BG64434B1 - Pellets containing core enveloped by intraconazol and polymer - Google Patents

Pellets containing core enveloped by intraconazol and polymer Download PDF

Info

Publication number: BG64434B1
Authority: BG; Bulgaria
Prior art keywords: itraconazole; polymer; coating; pellets; water
Prior art date: 1997-03-26

Application number

BG103356A

Other languages

Bulgarian (bg)

English (en)

Other versions

BG103356A (en

Inventor

Roger Vandecruys

Conde Valentin De

Paul Gilis

Jozef Peeters

Original Assignee

Janssen Pharmaceutica Nv

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-03-26

Filing date

1999-04-23

Publication date

2005-02-28

1999-04-23 Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv

2000-03-31 Publication of BG103356A publication Critical patent/BG103356A/xx

2005-02-28 Publication of BG64434B1 publication Critical patent/BG64434B1/bg

Links

239000008188 pellet Substances 0.000 title claims abstract description 57
229920000642 polymer Polymers 0.000 title claims abstract description 23
238000000576 coating method Methods 0.000 claims abstract description 34
238000000034 method Methods 0.000 claims abstract description 33
239000011248 coating agent Substances 0.000 claims abstract description 30
229920003169 water-soluble polymer Polymers 0.000 claims abstract description 23
238000007789 sealing Methods 0.000 claims abstract description 19
235000000346 sugar Nutrition 0.000 claims abstract description 13
229960004130 itraconazole Drugs 0.000 claims description 58
VHVPQPYKVGDNFY-DFMJLFEVSA-N 2-[(2r)-butan-2-yl]-4-[4-[4-[4-[[(2r,4s)-2-(2,4-dichlorophenyl)-2-(1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-1,2,4-triazol-3-one Chemical compound O=C1N([C@H](C)CC)N=CN1C1=CC=C(N2CCN(CC2)C=2C=CC(OC[C@@H]3O[C@](CN4N=CN=C4)(OC3)C=3C(=CC(Cl)=CC=3)Cl)=CC=2)C=C1 VHVPQPYKVGDNFY-DFMJLFEVSA-N 0.000 claims description 57
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims description 48
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 32
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CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
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235000015424 sodium Nutrition 0.000 description 1
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235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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238000004544 sputter deposition Methods 0.000 description 1
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150000005846 sugar alcohols Polymers 0.000 description 1
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239000000725 suspension Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
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UWHCKJMYHZGTIT-UHFFFAOYSA-N tetraethylene glycol Chemical compound OCCOCCOCCOCCO UWHCKJMYHZGTIT-UHFFFAOYSA-N 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
239000010678 thyme oil Substances 0.000 description 1
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ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
- A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Dermatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

BG103356A 1997-03-26 1999-04-23 Pellets containing core enveloped by intraconazol and polymer BG64434B1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
EP97200914		1997-03-26

Publications (2)

Publication Number	Publication Date
BG103356A BG103356A (en)	2000-03-31
BG64434B1 true BG64434B1 (en)	2005-02-28

Family

ID=8228147

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
BG103356A BG64434B1 (en)	1997-03-26	1999-04-23	Pellets containing core enveloped by intraconazol and polymer

Country Status (30)

Country	Link
EP (1)	EP0969821B1 (pl)
JP (1)	JP3608800B2 (pl)
KR (1)	KR100520936B1 (pl)
CN (1)	CN1206984C (pl)
AP (1)	AP1227A (pl)
AT (1)	ATE241969T1 (pl)
AU (1)	AU734248B2 (pl)
BG (1)	BG64434B1 (pl)
BR (1)	BR9806174A (pl)
CA (1)	CA2269501C (pl)
CY (1)	CY2384B1 (pl)
CZ (1)	CZ295502B6 (pl)
DE (1)	DE69815316T2 (pl)
DK (1)	DK0969821T3 (pl)
EE (1)	EE03904B1 (pl)
ES (1)	ES2201485T3 (pl)
HU (1)	HU224217B1 (pl)
ID (1)	ID21477A (pl)
IL (1)	IL129575A (pl)
NO (1)	NO325102B1 (pl)
NZ (1)	NZ335364A (pl)
OA (1)	OA11162A (pl)
PL (1)	PL190566B1 (pl)
PT (1)	PT969821E (pl)
RU (1)	RU2218153C2 (pl)
SI (1)	SI0969821T1 (pl)
SK (1)	SK284813B6 (pl)
TR (1)	TR199900990T2 (pl)
UA (1)	UA60318C2 (pl)
WO (1)	WO1998042318A1 (pl)

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DK1387842T3 (da)	2001-05-11	2009-08-10	Tibotec Pharm Ltd	Bredspektrede 2-amino-benzoxazolsulfonamid-HIV-protease-inhibitorer
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ES2283725T5 (es) *	2003-01-14	2014-11-28	Acino Pharma Ag	Composición bioequivalente de itraconazol dispersada en un polímero hidrófilo
DE60312635T3 (de) *	2003-01-14	2013-05-08	Cimex Pharma Ag	Zusammensetzung in Form eines festen Dispersion enthaltend Itraconazol und ein hydrophilisches Polymer mit einer verbesserten Bioverfügbarkeit
AU2004263130A1 (en) *	2003-08-06	2005-02-17	Nirmal Mulye	Pharmaceutical composition containing water soluble drug
EA010911B1 (ru)	2003-09-11	2008-12-30	Тиботек Фармасьютикалз Лтд.	Ингибиторы проникновения вируса вич
EP1568369A1 (en)	2004-02-23	2005-08-31	Boehringer Ingelheim Vetmedica Gmbh	Use of meloxicam for the treatment of respiratory diseases in pigs
AR048650A1 (es)	2004-05-04	2006-05-10	Tibotec Pharm Ltd	Derivados de (1,10b-dihidro-2-(aminocarbonil-fenil)-5h-pirazolo[1,5 c][1,3]benzoxazin-5-il)fenil metanona como inhibidores de la replicacion viral del vih
EP1750696B1 (en)	2004-05-07	2013-06-26	Sequoia Pharmaceuticals Inc	RETROVIRAL PROTEASE INHIBITORS RESISTING THEIR RESISTANCE
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TW200613307A (en)	2004-05-17	2006-05-01	Tibotec Pharm Ltd	4-substituted-1,5-dihydro-pyrido[3,2-b]indol-2-ones
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- 1998-03-18 CZ CZ19991398A patent/CZ295502B6/cs not_active IP Right Cessation
- 1998-03-18 UA UA99042468A patent/UA60318C2/uk unknown
- 1998-03-18 BR BR9806174-7A patent/BR9806174A/pt not_active Application Discontinuation
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1999
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Also Published As

Publication number	Publication date
TR199900990T2 (xx)	1999-10-21
DK0969821T3 (da)	2003-09-15
JP2001520663A (ja)	2001-10-30
WO1998042318A1 (en)	1998-10-01
HK1022840A1 (en)	2000-08-25
EP0969821A1 (en)	2000-01-12
HU224217B1 (hu)	2005-06-28
BR9806174A (pt)	1999-10-19
NO325102B1 (no)	2008-02-04
CY2384B1 (en)	2004-06-04
NZ335364A (en)	2000-08-25
JP3608800B2 (ja)	2005-01-12
KR100520936B1 (ko)	2005-10-17
BG103356A (en)	2000-03-31
OA11162A (en)	2003-04-16
AP1227A (en)	2003-11-24
SK284813B6 (sk)	2005-12-01
PL335542A1 (en)	2000-04-25
ID21477A (id)	1999-06-17
IL129575A (en)	2004-06-20
IL129575A0 (en)	2000-02-29
AP9901516A0 (en)	1999-06-30
DE69815316D1 (de)	2003-07-10
PT969821E (pt)	2003-10-31
KR20000052971A (ko)	2000-08-25
AU734248B2 (en)	2001-06-07
CN1244796A (zh)	2000-02-16
CZ295502B6 (cs)	2005-08-17
HUP0002056A3 (en)	2001-01-29
NO992114D0 (no)	1999-04-30
EE9900453A (et)	2000-04-17
ES2201485T3 (es)	2004-03-16
SK54499A3 (en)	2000-01-18
HUP0002056A2 (hu)	2000-12-28
SI0969821T1 (en)	2003-10-31
CN1206984C (zh)	2005-06-22
NO992114L (no)	1999-08-26
EE03904B1 (et)	2002-12-16
UA60318C2 (uk)	2003-10-15
ATE241969T1 (de)	2003-06-15
CZ139899A3 (cs)	1999-10-13
RU2218153C2 (ru)	2003-12-10
DE69815316T2 (de)	2004-04-29
EP0969821B1 (en)	2003-06-04
AU7210798A (en)	1998-10-20
CA2269501A1 (en)	1998-10-01
CA2269501C (en)	2005-11-08
PL190566B1 (pl)	2005-12-30

Publication	Publication Date	Title
BG64434B1 (en)	2005-02-28	Pellets containing core enveloped by intraconazol and polymer
AU766041B2 (en)	2003-10-09	Pellets having a core coated with an antifungal and a polymer
RU2125445C1 (ru)	1999-01-27	Гранула, способ ее получения и фармацевтическая композиция
CZ293841B6 (cs)	2004-08-18	Částice s obsahem itrakonazolu
HU225236B1 (en)	2006-08-28	Pharmaceutical formulations containing darifenacin
KR20010041460A (ko)	2001-05-25	지질 저하제 및 중합체로 피복된 핵을 갖는 펠릿
MXPA99004411A (en)	1999-09-01	Pellets having a core coated with an antifungal and a polymer
HK1022840B (en)	2003-09-05	Pellets having a core coated with an antifungal and a polymer
MXPA00008322A (en)	2001-07-09	Pellets having a core coated with an antifungal and a polymer