (es) 2007-08-31
UA95952C2 (ru) 2011-09-26
BRPI0710656A2 (pt) 2011-08-16
US20070293567A1 (en) 2007-12-20
EP1849762A1 (en) 2007-10-31
IL194852A0 (en) 2009-08-03
EA016129B1 (ru) 2012-02-28
JP5479088B2 (ja) 2014-04-23
EA016129B9 (ru) 2012-06-29
EA200802172A1 (ru) 2009-06-30
GT200900120A (es) 2009-11-16
MA30475B1 (fr) 2009-06-01
NZ573000A (en) 2011-11-25
ZA200809856B (en) 2009-06-24
KR101542255B1 (ko) 2015-08-06
PT1849762E (pt) 2009-09-16
NO20084517L (no) 2009-01-13
US7557244B2 (en) 2009-07-07
JP2009544573A (ja) 2009-12-17
ES2400530T3 (es) 2013-04-10
IL194790A0 (en) 2009-08-03
ES2328616T3 (es) 2009-11-16
MY148953A (en) 2013-06-14
PE20080364A1 (es) 2008-05-16
TWI399362B (zh) 2013-06-21
EP1849762B1 (en) 2009-07-15
TNSN08413A1 (en) 2010-04-14
CN101687758B (zh) 2014-05-14
CR10375A (es) 2009-02-26
SI1849762T1 (sl) 2009-12-31
CR10451A (es) 2009-03-31
AU2007240335B2 (en) 2013-05-02
EP2021314A1 (en) 2009-02-11
AU2007240335A1 (en) 2007-11-01
TW200815320A (en) 2008-04-01
CA2650006C (en) 2016-08-23
CA2650006A1 (en) 2007-11-01
DE602006007810D1 (de) 2009-08-27

Similar Documents

Publication Publication Date Title
AR060568A1 (es) Acidos bifenilcarboxilicos substituidos y sus derivados
NI200700107A (es) (bifenil) ácidos carboxílicos y sus derivados
UY30300A1 (es) Compuestos triarílicos y sus derivados
GT200600134A (es) Compuestos novedosos de derivados de aminosulfonilo
UY30426A1 (es) Derivados sustituidos del 3-(4-metoxi-fenil)-3h-isoindol-1-ilamina trifluoroacetado, sus sales o solvatos farmaceuticamente aceptables, formulaciones farmacéuticas y aplicaciones.
UY30274A1 (es) Derivados sustituidos de la n-(4-metil-1,3-tiazol-2-il)guanidina, formulaciones farmacéuticas conteniéndolo y aplicaciones
CR10250A (es) Derivados de amida y su aplicación para el tratamiento de enfermedades relacionadas con proteína-g
ECSP099755A (es) Derivados de pirrolopiridina y su uso como inhibidores de bace
ES2546198T3 (es) Tratamiento contra la glomerulonefritis
NI201000107A (es) Derivados de tiazol utilizados como inhibidores de pi 3 - cinasa.
NI200800227A (es) Acidos 1,3-dioxano carboxilicos
AR066077A1 (es) Tiadiazoliloxifenilamidinas y su uso como fungicidas
UY30025A1 (es) Derivados sustituidos de las 2-amino-5,6-dihidro pirimidin-4(3h)-onas y sus sales farmacéuticamente aceptables, composiciones farmacéuticas conteniéndolos y aplicaciones.
AR043783A1 (es) Difenilazetidinona con propiedades fisiologicas, medicamentos que comprenden este compuesto y su uso
AR054129A1 (es) Derivados de 2, 6-quinolinilo, una preparacion farmaceutica que los contiene y su empleo en la fabricacion de medicamentos para el tratamiento de enfermedades dependientes de integrinas alfa4beta1 y/o alfa4beta7
EA200900780A1 (ru) Аналоги эпотилона, модифицированные в положениях c12-c13, как противораковые лекарственные средства
AR063027A1 (es) Derivados de sulfonamida
ECSP099506A (es) Derivados de 2-quinolinona y 2 quinoxalinona y su utilización como agentes anti bacterianos
ES2478447T3 (es) Formulaciones del ácido desoxicólico y sus sales
AR077429A1 (es) Compuestos hidroxiasenapina sus derivados y composiciones farmaceuticas que comprenden los mismos
CO6270313A2 (es) Acidos carboxilicos bifenil y derivados de los mismos
NI201000067A (es) Intermediarios de gsm.
CR9070A (es) Acidos (bifenil) carboxilicos y derivados de estos
AR046212A1 (es) Derivados de 2-fenilbenzofurano, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
ECSP088650A (es) Compuestos de amido y su uso como productos farmaceuticos

Legal Events

Date Code Title Description
FA Abandonment or withdrawal