ES2409404T3 - Compuestos heterocíclicos de fenoximetilo - Google Patents
Compuestos heterocíclicos de fenoximetilo Download PDFInfo
- Publication number
- ES2409404T3 ES2409404T3 ES09796217T ES09796217T ES2409404T3 ES 2409404 T3 ES2409404 T3 ES 2409404T3 ES 09796217 T ES09796217 T ES 09796217T ES 09796217 T ES09796217 T ES 09796217T ES 2409404 T3 ES2409404 T3 ES 2409404T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- alkyl
- optionally substituted
- ring
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- -1 Heterocyclic phenoxymethyl compounds Chemical class 0.000 title abstract 4
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 2
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 abstract 2
- 125000004183 alkoxy alkyl group Chemical group 0.000 abstract 2
- 125000003282 alkyl amino group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- 125000003368 amide group Chemical group 0.000 abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 2
- 125000004663 dialkyl amino group Chemical group 0.000 abstract 2
- 125000001153 fluoro group Chemical group F* 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- 125000006413 ring segment Chemical group 0.000 abstract 2
- 125000001424 substituent group Chemical group 0.000 abstract 2
- 125000004001 thioalkyl group Chemical group 0.000 abstract 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 2
- JZTKNVMVUVSGJF-UHFFFAOYSA-N 1,2,3,5-oxatriazole Chemical compound C=1N=NON=1 JZTKNVMVUVSGJF-UHFFFAOYSA-N 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000004945 aromatic hydrocarbons Chemical class 0.000 abstract 1
- 125000002619 bicyclic group Chemical group 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000004122 cyclic group Chemical group 0.000 abstract 1
- 125000000000 cycloalkoxy group Chemical group 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 125000005112 cycloalkylalkoxy group Chemical group 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 150000002430 hydrocarbons Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002950 monocyclic group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- CQDAMYNQINDRQC-UHFFFAOYSA-N oxatriazole Chemical compound C1=NN=NO1 CQDAMYNQINDRQC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004043 oxo group Chemical group O=* 0.000 abstract 1
- 125000001820 oxy group Chemical group [*:1]O[*:2] 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229920006395 saturated elastomer Polymers 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 150000003536 tetrazoles Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4433—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with oxygen as a ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Psychology (AREA)
- Endocrinology (AREA)
- Addiction (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Reproductive Health (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Un compuesto de Fórmula (I) **Fórmula** o una de sus sales farmacéuticamente aceptables, en donde: HET es un anillo heterocíclico que tiene la fórmula A29 o A31 en donde el radical más a la izquierda está conectado al grupo X en la Fórmula (I); **Fórmula** X es arilo sustituido opcionalmente o heteroarilo sustituido opcionalmente, en donde los sustituyentes seseleccionan del grupo que consiste en alquilo C1-C4, cicloalquilo C3-C6, cicloalquil(C3-C6)oxi, alcoxi C1-C4, CF3,carboxi, alcoxialquilo, cicloalquilalcoxi C1-C4, amino, alquilamino, dialquilamino, amido, alquilamido, dialquilamido, tioalquilo, halógeno, ciano, alquilsulfonilo y nitro; Z es imidazo[1,2-a]piridin-2-ilo, imidazo[1,2-b]piridazin-2-ilo o imidazo[1,2-b]piridazin-6-ilo, cada uno de loscuales puede estar sustituido opcionalmente, en donde los sustituyentes se seleccionan del grupo que consisteen alquilo C1-C4, cicloalquilo C3-C6, cicloalcoxi C3-C6, alcoxi C1-C4, CF3, carboxi, alcoxialquilo, cicloalquilalcoxiC1-C4, amino, alquilamino, dialquilamino, amido, alquilamido, dialquilamido, tioalquilo, halógeno, ciano,alquilsulfonilo y nitro; y cada R2 es independientemente alquilo C1-C4 sustituido opcionalmente con flúor, o dos grupos R2 tomados juntocon el carbono al que están anclados forman un anillo de cicloalquilo de 3 miembros; y en donde: - alquilo indica un hidrocarburo C1-C8 alifático saturado o insaturado lineal o ramificado que puede estarsustituido opcionalmente con hasta 3 átomos de flúor y, si se especifica, sustituido con otros grupos; - arilo es un grupo fenilo o naftilo; - heteroarilo es un tetrazol, 1,2,3,4-oxatriazol, 1,2,3,5-oxatriazol, un sistema anular aromático mono o bicíclico, oun sistema anular heterobicíclico con un anillo aromático que tiene de 5 a 10 átomos anulares seleccionadosindependientemente entre C, N, O y S, siempre que no más de 3 átomos anulares en cualquier anillo sencillosean distintos de C; y - cicloalquilo es un hidrocarburo no aromático cíclico C3-C7 que puede contener un solo enlace doble y estásustituido opcionalmente e independientemente con hasta tres grupos seleccionados entre alquilo, alcoxi,hidroxilo y oxo.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17641309P | 2009-05-07 | 2009-05-07 | |
| US176413P | 2009-05-07 | ||
| PCT/US2009/068644 WO2010128995A1 (en) | 2009-05-07 | 2009-12-18 | Phenoxymethyl heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2409404T3 true ES2409404T3 (es) | 2013-06-26 |
Family
ID=41549054
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13150322.9T Active ES2554788T3 (es) | 2009-05-07 | 2009-12-18 | Compuestos Heterocíclicos de Fenoximetilo |
| ES09796217T Active ES2409404T3 (es) | 2009-05-07 | 2009-12-18 | Compuestos heterocíclicos de fenoximetilo |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES13150322.9T Active ES2554788T3 (es) | 2009-05-07 | 2009-12-18 | Compuestos Heterocíclicos de Fenoximetilo |
Country Status (32)
| Country | Link |
|---|---|
| US (3) | US8343973B2 (es) |
| EP (3) | EP3020716A1 (es) |
| JP (2) | JP5628902B2 (es) |
| KR (1) | KR101662699B1 (es) |
| CN (2) | CN105125547A (es) |
| AU (1) | AU2009345802B2 (es) |
| BR (1) | BRPI0924617A8 (es) |
| CA (1) | CA2761032A1 (es) |
| CL (1) | CL2011002792A1 (es) |
| CO (1) | CO6460744A2 (es) |
| CR (1) | CR20110648A (es) |
| DK (2) | DK2427454T3 (es) |
| EC (1) | ECSP11011479A (es) |
| ES (2) | ES2554788T3 (es) |
| HR (2) | HRP20130482T1 (es) |
| HU (1) | HUE026238T2 (es) |
| IL (2) | IL216149A (es) |
| ME (1) | ME02375B (es) |
| MX (1) | MX2011011755A (es) |
| MY (1) | MY183910A (es) |
| NZ (1) | NZ596753A (es) |
| PE (1) | PE20120900A1 (es) |
| PH (1) | PH12013501321A1 (es) |
| PL (2) | PL2427454T3 (es) |
| PT (2) | PT2617420E (es) |
| RS (2) | RS54529B1 (es) |
| RU (1) | RU2531274C2 (es) |
| SG (1) | SG175900A1 (es) |
| SI (2) | SI2427454T1 (es) |
| SM (2) | SMT201300070B (es) |
| WO (1) | WO2010128995A1 (es) |
| ZA (1) | ZA201108920B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2009262241B2 (en) | 2008-06-25 | 2014-05-22 | Forum Pharmaceuticals Inc. | 1, 2 disubstituted heterocyclic compounds |
| RS54529B1 (sr) | 2009-05-07 | 2016-06-30 | Forum Pharmaceuticals Inc. | Fenoksimetil heterociklična jedinjenja |
| MX2013009575A (es) | 2011-02-18 | 2014-10-14 | Exonhit Therapeutics Sa | Derivados de 6, 7-dialcoxi-3-isoquinolinol sustituidos como inhibidores de fosfodiesterasa 10 (pdei0a). |
| WO2013185284A1 (en) | 2012-06-12 | 2013-12-19 | Abbott Laboratories | Pyridinone and pyridazinone derivatives |
| WO2014071044A1 (en) | 2012-11-01 | 2014-05-08 | Allergan, Inc. | Substituted 6,7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (pde10a) |
| ES2480341B1 (es) | 2013-01-24 | 2015-01-22 | Palobiofarma S.L | Nuevos derivados de pirimidina como inhibidores de la fosfodiesterasa 10 (PDE-10) |
| TW201512201A (zh) * | 2013-03-14 | 2015-04-01 | Forum Pharmaceuticals Inc | 化合物的多晶型及鹽類 |
| TWI634114B (zh) * | 2013-05-08 | 2018-09-01 | 永恒生物科技公司 | 作為激酶抑制劑之呋喃酮化合物 |
| WO2015006689A1 (en) | 2013-07-12 | 2015-01-15 | University Of South Alabama | Treatment and diagnosis of cancer and precancerous conditions using pde10a inhibitors and methods to measure pde10a expression |
| US9200016B2 (en) | 2013-12-05 | 2015-12-01 | Allergan, Inc. | Substituted 6, 7-dialkoxy-3-isoquinoline derivatives as inhibitors of phosphodiesterase 10 (PDE 10A) |
| CA3121202A1 (en) | 2018-11-30 | 2020-06-04 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL149177A0 (en) * | 1999-11-05 | 2002-11-10 | Sod Conseils Rech Applic | Novel heterocyclic compounds and their use as medicines |
| US20030032579A1 (en) * | 2001-04-20 | 2003-02-13 | Pfizer Inc. | Therapeutic use of selective PDE10 inhibitors |
| AU2003244080A1 (en) | 2002-06-26 | 2004-01-19 | Kyowa Hakko Kogyo Co., Ltd. | Phosphodiesterase inhibitor |
| AU2005323794B2 (en) * | 2005-01-07 | 2012-07-19 | Pfizer Products Inc. | Heteroaromatic quinoline compounds and their use as PDE10 inhibitors |
| NL2000397C2 (nl) * | 2006-01-05 | 2007-10-30 | Pfizer Prod Inc | Bicyclische heteroarylverbindingen als PDE10 inhibitoren. |
| EP1845098A1 (en) * | 2006-03-29 | 2007-10-17 | Ferrer Internacional, S.A. | Imidazo[1,2-b]pyridazines, their processes of preparation and their use as GABA receptor ligands |
| CA2650976A1 (en) * | 2006-05-02 | 2007-11-15 | Pfizer Products Inc. | Bicyclic heteroaryl compounds as pde10 inhibitors |
| WO2008033455A2 (en) | 2006-09-13 | 2008-03-20 | The Institutes For Pharmaceutical Discovery, Llc | Biphenyl and heteroaryl phenyl derivatives as protein tyrosine phosphatases inhibitors |
| FR2928924B1 (fr) * | 2008-03-21 | 2010-04-23 | Sanofi Aventis | Derives polysubstitues de 6-heteroaryle-imidazo°1,2-a! pyridines, leur preparation et leur application en therapeutique |
| AU2009262241B2 (en) * | 2008-06-25 | 2014-05-22 | Forum Pharmaceuticals Inc. | 1, 2 disubstituted heterocyclic compounds |
| RS54529B1 (sr) | 2009-05-07 | 2016-06-30 | Forum Pharmaceuticals Inc. | Fenoksimetil heterociklična jedinjenja |
| AU2010289353B2 (en) * | 2009-09-03 | 2016-12-08 | Allergan, Inc. | Compounds as tyrosine kinase modulators |
| PT3311666T (pt) * | 2010-08-18 | 2021-06-21 | Biosplice Therapeutics Inc | Dicetonas e hidroxicetonas como ativadores da via de sinalização de catenina |
-
2009
- 2009-12-18 RS RS20150803A patent/RS54529B1/sr unknown
- 2009-12-18 BR BRPI0924617A patent/BRPI0924617A8/pt not_active IP Right Cessation
- 2009-12-18 CN CN201510438849.1A patent/CN105125547A/zh active Pending
- 2009-12-18 PT PT131503229T patent/PT2617420E/pt unknown
- 2009-12-18 DK DK09796217.9T patent/DK2427454T3/da active
- 2009-12-18 NZ NZ596753A patent/NZ596753A/xx not_active IP Right Cessation
- 2009-12-18 MY MYPI2011005358A patent/MY183910A/en unknown
- 2009-12-18 PT PT97962179T patent/PT2427454E/pt unknown
- 2009-12-18 CN CN200980159735.6A patent/CN102459242B/zh not_active Expired - Fee Related
- 2009-12-18 SG SG2011081437A patent/SG175900A1/en unknown
- 2009-12-18 EP EP15184753.0A patent/EP3020716A1/en not_active Withdrawn
- 2009-12-18 ME MEP-2015-210A patent/ME02375B/me unknown
- 2009-12-18 KR KR1020117028223A patent/KR101662699B1/ko not_active Expired - Fee Related
- 2009-12-18 AU AU2009345802A patent/AU2009345802B2/en not_active Ceased
- 2009-12-18 DK DK13150322.9T patent/DK2617420T3/da active
- 2009-12-18 SI SI200930609T patent/SI2427454T1/sl unknown
- 2009-12-18 EP EP09796217A patent/EP2427454B1/en active Active
- 2009-12-18 CA CA2761032A patent/CA2761032A1/en not_active Abandoned
- 2009-12-18 RU RU2011149637/04A patent/RU2531274C2/ru not_active IP Right Cessation
- 2009-12-18 PL PL09796217T patent/PL2427454T3/pl unknown
- 2009-12-18 WO PCT/US2009/068644 patent/WO2010128995A1/en not_active Ceased
- 2009-12-18 ES ES13150322.9T patent/ES2554788T3/es active Active
- 2009-12-18 MX MX2011011755A patent/MX2011011755A/es active IP Right Grant
- 2009-12-18 HU HUE13150322A patent/HUE026238T2/en unknown
- 2009-12-18 HR HRP20130482AT patent/HRP20130482T1/hr unknown
- 2009-12-18 JP JP2012509778A patent/JP5628902B2/ja not_active Expired - Fee Related
- 2009-12-18 SI SI200931314T patent/SI2617420T1/sl unknown
- 2009-12-18 PE PE2011001918A patent/PE20120900A1/es not_active Application Discontinuation
- 2009-12-18 RS RS20130218A patent/RS52838B/sr unknown
- 2009-12-18 US US12/642,026 patent/US8343973B2/en not_active Expired - Fee Related
- 2009-12-18 PL PL13150322T patent/PL2617420T3/pl unknown
- 2009-12-18 ES ES09796217T patent/ES2409404T3/es active Active
- 2009-12-18 EP EP13150322.9A patent/EP2617420B1/en active Active
-
2011
- 2011-11-03 IL IL216149A patent/IL216149A/en not_active IP Right Cessation
- 2011-11-07 CL CL2011002792A patent/CL2011002792A1/es unknown
- 2011-11-11 CO CO11153626A patent/CO6460744A2/es active IP Right Grant
- 2011-11-24 EC EC2011011479A patent/ECSP11011479A/es unknown
- 2011-12-05 ZA ZA2011/08920A patent/ZA201108920B/en unknown
- 2011-12-05 CR CR20110648A patent/CR20110648A/es unknown
-
2012
- 2012-12-20 US US13/722,595 patent/US8946222B2/en not_active Expired - Fee Related
-
2013
- 2013-06-20 SM SM201300070T patent/SMT201300070B/xx unknown
- 2013-06-20 PH PH12013501321A patent/PH12013501321A1/en unknown
-
2014
- 2014-10-02 JP JP2014204220A patent/JP5943053B2/ja not_active Expired - Fee Related
- 2014-12-09 US US14/564,507 patent/US20150322069A1/en not_active Abandoned
-
2015
- 2015-11-25 HR HRP20151273TT patent/HRP20151273T1/hr unknown
-
2016
- 2016-02-04 SM SM201600031T patent/SMT201600031B/it unknown
- 2016-02-10 IL IL244059A patent/IL244059A0/en unknown
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ES2409404T3 (es) | Compuestos heterocíclicos de fenoximetilo | |
| AR088029A1 (es) | Compuestos de pirimidina sustituidos, composiciones farmaceuticas que los contienen y uso de los mismos para el tratamiento del dolor, accidentes cerebrovasculares, epilepsia y otras enfermedades del sistema nervioso central | |
| AR061969A1 (es) | Derivados halogenados de imidazo-piridino, metodo de preparacion, composiciones farmaceuticas que los contienen y usos como agentes anti vhc | |
| GT201300291A (es) | Derivados de piridin-2(1h)-ona útiles como medicamentos para el tratamiento de trastornos mieloproliferativos, rechazo de trasplantes, enfermedades mediadas por el sistema inmune y enfermedades inflamatorias. | |
| AR087771A1 (es) | Moduladores de la pde10 | |
| AR060590A1 (es) | Compuestos imidazo | |
| AR090005A1 (es) | Imidazo[1,2-a]pirimidinas y piridinas sustituidas | |
| EA201000615A1 (ru) | Производные имидазо[1,2-а]пиридина, применимые в качестве ингибиторов апк (активиноподобной киназы) | |
| BR112014006840A2 (pt) | derivados de pirrolopirimidina e purina | |
| PE20190656A1 (es) | Compuestos de tiazolo-piridina sustituida como inhibidores de malt1 | |
| AR060591A1 (es) | Compuestos imidazo | |
| AR083058A1 (es) | Compuestos de estructura de imidazotriazinona | |
| PE20081159A1 (es) | Inhibidores de las quinasas y metodos para su utilizacion | |
| PE20091818A1 (es) | DERIVADOS POLISUSTITUIDOS DE 2-ARIL-6-FENIL-IMIDAZO[1,2-a] PIRIDINAS, SU PREPARACION Y SU APLICACION EN TERAPEUTICA | |
| TN2012000608A1 (en) | Imidazopyridine derivatives, process for the preparation thereof and therapeutic use thereof | |
| CO6300864A2 (es) | Derivados polisustituidos de 6-heteroaril-imidazo[1,2-a]piridinas su preparacion y su aplicacion en terapeutica | |
| AR088235A1 (es) | Derivados de pirazoloquinolina | |
| AR066583A1 (es) | Derivados de 3,3-espiroindolinona | |
| AR064608A1 (es) | Derivados de pirazolo-quinazolina sustituidos, composiciones farmaceuticas que los contienen. proceso para su preparacion y uso de los mismos como agentes anticancer. | |
| AR077695A1 (es) | Derivados de pirimidina como inhibidores del factor ixa | |
| CO6251264A2 (es) | Derivados de 1-ciano ciclopropilo como inhibidores de la captesina k | |
| PE20090049A1 (es) | Derivados de piridopirimidina como moduladores de la actividad de pde 4 | |
| AR082109A1 (es) | Derivados de bipiridilo | |
| AR088474A1 (es) | Derivados de alcoholes de 1-fenil-2-piridinilalquilo como inhibidores de la fosfodiesterasa | |
| WO2011101069A3 (en) | 1, 8 -naphthyridines as kinase inhibitors |