FI92934B - Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi - Google Patents

Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi

Info

Publication number: FI92934B
Authority: FI; Finland
Prior art keywords: deoxinojirimycin; derivatives; preparation; therapeutically useful; analogous process
Prior art date: 1988-06-02

Application number

FI892682A

Other languages

English (en)

Swedish (sv)

Other versions

FI892682L (fi

FI92934C (fi

FI892682A0 (fi

Inventor

Jean-Bernard Ducep

Charles Danzin

Original Assignee

Merrell Dow Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-06-02

Filing date

1989-06-01

Publication date

1994-10-14

1989-06-01 Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma

1989-06-01 Publication of FI892682A0 publication Critical patent/FI892682A0/fi

1989-12-03 Publication of FI892682L publication Critical patent/FI892682L/fi

1994-10-14 Publication of FI92934B publication Critical patent/FI92934B/fi

1995-01-25 Application granted granted Critical

1995-01-25 Publication of FI92934C publication Critical patent/FI92934C/fi

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/12—Acyclic radicals, not substituted by cyclic structures attached to a nitrogen atom of the saccharide radical
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/048—Pyridine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/06—Heterocyclic radicals

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Diabetes (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Obesity (AREA)
Crystallography & Structural Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Virology (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Child & Adolescent Psychology (AREA)
AIDS & HIV (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Hydrogenated Pyridines (AREA)

FI892682A 1988-06-02 1989-06-01 Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi FI92934C (fi)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP88401340		1988-06-02
EP88401340A EP0344383A1 (en)	1988-06-02	1988-06-02	Novel alpha-Glucosidase inhibitors

Publications (4)

Publication Number	Publication Date
FI892682A0 FI892682A0 (fi)	1989-06-01
FI892682L FI892682L (fi)	1989-12-03
FI92934B true FI92934B (fi)	1994-10-14
FI92934C FI92934C (fi)	1995-01-25

Family

ID=8200392

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
FI892682A FI92934C (fi)	1988-06-02	1989-06-01	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi

Country Status (22)

Country	Link
US (1)	US5157116A (fi)
EP (1)	EP0344383A1 (fi)
JP (1)	JP2791419B2 (fi)
KR (1)	KR0155541B1 (fi)
CN (1)	CN1023803C (fi)
AR (1)	AR247890A1 (fi)
AT (1)	ATE129716T1 (fi)
AU (1)	AU608711B2 (fi)
CA (1)	CA1339740C (fi)
DE (1)	DE68924670T2 (fi)
DK (1)	DK267489A (fi)
ES (1)	ES2081857T3 (fi)
FI (1)	FI92934C (fi)
GR (1)	GR3018354T3 (fi)
HU (1)	HU203559B (fi)
IE (1)	IE68455B1 (fi)
IL (1)	IL90463A0 (fi)
NO (1)	NO170023C (fi)
NZ (1)	NZ229337A (fi)
PH (1)	PH25908A (fi)
PT (1)	PT90713B (fi)
ZA (1)	ZA894068B (fi)

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DE3936295A1 (de) *	1989-11-01	1991-05-02	Bayer Ag	Verfahren zur herstellung von zwischenprodukten und zur synthese von n-(2-hydroxyethyl)-2-hydroxymethyl-3,4,5-trihydroxypiperidine
US5504078A (en) *	1990-06-08	1996-04-02	Merrell Dow Pharmaceuticals Inc.	α-glucosidase inhibitors
US5844102A (en) *	1994-07-07	1998-12-01	University Of Maryland Baltimore County	Glycohydrolase inhibitors, their preparation and use thereof
JP3580900B2 (ja) *	1995-04-20	2004-10-27	ホクレン農業協同組合連合会	α−グルコシダーゼ阻害剤を含む糖を主体とする組成物を有効成分とする食品及び飼料
AU4335997A (en) *	1996-09-09	1998-03-26	Wisconsin Alumni Research Foundation	Human salivary proteins and fragments thereof having alpha-glucosidase inhibitory activity
BR9808593A (pt) *	1997-04-15	2000-05-23	Csir	Composições farmacêuticas com atividade supressora do apetite
EP0983239A1 (en) *	1997-05-06	2000-03-08	Novo Nordisk A/S	Novel heterocyclic compounds
GB2355657B (en) *	1999-10-27	2004-07-28	Phytopharm Plc	Inhibitors Of Gastric Acid Secretion
GB2363985B (en) *	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
JP4486792B2 (ja) *	2003-06-12	2010-06-23	学校法人近畿大学	環状オニウム化合物およびグルコシダーゼ阻害剤
US7262318B2 (en) *	2004-03-10	2007-08-28	Pfizer, Inc.	Substituted heteroaryl- and phenylsulfamoyl compounds
US20060025449A1 (en) *	2004-03-25	2006-02-02	United Therapeutics	Use of N-substituted imino sugars for appetite suppression
US20050288340A1 (en) *	2004-06-29	2005-12-29	Pfizer Inc	Substituted heteroaryl- and phenylsulfamoyl compounds
CA2590533C (en) *	2004-11-23	2010-09-07	Warner-Lambert Company Llc	7-(2h-pyrazol-3-yl)-3,5-dihydroxy-heptanoic acid derivatives as hmg co-a reductase inhibitors for the treatment of lipidemia
EP2027137B1 (en) *	2005-06-08	2015-02-18	Amicus Therapeutics, Inc.	Imino and amino sugar purification
EP1888610A1 (en) *	2005-06-08	2008-02-20	Amicus Therapeutics, Inc.	Stabilization of triflated compounds
WO2006133447A1 (en) *	2005-06-08	2006-12-14	Amicus Therapeutics, Inc.	Crystalline sugar compositions and method of making
US7741317B2 (en)	2005-10-21	2010-06-22	Bristol-Myers Squibb Company	LXR modulators
US7888376B2 (en)	2005-11-23	2011-02-15	Bristol-Myers Squibb Company	Heterocyclic CETP inhibitors
GB0614947D0 (en) *	2006-07-27	2006-09-06	Isis Innovation	Epitope reduction therapy
ATE547394T1 (de)	2006-12-01	2012-03-15	Bristol Myers Squibb Co	N-((3-benzyl)-2,2-(bis-phenyl)-propan-1- aminderivate als cetp-hemmer für die behandlung von atherosklerose und herz-kreislauf- erkrankungen
EP2368560A1 (en)	2007-03-12	2011-09-28	Zadec ApS	An anti-diabetic extract of rooibos
US8969514B2 (en)	2007-06-04	2015-03-03	Synergy Pharmaceuticals, Inc.	Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
JP5546451B2 (ja)	2007-06-04	2014-07-09	シナジーファーマシューティカルズインコーポレイテッド	胃腸の障害、炎症、癌および他の障害の処置に有用なグアニル酸シクラーゼのアゴニスト
US20100120694A1 (en)	2008-06-04	2010-05-13	Synergy Pharmaceuticals, Inc.	Agonists of Guanylate Cyclase Useful for the Treatment of Gastrointestinal Disorders, Inflammation, Cancer and Other Disorders
EP3241839B1 (en)	2008-07-16	2019-09-04	Bausch Health Ireland Limited	Agonists of guanylate cyclase useful for the treatment of gastrointestinal, inflammation, cancer and other disorders
CA2799708A1 (en)	2010-05-21	2011-11-24	Pfizer Inc.	2-phenyl benzoylamides
US20130156720A1 (en)	2010-08-27	2013-06-20	Ironwood Pharmaceuticals, Inc.	Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders
US9616097B2 (en)	2010-09-15	2017-04-11	Synergy Pharmaceuticals, Inc.	Formulations of guanylate cyclase C agonists and methods of use
JP2014513923A (ja)	2011-03-04	2014-06-19	ファイザー・インク	Ｅｄｎ３様ペプチドおよびその使用
WO2013133685A1 (en)	2012-03-09	2013-09-12	Biotropics Malaysia Berhad	Extract formulations of rhodamnia cinerea and uses thereof
HK1220696A1 (zh)	2013-03-15	2017-05-12	Bausch Health Ireland Limited	鸟苷酸环化酶激动剂及其用途
AU2014235209B2 (en)	2013-03-15	2018-06-14	Bausch Health Ireland Limited	Guanylate cyclase receptor agonists combined with other drugs
MX2015014666A (es)	2013-04-17	2016-03-01	Pfizer	Derivados de n-piperidin-3-ilbenzamida para tratar enfermedades cardiovasculares.
EP4424697A3 (en)	2013-06-05	2024-12-25	Bausch Health Ireland Limited	Ultra-pure agonists of guanylate cyclase c, method of making and using same
BR112017003745A2 (pt)	2014-08-29	2017-12-05	Tes Pharma S R L	inibidores de semialdeído descarboxilase de ácido alfa-amino-beta-carboximucônico
WO2016055901A1 (en)	2014-10-08	2016-04-14	Pfizer Inc.	Substituted amide compounds
TWI767945B (zh)	2016-10-14	2022-06-21	義大利商Ｔｅｓ製藥（股份）責任有限公司	α-胺基-β-羧基己二烯二酸半醛去羧酶之抑制劑
CN113302189B (zh)	2018-11-20	2025-09-05	Tes制药有限责任公司	α-氨基-β-羧基己二烯二酸半醛去羧酶的抑制剂
DK3911648T3 (da)	2019-01-18	2025-01-13	Astrazeneca Ab	6'-[[(1s,3s)-3-[[5-(difluormethoxy)-2-pyrimidinyl]amino]cyclopentyl]amino][1(2h),3'-bipyridin]-2-on som pcsk9-hæmmer og fremgangsmåder til anvendelse deraf

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Publication number	Priority date	Publication date	Assignee	Title
GB1555654A (en) *	1977-06-25	1979-11-14	Exxon Research Engineering Co	Agricultural burner apparatus
NO154918C (no) *	1977-08-27	1987-01-14	Bayer Ag	Analogifremgangsmaate til fremstilling av terapeutisk aktive derivater av 3,4,5-trihydroksypiperidin.
DE2830469A1 (de) *	1978-07-11	1980-01-24	Bayer Ag	Herstellung von l-desoxy-nojirimycin und n-substituierten derivaten
DE2922760A1 (de) *	1979-06-05	1980-12-11	Bayer Ag	Neue derivate von 3,4,5-trihydroxypiperidin, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel sowie in der tierernaehrung
GB2064527B (en) *	1979-12-08	1984-05-02	Nippon Shinyaku Co Ltd	Moranoline derivatives and process for preparation thereof
DE3038901A1 (de) *	1980-10-15	1982-05-06	Bayer Ag, 5090 Leverkusen	Verfahren zur herstellung von n-substituierten derivaten des 1-desoxynojirimycins
JPS61115093A (ja) *	1984-11-09	1986-06-02	Nippon Shinyaku Co Ltd	モラノリン誘導体の製法
US4634765A (en) *	1984-12-18	1987-01-06	Merrell Dow Pharmaceuticals Inc.	Homodisaccharide hypoglycemic agents
GB2181729B (en) *	1985-10-12	1990-04-04	Nippon Shinyaku Co Ltd	Glucosylmoranoline derivatives and production thereof
DE3737523A1 (de) *	1987-11-05	1989-05-18	Bayer Ag	Verwendung von substituierten hydroxypiperidinen als antivirale mittel

1988
- 1988-06-02 EP EP88401340A patent/EP0344383A1/en not_active Withdrawn
1989
- 1989-04-28 ES ES89401227T patent/ES2081857T3/es not_active Expired - Lifetime
- 1989-04-28 AT AT89401227T patent/ATE129716T1/de not_active IP Right Cessation
- 1989-04-28 DE DE68924670T patent/DE68924670T2/de not_active Expired - Fee Related
- 1989-05-29 AR AR89314032A patent/AR247890A1/es active
- 1989-05-29 ZA ZA894068A patent/ZA894068B/xx unknown
- 1989-05-30 NZ NZ229337A patent/NZ229337A/en unknown
- 1989-05-30 IL IL90463A patent/IL90463A0/xx not_active IP Right Cessation
- 1989-05-30 CA CA000601196A patent/CA1339740C/en not_active Expired - Fee Related
- 1989-05-30 AU AU35801/89A patent/AU608711B2/en not_active Ceased
- 1989-05-31 HU HU892791A patent/HU203559B/hu not_active IP Right Cessation
- 1989-06-01 PT PT90713A patent/PT90713B/pt not_active IP Right Cessation
- 1989-06-01 PH PH38729A patent/PH25908A/en unknown
- 1989-06-01 FI FI892682A patent/FI92934C/fi not_active IP Right Cessation
- 1989-06-01 NO NO892230A patent/NO170023C/no not_active IP Right Cessation
- 1989-06-01 CN CN89103723A patent/CN1023803C/zh not_active Expired - Fee Related
- 1989-06-01 KR KR1019890007498A patent/KR0155541B1/ko not_active Expired - Fee Related
- 1989-06-01 DK DK267489A patent/DK267489A/da not_active Application Discontinuation
- 1989-06-02 JP JP1139401A patent/JP2791419B2/ja not_active Expired - Fee Related
- 1989-06-12 IE IE179889A patent/IE68455B1/en not_active IP Right Cessation
1992
- 1992-02-18 US US07/839,014 patent/US5157116A/en not_active Expired - Fee Related
1995
- 1995-12-08 GR GR950403473T patent/GR3018354T3/el unknown

Also Published As

Publication number	Publication date
AU3580189A (en)	1990-02-01
FI892682L (fi)	1989-12-03
JP2791419B2 (ja)	1998-08-27
ATE129716T1 (de)	1995-11-15
US5157116A (en)	1992-10-20
DE68924670T2 (de)	1996-05-23
KR0155541B1 (ko)	1998-10-15
AR247890A1 (es)	1995-04-28
NZ229337A (en)	1990-12-21
FI92934C (fi)	1995-01-25
ZA894068B (en)	1990-09-26
FI892682A0 (fi)	1989-06-01
EP0344383A1 (en)	1989-12-06
IL90463A0 (en)	1990-01-18
HU203559B (en)	1991-08-28
PH25908A (en)	1991-12-19
HUT50191A (en)	1989-12-28
NO892230D0 (no)	1989-06-01
IE891798L (en)	1989-12-02
NO170023B (no)	1992-05-25
CN1040032A (zh)	1990-02-28
PT90713A (pt)	1989-12-29
IE68455B1 (en)	1996-06-26
NO892230L (no)	1989-12-04
DK267489D0 (da)	1989-06-01
AU608711B2 (en)	1991-04-11
JPH0225498A (ja)	1990-01-26
DE68924670D1 (de)	1995-12-07
ES2081857T3 (es)	1996-03-16
CA1339740C (en)	1998-03-17
PT90713B (pt)	1993-09-30
GR3018354T3 (en)	1996-03-31
CN1023803C (zh)	1994-02-16
NO170023C (no)	1992-09-02
DK267489A (da)	1989-12-03
KR910000776A (ko)	1991-01-30

Publication	Publication Date	Title
FI92934B (fi)	1994-10-14	Analogiamenetelmä terapeuttisesti käyttökelpoisten 1-deoksinojirimysiinijohdannaisten valmistamiseksi
FI890282A0 (fi)	1989-01-19	Menetelmä terapeuttisesti käyttökelpoisten 23,24-didehydro-25-hydroksikalsiferolijohdannaisten valmistamiseksi
FI892881A0 (fi)	1989-06-13	Menetelmä terapeuttisesti käyttökelpoisten aminohappojohdannaisten va lmistamiseksi
FI874787A0 (fi)	1987-10-30	Menetelmä terapeuttisesti käyttökelpoisten nor-statiini- ja nor-syklostatiinipolypeptidien valmistamiseksi
FI883064A0 (fi)	1988-06-23	Menetelmä terapeuttisesti käyttökelpoisten heterosyklisten yhdisteiden valmistamiseksi
FI892182A0 (fi)	1989-05-05	Menetelmä terapeuttisesti käyttökelpoisten kromaanijohdannaisten valmistamiseksi
FI875660L (fi)	1987-12-22	Menetelmä terapeuttisesti käyttökelpoisten 5-fenyyli-2-pyrimidinonijohdannaisten valmistamiseksi
FI95704B (fi)	1995-11-30	Menetelmä uusien terapeuttisesti käyttökelpoisten pyridiinijohdannaisten valmistamiseksi
FI875024A7 (fi)	1988-05-15	Menetelmä terapeuttisesti käyttökelpoisten 1-alkyyli-6-halogeenitetrahydronaftaleenijohdannaisten valmistamiseksi
FI914905L (fi)	1992-04-19	Menetelmä uusien terapeuttisesti käyttökelpoisten merkaptoasetyyliamidopyrrolo- ja -pyridobentsatsepiinijohdannaisten valmistamiseksi
FI96861C (fi)	1996-09-10	Menetelmä terapeuttisesti aktiivisten substituoitujen indolyylipyrrolijohdannaisten valmistamiseksi
FI925737A7 (fi)	1993-06-20	Menetelmä uusien terapeuttisesti käyttökelpoisten indol-3-yylialkyylipiperatsiinijohdannaisten valmistamiseksi
FI874459A0 (fi)	1987-10-09	Menetelmä uusien terapeuttisesti käyttökelpoisten piperidiinijohdannaisten valmistamiseksi
FI94752C (fi)	1995-10-25	Menetelmä terapeuttisesti käyttökelpoisten propenonioksiimieettereiden valmistamiseksi
FI923527L (fi)	1992-08-05	Menetelmä terapeuttisesti käyttökelpoisten 3-piperidino-4-hydroksikromaanijohdannaisten valmistamiseksi
NO173334C (no)	1993-12-01	Analogifremgangsm}te for fremstilling av terapeutisk aktive alkylaminoalkylenderivater 2H-1-benzopyraner
FI93215C (fi)	1995-03-10	Menetelmä terapeuttisesti käyttökelpoisten aminoalkoksifenyylijohdannaisten valmistamiseksi
FI906408L (fi)	1991-06-29	Menetelmä terapeuttisesti käyttökelpoisten 2-aminopyrimidiini-4-karboksamidijohdannaisten valmistamiseksi
FI884553A7 (fi)	1989-04-06	Analogiamenetelmä terapeuttisesti käyttökelpoisten 9-aminotetrahydroakridiinijohdannaisten valmistamiseksi
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FI903077A0 (fi)	1990-06-19	Menetelmä valmistaa terapeuttisesti aktiivisia R(-)-3-kinuklidinolijohdannaisia
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1994-09-19	BB	Publication of examined application
2004-08-31	MM	Patent lapsed	Owner name: MERRELL DOW PHARMACEUTICALS INC.