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ES2165851T3 - Proteinas multivalentes que se unen a antigenos. - Google Patents

Proteinas multivalentes que se unen a antigenos.

Info

Publication number
ES2165851T3
ES2165851T3 ES93900545T ES93900545T ES2165851T3 ES 2165851 T3 ES2165851 T3 ES 2165851T3 ES 93900545 T ES93900545 T ES 93900545T ES 93900545 T ES93900545 T ES 93900545T ES 2165851 T3 ES2165851 T3 ES 2165851T3
Authority
ES
Spain
Prior art keywords
proteins
multivalent
binding
antigens
production
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93900545T
Other languages
English (en)
Inventor
Marc D Whitlow
James F Wood
Karl Hardman
Robert E Bird
David Filpula
Michele Rollence
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=25169441&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2165851(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Enzon Inc filed Critical Enzon Inc
Application granted granted Critical
Publication of ES2165851T3 publication Critical patent/ES2165851T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/626—Diabody or triabody
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

SE DESCRIBEN Y REIVINDICAN COMPOSICIONES DE PROTEINAS MULTIVALENTES AGLUTINANTES DE ANTIGENOS, LAS ESTRUCTURAS GENETICAS QUE LAS CODIFICAN Y LOS METODOS PARA LA PRODUCCION DE LAS MISMAS. LOS METODOS INCLUYEN LA PURIFICACION DE COMPOSICIONES QUE CONTIENEN TIPOS MONOMERICOS Y MULTIVALENTES DE MOLECULAS DE CADENA POLIPEPTIDA SENCILLA Y LA PRODUCCION DE PROTEINAS MULTIVALENTES A PARTIR DE MONOMEROS PURIFICADOS. LA PRODUCCION DE PROTEINAS MULTIVALENTES SE PUEDE LLEVAR A CABO A TRAVES DE UNA ASOCIACION DEPENDIENTE DE UNA CONCENTRACION DE PROTEINAS MONOMERICAS O A BASE DE REDISTRIBUIR LAS REGIONES EN LAS QUE TIENE LUGAR UNA DISOCIACION SEGUIDO DE UNA REASOCIACION DE LAS DIFERENTES REGIONES. CON LA PRESENTE INVENCION SE PUEDEN PRODUCIR PROTEINAS BIVALENTES, INCLUIDAS LAS PROTEINAS HOMOBIVALENTES Y HETEROBIVALENTES. SE PRESENTAN LAS SECUENCIAS GENETICAS QUE CODIFICAN PROTEINAS AGLUTINANTES DE ANTIGENOS DE CADENA SENCILLA BIVALENTES. ENTRE LOS USOS CABE INCLUIR TODOS AQUELLOS ADECUADOS PARA LOS ANTICUERPOS MONOCLONALES Y POLICLONALES Y LOS FRAGMENTOS DE LOS MISMOS, INCLUIDO EL USO COMO MOLECULA AGLUTINANTE DE ANTIGENOS BIESPECIFICA.
ES93900545T 1991-11-25 1992-11-20 Proteinas multivalentes que se unen a antigenos. Expired - Lifetime ES2165851T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79693691A 1991-11-25 1991-11-25

Publications (1)

Publication Number Publication Date
ES2165851T3 true ES2165851T3 (es) 2002-04-01

Family

ID=25169441

Family Applications (2)

Application Number Title Priority Date Filing Date
ES01109203T Expired - Lifetime ES2241710T3 (es) 1991-11-25 1992-11-20 Procedimiento para producir proteinas multivalentes de union a antigeno.
ES93900545T Expired - Lifetime ES2165851T3 (es) 1991-11-25 1992-11-20 Proteinas multivalentes que se unen a antigenos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES01109203T Expired - Lifetime ES2241710T3 (es) 1991-11-25 1992-11-20 Procedimiento para producir proteinas multivalentes de union a antigeno.

Country Status (10)

Country Link
US (1) US20060063715A1 (es)
EP (2) EP1136556B1 (es)
JP (1) JPH07501451A (es)
AT (2) ATE207080T1 (es)
AU (1) AU3178993A (es)
CA (1) CA2122732C (es)
DE (2) DE69232137T2 (es)
DK (2) DK0617706T3 (es)
ES (2) ES2241710T3 (es)
WO (1) WO1993011161A1 (es)

Families Citing this family (1671)

* Cited by examiner, † Cited by third party
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EP1136556B1 (en) 2005-06-08
ATE297465T1 (de) 2005-06-15
AU3178993A (en) 1993-06-28
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EP1136556A1 (en) 2001-09-26
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EP0617706A4 (en) 1995-09-27
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EP0617706B1 (en) 2001-10-17
DK1136556T3 (da) 2005-10-03
ES2241710T3 (es) 2005-11-01
DE69233528D1 (de) 2005-07-14
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DE69233528T2 (de) 2006-03-16
ATE207080T1 (de) 2001-11-15

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