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DK3010523T3 - Roseburia flagellin og immunmodulation - Google Patents

Roseburia flagellin og immunmodulation Download PDF

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Publication number
DK3010523T3
DK3010523T3 DK14717823.0T DK14717823T DK3010523T3 DK 3010523 T3 DK3010523 T3 DK 3010523T3 DK 14717823 T DK14717823 T DK 14717823T DK 3010523 T3 DK3010523 T3 DK 3010523T3
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polynucleotide sequence
roseburia
vector
host cell
flagellin
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Denise Kelly
Angela Patterson
Edouard Monnais
Imke Mulder
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4D Pharma Res Ltd
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Claims (18)

1. Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse til behandling og/eller forebyggelse af en inflammatorisk lidelse og/eller en autoimmun lidelse hos et individ.
2. Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor Roseburia flagellin er valgt fra gruppen bestående af: polypeptider som er mindst 75% identiske med SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, SEQ ID NO 10 eller SEQ ID NO 12 eller varianter, homologer, fragmenter eller derivater deraf og kombinationer deraf; og hvor polynukleotidsekvensen der koder for Roseburia flagellin er valgt fra gruppen bestående af: polynukleotidsekvenser der koder for et polypeptid der er mindst 75% identisk med SEQ ID NO 2, SEQ ID NO 4, SEQ ID NO 6, SEQ ID NO 8, SEQ ID NO 10 eller SEQ ID NO 12 eller varianter, homologer, fragmenter eller derivater deraf; polynukleotidsekvenser der er mindst 75% identiske med SEQ ID NO 1, SEQ ID NO 3, SEQ ID NO 5, SEQ ID NO 7, SEQ ID NO 9 eller SEQ ID NO 11 eller varianter, homologer, fragmenter eller derivater deraf;og kombinationer deraf.
3. Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor lidelsen er valgt fra gruppen bestående af rheumatoid arthritis, psoriasis, multipel sklerose, type I diabetes, cøliaki, atopisk dermatitis, rhinitis, irritabel tyktarm (IBS), colitis, inflammatorisk tarmsygdom (IBD), ulcerativ colitis, pouchitis, Crohns sygdom, funktionel dyspepsi, atopiske sygdomme, nekrotiserende enterokolit og kombinationer deraf.
4. Roseburia flagellin, eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor Roseburia flagellin, eller polynukleotidsekvenens der koder for Roseburia flagellin, og/eller vektoren omfattende polynukleotidsekvensen, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen øger produktionen af regulatoriske T-celler hos et individ.
5. Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor Roseburia flagellin, eller polynukleotidsekvensen der koder for Roseburia flagellin, og/eller vektoren omfattende polynukleotidsekvensen, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen øger produktionen af IL-10 og/eller TGFp i en celle eller celler hos et individ.
6. Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor Roseburia flagellin, eller polynukleotidsekvensen der koder for Roseburia flagellin, og/eller vektoren omfattende polynukleotidsekvensen, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen øger produktionen af celleoverflademarkører involveret i immunreaktioner og antigengenkendelse såsom CD40, I-A/I-E, CD317/BST-2, CD103, CD80, CD86, CD83 og/eller Siglec-H og/eller tilsvarende arter i en celle eller celler hos et individ.
7. Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 6 hvor produktionen af celleoverflademarkører involveret i immunreaktioner og antigengenkendelse såsom CD40, I-A/I-E, CD317/BST-2, CD103, CD80, CD86, CD83 og/eller Siglec-H og/eller tilsvarende arter er med dendritiske celler.
8. Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 1 hvor Roseburia flagellin, eller polynukleotidsekvensen der koder for Roseburia flagellin, og/eller vektoren omfattende polynukleotidsekvensen, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen reducerer ekspressionen af et eller flere Type I IFN gener i en celle eller celler hos et individ.
9. Anvendelse af Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, til at stimulere appetitten hos et individ.
10. Anvendelse af Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, ifølge krav 9 hvor niveauet af cholecystokinin (Cck) og/eller glucagon (Gcg) i reduceres i blodet hos et individ.
11. Farmaceutisk sammensætning og/eller et næringstilskud omfattende Roseburia flagellin, og/eller en polynukleotidsekvens der koder for Roseburia flagellin, og/eller en vektor omfattende polynukleotidsekvensen, og/eller en I værtscelle, omfattende bakterier, omfattende vektoren, og/eller en værtscelle, omfattende bakterier, omfattende polynukleotidsekvensen, og en farmaceutisk og/eller ernæringsmæssig acceptabel excipiens, bærer eller diluent.
12. Farmaceutisk sammensætning og/eller næringstilskud ifølge krav 11 hvor Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, er indkapslet.
13. Farmaceutisk sammensætning og/eller næringstilskud ifølge krav 11 eller krav 12 til anvendelse til behandling af en lidelse hos et individ, hvor lidelsen er en inflammatorisk lidelse og/eller en autoimmun lidelse.
14. Anvendelse af den farmaceutiske sammensætning og/eller næringstilskuddet ifølge krav 11 eller krav 12 til at stimulere appetitten hos et individ.
15. Fremgangsmåde til fremstilling af en farmaceutisk sammensætning og/eller et næringtilskud ifølge krav 11, hvilken fremgangsmåde omfatter at blande Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, med en farmaceutisk eller ernæringsmæssig acceptabel excipiens, bærer eller diluent; eventuelt Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, er indkapslet.
16. Roseburia flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelsen ifølge et hvilket som helst af kravene 1-10, den farmaceutiske sammensætning og/eller næringstilskuddet ifølge et hvilket som helst af kravene 11-14 og fremgangsmåden ifølge krav 15, hvor Roseburia flagellin er afledt fra eller kan afledes fra Roseburia hominis.
17. Roseburia hominis flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 16 hvor Roseburia hominis flagellin er et polypeptid der er mindst 99% identisk med SEQ ID NO 2 eller SEQ ID NO 4, og hvor polynukleotidsekvensen der koder for Roseburia hominis flagellin er en polynukleotidsekvens der koder for et polypeptid der er mindst 99% identisk med SEQ ID NO 2 eller SEQ ID NO 4, eller en polynukleotidsekvens der er mindst 99% identisk med SEQ ID NO 1 eller SEQ ID NO 3.
18. Roseburia hominis flagellin, og/eller polynukleotidsekvensen, og/eller vektoren, og/eller værtscellen, omfattende bakterier, omfattende vektoren, og/eller værtscellen, omfattende bakterier, omfattende polynukleotidsekvensen, til anvendelse ifølge krav 16 eller 17 hvor Roseburia hominis flagellin har polypeptidsekvensen vist som SEQ ID NO 2 eller SEQ ID NO 4, og hvor polynukleotidsekvensen der koder for Roseburia hominis flagellin har polynukleotidsekvensen der koder for et polypeptid der har sekvensen vist som SEQ ID NO 2 eller SEQ ID NO 4, eller polynukleotidsekvensen vist som SEQ ID NO 1 eller SEQ ID NO 3.
DK14717823.0T 2013-04-10 2014-04-10 Roseburia flagellin og immunmodulation DK3010523T3 (da)

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