NO171856C - Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosinderivater - Google Patents

Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosinderivater

Info

Publication number: NO171856C
Authority: NO; Norway
Prior art keywords: preparation; therapeutic active; analogy procedure; adenosin; derivatives
Prior art date: 1988-03-25

Application number

NO891248A

Other languages

English (en)

Other versions

NO171856B (no

NO891248D0 (no

NO891248L (no

Inventor

Michael L Edwards

James R Mccarthy

Nellikunja J Prakash

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-03-25

Filing date

1989-03-21

Publication date

1993-05-12

1989-03-21 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-03-21 Publication of NO891248D0 publication Critical patent/NO891248D0/no

1989-09-26 Publication of NO891248L publication Critical patent/NO891248L/no

1993-02-01 Publication of NO171856B publication Critical patent/NO171856B/no

1993-05-12 Publication of NO171856C publication Critical patent/NO171856C/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Biotechnology (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

NO891248A 1988-03-25 1989-03-21 Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosinderivater NO171856C (no)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US07/173,782 US4996308A (en)	1988-03-25	1988-03-25	Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group

Publications (4)

Publication Number	Publication Date
NO891248D0 NO891248D0 (no)	1989-03-21
NO891248L NO891248L (no)	1989-09-26
NO171856B NO171856B (no)	1993-02-01
NO171856C true NO171856C (no)	1993-05-12

Family

ID=22633462

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO891248A NO171856C (no)	1988-03-25	1989-03-21	Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosinderivater

Country Status (21)

Country	Link
US (1)	US4996308A (no)
EP (1)	EP0334361B1 (no)
JP (1)	JP2829737B2 (no)
KR (1)	KR0135529B1 (no)
CN (1)	CN1023804C (no)
AR (1)	AR247403A1 (no)
AT (1)	ATE121415T1 (no)
AU (1)	AU606792B2 (no)
CA (1)	CA1322195C (no)
DE (1)	DE68922235T2 (no)
DK (1)	DK171645B1 (no)
ES (1)	ES2074060T3 (no)
FI (1)	FI90877C (no)
HU (1)	HU203561B (no)
IE (1)	IE67543B1 (no)
IL (1)	IL89689A0 (no)
NO (1)	NO171856C (no)
NZ (1)	NZ228422A (no)
PH (1)	PH26776A (no)
PT (1)	PT90080B (no)
ZA (1)	ZA892105B (no)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3924424A1 (de) *	1989-07-24	1991-01-31	Boehringer Mannheim Gmbh	Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung
AU632856B2 (en) *	1989-10-11	1993-01-14	Merrell Dow Pharmaceuticals Inc.	Novel inosine/guanosine derivatives
AU629988B2 (en) *	1989-10-11	1992-10-15	Merrell Dow Pharmaceuticals Inc.	Inosine/guanosine derivatives as antineoplastic agents
GB8926417D0 (en) *	1989-11-22	1990-01-10	Wellcome Found	Heterocyclic compounds
JPH0421682A (ja) *	1990-05-11	1992-01-24	Asahi Chem Ind Co Ltd	２―フルオロネプラノシンａおよびその製造法
GB9205071D0 (en) *	1992-03-09	1992-04-22	Wellcome Found	Therapeutic nucleosides
US5399580A (en) *	1993-03-08	1995-03-21	Burroughs Wellcome Co.	Therapeutic nucleosides-uses
US5696097A (en) *	1993-03-18	1997-12-09	Yamasa Corporation	Antineoplastic 5'-diacylglycerylphosphatidyl-2-deoxy-2'-methylenylcytidines and method of making
JPH10507171A (ja) *	1994-10-05	1998-07-14	カイロサイエンス・リミテッド	Ｐｎｐインヒビターとしてのプリンおよびグアニン化合物
GB9600142D0 (en) *	1996-01-05	1996-03-06	Wellcome Found	Chemical compounds
CZ9901996A3 (cs) *	1999-06-04	2001-01-17	Ústav organické chemie a biochemie AV ČR	Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují
EP1183034B1 (en)	1999-06-09	2005-11-23	Anticancer, Inc.	Modulators of methylation for control of bacterial virulence
US6579857B1 (en) *	1999-06-11	2003-06-17	Evanston Northwestern Healthcare Research Institute	Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors
YU92202A (sh) *	2000-05-26	2006-01-16	Idenix (Cayman) Limited	Metode i smeše za lečenje flavi virusa i pesti virusa
US20040162422A1 (en) *	2001-03-20	2004-08-19	Adrian Hall	Chemical compounds
KR20040036417A (ko) *	2002-10-25	2004-04-30	정낙신	항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물
JP5002851B2 (ja) *	2005-01-20	2012-08-15	独立行政法人理化学研究所	イミダゾピリジン誘導体
CN102746304B (zh) *	2012-06-21	2014-03-19	成都苑东药业有限公司	一种嘌呤胺类化合物及其制备方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB1113851A (en) *	1965-05-29	1968-05-15	Upjohn Co	Decoyinine derivatives
US3472837A (en) *	1966-10-10	1969-10-14	Syntex Corp	Unsaturated nucleosides and process for their preparation
US3575959A (en) *	1969-05-13	1971-04-20	Merck & Co Inc	5'-substituted ribofuranosyl nucleosides
US3585189A (en) *	1969-06-27	1971-06-15	Syntex Corp	Unsaturated nucleosides and processes for their preparation
US3910885A (en) *	1974-03-12	1975-10-07	Syntex Inc	4-Alkoxy nucleosides and intermediates therefore
DE3587500T2 (de) *	1984-12-04	1993-12-16	Lilly Co Eli	Tumorbehandlung bei Säugetieren.
GB8708050D0 (en) *	1987-04-03	1987-05-07	Wellcome Found	Therapeutic nucleosides
NZ225906A (en) *	1987-08-26	1990-10-26	Merrell Dow Pharma	Aristeromycin/adenosine derivatives and pharmaceutical compositions

1988
- 1988-03-25 US US07/173,782 patent/US4996308A/en not_active Expired - Lifetime
1989
- 1989-03-20 CA CA000594206A patent/CA1322195C/en not_active Expired - Fee Related
- 1989-03-20 ZA ZA892105A patent/ZA892105B/xx unknown
- 1989-03-21 NZ NZ228422A patent/NZ228422A/en unknown
- 1989-03-21 IL IL89689A patent/IL89689A0/xx not_active IP Right Cessation
- 1989-03-21 FI FI891339A patent/FI90877C/fi not_active IP Right Cessation
- 1989-03-21 NO NO891248A patent/NO171856C/no unknown
- 1989-03-22 DK DK145289A patent/DK171645B1/da not_active IP Right Cessation
- 1989-03-22 PT PT90080A patent/PT90080B/pt not_active IP Right Cessation
- 1989-03-22 AR AR89313479A patent/AR247403A1/es active
- 1989-03-23 EP EP89105254A patent/EP0334361B1/en not_active Expired - Lifetime
- 1989-03-23 ES ES89105254T patent/ES2074060T3/es not_active Expired - Lifetime
- 1989-03-23 IE IE95389A patent/IE67543B1/en not_active IP Right Cessation
- 1989-03-23 AT AT89105254T patent/ATE121415T1/de not_active IP Right Cessation
- 1989-03-23 DE DE68922235T patent/DE68922235T2/de not_active Expired - Fee Related
- 1989-03-24 CN CN89101682A patent/CN1023804C/zh not_active Expired - Fee Related
- 1989-03-24 KR KR1019890003722A patent/KR0135529B1/ko not_active Expired - Fee Related
- 1989-03-24 JP JP1070752A patent/JP2829737B2/ja not_active Expired - Fee Related
- 1989-03-24 HU HU891526A patent/HU203561B/hu unknown
- 1989-03-27 PH PH38380A patent/PH26776A/en unknown
- 1989-03-28 AU AU31737/89A patent/AU606792B2/en not_active Ceased

Also Published As

Publication number	Publication date
CN1023804C (zh)	1994-02-16
HUT49367A (en)	1989-09-28
JPH01283285A (ja)	1989-11-14
DK145289D0 (da)	1989-03-22
PT90080A (pt)	1989-11-10
JP2829737B2 (ja)	1998-12-02
NO171856B (no)	1993-02-01
HU203561B (en)	1991-08-28
DE68922235D1 (de)	1995-05-24
DK145289A (da)	1989-09-26
KR890014573A (ko)	1989-10-24
US4996308A (en)	1991-02-26
PT90080B (pt)	1994-06-30
AU3173789A (en)	1989-09-28
FI90877B (fi)	1993-12-31
DK171645B1 (da)	1997-03-03
CN1036579A (zh)	1989-10-25
ZA892105B (en)	1989-11-29
DE68922235T2 (de)	1995-08-31
KR0135529B1 (ko)	1998-04-23
ES2074060T3 (es)	1995-09-01
FI891339A0 (fi)	1989-03-21
ATE121415T1 (de)	1995-05-15
AR247403A1 (es)	1994-12-29
IE67543B1 (en)	1996-04-17
NO891248D0 (no)	1989-03-21
AU606792B2 (en)	1991-02-14
EP0334361B1 (en)	1995-04-19
NZ228422A (en)	1991-04-26
FI90877C (fi)	1994-04-11
IE890953L (en)	1989-09-25
NO891248L (no)	1989-09-26
IL89689A0 (en)	1989-09-28
PH26776A (en)	1992-10-13
EP0334361A3 (en)	1991-04-03
EP0334361A2 (en)	1989-09-27
FI891339A7 (fi)	1989-09-26
CA1322195C (en)	1993-09-14

Publication	Publication Date	Title
NO172801C (no)	1993-09-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive kinuklidin-derivater
NO168770C (no)	1992-04-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO171506C (no)	1993-03-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive adenosin-derivater
NO169493C (no)	1992-07-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive peptid-derivater
NO170629C (no)	1992-11-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive dikloranilin-derivater
NO170727C (no)	1992-11-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzopyran-derivater
NO163406C (no)	1990-05-23	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinolinonderivater.
NO167384C (no)	1991-10-30	Analogifremgangsmaate for fremstilling av terapeutisk aktive n-aralkylpiperidinmethanolderivater.
NO862477D0 (no)	1986-06-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-arylimidazol-derivater.
NO167026C (no)	1991-09-25	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzimidazolderivater
NO171856C (no)	1993-05-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive adenosinderivater
NO843084L (no)	1985-02-04	Fremgangsmaate for fremstilling av terapeutisk aktive adenosin-derivater
NO168361C (no)	1992-02-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive nye adenosinderivater
NO168299C (no)	1992-02-05	Analogifremgangsmaate for fremstilling av terapeutisk aktive alkansulfonanilid-derivater
NO172539C (no)	1993-08-04	Analogifremgangsmaate for fremstilling av terapeutisk aktive indolpiperidin-forbindelser
NO171857C (no)	1993-05-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2'-halomethyliden-adenosin-derivater
NO173185C (no)	1993-11-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive imidazokinoxalinforbindelser
NO173061C (no)	1993-10-20	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2-benzotiazoliner
NO169069C (no)	1992-05-06	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3-alkoksy-2-aminopropylaminderivater
NO891723L (no)	1989-10-30	Fremgangsmaate for fremstilling av terapeutisk aktive kinazolin-derivater.
NO169648C (no)	1992-07-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive arakidonsyre-derivater
NO172643C (no)	1993-08-18	Analogifremgangsmaate ved fremstilling av terapeutisk aktive benzopyranolderivater
NO172802C (no)	1993-09-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive tienopyraner
NO171847C (no)	1993-05-12	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzenderivater
NO167802C (no)	1991-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive benzotiazepinderivater.