FI90877C - Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi - Google Patents

Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi

Info

Publication number: FI90877C
Authority: FI; Finland
Prior art keywords: aristeromycin; preparation; therapeutically useful; adenosine derivatives; novel therapeutically
Prior art date: 1988-03-25

Application number

FI891339A

Other languages

English (en)

Swedish (sv)

Other versions

FI90877B (fi

FI891339A0 (fi

FI891339A7 (fi

Inventor

Michael L Edwards

James R Mccarthy

Nellijunja J Prakash

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-25

Filing date

1989-03-21

Publication date

1994-04-11

1989-03-21 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-03-21 Publication of FI891339A0 publication Critical patent/FI891339A0/fi

1989-09-26 Publication of FI891339A7 publication Critical patent/FI891339A7/fi

1993-12-31 Publication of FI90877B publication Critical patent/FI90877B/fi

1994-04-11 Application granted granted Critical

1994-04-11 Publication of FI90877C publication Critical patent/FI90877C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

FI891339A 1988-03-25 1989-03-21 Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi FI90877C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US17378288		1988-03-25
US07/173,782 US4996308A (en)	1988-03-25	1988-03-25	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (4)

Publication Number	Publication Date
FI891339A0 FI891339A0 (fi)	1989-03-21
FI891339A7 FI891339A7 (fi)	1989-09-26
FI90877B FI90877B (fi)	1993-12-31
FI90877C true FI90877C (fi)	1994-04-11

Family

ID=22633462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI891339A FI90877C (fi)	1988-03-25	1989-03-21	Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi

Country Status (21)

Country	Link
US (1)	US4996308A (fi)
EP (1)	EP0334361B1 (fi)
JP (1)	JP2829737B2 (fi)
KR (1)	KR0135529B1 (fi)
CN (1)	CN1023804C (fi)
AR (1)	AR247403A1 (fi)
AT (1)	ATE121415T1 (fi)
AU (1)	AU606792B2 (fi)
CA (1)	CA1322195C (fi)
DE (1)	DE68922235T2 (fi)
DK (1)	DK171645B1 (fi)
ES (1)	ES2074060T3 (fi)
FI (1)	FI90877C (fi)
HU (1)	HU203561B (fi)
IE (1)	IE67543B1 (fi)
IL (1)	IL89689A0 (fi)
NO (1)	NO171856C (fi)
NZ (1)	NZ228422A (fi)
PH (1)	PH26776A (fi)
PT (1)	PT90080B (fi)
ZA (1)	ZA892105B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3924424A1 (de) *	1989-07-24	1991-01-31	Boehringer Mannheim Gmbh	Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
ZA907998B (en) *	1989-10-11	1991-07-31	Merrell Dow Pharma	Inosine/guanosine derivatives as antineoplastic agents
AU632856B2 (en) *	1989-10-11	1993-01-14	Merrell Dow Pharmaceuticals Inc.	Novel inosine/guanosine derivatives
GB8926417D0 (en) *	1989-11-22	1990-01-10	Wellcome Found	Heterocyclic compounds
JPH0421682A (ja) *	1990-05-11	1992-01-24	Asahi Chem Ind Co Ltd	２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides
US5399580A (en) *	1993-03-08	1995-03-21	Burroughs Wellcome Co.	Therapeutic nucleosides-uses
WO1994021659A1 (fr) *	1993-03-18	1994-09-29	Yamasa Corporation	Nouveau compose de 2'-methylidenenucleotide, procede d'obtention de ce compose et son utilisation pharmaceutique
HUT77436A (hu) *	1994-10-05	1998-04-28	Darwin Discovery Limited	Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására
GB9600142D0 (en) *	1996-01-05	1996-03-06	Wellcome Found	Chemical compounds
CZ9901996A3 (cs) *	1999-06-04	2001-01-17	Ústav organické chemie a biochemie AV ČR	Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
EP1183034B1 (en) *	1999-06-09	2005-11-23	Anticancer, Inc.	Modulators of methylation for control of bacterial virulence
US6579857B1 (en) *	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
CZ301182B6 (cs) *	2000-05-26	2009-12-02	Idenix (Cayman) Limited	Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry
US20040162422A1 (en) *	2001-03-20	2004-08-19	Adrian Hall	Chemical compounds
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) *	2005-01-20	2012-08-15	独立行政法人理化学研究所	イミダゾピリジン誘導体
CN102746304B (zh) *	2012-06-21	2014-03-19	成都苑东药业有限公司	一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1113851A (en) *	1965-05-29	1968-05-15	Upjohn Co	Decoyinine derivatives
US3472837A (en) *	1966-10-10	1969-10-14	Syntex Corp	Unsaturated nucleosides and process for their preparation
US3575959A (en) *	1969-05-13	1971-04-20	Merck & Co Inc	5'-substituted ribofuranosyl nucleosides
US3585189A (en) *	1969-06-27	1971-06-15	Syntex Corp	Unsaturated nucleosides and processes for their preparation
US3910885A (en) *	1974-03-12	1975-10-07	Syntex Inc	4-Alkoxy nucleosides and intermediates therefore
DE3587500T2 (de) *	1984-12-04	1993-12-16	Lilly Co Eli	Tumorbehandlung bei Säugetieren.
GB8708050D0 (en) *	1987-04-03	1987-05-07	Wellcome Found	Therapeutic nucleosides
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions

1988
- 1988-03-25 US US07/173,782 patent/US4996308A/en not_active Expired - Lifetime
1989
- 1989-03-20 CA CA000594206A patent/CA1322195C/en not_active Expired - Fee Related
- 1989-03-20 ZA ZA892105A patent/ZA892105B/xx unknown
- 1989-03-21 FI FI891339A patent/FI90877C/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228422A patent/NZ228422A/en unknown
- 1989-03-21 NO NO891248A patent/NO171856C/no unknown
- 1989-03-21 IL IL89689A patent/IL89689A0/xx not_active IP Right Cessation
- 1989-03-22 PT PT90080A patent/PT90080B/pt not_active IP Right Cessation
- 1989-03-22 AR AR89313479A patent/AR247403A1/es active
- 1989-03-22 DK DK145289A patent/DK171645B1/da not_active IP Right Cessation
- 1989-03-23 IE IE95389A patent/IE67543B1/en not_active IP Right Cessation
- 1989-03-23 DE DE68922235T patent/DE68922235T2/de not_active Expired - Fee Related
- 1989-03-23 ES ES89105254T patent/ES2074060T3/es not_active Expired - Lifetime
- 1989-03-23 EP EP89105254A patent/EP0334361B1/en not_active Expired - Lifetime
- 1989-03-23 AT AT89105254T patent/ATE121415T1/de not_active IP Right Cessation
- 1989-03-24 CN CN89101682A patent/CN1023804C/zh not_active Expired - Fee Related
- 1989-03-24 KR KR1019890003722A patent/KR0135529B1/ko not_active Expired - Fee Related
- 1989-03-24 JP JP1070752A patent/JP2829737B2/ja not_active Expired - Fee Related
- 1989-03-24 HU HU891526A patent/HU203561B/hu unknown
- 1989-03-27 PH PH38380A patent/PH26776A/en unknown
- 1989-03-28 AU AU31737/89A patent/AU606792B2/en not_active Ceased

Also Published As

Publication number	Publication date
IL89689A0 (en)	1989-09-28
NO171856C (no)	1993-05-12
HUT49367A (en)	1989-09-28
NO171856B (no)	1993-02-01
AR247403A1 (es)	1994-12-29
EP0334361A3 (en)	1991-04-03
KR890014573A (ko)	1989-10-24
DK145289D0 (da)	1989-03-22
JP2829737B2 (ja)	1998-12-02
US4996308A (en)	1991-02-26
FI90877B (fi)	1993-12-31
IE890953L (en)	1989-09-25
EP0334361A2 (en)	1989-09-27
ZA892105B (en)	1989-11-29
PH26776A (en)	1992-10-13
HU203561B (en)	1991-08-28
PT90080B (pt)	1994-06-30
IE67543B1 (en)	1996-04-17
ES2074060T3 (es)	1995-09-01
FI891339A0 (fi)	1989-03-21
PT90080A (pt)	1989-11-10
EP0334361B1 (en)	1995-04-19
NO891248D0 (no)	1989-03-21
CN1036579A (zh)	1989-10-25
ATE121415T1 (de)	1995-05-15
AU3173789A (en)	1989-09-28
CA1322195C (en)	1993-09-14
JPH01283285A (ja)	1989-11-14
FI891339A7 (fi)	1989-09-26
KR0135529B1 (ko)	1998-04-23
DE68922235T2 (de)	1995-08-31
NZ228422A (en)	1991-04-26
NO891248L (no)	1989-09-26
CN1023804C (zh)	1994-02-16
AU606792B2 (en)	1991-02-14
DK171645B1 (da)	1997-03-03
DE68922235D1 (de)	1995-05-24
DK145289A (da)	1989-09-26

Publication	Publication Date	Title
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI875024A7 (fi)	1988-05-15	Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
FI905941A0 (fi)	1990-12-03	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten 2-asyyliaminotiatsolijohdannaisten valmistamiseksi
FI900886A0 (fi)	1990-02-22	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
FI885409A7 (fi)	1989-05-24	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridatsiiniamiinijohdannaisten valmistamiseksi
FI914905L (fi)	1992-04-19	Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
FI92934B (fi)	1994-10-14	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI874459A7 (fi)	1988-05-04	Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
FI90877C (fi)	1994-04-11	Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi
FI891003A7 (fi)	1989-09-04	Menetelmä terapeuttisesti käyttökelpoisten 6-substituoitujen purinyylipiperatsiinijohdannaisten valmistamiseksi
FI873069A7 (fi)	1988-01-12	Menetelmä uusien terapeuttisesti käyttökelpoisten difenyylipropyyliamiinijohdannaisten valmistamiseksi
FI92696C (fi)	1994-12-27	Menetelmä terapeuttisesti käyttökelpoisten tiatsolidiinidionijohdannaisten valmistamiseksi
FI895417A0 (fi)	1989-11-14	Menetelmä uusien terapeuttisesti käyttökelpoisten 2'-halometylideeninukleosidien valmistamiseksi
FI883889A0 (fi)	1988-08-23	Menetelmä uusien terapeuttisesti käyttökelpoisten aristeromysiini/adenosiinijohdannaisten valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI884553A7 (fi)	1989-04-06	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
FI890283A0 (fi)	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten 25-hydroksi-vitamiinin D-johdannaisten valmistamiseksi
FI895393A0 (fi)	1989-11-13	Menetelmä terapeuttisesti käyttökelpoisten alkyylisubstituoitujen 2-alkyyliamiinibentsopyran-6-olien valmistamiseksi
FI883672A7 (fi)	1989-02-08	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI884910A0 (fi)	1988-10-24	Menetelmä terapeuttisesti käyttökelpoisten bentsopyraanijohdannaisten valmistamiseksi
FI892948A0 (fi)	1989-06-15	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI881525A7 (fi)	1988-10-02	Menetelmä uusien terapeuttisesti käyttökelpoisten N-aryylipiperatsiiniasetamidijohdannaisten valmistamiseksi
FI893003A0 (fi)	1989-06-19	Menetelmä uusien terapeuttisesti käyttökelpoisten neplanosiinijohdannaisten valmistamiseksi
FI885560A7 (fi)	1988-11-30	Menetelmä uusien terapeuttisesti käyttökelpoisten bisfenyylialkyylipiperatsiinijohdannaisten valmistamiseksi
FI92064C (fi)	1994-09-26	Menetelmä terapeuttisesti käyttökelpoisten N-bentsopyranyylilaktaamien valmistamiseksi

Legal Events

Date	Code	Title	Description
1993-12-01	BB	Publication of examined application
2004-08-31	FG	Patent granted	Owner name: MERRELL DOW PHARMACEUTICALS INC.
2005-09-30	MA	Patent expired