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PE20011166A1 - Piridinas, pirimidinas, purinonas, pirrolopirimidinonas y pirrolopiridinonas como antagonistas del factor liberador de corticotropina - Google Patents

Piridinas, pirimidinas, purinonas, pirrolopirimidinonas y pirrolopiridinonas como antagonistas del factor liberador de corticotropina

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Publication number
PE20011166A1
PE20011166A1 PE2001000038A PE2001000038A PE20011166A1 PE 20011166 A1 PE20011166 A1 PE 20011166A1 PE 2001000038 A PE2001000038 A PE 2001000038A PE 2001000038 A PE2001000038 A PE 2001000038A PE 20011166 A1 PE20011166 A1 PE 20011166A1
Authority
PE
Peru
Prior art keywords
alkyl
antagonists
releasing factor
corticotropin releasing
methyl
Prior art date
Application number
PE2001000038A
Other languages
English (en)
Inventor
Yuhpyng Liang Chen
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of PE20011166A1 publication Critical patent/PE20011166A1/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/62—Oxygen or sulfur atoms
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Abstract

SE REFIERE A COMPUESTOS DE FORMULA I , II , III DONDE A ES CR7, N; B ES NR1R2, CR1R2R11, -C(=CR2R12)R1, NHCHR1R2, ENTRE OTROS; CUANDO LA UNION ENTRE C Y G ES UN DOBLE ENLACE G ES H, O, S, NH, N(ALQUILO C1-C4), DE LO CONTRARIO ES -C(H)(NH2), CH2, -CH-(METOXI), ENTRE OTROS; Y ES CH, N; Z ES NH, O, S, -N(ALQUILO C1-C2) , ENTRE OTROS; R1 ES C(O)H, CO-(ALQUILO C1-C6), ENTRE OTROS; R2 ES H, ALQUILO C1-C12, ENTRE OTROS; R3 ES METILO, ETILO, HALO, CIANO, METOXI, OCF3, ENTRE OTROS; R4 ES H, ALQUILO C1-C4, CICLOALQUILO C3-C5, ENTRE OTROS; R5 ES ARILO, HETEROARILO, ENTRE OTROS; R6 ES H, ALQUILO C1-C6, ENTRE OTROS; R7 ES H, METILO HALO, CIANO, HIDROXI, ENTRE OTROS; R11 ES H, HIDROXI, ENTRE OTROS; R12 ES H, ALQUILO C1-C4; R16 Y R17 SON H, OH, METILO, ENTRE OTROS. UN COMPUESTO PREFERIDO ES -(4-CLORO-2,6-DIMETIL-FENOXI)-4-(1-HIDROXIMETIL-PROPILAMINO) -6,N-DIMETIL-NICOTINAMIDA, ENTRE OTROS. SE REFIERE TAMBIEN A UNA COMPOSICION FARMACEUTICA. LOS COMPUESTOS SON ANTAGONISTAS DEL FACTOR LIBERADOR DE CORTICOTROPINA (CRF) Y SON UTILES PARA EL TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO CENTRAL Y OTROS TRASTORNOS
PE2001000038A 2000-01-18 2001-01-16 Piridinas, pirimidinas, purinonas, pirrolopirimidinonas y pirrolopiridinonas como antagonistas del factor liberador de corticotropina PE20011166A1 (es)

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