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DK1169460T3 - Fremstilling af biologisk aktive molekyler - Google Patents

Fremstilling af biologisk aktive molekyler

Info

Publication number
DK1169460T3
DK1169460T3 DK00919108T DK00919108T DK1169460T3 DK 1169460 T3 DK1169460 T3 DK 1169460T3 DK 00919108 T DK00919108 T DK 00919108T DK 00919108 T DK00919108 T DK 00919108T DK 1169460 T3 DK1169460 T3 DK 1169460T3
Authority
DK
Denmark
Prior art keywords
preparation
biologically active
active molecules
molecules
biologically
Prior art date
Application number
DK00919108T
Other languages
Danish (da)
English (en)
Inventor
Menachem Rubinstein
Daniela Novick
Bianling Liu
Pierre Graber
Original Assignee
Yeda Res & Dev
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Res & Dev filed Critical Yeda Res & Dev
Application granted granted Critical
Publication of DK1169460T3 publication Critical patent/DK1169460T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
DK00919108T 1999-04-13 2000-04-13 Fremstilling af biologisk aktive molekyler DK1169460T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules

Publications (1)

Publication Number Publication Date
DK1169460T3 true DK1169460T3 (da) 2006-09-18

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
DK00919108T DK1169460T3 (da) 1999-04-13 2000-04-13 Fremstilling af biologisk aktive molekyler

Country Status (23)

Country Link
US (1) US7098002B1 (fr)
EP (1) EP1169460B1 (fr)
JP (1) JP4822587B2 (fr)
KR (1) KR100682185B1 (fr)
CN (1) CN1324140C (fr)
AR (1) AR023468A1 (fr)
AT (1) ATE326536T1 (fr)
AU (1) AU781342B2 (fr)
BR (1) BR0009782A (fr)
CA (1) CA2368994C (fr)
DE (1) DE60028022T2 (fr)
DK (1) DK1169460T3 (fr)
EA (1) EA006825B1 (fr)
EE (1) EE05591B1 (fr)
ES (1) ES2259287T3 (fr)
IL (3) IL129427A0 (fr)
MX (1) MXPA01010487A (fr)
NO (1) NO329525B1 (fr)
PT (1) PT1169460E (fr)
SI (1) SI1169460T1 (fr)
UA (1) UA73940C2 (fr)
WO (1) WO2000061768A2 (fr)
ZA (1) ZA200108364B (fr)

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AU1336701A (en) * 1999-10-20 2001-04-30 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
WO2002101049A2 (fr) 2001-03-08 2002-12-19 Ares Trading S.A. Production et utilisation de mutants d'interleukine-18
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
CA2475177A1 (fr) 2002-02-11 2003-08-21 Zymogenetics, Inc. Materiaux et procedes pour la preparation de facteurs de croissance dimeres
DE602004009292T2 (de) * 2003-02-21 2009-03-19 Biotecnol S.A. Verwendung von caspasen zur herstellung von reifen rekombinanten fusionsproteinen
JP5639324B2 (ja) * 2003-08-06 2014-12-10 ユニバーシティー オブ メリーランド，カレッジ パーク 融合タンパク質のアフィニティ精製およびプロセッシングのための修飾されたプロテアーゼ
CA2545024A1 (fr) * 2003-11-24 2005-06-02 Novo Nordisk A/S Proteines de fusion et methodes de clivage de ces proteines
ATE517914T1 (de) 2004-03-08 2011-08-15 Zymogenetics Inc Dimere fusionsproteine und materialien und verfahren zu deren herstellung
DK2154151T3 (da) * 2005-09-19 2011-09-05 Allergan Inc Clostridiumtoksinaktiverbare clostridiumtoksiner
EP2014676B1 (fr) * 2006-04-20 2012-03-07 Kringle Pharma Inc. Mutant de la protéine précurseur du hgf et sa forme activée
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
EP2190861A4 (fr) 2007-08-22 2011-03-30 Univ California Polypeptides de liaison activables et procédés d'identification et utilisation de ceux-ci
WO2009044988A1 (fr) * 2007-10-01 2009-04-09 Korea Research Institute Of Bioscience And Biotechnology Procédé de préparation à grande échelle de procaspases pouvant être activées artificiellement dans un système d'expression de e. coli et leur activation
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
EP2385955B1 (fr) * 2009-01-12 2020-08-12 CytomX Therapeutics, Inc. Compositions d anticorps modifiées et leurs procédés de production et d utilisation
CA2753294A1 (fr) * 2009-02-23 2010-08-26 Cytomx Therapeutics, Inc. Proproteines et leurs procedes d'utilisation
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
RU2711322C1 (ru) 2013-12-20 2020-01-16 Ф. Хоффманн-Ля Рош Аг Улучшенные способы получения рекомбинантного полипептида
WO2016160936A1 (fr) 2015-03-30 2016-10-06 Greenlight Biosciences, Inc. Production acellulaire d'acide ribonucléique
HUE057952T2 (hu) 2015-06-24 2022-06-28 Hoffmann La Roche Anti-transzferrin receptor antitestek testreszabott affinitással
CN114057884A (zh) 2015-10-02 2022-02-18 豪夫迈·罗氏有限公司 双特异性抗人cd20/人转铁蛋白受体抗体及使用方法
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
WO2017176963A1 (fr) 2016-04-06 2017-10-12 Greenlight Biosciences, Inc. Production acellulaire d'acide ribonucléique
WO2019075167A1 (fr) 2017-10-11 2019-04-18 Greenlight Biosciences, Inc. Procédés et compositions pour la production de nucléoside triphosphate et d'acide ribonucléique
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
CA3150818A1 (fr) * 2019-08-13 2021-02-18 King's College London Cellules immunoreactives dotees d'une activite a limitation spatiotemporelle de cytokines de la superfamille de l'il-1

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
EP0538398A4 (en) * 1990-06-25 1993-12-29 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods for preparation and uses thereof
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
AU683834B2 (en) * 1991-12-31 1997-11-27 Zymogenetics Inc. Methods for producing thrombin
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
EP0870028A1 (fr) 1995-12-29 1998-10-14 Incyte Pharmaceuticals, Inc. Acides nucleiques codant le facteur 2 inducteur de l'interferon gamma
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
DE69842119D1 (de) * 1997-08-07 2011-03-17 Toray Industries Methode zur herstellung von canine interleukin 18

Also Published As

Publication number Publication date
SI1169460T1 (sl) 2006-08-31
IL145842A (en) 2008-06-05
CN1324140C (zh) 2007-07-04
JP4822587B2 (ja) 2011-11-24
US7098002B1 (en) 2006-08-29
IL129427A0 (en) 2000-02-17
NO20014966L (no) 2001-12-11
PT1169460E (pt) 2006-07-31
UA73940C2 (uk) 2005-10-17
CA2368994C (fr) 2010-03-09
CA2368994A1 (fr) 2000-10-19
WO2000061768A2 (fr) 2000-10-19
CN1353761A (zh) 2002-06-12
AR023468A1 (es) 2002-09-04
EE05591B1 (et) 2012-10-15
EP1169460B1 (fr) 2006-05-17
ATE326536T1 (de) 2006-06-15
EA200101078A1 (ru) 2002-04-25
ES2259287T3 (es) 2006-10-01
IL145842A0 (en) 2002-07-25
EP1169460A2 (fr) 2002-01-09
ZA200108364B (en) 2002-10-11
KR100682185B1 (ko) 2007-02-12
HK1044351A1 (en) 2002-10-18
NO329525B1 (no) 2010-11-01
JP2002541813A (ja) 2002-12-10
BR0009782A (pt) 2002-01-08
KR20020007365A (ko) 2002-01-26
EE200100530A (et) 2002-12-16
AU781342B2 (en) 2005-05-19
DE60028022D1 (de) 2006-06-22
WO2000061768A3 (fr) 2001-02-08
MXPA01010487A (es) 2002-05-06
AU3985100A (en) 2000-11-14
EA006825B1 (ru) 2006-04-28
NO20014966D0 (no) 2001-10-12
DE60028022T2 (de) 2006-09-28

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