EE200400029A - Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks - Google Patents

Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks

Info

Publication number: EE200400029A
Authority: EE; Estonia
Prior art keywords: medicament; manufacture; preparation; anticholinergic; crystalline
Prior art date: 2001-06-22

Application number

EEP200400029A

Other languages

English (en)

Inventor

Sieger Peter

Werthmann Ulrike

Original Assignee

Boehringer Ingelheim Pharma Gmbh & Co. Kg

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-06-22

Filing date

2002-06-08

Publication date

2004-04-15

2002-06-08 Application filed by Boehringer Ingelheim Pharma Gmbh & Co. Kg filed Critical Boehringer Ingelheim Pharma Gmbh & Co. Kg

2004-04-15 Publication of EE200400029A publication Critical patent/EE200400029A/et

2010-08-16 Publication of EE05316B1 publication Critical patent/EE05316B1/et

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
- C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, cocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pulmonology (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Emergency Medicine (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicinal Preparation (AREA)
Steroid Compounds (AREA)

EEP200400029A 2001-06-22 2002-06-08 Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks EE05316B1 (et)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
DE10129710		2001-06-22
DE10215436		2002-04-08
PCT/EP2002/006291 WO2003000265A1 (de)	2001-06-22	2002-06-08	Kristallines anticholinergikum, verfahren zu dessen herstellung und dessen verwendung zur herstellung eines arzneimittels

Publications (2)

Publication Number	Publication Date
EE200400029A true EE200400029A (et)	2004-04-15
EE05316B1 EE05316B1 (et)	2010-08-16

Family

ID=26009556

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EEP200400029A EE05316B1 (et)	2001-06-22	2002-06-08	Kristalliline antikolinergikum, meetod selle valmistamiseks ja selle kasutamine ravimi valmistamiseks

Country Status (37)

Country	Link
EP (1)	EP1401445B1 (et)
JP (1)	JP2005504015A (et)
KR (2)	KR100971616B1 (et)
CN (1)	CN100586948C (et)
AR (1)	AR037491A1 (et)
AT (1)	ATE337006T1 (et)
AU (1)	AU2002345016B2 (et)
BG (1)	BG66303B1 (et)
BR (1)	BR0210537A (et)
CA (1)	CA2450961C (et)
CO (1)	CO5550423A2 (et)
CY (1)	CY1105223T1 (et)
CZ (1)	CZ302786B6 (et)
DE (1)	DE50207943D1 (et)
DK (1)	DK1401445T3 (et)
EA (1)	EA005813B1 (et)
EE (1)	EE05316B1 (et)
EG (1)	EG24851A (et)
ES (1)	ES2271280T3 (et)
HR (1)	HRP20031066B1 (et)
HU (1)	HUP0400333A3 (et)
IL (2)	IL159238A0 (et)
ME (1)	ME00412B (et)
MX (1)	MXPA03011718A (et)
MY (1)	MY122779A (et)
NO (1)	NO334301B1 (et)
NZ (1)	NZ530690A (et)
PE (2)	PE20081305A1 (et)
PL (1)	PL208137B1 (et)
PT (1)	PT1401445E (et)
RS (1)	RS50441B (et)
SA (1)	SA02230255B1 (et)
SI (1)	SI1401445T1 (et)
SK (1)	SK287262B6 (et)
TW (2)	TWI261589B (et)
UY (1)	UY27342A1 (et)
WO (1)	WO2003000265A1 (et)

Families Citing this family (59)

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DE10212264A1 (de)	2002-03-20	2003-10-02	Boehringer Ingelheim Pharma	Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7056916B2 (en)	2002-11-15	2006-06-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Medicaments for the treatment of chronic obstructive pulmonary disease
US20050038004A1 (en) *	2003-07-31	2005-02-17	Robinson Cynthia B.	Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
KR101285571B1 (ko) *	2003-11-03	2013-07-15	베링거 인겔하임 인터내셔날 게엠베하	항콜린성 효과를 지닌 신규한 무수 결정
DE102004016179A1 (de) *	2004-03-30	2005-10-20	Boehringer Ingelheim Pharma	Verbindungen zur Behandlung von proliferativen Prozessen
PT1781298E (pt)	2004-04-22	2012-02-03	Boehringer Ingelheim Int	Combinações farmacêuticas contendo benzoxazinas para o tratamento de doenças respiratórias
DE102004024454A1 (de)	2004-05-14	2005-12-08	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Enantiomerenreine Betaagonisten, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
US7220742B2 (en)	2004-05-14	2007-05-22	Boehringer Ingelheim International Gmbh	Enantiomerically pure beta agonists, process for the manufacture thereof and use thereof as medicaments
DE602004020337D1 (de)	2004-08-11	2009-05-14	Boehringer Ingelheim Pharma	Anticholinergika enthaltende Arzneimittel zur Behandlung von Krankheiten der ableitenden Harnwege
US20060079544A1 (en) *	2004-08-13	2006-04-13	Boehringer Ingelheim International Gmbh	Medicaments for the prevention or treatment of alveolar pneumonia comprising an anticholinergic
DE102004048389A1 (de)	2004-10-01	2006-04-06	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
CN101163706A (zh)	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	用于治疗炎性疾病的二氢噻吩并嘧啶
KR20080007645A (ko)	2005-04-28	2008-01-22	베링거 인겔하임 인터내셔날 게엠베하	염증성 질환 치료용 신규 화합물
AU2006243239A1 (en) *	2005-05-02	2006-11-09	Boehringer Ingelheim International Gmbh	Crystalline forms of tiotropium bromide
DK1881980T3 (da) *	2005-05-02	2012-10-01	Boehringer Ingelheim Int	Nye krystalline former af tiotropiumbromid
DE102005030733A1 (de)	2005-07-01	2007-01-04	Boehringer Ingelheim Pharma Gmbh & Co. Kg	Neue Arzneimittelkombinationen zur Behandlung von Atemwegserkrankungen enthaltend langwirksame Beta-2-Agonisten und wenigstens einen weiteren Wirkstoff
WO2007020227A1 (de)	2005-08-15	2007-02-22	Boehringer Ingelheim International Gmbh	Verfahren zur herstellung von betamimetika
TWI396541B (zh)	2005-10-10	2013-05-21	Boehringer Ingelheim Int	用於治療呼吸疾病之新穎藥物組合
US7423146B2 (en)	2005-11-09	2008-09-09	Boehringer Ingelheim International Gmbh	Process for the manufacturing of pharmaceutically active 3,1-benzoxazine-2-ones
JP5086267B2 (ja) *	2005-12-19	2012-11-28	シコールインコーポレイティド	臭化チオトロピウムの新規な形態およびそれを製造する方法
US9108962B2 (en)	2005-12-19	2015-08-18	Sicor, Inc.	Forms of tiotropium bromide and processes for preparation thereof
CN100999521B (zh) *	2006-01-13	2010-12-08	江苏正大天晴药业股份有限公司	结晶性抗胆碱药噻托溴铵
EP1847543A1 (de)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
WO2008017637A1 (de)	2006-08-07	2008-02-14	Boehringer Ingelheim International Gmbh	Arzneimittelkombinationen zur behandlung von atemwegserkrankungen
UY30550A1 (es)	2006-08-22	2008-03-31	Boehringer Ingelheim Int	Nuevos beta-agonistas enantioméricamente puros, procedimientos para su preparacion y su uso como medicamentos
GB0716026D0 (en)	2007-08-16	2007-09-26	Norton Healthcare Ltd	An inhalable medicament
MY153979A (en)	2007-10-19	2015-04-30	Boehringer Ingelheim Int	Substituted piperidino-dihydrothienopyrimidine
EP2093219A1 (de)	2008-02-22	2009-08-26	Boehringer Ingelheim International Gmbh	Kristalline, enantiomerenreine Salzform eines Betamimetikums und dessen Verwendung als Arzneimittel
CN102256963B (zh)	2008-12-19	2014-06-11	贝林格尔.英格海姆国际有限公司	作为ccr2受体拮抗剂用于治疗炎症、哮喘和copd的环状嘧啶-4-甲酰胺
WO2010101538A2 (en)	2009-03-06	2010-09-10	Bilgic Mahmut	New crystal forms
US20130143905A1 (en)	2009-12-17	2013-06-06	Boehringer Ingelheim International Gmbh	Novel antagonists for ccr2 and uses thereof
PT2513093E (pt)	2009-12-17	2014-10-22	Boehringer Ingelheim Int	Novos antagonistas do receptor ccr2 e suas utilizações
CN102822172A (zh)	2010-01-29	2012-12-12	贝林格尔.英格海姆国际有限公司	取代的二氮杂萘及其作为syk 激酶抑制剂的用途
US8946218B2 (en)	2010-05-12	2015-02-03	Boehringer Ingelheim International Gmbh	CCR2 receptor antagonists, method for producing the same, and use thereof as medicaments
EP2569298B1 (en)	2010-05-12	2015-11-25	Boehringer Ingelheim International GmbH	Novel ccr2 receptor antagonists, method for producing the same, and use thereof as medicaments
JP5647339B2 (ja)	2010-05-17	2014-12-24	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２アンタゴニスト及びこれらの使用
JP5636094B2 (ja)	2010-05-25	2014-12-03	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	Ｃｃｒ２受容体アンタゴニスト
US8962656B2 (en)	2010-06-01	2015-02-24	Boehringer Ingelheim International Gmbh	CCR2 antagonists
TR201007108A2 (tr) *	2010-08-25	2012-03-21	B�Lg�� Mahmut	Yeni tiotropyum bromür kristali ve üretim yöntemi.@
EP2668177B1 (en)	2011-01-28	2014-10-22	Boehringer Ingelheim International GmbH	Substituted pyridinyl-pyrimidines and their use as medicaments
TR201101897A2 (tr)	2011-02-28	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropyum bromür içeren kristal madde
TR201102068A2 (tr)	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropyum bromür içeren kristal maddeler
TR201111589A2 (tr) *	2011-03-03	2012-09-21	Bi̇lgi̇ç Mahmut	Tiotropyum bromür susuz kristal formu.
EP2721025B1 (en)	2011-06-16	2015-11-25	Boehringer Ingelheim International Gmbh	New selective ccr2 antagonists
JP5786258B2 (ja)	2011-07-15	2015-09-30	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	新規かつ選択的なｃｃｒ２拮抗薬
MX336224B (es)	2011-07-26	2016-01-12	Boehringer Ingelheim Int	Quinolinas sustituidas y su uso como medicamentos.
US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
LT3421470T (lt)	2011-11-25	2021-04-26	Adverio Pharma Gmbh	Pakeistieji 5-fluor-1h-pirazolopiridinai kristalų pavidale
CZ304368B6 (cs)	2011-11-28	2014-04-02	Zentiva, K.S.	Směsný solvát tiotropium bromidu a způsob jeho přípravy
GB201200525D0 (en)	2011-12-19	2012-02-29	Teva Branded Pharmaceutical Prod R & D Inc	An inhalable medicament
PT106142B (pt) *	2012-02-10	2014-07-18	Hovione Farmaci Ncia S A	Processo para a preparação de brometo de tiotrópio
US9096579B2 (en)	2012-04-20	2015-08-04	Boehringer Ingelheim International Gmbh	Amino-indolyl-substituted imidazolyl-pyrimidines and their use as medicaments
EP2897955B1 (en) *	2012-09-11	2019-11-06	Bilgic, Mahmut	New tiotropium bromide crystalline form
SI2914593T1 (sl)	2012-11-05	2017-05-31	Zentiva, K.S.	Stabilizacija tiotropijevih solvatov
CN104341412A (zh) *	2013-07-29	2015-02-11	天津金耀集团有限公司	一种无水噻托溴铵结晶的制备方法
JP6535022B2 (ja)	2014-03-19	2019-06-26	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ヘテロアリールｓｙｋ阻害剤
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2002
- 2002-06-08 HU HU0400333A patent/HUP0400333A3/hu unknown
- 2002-06-08 AT AT02743165T patent/ATE337006T1/de active
- 2002-06-08 SI SI200230431T patent/SI1401445T1/sl unknown
- 2002-06-08 SK SK52-2004A patent/SK287262B6/sk unknown
- 2002-06-08 EP EP02743165A patent/EP1401445B1/de not_active Expired - Lifetime
- 2002-06-08 BR BR0210537-3A patent/BR0210537A/pt not_active Application Discontinuation
- 2002-06-08 PT PT02743165T patent/PT1401445E/pt unknown
- 2002-06-08 MX MXPA03011718A patent/MXPA03011718A/es active IP Right Grant
- 2002-06-08 DE DE50207943T patent/DE50207943D1/de not_active Expired - Lifetime
- 2002-06-08 CZ CZ20040120A patent/CZ302786B6/cs not_active IP Right Cessation
- 2002-06-08 PL PL364489A patent/PL208137B1/pl unknown
- 2002-06-08 AU AU2002345016A patent/AU2002345016B2/en not_active Expired
- 2002-06-08 WO PCT/EP2002/006291 patent/WO2003000265A1/de not_active Ceased
- 2002-06-08 KR KR1020037016769A patent/KR100971616B1/ko not_active Expired - Lifetime
- 2002-06-08 NZ NZ530690A patent/NZ530690A/en not_active IP Right Cessation
- 2002-06-08 HR HR20031066A patent/HRP20031066B1/xx not_active IP Right Cessation
- 2002-06-08 DK DK02743165T patent/DK1401445T3/da active
- 2002-06-08 CN CN02812303A patent/CN100586948C/zh not_active Expired - Lifetime
- 2002-06-08 JP JP2003506910A patent/JP2005504015A/ja active Pending
- 2002-06-08 RS YUP-997/03A patent/RS50441B/sr unknown
- 2002-06-08 IL IL15923802A patent/IL159238A0/xx unknown
- 2002-06-08 KR KR1020097004823A patent/KR101011353B1/ko not_active Expired - Lifetime
- 2002-06-08 CA CA2450961A patent/CA2450961C/en not_active Expired - Fee Related
- 2002-06-08 EA EA200301293A patent/EA005813B1/ru not_active IP Right Cessation
- 2002-06-08 ME MEP-2008-620A patent/ME00412B/me unknown
- 2002-06-08 ES ES02743165T patent/ES2271280T3/es not_active Expired - Lifetime
- 2002-06-08 EE EEP200400029A patent/EE05316B1/et unknown
- 2002-06-19 TW TW091113373A patent/TWI261589B/zh not_active IP Right Cessation
- 2002-06-19 EG EG2002060698A patent/EG24851A/xx active
- 2002-06-19 TW TW095100968A patent/TW200617007A/zh unknown
- 2002-06-20 MY MYPI20022316A patent/MY122779A/en unknown
- 2002-06-20 UY UY27342A patent/UY27342A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2007000660A patent/PE20081305A1/es not_active Application Discontinuation
- 2002-06-21 PE PE2002000538A patent/PE20030130A1/es active IP Right Grant
- 2002-06-21 AR ARP020102337A patent/AR037491A1/es not_active Application Discontinuation
- 2002-08-19 SA SA2230255A patent/SA02230255B1/ar unknown
2003
- 2003-12-08 IL IL159238A patent/IL159238A/en active IP Right Grant
- 2003-12-12 BG BG108440A patent/BG66303B1/bg unknown
- 2003-12-19 NO NO20035696A patent/NO334301B1/no not_active IP Right Cessation
2004
- 2004-01-20 CO CO04003764A patent/CO5550423A2/es not_active Application Discontinuation
2006
- 2006-09-20 CY CY20061101339T patent/CY1105223T1/el unknown

Also Published As

Publication number	Publication date
JP2005504015A (ja)	2005-02-10
BR0210537A (pt)	2004-06-22
NO20035696D0 (no)	2003-12-19
BG108440A (bg)	2004-08-31
MXPA03011718A (es)	2004-12-06
CN100586948C (zh)	2010-02-03
CZ2004120A3 (cs)	2004-05-12
HUP0400333A2 (hu)	2004-12-28
CY1105223T1 (el)	2010-03-03
KR101011353B1 (ko)	2011-01-28
SK522004A3 (en)	2004-06-08
AU2002345016B2 (en)	2008-04-17
DE50207943D1 (de)	2006-10-05
RS50441B (sr)	2010-03-02
SK287262B6 (sk)	2010-04-07
ME00412B (me)	2011-10-10
AR037491A1 (es)	2004-11-17
IL159238A (en)	2010-04-15
HUP0400333A3 (en)	2012-10-29
CZ302786B6 (cs)	2011-11-09
KR20090031638A (ko)	2009-03-26
ATE337006T1 (de)	2006-09-15
CA2450961A1 (en)	2003-01-03
EG24851A (en)	2010-10-27
MEP62008A (en)	2011-05-10
DK1401445T3 (da)	2006-11-27
SI1401445T1 (sl)	2007-02-28
NZ530690A (en)	2005-05-27
ES2271280T3 (es)	2007-04-16
EA005813B1 (ru)	2005-06-30
BG66303B1 (bg)	2013-03-29
YU99703A (sh)	2006-05-25
EP1401445B1 (de)	2006-08-23
TW200617007A (en)	2006-06-01
PL208137B1 (pl)	2011-03-31
PT1401445E (pt)	2006-10-31
NO334301B1 (no)	2014-02-03
UY27342A1 (es)	2003-02-28
KR100971616B1 (ko)	2010-07-22
KR20040018285A (ko)	2004-03-02
PE20030130A1 (es)	2003-04-02
EP1401445A1 (de)	2004-03-31
TWI261589B (en)	2006-09-11
HRP20031066A2 (en)	2004-04-30
CO5550423A2 (es)	2005-08-31
HK1068540A1 (zh)	2005-04-29
EA200301293A1 (ru)	2004-08-26
IL159238A0 (en)	2004-06-01
SA02230255B1 (ar)	2006-10-31
PE20081305A1 (es)	2008-10-01
HRP20031066B1 (en)	2011-10-31
PL364489A1 (en)	2004-12-13
WO2003000265A1 (de)	2003-01-03
CA2450961C (en)	2010-03-30
EE05316B1 (et)	2010-08-16
CN1520294A (zh)	2004-08-11
MY122779A (en)	2006-05-31

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