ZA892105B - Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives - Google Patents
Novel acetylenic,cyano and allenic aristeromycin/adenosine derivativesInfo
- Publication number
- ZA892105B ZA892105B ZA892105A ZA892105A ZA892105B ZA 892105 B ZA892105 B ZA 892105B ZA 892105 A ZA892105 A ZA 892105A ZA 892105 A ZA892105 A ZA 892105A ZA 892105 B ZA892105 B ZA 892105B
- Authority
- ZA
- South Africa
- Prior art keywords
- cyano
- adenosine derivatives
- aristeromycin
- allenic
- novel acetylenic
- Prior art date
Links
- UGRNVLGKAGREKS-GCXDCGAKSA-N (1r,2s,3r,5r)-3-(6-aminopurin-9-yl)-5-(hydroxymethyl)cyclopentane-1,2-diol Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1C[C@H](CO)[C@@H](O)[C@H]1O UGRNVLGKAGREKS-GCXDCGAKSA-N 0.000 title 1
- 125000004093 cyano group Chemical group *C#N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/052—Imidazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/056—Triazole or tetrazole radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/173,782 US4996308A (en) | 1988-03-25 | 1988-03-25 | Derivatives with unsaturated substitutions for the 5'-hydroxymethyl group |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA892105B true ZA892105B (en) | 1989-11-29 |
Family
ID=22633462
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA892105A ZA892105B (en) | 1988-03-25 | 1989-03-20 | Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US4996308A (xx) |
| EP (1) | EP0334361B1 (xx) |
| JP (1) | JP2829737B2 (xx) |
| KR (1) | KR0135529B1 (xx) |
| CN (1) | CN1023804C (xx) |
| AR (1) | AR247403A1 (xx) |
| AT (1) | ATE121415T1 (xx) |
| AU (1) | AU606792B2 (xx) |
| CA (1) | CA1322195C (xx) |
| DE (1) | DE68922235T2 (xx) |
| DK (1) | DK171645B1 (xx) |
| ES (1) | ES2074060T3 (xx) |
| FI (1) | FI90877C (xx) |
| HU (1) | HU203561B (xx) |
| IE (1) | IE67543B1 (xx) |
| IL (1) | IL89689A0 (xx) |
| NO (1) | NO171856C (xx) |
| NZ (1) | NZ228422A (xx) |
| PH (1) | PH26776A (xx) |
| PT (1) | PT90080B (xx) |
| ZA (1) | ZA892105B (xx) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3924424A1 (de) * | 1989-07-24 | 1991-01-31 | Boehringer Mannheim Gmbh | Nucleosid-derivate, verfahren zu deren herstellung, deren verwendung als arzneimittel sowie deren verwendung bei der nucleinsaeure-sequenzierung |
| ZA907998B (en) * | 1989-10-11 | 1991-07-31 | Merrell Dow Pharma | Inosine/guanosine derivatives as antineoplastic agents |
| AU632856B2 (en) * | 1989-10-11 | 1993-01-14 | Merrell Dow Pharmaceuticals Inc. | Novel inosine/guanosine derivatives |
| GB8926417D0 (en) * | 1989-11-22 | 1990-01-10 | Wellcome Found | Heterocyclic compounds |
| JPH0421682A (ja) * | 1990-05-11 | 1992-01-24 | Asahi Chem Ind Co Ltd | ２―フルオロネプラノシンａおよびその製造法 |
| GB9205071D0 (en) * | 1992-03-09 | 1992-04-22 | Wellcome Found | Therapeutic nucleosides |
| US5399580A (en) * | 1993-03-08 | 1995-03-21 | Burroughs Wellcome Co. | Therapeutic nucleosides-uses |
| WO1994021659A1 (fr) * | 1993-03-18 | 1994-09-29 | Yamasa Corporation | Nouveau compose de 2'-methylidenenucleotide, procede d'obtention de ce compose et son utilisation pharmaceutique |
| HUT77436A (hu) * | 1994-10-05 | 1998-04-28 | Darwin Discovery Limited | Purin- és guaninszármazékok, eljárás előállításukra, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk gyógyszerkészítmények előállítására |
| GB9600142D0 (en) * | 1996-01-05 | 1996-03-06 | Wellcome Found | Chemical compounds |
| CZ9901996A3 (cs) * | 1999-06-04 | 2001-01-17 | Ústav organické chemie a biochemie AV ČR | Nové 6-fenylpurinové 9-ß-D-ribonukleosidy s antineoplastickým účinkem, jejich použití k přípravě farmaceutických preparátů a farmaceutické přípravky, které je obsahují |
| EP1183034B1 (en) * | 1999-06-09 | 2005-11-23 | Anticancer, Inc. | Modulators of methylation for control of bacterial virulence |
| US6579857B1 (en) * | 1999-06-11 | 2003-06-17 | Evanston Northwestern Healthcare Research Institute | Combination cancer therapy comprising adenosine and deaminase enzyme inhibitors |
| CZ301182B6 (cs) * | 2000-05-26 | 2009-12-02 | Idenix (Cayman) Limited | Použití nukleosidových derivátu pro výrobu farmaceutických prostredku pro lécení infekcí vyvolaných flaviviry a pestiviry |
| US20040162422A1 (en) * | 2001-03-20 | 2004-08-19 | Adrian Hall | Chemical compounds |
| KR20040036417A (ko) * | 2002-10-25 | 2004-04-30 | 정낙신 | 항암 활성을 갖는 티오뉴클레오시드 유도체 및 이를함유하는 약학적 조성물 |
| JP5002851B2 (ja) * | 2005-01-20 | 2012-08-15 | 独立行政法人理化学研究所 | イミダゾピリジン誘導体 |
| CN102746304B (zh) * | 2012-06-21 | 2014-03-19 | 成都苑东药业有限公司 | 一种嘌呤胺类化合物及其制备方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1113851A (en) * | 1965-05-29 | 1968-05-15 | Upjohn Co | Decoyinine derivatives |
| US3472837A (en) * | 1966-10-10 | 1969-10-14 | Syntex Corp | Unsaturated nucleosides and process for their preparation |
| US3575959A (en) * | 1969-05-13 | 1971-04-20 | Merck & Co Inc | 5'-substituted ribofuranosyl nucleosides |
| US3585189A (en) * | 1969-06-27 | 1971-06-15 | Syntex Corp | Unsaturated nucleosides and processes for their preparation |
| US3910885A (en) * | 1974-03-12 | 1975-10-07 | Syntex Inc | 4-Alkoxy nucleosides and intermediates therefore |
| DE3587500T2 (de) * | 1984-12-04 | 1993-12-16 | Lilly Co Eli | Tumorbehandlung bei Säugetieren. |
| GB8708050D0 (en) * | 1987-04-03 | 1987-05-07 | Wellcome Found | Therapeutic nucleosides |
| NZ225906A (en) * | 1987-08-26 | 1990-10-26 | Merrell Dow Pharma | Aristeromycin/adenosine derivatives and pharmaceutical compositions |
-
1988
- 1988-03-25 US US07/173,782 patent/US4996308A/en not_active Expired - Lifetime
-
1989
- 1989-03-20 CA CA000594206A patent/CA1322195C/en not_active Expired - Fee Related
- 1989-03-20 ZA ZA892105A patent/ZA892105B/xx unknown
- 1989-03-21 FI FI891339A patent/FI90877C/fi not_active IP Right Cessation
- 1989-03-21 NZ NZ228422A patent/NZ228422A/en unknown
- 1989-03-21 NO NO891248A patent/NO171856C/no unknown
- 1989-03-21 IL IL89689A patent/IL89689A0/xx not_active IP Right Cessation
- 1989-03-22 PT PT90080A patent/PT90080B/pt not_active IP Right Cessation
- 1989-03-22 AR AR89313479A patent/AR247403A1/es active
- 1989-03-22 DK DK145289A patent/DK171645B1/da not_active IP Right Cessation
- 1989-03-23 IE IE95389A patent/IE67543B1/en not_active IP Right Cessation
- 1989-03-23 DE DE68922235T patent/DE68922235T2/de not_active Expired - Fee Related
- 1989-03-23 ES ES89105254T patent/ES2074060T3/es not_active Expired - Lifetime
- 1989-03-23 EP EP89105254A patent/EP0334361B1/en not_active Expired - Lifetime
- 1989-03-23 AT AT89105254T patent/ATE121415T1/de not_active IP Right Cessation
- 1989-03-24 CN CN89101682A patent/CN1023804C/zh not_active Expired - Fee Related
- 1989-03-24 KR KR1019890003722A patent/KR0135529B1/ko not_active Expired - Fee Related
- 1989-03-24 JP JP1070752A patent/JP2829737B2/ja not_active Expired - Fee Related
- 1989-03-24 HU HU891526A patent/HU203561B/hu unknown
- 1989-03-27 PH PH38380A patent/PH26776A/en unknown
- 1989-03-28 AU AU31737/89A patent/AU606792B2/en not_active Ceased
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE3665856D1 (en) | Metal-ceramics jointed articles | |
| ZA892105B (en) | Novel acetylenic,cyano and allenic aristeromycin/adenosine derivatives | |
| AU3978689A (en) | Nucleoside derivatives | |
| ZA899725B (en) | N-aryl-azetidinones,their preparation process and their use as elastage inhibitors | |
| AU8589491A (en) | Adenosine derivatives | |
| DE3473875D1 (en) | Pyrimidine derivatives, preparation thereof and use thereof | |
| IL88999A0 (en) | Dideoxydidehydrocarbocyclic nucleosides | |
| KR970002660B1 (en) | Novel aristeromycin/adenosine derivatives | |
| GB8923820D0 (en) | Compound,composition,process and use | |
| AU4176089A (en) | Novel 2'-halomethylidene, 2'-ethenylidene and 2'-ethynyl adenosine derivatives | |
| OA09697A (en) | Nucleoside derivatives | |
| EG19298A (en) | Fibre-reactive dyestuffs | |
| ZA864888B (en) | 5-substituted-6-aminopyrimidine derivatives,composition and uses | |
| AU2169188A (en) | (2,3-anhydro-lyxofuranosyl) nucleosides | |
| AU590173B2 (en) | Smoking articles | |
| AU581391B2 (en) | Smoking articles | |
| GB2222164B (en) | Nucleotide derivatives | |
| AU581390B2 (en) | Smoking articles | |
| AU7383487A (en) | Purine derivatives | |
| GB8625635D0 (en) | Adjustable spanner | |
| GB9110987D0 (en) | Dideoxydidehydrocarboxyclic nucleosides | |
| IL81718A0 (en) | Aromatic-omega-alkylimino-tetra-hydro-6h-1,3-thiazin-6-one derivatives | |
| GB8520613D0 (en) | Adjustable spanner | |
| IE881709L (en) | Cyano oximinoacetamide derivatives. | |
| GB8814253D0 (en) | Adjustable spanner |