FI884553A7 - Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi - Google Patents

Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi

Info

Publication number: FI884553A7
Authority: FI; Finland
Prior art keywords: aminotetrahydroacridine; derivatives; preparation; therapeutically useful; analogous method
Prior art date: 1987-10-05

Application number

FI884553A

Other languages

English (en)

Swedish (sv)

Other versions

FI884553A0 (fi

FI93117B (fi

FI93117C (fi

Inventor

Manoj Chandrasinhji Desai

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1987-10-05

Filing date

1988-10-04

Publication date

1989-04-06

1988-10-04 Application filed by Pfizer filed Critical Pfizer

1988-10-04 Publication of FI884553A0 publication Critical patent/FI884553A0/fi

1989-04-06 Publication of FI884553A7 publication Critical patent/FI884553A7/fi

1994-11-15 Publication of FI93117B publication Critical patent/FI93117B/fi

1995-02-27 Application granted granted Critical

1995-02-27 Publication of FI93117C publication Critical patent/FI93117C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/61—Carboxylic acid nitriles containing cyano groups and nitrogen atoms being part of imino groups bound to the same carbon skeleton
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D219/00—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems
- C07D219/04—Heterocyclic compounds containing acridine or hydrogenated acridine ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the ring system
- C07D219/08—Nitrogen atoms
- C07D219/10—Nitrogen atoms attached in position 9
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/04—Ortho- or peri-condensed ring systems
- C07D221/06—Ring systems of three rings
- C07D221/16—Ring systems of three rings containing carbocyclic rings other than six-membered
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/58—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4
- C07D311/68—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring other than with oxygen or sulphur atoms in position 2 or 4 with nitrogen atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
- C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
- C07D491/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D495/14—Ortho-condensed systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurology (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

FI884553A 1987-10-05 1988-10-04 Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi FI93117C (fi)

Applications Claiming Priority (4)

Application Number	Priority Date	Filing Date	Title
US8702546		1987-10-05
PCT/US1987/002546 WO1989002739A1 (en)	1987-10-05	1987-10-05	4-aminopyridine derivatives
PCT/US1988/001070 WO1989002740A1 (en)	1987-10-05	1988-03-30	4-aminopyridine derivatives
US8801070		1988-03-30

Publications (4)

Publication Number	Publication Date
FI884553A0 FI884553A0 (fi)	1988-10-04
FI884553A7 true FI884553A7 (fi)	1989-04-06
FI93117B FI93117B (fi)	1994-11-15
FI93117C FI93117C (fi)	1995-02-27

Family

ID=22202587

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI884553A FI93117C (fi)	1987-10-05	1988-10-04	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi

Country Status (12)

Country	Link
KR (1)	KR900007243B1 (fi)
AT (1)	ATE123024T1 (fi)
DD (1)	DD273633A5 (fi)
EG (1)	EG19973A (fi)
FI (1)	FI93117C (fi)
MX (1)	MX13270A (fi)
MY (1)	MY104335A (fi)
PL (1)	PL159258B1 (fi)
PT (1)	PT88656B (fi)
RU (1)	RU1816283C (fi)
WO (2)	WO1989002739A1 (fi)
ZA (1)	ZA887399B (fi)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4897400A (en) *	1987-02-13	1990-01-30	Hoeschst-Roussel Pharmaceuticals, Inc.	9-amino-1,4-ethano-1,2,3,4-tetrahydroacridine and related compounds useful for incresing the cholinergic function in a mammal
US5002955A (en) *	1987-04-23	1991-03-26	Hoechst-Roussel Pharmaceuticals Inc.	Fused heteroalkylene quinolinamines and use as cholinergic agents
US5037833A (en) *	1988-07-25	1991-08-06	Hoechst-Roussel Pharmaceuticals Inc.	N-[substituted alkylidene]fused-bicycloalkylidene quinolinamines useful for enhancing the cholinergic function in a mammal
US5013741A (en) *	1987-09-08	1991-05-07	Hoechst-Roussel Pharmaceuticals Incorporated	N-[substituted alkylidene]-1,2,3,4-tetrahydro-9-acridinamines useful for enhancing the cholinergic function in a mammal
US4927820A (en) *	1988-11-25	1990-05-22	Hoechst Roussel Pharmaceuticals Inc.	Fused heterocyclic derivatives of 1,2,3,4-tetrahydroacridine
CA2029497C (en) *	1989-11-08	2002-06-04	Kunihiro Ninomiya (Deceased)	4-acylaminopyridine derivative
US4994452A (en) *	1989-11-28	1991-02-19	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US5112829A (en) *	1989-11-28	1992-05-12	Hoechst-Roussel Pharmaceuticals Inc.	Hexahydro-1H-quino[4,3,2-ef][1,4]benzoxazepines and related compounds
US5210087A (en) *	1991-02-13	1993-05-11	Hoechst-Roussel Pharmaceuticals Inc.	9-aminotetrahydroacridines and related compounds
US5234947A (en) *	1991-11-07	1993-08-10	New York University	Potassium channel activating compounds and methods of use thereof
US5422350A (en) *	1992-09-10	1995-06-06	Warner-Lambert Company	Nitrogen substituted acridine and cytochrome P450 inhibitors and methods of use
US5466696A (en) *	1992-09-10	1995-11-14	Warner Lambert Company	Tacrine and cytochrome P450 oxidase inhibitors and methods of use
US5783584A (en) *	1995-12-11	1998-07-21	Mayo Foundation For Medical Education And Research	THA analogs useful as cholinesterase inhibitors
US5929093A (en) *	1996-06-13	1999-07-27	Mayo Foundation For Medical Education And Research	Bifunctional acetylcholinesterase reactivators
DE19707655A1 (de) *	1997-02-26	1998-08-27	Hoechst Ag	Kombinationspräparat zur Anwendung bei Demenz
DE10111728A1 (de) *	2001-03-09	2002-09-12	Merck Patent Gmbh	UV-Filter
CA2578164A1 (en)	2004-09-07	2006-03-16	Wyeth	6h-[1]benzopyrano[4,3-b]quinolines and their use as estrogenic agents
CN114853672B (zh) *	2022-05-12	2023-06-23	中国人民解放军北部战区总医院	作为CDKs抑制剂的他克林衍生物及其应用

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3232945A (en) *	1962-08-13	1966-02-01	S E Massengill Company	7,8,9,10-tetrahalo-6h-cyclohepta-(b)-quinolines
US3318896A (en) *	1963-12-05	1967-05-09	Squibb & Sons Inc	Production of 12-substituted-6, 7, 8, 9, 10, 11-hexahydrocycloocta[b]quinolines
GB1186061A (en) *	1966-03-14	1970-04-02	American Home Prod	Benzonaphthyridine Derivatives
US3541066A (en) *	1968-09-16	1970-11-17	American Home Prod	2,3-dihydro-1,4-ethanobenzo(b)(1,5)naphthyridine derivatives
US4180580A (en) *	1976-11-08	1979-12-25	American Home Products Corp.	Furo(3,4-b)quinolines
US4550113A (en) *	1982-08-19	1985-10-29	Nauchno-Issledovatelsky Institut Po Biologicheskikm Ispytaniyam Khimicheskikh Soedineny	9-Amino-2,3,5,6,7,8-hexahydro-1H-cyclopenta(b)quinoline monohydrate hydrochloride as stimulant of neuro-muscular transmission of smooth muscles
US4680298A (en) *	1983-05-31	1987-07-14	Schering Corporation	Tricyclic anti-allergy and use as anti-inflammatory agents
US4680297A (en) *	1983-07-14	1987-07-14	Schering Corporation	Tricyclic positive inotropic agents
US4631286A (en) *	1984-10-25	1986-12-23	Hoechst-Roussel Pharmaceuticals Inc.	9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4695573A (en) *	1984-10-25	1987-09-22	Hoechst-Roussel Pharmaceuticals Inc.	9-amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds
US4578394A (en) *	1984-12-10	1986-03-25	Hoechst-Roussel Pharmaceuticals Incorporated	Cholinergic function increasing 3-[N-(pyridyl) carbamoyl]-1,4-dihydropyridines
US4652567A (en) *	1985-03-13	1987-03-24	Hoechst-Roussel Pharmaceuticals Inc.	Benzo(c)-1,5-naphthyridines useful for treating a patient having drug induced memory impairment in need of memory enhancement

1987
- 1987-10-05 WO PCT/US1987/002546 patent/WO1989002739A1/en not_active Ceased
- 1987-10-05 MX MX1327088A patent/MX13270A/es unknown
1988
- 1988-03-30 WO PCT/US1988/001070 patent/WO1989002740A1/en not_active Ceased
- 1988-09-29 AT AT88309040T patent/ATE123024T1/de not_active IP Right Cessation
- 1988-10-03 MY MYPI88001105A patent/MY104335A/en unknown
- 1988-10-03 PL PL1988275056A patent/PL159258B1/pl unknown
- 1988-10-03 ZA ZA887399A patent/ZA887399B/xx unknown
- 1988-10-03 PT PT88656A patent/PT88656B/pt not_active IP Right Cessation
- 1988-10-04 DD DD88320447A patent/DD273633A5/de not_active IP Right Cessation
- 1988-10-04 FI FI884553A patent/FI93117C/fi not_active IP Right Cessation
- 1988-10-04 RU SU884356604A patent/RU1816283C/ru active
- 1988-10-04 KR KR1019880012933A patent/KR900007243B1/ko not_active Expired
- 1988-10-05 EG EG51088A patent/EG19973A/xx active

Also Published As

Publication number	Publication date
FI884553A0 (fi)	1988-10-04
DD273633A5 (de)	1989-11-22
MY104335A (en)	1994-03-31
PT88656A (pt)	1988-11-01
WO1989002739A1 (en)	1989-04-06
PL159258B1 (pl)	1992-12-31
PT88656B (pt)	1992-12-31
KR890006590A (ko)	1989-06-14
FI93117B (fi)	1994-11-15
KR900007243B1 (ko)	1990-10-06
RU1816283C (ru)	1993-05-15
ZA887399B (en)	1990-05-30
EG19973A (en)	1996-10-31
ATE123024T1 (de)	1995-06-15
MX13270A (es)	1993-06-01
PL275056A1 (en)	1989-05-30
FI93117C (fi)	1995-02-27
WO1989002740A1 (en)	1989-04-06

Publication	Publication Date	Title
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI875024A7 (fi)	1988-05-15	Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
FI885409A7 (fi)	1989-05-24	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridatsiiniamiinijohdannaisten valmistamiseksi
FI893100L (fi)	1989-06-26	Analogiamenetelmä asyylideoksiribonukleosidijohdannaisten valmistamiseksi
FI892682L (fi)	1989-12-03	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI883739A7 (fi)	1989-02-15	Menetelmä terapeuttisesti aktiivisten fenoksi-indaanimetyyliamiinijohdannaisten valmistamiseksi
FI905941A0 (fi)	1990-12-03	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten 2-asyyliaminotiatsolijohdannaisten valmistamiseksi
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI881900A7 (fi)	1988-10-25	Analogiamenetelmä terapeuttisesti käyttökelpoisten substituoitujen imidatsolyylialkyylipiperatsiini- ja -diatsepiinijohdannaisten valmistamiseksi
FI883249A7 (fi)	1989-01-11	Menetelmä terapeuttisesti käyttökelpoisten 3-desmetyylimevalonihappojohdannaisten valmistamiseksi
FI914905L (fi)	1992-04-19	Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
FI881180L (fi)	1988-09-14	Menetelmä terapeuttisesti käytettävien tetrahydronaftaleenijohdannaisten valmistamiseksi
FI883050L (fi)	1988-12-25	Menetelmä terapeuttisesti aktiivisten pyranoindolitsinokinoliinijohdannaisten valmistamiseksi
FI880816A7 (fi)	1988-09-24	Menetelmä uusien terapeuttisesti käyttökelpoisten kinoksaliinijohdannaisten valmistamiseksi
IS3529A7 (is)	1990-07-24	Hliðstæð aðferð við framleiðslu á meðferðarvirkum bis-aza-bísýklískum efnasamböndum
FI874459A7 (fi)	1988-05-04	Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
FI923527L (fi)	1992-08-05	Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi
FI891003A7 (fi)	1989-09-04	Menetelmä terapeuttisesti käyttökelpoisten 6-substituoitujen purinyylipiperatsiinijohdannaisten valmistamiseksi
FI884553A7 (fi)	1989-04-06	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
FI880742A7 (fi)	1988-08-19	Menetelmä uusien, terapeuttisesti käyttökelpoisten, 7-asemassa substituoitujen 19-norsteroidien valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI895393A0 (fi)	1989-11-13	Menetelmä terapeuttisesti käyttökelpoisten alkyylisubstituoitujen 2-alkyyliamiinibentsopyran-6-olien valmistamiseksi
PT87153A (pt)	1988-05-01	Process for the preparation of acid ribofuranuronic derivatives
FI883997A0 (fi)	1988-08-30	Menetelmä terapeuttisesti käyttökelpoisten substituoitujen 2-fenyyli-4-kinoliinikarboksyylihappojen valmistamiseksi
FI93215C (fi)	1995-03-10	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi

Legal Events

Date	Code	Title	Description
1994-10-17	BB	Publication of examined application
1997-10-04	MM	Patent lapsed
2004-08-31	MM	Patent lapsed	Owner name: PFIZER INC.