IL129575A - Pills with a core coated with a fungicide and polymer - Google Patents

Pills with a core coated with a fungicide and polymer

Info

Publication number: IL129575A
Authority: IL; Israel
Prior art keywords: itraconazole; coating; percent; pellets; water
Prior art date: 1997-03-26

Application number

IL12957598A

Other languages

English (en)

Hebrew (he)

Other versions

IL129575A0 (en

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-26

Filing date

1998-03-18

Publication date

2004-06-20

1998-03-18 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2000-02-29 Publication of IL129575A0 publication Critical patent/IL129575A0/xx

2004-06-20 Publication of IL129575A publication Critical patent/IL129575A/en

Links

239000008188 pellet Substances 0.000 title claims abstract description 61
229940121375 antifungal agent Drugs 0.000 title claims description 20
230000000843 anti-fungal effect Effects 0.000 title claims description 8
229920000642 polymer Polymers 0.000 title description 13
229960004130 itraconazole Drugs 0.000 claims abstract description 57
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims abstract description 56
238000000576 coating method Methods 0.000 claims abstract description 39
239000011248 coating agent Substances 0.000 claims abstract description 24
229920003169 water-soluble polymer Polymers 0.000 claims abstract description 22
229920001688 coating polymer Polymers 0.000 claims abstract description 14
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 48
239000003814 drug Substances 0.000 claims description 39
229940079593 drug Drugs 0.000 claims description 37
239000011162 core material Substances 0.000 claims description 34
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 28
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UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 26
238000005507 spraying Methods 0.000 claims description 24
239000002552 dosage form Substances 0.000 claims description 23
238000000034 method Methods 0.000 claims description 20
235000000346 sugar Nutrition 0.000 claims description 12
238000001035 drying Methods 0.000 claims description 11
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239000007921 spray Substances 0.000 claims description 6
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 5
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239000003960 organic solvent Substances 0.000 claims description 3
239000000243 solution Substances 0.000 description 27
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238000004090 dissolution Methods 0.000 description 15
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239000002904 solvent Substances 0.000 description 11
239000003429 antifungal agent Substances 0.000 description 10
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 9
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239000011247 coating layer Substances 0.000 description 9
239000000463 material Substances 0.000 description 9
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HUADITLKOCMHSB-AVQIMAJZSA-N 2-butan-2-yl-4-[4-[4-[4-[[(2s,4r)-2-(2,4-difluorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N(C(C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@H]3O[C@@](CN4N=CN=C4)(OC3)C=3C(=CC(F)=CC=3)F)=CC=2)C=C1 HUADITLKOCMHSB-AVQIMAJZSA-N 0.000 description 7
239000002253 acid Substances 0.000 description 7
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HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
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229920001213 Polysorbate 20 Polymers 0.000 description 3
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MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
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239000012153 distilled water Substances 0.000 description 3
229940088679 drug related substance Drugs 0.000 description 3
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FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
229920001353 Dextrin Polymers 0.000 description 2
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JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 2
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NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 2
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QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
229910052783 alkali metal Inorganic materials 0.000 description 2
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WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
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238000002474 experimental method Methods 0.000 description 1
239000000284 extract Substances 0.000 description 1
238000005243 fluidization Methods 0.000 description 1
235000013305 food Nutrition 0.000 description 1
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235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
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239000001103 potassium chloride Substances 0.000 description 1
235000011164 potassium chloride Nutrition 0.000 description 1
238000011165 process development Methods 0.000 description 1
238000011084 recovery Methods 0.000 description 1
229920005989 resin Polymers 0.000 description 1
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238000007789 sealing Methods 0.000 description 1
238000007873 sieving Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000006104 solid solution Substances 0.000 description 1
238000000935 solvent evaporation Methods 0.000 description 1
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150000005846 sugar alcohols Polymers 0.000 description 1
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239000007916 tablet composition Substances 0.000 description 1
UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000010678 thyme oil Substances 0.000 description 1
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ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
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235000013343 vitamin Nutrition 0.000 description 1
239000009637 wintergreen oil Substances 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

IL12957598A 1997-03-26 1998-03-18 Pills with a core coated with a fungicide and polymer IL129575A (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP97200914		1997-03-26
PCT/EP1998/001773 WO1998042318A1 (en)	1997-03-26	1998-03-18	Pellets having a core coated with an antifungal and a polymer

Publications (2)

Publication Number	Publication Date
IL129575A0 IL129575A0 (en)	2000-02-29
IL129575A true IL129575A (en)	2004-06-20

Family

ID=8228147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
IL12957598A IL129575A (en)	1997-03-26	1998-03-18	Pills with a core coated with a fungicide and polymer

Country Status (30)

Country	Link
EP (1)	EP0969821B1 (pl)
JP (1)	JP3608800B2 (pl)
KR (1)	KR100520936B1 (pl)
CN (1)	CN1206984C (pl)
AP (1)	AP1227A (pl)
AT (1)	ATE241969T1 (pl)
AU (1)	AU734248B2 (pl)
BG (1)	BG64434B1 (pl)
BR (1)	BR9806174A (pl)
CA (1)	CA2269501C (pl)
CY (1)	CY2384B1 (pl)
CZ (1)	CZ295502B6 (pl)
DE (1)	DE69815316T2 (pl)
DK (1)	DK0969821T3 (pl)
EE (1)	EE03904B1 (pl)
ES (1)	ES2201485T3 (pl)
HU (1)	HU224217B1 (pl)
ID (1)	ID21477A (pl)
IL (1)	IL129575A (pl)
NO (1)	NO325102B1 (pl)
NZ (1)	NZ335364A (pl)
OA (1)	OA11162A (pl)
PL (1)	PL190566B1 (pl)
PT (1)	PT969821E (pl)
RU (1)	RU2218153C2 (pl)
SI (1)	SI0969821T1 (pl)
SK (1)	SK284813B6 (pl)
TR (1)	TR199900990T2 (pl)
UA (1)	UA60318C2 (pl)
WO (1)	WO1998042318A1 (pl)

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ES2157731B1 (es) *	1998-07-21	2002-05-01	Liconsa Liberacion Controlada	Preparacion farmaceutica oral de un compuesto de actividad antifungica y procedimiento para su preparacion.
ATE307808T1 (de)	1999-03-24	2005-11-15	Scherer Technologies Inc R P	Pharmazeutische formulierungen mit verbesserter löslichkeit in wasser
KR100432949B1 (ko) *	2000-06-13	2004-05-31	코오롱제약주식회사	생체이용율이 향상된 이트라코나졸의 분립체 조성물과이를 이용한 이트라코나졸 제제 및 그 제조방법
US6663897B2 (en) *	2001-02-06	2003-12-16	Dsm Ip Assets B.V.	Oral itraconazole formulations and methods of making the same
DK1370543T3 (da)	2001-02-14	2007-02-19	Tibotec Pharm Ltd	Bredspektrede 2-(substitueret amino) benzothiazol- sulfonamid-HIV-proteaseinhibitorer
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DK1387842T3 (da)	2001-05-11	2009-08-10	Tibotec Pharm Ltd	Bredspektrede 2-amino-benzoxazolsulfonamid-HIV-protease-inhibitorer
AU2002317063A (en) *	2001-06-12	2002-12-23	Smartrix Technologies Inc	Itraconazole granulations: pharmaceutical formulations for oral administration and method of preparing same
US8071133B2 (en)	2001-08-20	2011-12-06	Stiefel Laboratories, Inc.	Oral dosage forms of water insoluble drugs and methods of making the same
IL162574A0 (en)	2001-12-21	2005-11-20	Tibotec Pharm Ltd	Broadspectrum heterocyclic substituted phenyl containing sulfonamide hiv protease inhibitors
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JP4681296B2 (ja)	2002-08-14	2011-05-11	テイボテク・フアーマシユーチカルズ・リミテツド	スペクトルの広い置換オキシインドールスルホンアミドｈｉｖプロテアーゼ阻害剤
KR100557680B1 (ko) *	2002-11-23	2006-03-07	한국유나이티드제약 주식회사	이트라코나졸의 용해도 개선을 위한 펠렛제제 및 그제조방법
ES2283725T5 (es) *	2003-01-14	2014-11-28	Acino Pharma Ag	Composición bioequivalente de itraconazol dispersada en un polímero hidrófilo
DE60312635T3 (de) *	2003-01-14	2013-05-08	Cimex Pharma Ag	Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
AU2004263130A1 (en) *	2003-08-06	2005-02-17	Nirmal Mulye	Pharmaceutical composition containing water soluble drug
EA010911B1 (ru)	2003-09-11	2008-12-30	Тиботек Фармасьютикалз Лтд.	Ингибиторы проникновения вируса вич
EP1568369A1 (en)	2004-02-23	2005-08-31	Boehringer Ingelheim Vetmedica Gmbh	Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es)	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
EP1750696B1 (en)	2004-05-07	2013-06-26	Sequoia Pharmaceuticals Inc	RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
BRPI0511175A (pt)	2004-05-17	2007-12-04	Tibotec Pharm Ltd	1-hetero-ciclil-1,5-diidro-pirido[3,2-b]indol-2-onas
AR049637A1 (es)	2004-05-17	2006-08-23	Tibotec Pharm Ltd	1-fenil-1,5-dihidro-pirido[3,2-b]indol-2-onas sustituidas en las posiciones 6, 7, 8, 9
TW200613307A (en)	2004-05-17	2006-05-01	Tibotec Pharm Ltd	4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
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1998
- 1998-03-18 ID IDW990316A patent/ID21477A/id unknown
- 1998-03-18 EP EP98919155A patent/EP0969821B1/en not_active Expired - Lifetime
- 1998-03-18 AU AU72107/98A patent/AU734248B2/en not_active Expired
- 1998-03-18 CZ CZ19991398A patent/CZ295502B6/cs not_active IP Right Cessation
- 1998-03-18 UA UA99042468A patent/UA60318C2/uk unknown
- 1998-03-18 BR BR9806174-7A patent/BR9806174A/pt not_active Application Discontinuation
- 1998-03-18 CA CA002269501A patent/CA2269501C/en not_active Expired - Lifetime
- 1998-03-18 ES ES98919155T patent/ES2201485T3/es not_active Expired - Lifetime
- 1998-03-18 EE EEP199900453A patent/EE03904B1/xx unknown
- 1998-03-18 SK SK544-99A patent/SK284813B6/sk not_active IP Right Cessation
- 1998-03-18 AP APAP/P/1999/001516A patent/AP1227A/en active
- 1998-03-18 AT AT98919155T patent/ATE241969T1/de active
- 1998-03-18 KR KR10-1999-7003848A patent/KR100520936B1/ko not_active Expired - Lifetime
- 1998-03-18 HU HU0002056A patent/HU224217B1/hu active IP Right Grant
- 1998-03-18 DE DE69815316T patent/DE69815316T2/de not_active Expired - Lifetime
- 1998-03-18 JP JP54490198A patent/JP3608800B2/ja not_active Expired - Lifetime
- 1998-03-18 PT PT98919155T patent/PT969821E/pt unknown
- 1998-03-18 DK DK98919155T patent/DK0969821T3/da active
- 1998-03-18 PL PL98335542A patent/PL190566B1/pl unknown
- 1998-03-18 NZ NZ335364A patent/NZ335364A/xx not_active IP Right Cessation
- 1998-03-18 CN CNB988020181A patent/CN1206984C/zh not_active Expired - Lifetime
- 1998-03-18 RU RU99112123/15A patent/RU2218153C2/ru active
- 1998-03-18 TR TR1999/00990T patent/TR199900990T2/xx unknown
- 1998-03-18 WO PCT/EP1998/001773 patent/WO1998042318A1/en not_active Ceased
- 1998-03-18 IL IL12957598A patent/IL129575A/en not_active IP Right Cessation
- 1998-03-18 SI SI9830489T patent/SI0969821T1/xx unknown
1999
- 1999-04-23 BG BG103356A patent/BG64434B1/bg unknown
- 1999-04-30 NO NO19992114A patent/NO325102B1/no not_active IP Right Cessation
- 1999-09-24 OA OA9900215A patent/OA11162A/en unknown
2003
- 2003-11-04 CY CY0300079A patent/CY2384B1/xx unknown

Also Published As

Publication number	Publication date
TR199900990T2 (xx)	1999-10-21
DK0969821T3 (da)	2003-09-15
JP2001520663A (ja)	2001-10-30
WO1998042318A1 (en)	1998-10-01
HK1022840A1 (en)	2000-08-25
EP0969821A1 (en)	2000-01-12
HU224217B1 (hu)	2005-06-28
BR9806174A (pt)	1999-10-19
NO325102B1 (no)	2008-02-04
CY2384B1 (en)	2004-06-04
NZ335364A (en)	2000-08-25
JP3608800B2 (ja)	2005-01-12
KR100520936B1 (ko)	2005-10-17
BG103356A (en)	2000-03-31
OA11162A (en)	2003-04-16
AP1227A (en)	2003-11-24
SK284813B6 (sk)	2005-12-01
PL335542A1 (en)	2000-04-25
ID21477A (id)	1999-06-17
IL129575A0 (en)	2000-02-29
AP9901516A0 (en)	1999-06-30
DE69815316D1 (de)	2003-07-10
PT969821E (pt)	2003-10-31
KR20000052971A (ko)	2000-08-25
AU734248B2 (en)	2001-06-07
CN1244796A (zh)	2000-02-16
CZ295502B6 (cs)	2005-08-17
HUP0002056A3 (en)	2001-01-29
NO992114D0 (no)	1999-04-30
EE9900453A (et)	2000-04-17
ES2201485T3 (es)	2004-03-16
SK54499A3 (en)	2000-01-18
HUP0002056A2 (hu)	2000-12-28
BG64434B1 (en)	2005-02-28
SI0969821T1 (en)	2003-10-31
CN1206984C (zh)	2005-06-22
NO992114L (no)	1999-08-26
EE03904B1 (et)	2002-12-16
UA60318C2 (uk)	2003-10-15
ATE241969T1 (de)	2003-06-15
CZ139899A3 (cs)	1999-10-13
RU2218153C2 (ru)	2003-12-10
DE69815316T2 (de)	2004-04-29
EP0969821B1 (en)	2003-06-04
AU7210798A (en)	1998-10-20
CA2269501A1 (en)	1998-10-01
CA2269501C (en)	2005-11-08
PL190566B1 (pl)	2005-12-30

Publication	Publication Date	Title
CA2269501C (en)	2005-11-08	Pellets having a core coated with an antifungal and a polymer
CA2315110C (en)	2006-09-12	Pellets having a core coated with an antifungal and a polymer
US9642806B2 (en)	2017-05-09	Antifungal compositions with improved bioavailability
EP1073424A1 (en)	2001-02-07	Pellets having a core coated with a lipid lowering agent and a polymer
HK1022840B (en)	2003-09-05	Pellets having a core coated with an antifungal and a polymer
MXPA99004411A (en)	1999-09-01	Pellets having a core coated with an antifungal and a polymer
MXPA00008322A (en)	2001-07-09	Pellets having a core coated with an antifungal and a polymer

Legal Events

Date	Code	Title
2004-11-24	FF	Patent granted
2005-02-20	KB	Patent renewed
2008-04-13	KB	Patent renewed
2012-03-29	KB	Patent renewed
2016-02-29	KB	Patent renewed
2018-10-31	EXP	Patent expired