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DK3209309T3 - Sammensætninger omfattende bakteriestammer - Google Patents

Sammensætninger omfattende bakteriestammer Download PDF

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Publication number
DK3209309T3
DK3209309T3 DK16804858.5T DK16804858T DK3209309T3 DK 3209309 T3 DK3209309 T3 DK 3209309T3 DK 16804858 T DK16804858 T DK 16804858T DK 3209309 T3 DK3209309 T3 DK 3209309T3
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composition
compositions
disease
preventing
cancer
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DK16804858.5T
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Imke Elisabeth MULDER
Amy Beth HOLT
Seanin Marie Mccluskey
Grainne Clare Lennon
Suaad Ahmed
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4D Pharma Res Ltd
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    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
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Claims (18)

1. Sammensætning omfattende en bakteriestamme af arten Eubacterium contortum, til anvendelse i en fremgangsmåde til behandling eller forebyggelse af en inflammatorisk eller autoimmun sygdom, eller cancer.
2. Sammensætningen ifølge krav 1, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af en sygdom eller tilstand valgt fra gruppen bestående af uveitis; cancer, såsom brystcancer, lungecancer, levercancer, koloncancer, eller æggestokcancer; multipel sclerose; arthritis, såsom rheumatoid arthritis, osteoarthritis, psoriatrisk arthritis, eller juvenil idiopatisk arthritis; neuromyelitis optica (Devic's sygdom); ankylosing spondylitis; spondyloarthritis; psoriasis; systemisk lupus erythematosus; inflammatorisk tarmsygdom, såsom Crohn's sygdom eller ulcerativ colitis; cøliakisygdom; astma, såsom allergisk astma eller neutrophil astma; kronisk obstruktær pulmonær sygdom (COPD); scleritis; vasculitis; Behcet's sygdom; atherosclerose; atopisk dermatitis; emphysem; periodontitis; allergisk rhinitis; og allograft afviselse.
3. Sammensætningen ifølge krav 2, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af uveitis, og hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere eller forebygge retinal skade i uveitis.
4. Sammensætningen ifølge krav 2, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af cancer, såsom lungecancer, brystcancer eller levercancer, og hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere tumorstørrelse, reducere tumorvækst, forebygge metastaser eller forebygge angiogenese.
5. Sammensætningen ifølge krav 2, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af astma, såsom neutrophil astma eller allergisk astma, og hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere neutrofili eller eosinofili i behandlingen af astma.
6. Sammensætningen ifølge krav 2, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af rheumatoid arthritis, og hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere ledhævelse i rheumatoid arthritis.
7. Sammensætningen ifølge krav 2, hvor sammensætningen er til anvendelse i en fremgangsmåde til behandling eller forebyggelse af multipel sklerose, og hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere sygdoms-incidens eller sygdomsalvorlighed.
8. Sammensætningen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er til anvendelse i en fremgangsmåde til at reducere IL-17 produktion eller reducere Thl7-celledifferentiering i behandlingen eller forebyggelse af inflammatorisk eller autoimmun sygdom, eller cancer.
9. Sammensætningen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er til anvendelse i en patient med forhøjede IL-17-niveauer eller Thl7-celler.
10. Sammensætningen ifølge et hvilket som helst af kravene 1-9, til anvendelsen ifølge et hvilket som helst af kravene 1-9, hvor bakteriestammen har en 16s rRNA-sekvens der er mindst 95%, 96%, 97%, 98%, 99%, 99,5% eller 99,9% identisk med 16s rNA-sekvensen af en bakteriestamme af Eubacterium contortum eller SEQ ID NO: 1, 2, 3 eller 4.
11. Sammensætningen ifølge et hvilket som helst af de foregående krav, til anvendelsen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen er til oral administration, hvor sammensætningen omfatter én eller flere farmaceutisk acceptable excipienser eller bærere og/eller hvor bakteriestammen er lyofiliseret.
12. Sammensætningen ifølge et hvilket som helst af de foregående krav, til anvendelsen ifølge et hvilket som helst af de foregående krav, hvor bakteriestammen er levedygtig og i stand til delvist eller totalt at kolonisere tarmen.
13. Sammensætningen ifølge et hvilket som helst af de foregående krav, til anvendelsen ifølge et hvilket som helst af de foregående krav, hvor sammensætningen omfatter en enkelt stamme af arten Eubacterium contortum.
14. Sammensætningen ifølge et hvilket som helst af de foregående krav, til anvendelsen ifølge et hvilket som helst af de foregående krav, der omfatter Eubacterium contortum-bakteriestammen som del af et mikrobielt konsortium.
15. Fødevareprodukt eller en vaccine omfattende sammensætningen ifølge et hvilket som helst af de foregående krav, til anvendelsen ifølge et hvilket som helst af de foregående krav.
16. Celle eller biologisk ren kultur af Eubacterium contortum stamme MRX050 deponeret som NCIMB 42689, eventuelt til anvendelse i terapi, yderligere eventuelt hvor cellen er til anvendelse i en fremgangsmåde defineret i et hvilket som helst af kravene 1-9.
17. Sammensætning omfattende cellen ifølge krav 16, eventuelt omfattende en farmaceutisk acceptabel bærer eller excipiens.
18. Sammensætning omfattende én eller flere bakteriestammer af arten Eubacterium contortum, til anvendelse i terapi.
DK16804858.5T 2015-11-23 2016-11-23 Sammensætninger omfattende bakteriestammer DK3209309T3 (da)

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GBGB1520638.6A GB201520638D0 (en) 2015-11-23 2015-11-23 Compositions comprising bacterial strains
PCT/GB2016/053677 WO2017089795A1 (en) 2015-11-23 2016-11-23 Compositions comprising bacterial strains

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DK3209309T3 true DK3209309T3 (da) 2018-05-07

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US (3) US10391128B2 (da)
EP (4) EP4029511A1 (da)
JP (3) JP2018501188A (da)
KR (2) KR20180120797A (da)
CN (2) CN112353821A (da)
AR (1) AR106801A1 (da)
AU (2) AU2016358972B2 (da)
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