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PE20081448A1 - Inhibidores de transcriptasa inversa no nucleosidicos - Google Patents

Inhibidores de transcriptasa inversa no nucleosidicos

Info

Publication number
PE20081448A1
PE20081448A1 PE2007001749A PE2007001749A PE20081448A1 PE 20081448 A1 PE20081448 A1 PE 20081448A1 PE 2007001749 A PE2007001749 A PE 2007001749A PE 2007001749 A PE2007001749 A PE 2007001749A PE 20081448 A1 PE20081448 A1 PE 20081448A1
Authority
PE
Peru
Prior art keywords
chloro
alkyl
reverse transcriptase
halogen
transcriptase inhibitors
Prior art date
Application number
PE2007001749A
Other languages
English (en)
Inventor
Anthony J Neville
Robert Gomez
Jolly M Samson
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of PE20081448A1 publication Critical patent/PE20081448A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/16—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C07D249/18—Benzotriazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

SE REFIERE A UN COMPUESTO DE FORMULA I, DONDE T1, T2 Y T3 SON CADA UNO H, ALQUILO C1-C4, HALOGENO, CN, CH=CH-CN, C(O)RA O (CH2)1-2N(RA)RB; RA Y RB SON CADA UNO H, ALQUILO C1-C4; R2 Y R3 SON H, HALOGENO, C(O)N(RA)RB, OCF3, ENTRE OTROS; R6 ES (1), (2), (3), ENTRE OTROS; J1 Y J2 SON CADA UNO H, ALQUILO C1-C4, CF3, C(O)NH2, C(O)N(RA)RB, SO2RA, ENTRE OTROS; R7 Y R8 SON OH, CN, NO2, ENTRE OTROS; Q ES -CH(R4), -CH(R4)-CH(R5), -C(R4)=N-, DONDE R4 Y R5 SON ALQUILO C1-C4, CF3, HALOGENO, ENTRE OTROS, EN EL QUE EL EXTREMO IZQUIERDO DE Q SE UNE DIRECTAMENTE AL BENZO CONDENSADO. SON PREFERIDOS: 3-CLORO-5-{[5-CLORO-1-(1H-PIRAZOLO[3,4-b]PIRIDIN-3-ILMETIL)-1H-INDAZOL-4-IL]OXI}BENZONITRILO; 3-CLORO-5-{[5-CLORO-1-(1H-PIRAZOL[3,4-b]PIRIDIN-3-ILMETIL)-1H-1,2,3-BENZOTRIAZOL-4-IL]OXI}BENZONITRILO; ENTRE OTROS. SE REFIERE TAMBIEN A UN PROCEDIMIENTO DE PREPARACION Y COMPOSICION FARMACEUTICA. DICHO COMPUESTO ES INHIBIDOR DE TRANSCRIPTASA INVERSA DE VIH UTIL EN LA PROFILAXIS Y TRATAMIENTO DE INFECCION POR VIH
PE2007001749A 2006-12-13 2007-12-10 Inhibidores de transcriptasa inversa no nucleosidicos PE20081448A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87462906P 2006-12-13 2006-12-13

Publications (1)

Publication Number Publication Date
PE20081448A1 true PE20081448A1 (es) 2008-10-19

Family

ID=39277099

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2007001749A PE20081448A1 (es) 2006-12-13 2007-12-10 Inhibidores de transcriptasa inversa no nucleosidicos

Country Status (29)

Country Link
US (2) US7781454B2 (es)
EP (1) EP2121638B1 (es)
JP (1) JP5123949B2 (es)
KR (1) KR20090087481A (es)
CN (1) CN101558050A (es)
AR (1) AR064199A1 (es)
AU (1) AU2007334598B2 (es)
BR (1) BRPI0720196A2 (es)
CA (1) CA2673093A1 (es)
CL (1) CL2007003594A1 (es)
CR (1) CR10843A (es)
DO (1) DOP2009000138A (es)
EA (1) EA200970572A1 (es)
EC (1) ECSP099373A (es)
GE (1) GEP20115320B (es)
GT (1) GT200900158A (es)
HN (1) HN2009001160A (es)
IL (1) IL199103A0 (es)
MA (1) MA31036B1 (es)
MX (1) MX2009006285A (es)
NI (1) NI200900103A (es)
NO (1) NO20092636L (es)
NZ (1) NZ577637A (es)
PE (1) PE20081448A1 (es)
SV (1) SV2009003294A (es)
TN (1) TN2009000243A1 (es)
TW (1) TW200831085A (es)
WO (2) WO2008076223A1 (es)
ZA (1) ZA200903395B (es)

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Also Published As

Publication number Publication date
CL2007003594A1 (es) 2008-05-30
ECSP099373A (es) 2009-07-31
CR10843A (es) 2009-08-12
GT200900158A (es) 2009-10-14
TN2009000243A1 (en) 2010-10-18
JP5123949B2 (ja) 2013-01-23
MA31036B1 (fr) 2009-12-01
WO2008076223A1 (en) 2008-06-26
KR20090087481A (ko) 2009-08-17
ZA200903395B (en) 2010-05-26
JP2010510989A (ja) 2010-04-08
EP2121638B1 (en) 2016-05-25
CN101558050A (zh) 2009-10-14
US7781454B2 (en) 2010-08-24
NI200900103A (es) 2010-01-26
DOP2009000138A (es) 2009-11-15
BRPI0720196A2 (pt) 2013-12-31
TW200831085A (en) 2008-08-01
NO20092636L (no) 2009-09-08
MX2009006285A (es) 2009-06-23
SV2009003294A (es) 2009-11-09
WO2008076225A3 (en) 2008-08-07
HN2009001160A (es) 2011-10-11
AU2007334598B2 (en) 2013-01-17
IL199103A0 (en) 2010-03-28
AR064199A1 (es) 2009-03-18
EA200970572A1 (ru) 2009-12-30
NZ577637A (en) 2011-05-27
AU2007334598A1 (en) 2008-06-26
CA2673093A1 (en) 2008-06-26
EP2121638A2 (en) 2009-11-25
GEP20115320B (en) 2011-10-25
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WO2008076225A2 (en) 2008-06-26
US20100286192A1 (en) 2010-11-11

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