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PE20070808A1 - COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA - Google Patents

COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA

Info

Publication number
PE20070808A1
PE20070808A1 PE2006001566A PE2006001566A PE20070808A1 PE 20070808 A1 PE20070808 A1 PE 20070808A1 PE 2006001566 A PE2006001566 A PE 2006001566A PE 2006001566 A PE2006001566 A PE 2006001566A PE 20070808 A1 PE20070808 A1 PE 20070808A1
Authority
PE
Peru
Prior art keywords
rho
isoquinoline
kinase
inhibitors
compounds derived
Prior art date
Application number
PE2006001566A
Other languages
English (en)
Inventor
Peter Christopher Ray
Original Assignee
Organon Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=36569955&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20070808(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Organon Nv filed Critical Organon Nv
Publication of PE20070808A1 publication Critical patent/PE20070808A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE ISOQUINOLINA DE FORMULA (I) DONDE X ES O, S O NH; Y ES OH O NH2; m ES DE 0 A 2; n ES 1 O 2; R1 ES H, HALOGENO O ALQUILO(C1-C4); R2 Y R3 SON CADA UNO H, HALOGENO O ALQUILO(C1-C4); R ES H O ALQUILO(C1-C6) OPCIONALMENTE SUSTITUIDO CON OH, ALQUILOXI(C1-C4), ALQUILOXICARBONILO(C1-C4), ENTRE OTROS SUSTITUYENTES. SON COMPUESTOS PREFERIDOS: (S)-6-(PIPERIDIN-3-ILOXI)-2H-ISOQUINOLIN-1-ONA, (S)-7-METIL-6-(PIPERIDIN-3-ILOXI)-2H-ISOQUINOLIN-1-ONA, (S)-6-[1-(1H-PIRROL-2-ILMETIL)-PIPERIDIN-3-ILOXI]-ISOQUINOLIN-1-ILAMINA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE LA Rho-QUINASA SIENDO UTILES PARA EL TRATAMIENTO DE HIPERTENSION, ARTERIOSCLEROSIS, GLAUCOMA
PE2006001566A 2005-12-08 2006-12-06 COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA PE20070808A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP05111813 2005-12-08

Publications (1)

Publication Number Publication Date
PE20070808A1 true PE20070808A1 (es) 2007-08-27

Family

ID=36569955

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2006001566A PE20070808A1 (es) 2005-12-08 2006-12-06 COMPUESTOS DERIVADOS DE ISOQUINOLINA COMO INHIBIDORES DE Rho-QUINASA

Country Status (17)

Country Link
EP (1) EP1963304B2 (es)
JP (1) JP5313682B2 (es)
CN (1) CN101321748B (es)
AR (1) AR058287A1 (es)
AT (1) ATE434613T1 (es)
CA (1) CA2629915C (es)
CY (1) CY1110489T1 (es)
DE (1) DE602006007488D1 (es)
DK (1) DK1963304T3 (es)
ES (1) ES2327677T3 (es)
HR (1) HRP20090400T1 (es)
PE (1) PE20070808A1 (es)
PL (1) PL1963304T3 (es)
PT (1) PT1963304E (es)
SI (1) SI1963304T1 (es)
TW (1) TW200738682A (es)
WO (1) WO2007065916A1 (es)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2331853T3 (es) 2005-06-28 2010-01-18 Sanofi-Aventis Derivados de isoquinolina como inhibidores de rho-cinasa.
US7470787B2 (en) 2005-07-11 2008-12-30 Aerie Pharmaceuticals, Inc. Isoquinoline compounds
NZ565668A (en) 2005-07-26 2010-09-30 Sanofi Aventis Piperidinyl-substituted isoquinolone derivatives as RHO-kinase inhibitors
ES2372067T3 (es) 2005-07-26 2012-01-13 Sanofi Derivados de ciclohexilamina isoquinolona como inhibidores de la rho-quinasa.
JP5235887B2 (ja) 2006-09-20 2013-07-10 アエリー ファーマシューティカルズ インコーポレイテッド Ｒｈｏキナーゼ阻害剤
CN101595094B (zh) 2006-12-27 2013-02-20 塞诺菲-安万特股份有限公司 环烷基胺取代的异喹诺酮衍生物
HRP20100705T1 (hr) 2006-12-27 2011-01-31 Sanofi-Aventis Cikloalkilaminski supstituirani izokinolinski i izokinolinonski derivati
ATE502027T1 (de) 2006-12-27 2011-04-15 Sanofi Aventis Substituierte isochinoline und ihre verwendung als rho-kinase-inhibitoren
RU2009128693A (ru) * 2006-12-27 2011-02-10 Санофи-Авентис (Fr) Замещенные производные изохинолина и изохинолинона
CA2673920C (en) 2006-12-27 2015-03-24 Sanofi-Aventis Cycloalkylamine substituted isoquinoline derivatives
KR101517154B1 (ko) * 2006-12-27 2015-04-30 사노피 Ｒｈｏ-키나제의 억제제로서의 치환된 이소퀴놀린 및 이소퀴놀리논 유도체
US8455513B2 (en) 2007-01-10 2013-06-04 Aerie Pharmaceuticals, Inc. 6-aminoisoquinoline compounds
BRPI0821837A2 (pt) * 2007-12-26 2015-06-16 Sanofi Aventis Processo para a preparação de 6-substituídas-1-(2h)-isoquinolinonas
US8455514B2 (en) 2008-01-17 2013-06-04 Aerie Pharmaceuticals, Inc. 6-and 7-amino isoquinoline compounds and methods for making and using the same
ES2436531T3 (es) 2008-06-24 2014-01-02 Sanofi Isoquinolinas e isoquinolinonas sustituidas en posición 6
AU2009262517B2 (en) 2008-06-24 2014-01-09 Sanofi Substituted isoquinolines and isoquinolinones as Rho kinase inhibitors
AU2009262509B2 (en) 2008-06-24 2014-01-30 Sanofi Bi-and polycyclic substituted isoquinoline and isoquinoline derivatives as Rho kinase inhibitors
TW201006821A (en) * 2008-07-16 2010-02-16 Bristol Myers Squibb Co Pyridone and pyridazone analogues as GPR119 modulators
US8450344B2 (en) 2008-07-25 2013-05-28 Aerie Pharmaceuticals, Inc. Beta- and gamma-amino-isoquinoline amide compounds and substituted benzamide compounds
WO2010126626A2 (en) 2009-05-01 2010-11-04 Aerie Pharmaceuticals, Inc. Dual mechanism inhibitors for the treatment of disease
HUE025936T2 (en) 2011-07-08 2016-05-30 Sanofi Sa Substituted phenyl compounds
DK2729460T3 (en) 2011-07-08 2016-04-18 Sanofi Sa Crystalline solvates of 6- (piperidin-4-yloxy) -2H-isoquinolin-1-one hydrochloride
SI2729461T1 (sl) 2011-07-08 2016-06-30 Sanofi Polimorfi 6-(piperidin-4-iloksi)-2H-izokinolin-1-on hidroklorida
EP3141235A1 (en) 2012-12-06 2017-03-15 IP Gesellschaft für Management mbH N-(6-((2r,3s)-3,4-dihydroxybutan-2-yloxy)-2-(4-fluorobenzylthio)pyrimidin-4-yl)-3-methylazetidine-l -sulfonamide
PT3811943T (pt) 2013-03-15 2023-03-15 Aerie Pharmaceuticals Inc Composto para uso no tratamento de distúrbios oculares
US9643927B1 (en) 2015-11-17 2017-05-09 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
WO2017086941A1 (en) 2015-11-17 2017-05-26 Aerie Pharmaceuticals, Inc. Process for the preparation of kinase inhibitors and intermediates thereof
US11389441B2 (en) 2016-08-31 2022-07-19 Aerie Pharmaceuticals, Inc. Ophthalmic compositions
TWI795381B (zh) * 2016-12-21 2023-03-11 比利時商健生藥品公司 作為ｍａｌｔ１抑制劑之吡唑衍生物
CA3057872A1 (en) 2017-03-31 2018-10-04 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
EP3640242B1 (en) * 2017-06-16 2023-04-19 Hitgen Ltd. Rock-inhibiting compound and uses thereof
AU2019337703B2 (en) 2018-09-14 2023-02-02 Aerie Pharmaceuticals, Inc. Aryl cyclopropyl-amino-isoquinolinyl amide compounds
CN113877483B (zh) * 2021-07-20 2023-11-24 烟台宁远药业有限公司 医药中间体卤代异喹啉类硼酸的低温连续合成装置与方法
CN119630643A (zh) * 2022-08-01 2025-03-14 瓦洛健康公司 用于制备6-取代的-1-(2h)-异喹啉酮的方法和中间化合物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2002100833A1 (en) * 2001-06-12 2002-12-19 Sumitomo Pharmaceuticals Company, Limited Rho KINASE INHIBITORS
AU2003281623B8 (en) * 2002-07-22 2009-06-11 Asahi Kasei Pharma Corporation 5-substituted isoquinoline derivative
CA2502583A1 (en) * 2002-09-12 2004-03-25 Kirin Beer Kabushiki Kaisha Isoquinoline derivatives having kinase inhibitory activity and medicament containing the same
NZ565668A (en) * 2005-07-26 2010-09-30 Sanofi Aventis Piperidinyl-substituted isoquinolone derivatives as RHO-kinase inhibitors

Also Published As

Publication number Publication date
ES2327677T3 (es) 2009-11-02
EP1963304B1 (en) 2009-06-24
DE602006007488D1 (de) 2009-08-06
AR058287A1 (es) 2008-01-30
JP5313682B2 (ja) 2013-10-09
ATE434613T1 (de) 2009-07-15
WO2007065916A1 (en) 2007-06-14
CA2629915C (en) 2014-03-18
JP2009518360A (ja) 2009-05-07
CA2629915A1 (en) 2007-06-14
CY1110489T1 (el) 2015-04-29
EP1963304A1 (en) 2008-09-03
DK1963304T3 (da) 2009-10-12
EP1963304B2 (en) 2015-05-13
HRP20090400T1 (hr) 2009-08-31
PT1963304E (pt) 2009-09-14
PL1963304T3 (pl) 2009-12-31
SI1963304T1 (sl) 2009-12-31
TW200738682A (en) 2007-10-16
CN101321748A (zh) 2008-12-10
CN101321748B (zh) 2013-03-27

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