PE20090211A1 - Inhibidores de las iap - Google Patents
Inhibidores de las iapInfo
- Publication number
- PE20090211A1 PE20090211A1 PE2008000757A PE2008000757A PE20090211A1 PE 20090211 A1 PE20090211 A1 PE 20090211A1 PE 2008000757 A PE2008000757 A PE 2008000757A PE 2008000757 A PE2008000757 A PE 2008000757A PE 20090211 A1 PE20090211 A1 PE 20090211A1
- Authority
- PE
- Peru
- Prior art keywords
- alkyl
- members
- heterocicle
- carbocycle
- mercapto
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title 1
- -1 ISOPROPYL Chemical group 0.000 abstract 5
- RUYZJEIKQYLEGZ-UHFFFAOYSA-N 1-fluoro-4-phenylbenzene Chemical compound C1=CC(F)=CC=C1C1=CC=CC=C1 RUYZJEIKQYLEGZ-UHFFFAOYSA-N 0.000 abstract 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 abstract 1
- XBDQKXXYIPTUBI-UHFFFAOYSA-N Propionic acid Substances CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 230000003211 malignant effect Effects 0.000 abstract 1
- WCYWZMWISLQXQU-UHFFFAOYSA-N methyl Chemical class [CH3] WCYWZMWISLQXQU-UHFFFAOYSA-N 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- PXQLVRUNWNTZOS-UHFFFAOYSA-N sulfanyl Chemical class [SH] PXQLVRUNWNTZOS-UHFFFAOYSA-N 0.000 abstract 1
- RWRDLPDLKQPQOW-UHFFFAOYSA-N tetrahydropyrrole Substances C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pyrrole Compounds (AREA)
- Indole Compounds (AREA)
Abstract
SE REFIERE A COMPUESTOS DE FORMULA U1-M-U2; EN EL QUE U1 Y U2 SON DE FORMULA I, DONDE X1 Y X2 SON O O S; R2 ES ISOPROPILO, CICLOHEXILO, TETRAHIDROPIRAN-4-ILO, ENTRE OTROS; R3 ES H, (C1-C4)ALQUILO O FORMAR CON R4 UN HETEROCICLO DE 3 A 6 MIEMBROS; R3' ES H O JUNTO A R3 FORMAN UN CARBOCICLO DE 3 A 6 MIEMBROS; R4 Y R4' SON H, AMINO, METILO, MERCAPTO, HETEROCICLOALQUILO, ENTRE OTROS; R5 ES H O METILO; G ES SELECCIONADO DE IVa, IVe, ENTRE OTROS, DONDE R1 ES H, OH, ALQUILO O FORMAR CON R2 UN HETEROCICLO DE 5 A 8 MIEMBROS; R5' ES H O ALQUILO; R6 Y R6' SON H, ALQUILO, ARILO O ARALQUILO; R7 ES H, CIANO, MERCAPTO, GUANIDINO, ENTRE OTROS; n ES DE 1 A 4; R9' ES H, ALQUILO, CARBOCICLO, ENTRE OTROS; X3 ES O O S; Y ES UN ENLACE (CR7R7)n', O O S; n' ES 1 O 2; R7 ES H, HALOGENO, ARILO, ENTRE OTROS; M ES -CH2-[C=C]0-4-CH2-, -(CH2)1-14, ENTRE OTROS. SON SELECCIONADOS: ACIDO 2-[TERT-BUTOXICARBONIL-(1H-PIRROL-2-ILMETIL)-AMINO]-PROPIONICO, ACIDO 2(S)-[[(2-(4'-FLUORO(1,1'-BIFENIL))AMINO]CARBONIL]-1-(1,1-DIMETILETILESTER)-1-PIRROLIDINOCARBOXILICO, ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LAS PROTEINAS DE APOPTOSIS UTILES EN EL TRATAMIENTO DE NEOPLASIAS MALIGNAS
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91501007P | 2007-04-30 | 2007-04-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PE20090211A1 true PE20090211A1 (es) | 2009-04-02 |
Family
ID=39926122
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012001805A PE20130150A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
| PE2008000757A PE20090211A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PE2012001805A PE20130150A1 (es) | 2007-04-30 | 2008-04-29 | Inhibidores de las iap |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US8907092B2 (es) |
| EP (1) | EP2148858A4 (es) |
| JP (1) | JP5368428B2 (es) |
| KR (1) | KR20100024923A (es) |
| CN (1) | CN101687787A (es) |
| AR (1) | AR066348A1 (es) |
| AU (1) | AU2008245447C1 (es) |
| BR (1) | BRPI0809867A2 (es) |
| CA (1) | CA2683392A1 (es) |
| CL (1) | CL2008001234A1 (es) |
| IL (1) | IL201379A0 (es) |
| MX (1) | MX2009011783A (es) |
| NZ (2) | NZ580226A (es) |
| PE (2) | PE20130150A1 (es) |
| RU (1) | RU2491276C2 (es) |
| TW (1) | TWI432212B (es) |
| WO (1) | WO2008134679A1 (es) |
| ZA (1) | ZA200906946B (es) |
Families Citing this family (93)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2475207T3 (es) | 2004-07-15 | 2014-07-10 | Tetralogic Pharmaceuticals Corporation | Compuestos de unión a IAP |
| EP1836201B2 (en) | 2004-12-20 | 2013-09-04 | Genentech, Inc. | Pyrrolidine inhibitors of iap |
| BRPI0607988A2 (pt) | 2005-02-25 | 2009-10-27 | Tetralogic Pharmaceuticals | composto, composição farmacêutica, e método para induzir apoptose em uma célula |
| WO2006122408A1 (en) | 2005-05-18 | 2006-11-23 | Aegera Therapeutics Inc. | Bir domain binding compounds |
| JP2009512719A (ja) | 2005-10-25 | 2009-03-26 | アエゲラ セラピューティクス インコーポレイテッド | Ｉａｐｂｉｒドメイン結合化合物 |
| TWI504597B (zh) | 2006-03-16 | 2015-10-21 | Pharmascience Inc | 結合於細胞凋亡抑制蛋白（ｉａｐ）之桿狀病毒ｉａｐ重複序列（ｂｉｒ）區域之化合物 |
| AR063943A1 (es) | 2006-07-24 | 2009-03-04 | Tetralogic Pharmaceuticals Cor | Dipeptidos antagonistas de iap, una composicion farmaceutica que los comprende y el uso de los mismos para el tratamiento del cancer. |
| CL2007002166A1 (es) | 2006-07-24 | 2008-01-25 | Tetralogic Pharm Corp | Compuestos derivados de heterociclos de nitrogeno, antagonistas de los inhibidores de las proteinas de la apoptosis; sus composiciones farmaceuticas; y uso de dichos compuestos para el tratamiento del cancer. |
| ES2398791T3 (es) * | 2008-01-11 | 2013-03-21 | Genentech, Inc. | Inhibidores de IAP |
| JP5581219B2 (ja) | 2008-01-25 | 2014-08-27 | ミレニアム ファーマシューティカルズ， インコーポレイテッド | チオフェンおよびホスファチジルイノシトール３−キナーゼ（ｐｉ３ｋ）阻害薬としてのその使用 |
| EP2318395A4 (en) | 2008-08-02 | 2011-10-26 | Genentech Inc | IPA INHIBITORS |
| CN102395585A (zh) | 2009-01-30 | 2012-03-28 | 米伦纽姆医药公司 | 杂芳基化合物和其作为pi3k抑制剂的用途 |
| US8796314B2 (en) | 2009-01-30 | 2014-08-05 | Millennium Pharmaceuticals, Inc. | Heteroaryls and uses thereof |
| US9090601B2 (en) | 2009-01-30 | 2015-07-28 | Millennium Pharmaceuticals, Inc. | Thiazole derivatives |
| EA201171415A1 (ru) * | 2009-05-28 | 2013-01-30 | Тетралоджик Фармасьютикалз Корп. | Ингибиторы белков семейства iap |
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| NO2755614T3 (es) | 2012-01-03 | 2018-03-31 | ||
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- 2008-04-29 CA CA002683392A patent/CA2683392A1/en not_active Abandoned
- 2008-04-29 EP EP08747109A patent/EP2148858A4/en not_active Withdrawn
- 2008-04-29 WO PCT/US2008/061891 patent/WO2008134679A1/en not_active Ceased
- 2008-04-29 CL CL200801234A patent/CL2008001234A1/es unknown
- 2008-04-29 PE PE2012001805A patent/PE20130150A1/es not_active Application Discontinuation
- 2008-04-29 MX MX2009011783A patent/MX2009011783A/es not_active Application Discontinuation
- 2008-04-29 US US12/598,027 patent/US8907092B2/en not_active Expired - Fee Related
- 2008-04-29 NZ NZ580226A patent/NZ580226A/xx not_active IP Right Cessation
- 2008-04-29 KR KR1020097024828A patent/KR20100024923A/ko not_active Abandoned
- 2008-04-29 NZ NZ598890A patent/NZ598890A/xx not_active IP Right Cessation
- 2008-04-29 CN CN200880022901A patent/CN101687787A/zh active Pending
- 2008-04-29 RU RU2009144094/04A patent/RU2491276C2/ru not_active IP Right Cessation
- 2008-04-29 AR ARP080101812A patent/AR066348A1/es not_active Application Discontinuation
- 2008-04-29 PE PE2008000757A patent/PE20090211A1/es not_active Application Discontinuation
- 2008-04-29 BR BRPI0809867-0A patent/BRPI0809867A2/pt not_active IP Right Cessation
- 2008-04-29 TW TW097115740A patent/TWI432212B/zh not_active IP Right Cessation
- 2008-04-29 JP JP2010506573A patent/JP5368428B2/ja not_active Expired - Fee Related
- 2008-04-29 AU AU2008245447A patent/AU2008245447C1/en not_active Ceased
-
2009
- 2009-10-06 ZA ZA2009/06946A patent/ZA200906946B/en unknown
- 2009-10-11 IL IL201379A patent/IL201379A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| RU2491276C2 (ru) | 2013-08-27 |
| AU2008245447B2 (en) | 2014-01-23 |
| RU2009144094A (ru) | 2011-06-10 |
| BRPI0809867A2 (pt) | 2014-09-30 |
| ZA200906946B (en) | 2011-05-25 |
| PE20130150A1 (es) | 2013-02-27 |
| CL2008001234A1 (es) | 2008-09-22 |
| EP2148858A1 (en) | 2010-02-03 |
| AU2008245447C1 (en) | 2014-11-20 |
| NZ598890A (en) | 2013-10-25 |
| AR066348A1 (es) | 2009-08-12 |
| TW200902067A (en) | 2009-01-16 |
| JP5368428B2 (ja) | 2013-12-18 |
| WO2008134679A1 (en) | 2008-11-06 |
| JP2010526079A (ja) | 2010-07-29 |
| KR20100024923A (ko) | 2010-03-08 |
| IL201379A0 (en) | 2010-05-31 |
| TWI432212B (zh) | 2014-04-01 |
| CN101687787A (zh) | 2010-03-31 |
| US20110077265A1 (en) | 2011-03-31 |
| US8907092B2 (en) | 2014-12-09 |
| AU2008245447A1 (en) | 2008-11-06 |
| NZ580226A (en) | 2012-11-30 |
| CA2683392A1 (en) | 2008-11-06 |
| EP2148858A4 (en) | 2011-01-26 |
| MX2009011783A (es) | 2009-12-04 |
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