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EE200100530A - Meetod bioloogiliselt aktiivse molekuli valmistamiseks, sel viisil saadud molekul ning molekuli muteerunud prekursorit kodeeriv cDNA - Google Patents

Meetod bioloogiliselt aktiivse molekuli valmistamiseks, sel viisil saadud molekul ning molekuli muteerunud prekursorit kodeeriv cDNA

Info

Publication number
EE200100530A
EE200100530A EEP200100530A EEP200100530A EE200100530A EE 200100530 A EE200100530 A EE 200100530A EE P200100530 A EEP200100530 A EE P200100530A EE P200100530 A EEP200100530 A EE P200100530A EE 200100530 A EE200100530 A EE 200100530A
Authority
EE
Estonia
Prior art keywords
molecule
preparing
biologically active
cdna encoding
mutated precursor
Prior art date
Application number
EEP200100530A
Other languages
English (en)
Inventor
Rubinstein Menachem
Liu Bianling
Novick Daniela
Dinarello Charles
Graber Pierre
Original Assignee
Yeda Research And Development Co. Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Yeda Research And Development Co. Ltd. filed Critical Yeda Research And Development Co. Ltd.
Publication of EE200100530A publication Critical patent/EE200100530A/et
Publication of EE05591B1 publication Critical patent/EE05591B1/et

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6472—Cysteine endopeptidases (3.4.22)
    • C12N9/6475—Interleukin 1-beta convertase-like enzymes (3.4.22.10; 3.4.22.36; 3.4.22.63)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/545—IL-1

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Toxicology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Steroid Compounds (AREA)
EEP200100530A 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA EE05591B1 (et)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IL12942799A IL129427A0 (en) 1999-04-13 1999-04-13 Preparation of biologically active molecules
PCT/IL2000/000220 WO2000061768A2 (en) 1999-04-13 2000-04-13 Preparation of biologically active molecules

Publications (2)

Publication Number Publication Date
EE200100530A true EE200100530A (et) 2002-12-16
EE05591B1 EE05591B1 (et) 2012-10-15

Family

ID=11072700

Family Applications (1)

Application Number Title Priority Date Filing Date
EEP200100530A EE05591B1 (et) 1999-04-13 2000-04-13 Meetod bioloogiliselt aktiivse tstokiini valmistamiseks ja bioloogiliselt aktiivse tstokiini muteerunud prekursorit kodeeriv cDNA

Country Status (23)

Country Link
US (1) US7098002B1 (et)
EP (1) EP1169460B1 (et)
JP (1) JP4822587B2 (et)
KR (1) KR100682185B1 (et)
CN (1) CN1324140C (et)
AR (1) AR023468A1 (et)
AT (1) ATE326536T1 (et)
AU (1) AU781342B2 (et)
BR (1) BR0009782A (et)
CA (1) CA2368994C (et)
DE (1) DE60028022T2 (et)
DK (1) DK1169460T3 (et)
EA (1) EA006825B1 (et)
EE (1) EE05591B1 (et)
ES (1) ES2259287T3 (et)
IL (3) IL129427A0 (et)
MX (1) MXPA01010487A (et)
NO (1) NO329525B1 (et)
PT (1) PT1169460E (et)
SI (1) SI1169460T1 (et)
UA (1) UA73940C2 (et)
WO (1) WO2000061768A2 (et)
ZA (1) ZA200108364B (et)

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WO2001029232A2 (en) * 1999-10-20 2001-04-26 Scios Inc. Functional cloning of genes encoding proteins/enzymes involved in proteolytic cleavage
US7273722B2 (en) 2000-11-29 2007-09-25 Allergan, Inc. Neurotoxins with enhanced target specificity
EA005769B1 (ru) 2001-03-08 2005-06-30 Арес Трейдинг С.А. Мутанты интерлейкина-18, их продуцирование и применение
IL142246A0 (en) * 2001-03-26 2002-03-10 Applied Research Systems Method and kit for quantitation of polypeptides
EP1483298A4 (en) 2002-02-11 2007-03-14 Zymogenetics Inc MATERIALS AND METHODS FOR PREPARING DIMERED GROWTH FACTORS
DE602004009292T2 (de) * 2003-02-21 2009-03-19 Biotecnol S.A. Verwendung von caspasen zur herstellung von reifen rekombinanten fusionsproteinen
AU2004265613B2 (en) * 2003-08-06 2010-12-09 University Of Maryland, College Park Engineered proteases for affinity purification and processing of fusion proteins
EP1689877A1 (en) * 2003-11-24 2006-08-16 Novo Nordisk A/S Fusion proteins and methods of cleavage of such proteins
WO2005087810A2 (en) 2004-03-08 2005-09-22 Zymogenetics, Inc. Dimeric fusion proteins and materials and methods for producing them
ATE463506T1 (de) 2005-09-19 2010-04-15 Allergan Inc Mit clostriedientoxin aktivierbare clostridientoxine
JP5093783B2 (ja) * 2006-04-20 2012-12-12 クリングルファーマ株式会社 Ｈｇｆ前駆体蛋白質改変体及びその活性型蛋白質
DE102007008596B4 (de) * 2007-02-15 2010-09-02 Friedrich-Schiller-Universität Jena Biologisch wirksame Moleküle auf Grundlage von PNA und siRNA, Verfahren zu deren zellspezifischen Aktivierung sowie Applikationskit zur Verabreichung
JP6035009B2 (ja) 2007-08-22 2016-11-30 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 活性化可能な結合ポリペプチドおよびその同定方法ならびに使用
KR100980315B1 (ko) * 2007-10-01 2010-09-07 한국생명공학연구원 대장균시스템을 이용한 인위적 활성화가 가능한 카스파제전구체 대량생산 및 활성화 방법
DE102009043743B4 (de) 2009-03-13 2016-10-13 Friedrich-Schiller-Universität Jena Zellspezifisch wirksame Moleküle auf Grundlage von siRNA sowie Applikationskits zu deren Herstellung und Verwendung
EP3543256A1 (en) * 2009-01-12 2019-09-25 Cytomx Therapeutics Inc. Modified antibody compositions, methods of making and using thereof
EP2398494A4 (en) 2009-02-23 2015-10-28 Cytomx Therapeutics Inc Proproteins and their methods of use
CN103923897B (zh) * 2013-01-11 2016-06-01 中国人民解放军军事医学科学院生物工程研究所 caspase重组酶原及其编码基因与应用
CN103388001B (zh) * 2013-07-16 2016-01-20 中国人民解放军第四军医大学 一种含凝血酶切割位点gst膜型表达载体及转染阳性细胞的方法
WO2015091144A1 (en) 2013-12-20 2015-06-25 F. Hoffmann-La Roche Ag Improved recombinant polypeptide production methods
BR112017020690A2 (pt) 2015-03-30 2018-06-26 Greenlight Biosciences Inc produção livre de células de ácido ribonucleico
UA123053C2 (uk) 2015-06-24 2021-02-10 Ф. Хоффманн-Ля Рош Аг Антитіло до рецептора трансферину зі спеціально підібраною афінністю
MA43023A (fr) 2015-10-02 2018-08-08 Hoffmann La Roche Anticorps de récepteur de la transferrine humaine/anti-humaine cd20 bispécifique et leurs procédés d'utilisation
AR106189A1 (es) 2015-10-02 2017-12-20 Hoffmann La Roche ANTICUERPOS BIESPECÍFICOS CONTRA EL A-b HUMANO Y EL RECEPTOR DE TRANSFERRINA HUMANO Y MÉTODOS DE USO
CN109196109B (zh) 2016-04-06 2024-06-25 绿光生物科技股份有限公司 无细胞生成核糖核酸
BR112020007068A2 (pt) 2017-10-11 2020-10-06 Greenlight Biosciences, Inc. métodos e composições para produção de nucleosídeo trifosfato e ácido ribonucleico
KR20200080749A (ko) * 2018-12-27 2020-07-07 주식회사 폴루스 N-말단의 메티오닌이 절단된 목적 단백질 발현용 유전자 발현 카세트 및 이를 이용하여 n-말단의 메티오닌이 절단된 목적 단백질을 생산하는 방법
JP2022545643A (ja) * 2019-08-13 2022-10-28 キングス・カレッジ・ロンドン Ｉｌ－１スーパーファミリーのサイトカインの空間時間的に制限された活性が武装化された免疫応答性細胞

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JPH05509320A (ja) * 1990-06-25 1993-12-22 オーエスアイ　ファーマシューティカルズ，インコーポレイティド 組織誘導型腫瘍成長抑制物質、その調製及び使用方法
US5824297A (en) * 1990-06-25 1998-10-20 Oncogene Science, Inc. Tissue-derived tumor growth inhibitors, methods of preparation and uses thereof
DE69229252T2 (de) * 1991-08-16 1999-12-16 Merck & Co., Inc. DNS, welche das Interleukin-1B-Vorläufer-Converting-Enzym kodiert
JP3404038B2 (ja) * 1991-12-31 2003-05-06 ザイモジェネティクス，インコーポレイティド トロンビンの製造方法
JPH06125784A (ja) * 1992-01-17 1994-05-10 Takeda Chem Ind Ltd モノクローナル抗体，ハイブリドーマ，その製造法および用途
US6303369B1 (en) * 1993-09-30 2001-10-16 Carl Spana Protein expression system
EP0870028A1 (en) * 1995-12-29 1998-10-14 Incyte Pharmaceuticals, Inc. Nucleic acids encoding interferon gamma inducing factor-2
JP4059941B2 (ja) * 1996-08-26 2008-03-12 社団法人芝蘭会 Ｒｈｏ標的タンパク質ｐ１４０ｍＤｉａ
AT405516B (de) * 1997-02-27 1999-09-27 Immuno Ag Faktor x-analoge mit modifizierter proteasespaltstelle
JPH10327872A (ja) * 1997-05-30 1998-12-15 Otsuka Pharmaceut Co Ltd Ｂｃｌ−２相互作用蛋白遺伝子ｂｉｓ
US6600020B1 (en) * 1997-08-07 2003-07-29 Toray Industries, Inc. Canine interleukin 18 polypeptide

Also Published As

Publication number Publication date
CA2368994A1 (en) 2000-10-19
WO2000061768A2 (en) 2000-10-19
CN1353761A (zh) 2002-06-12
JP4822587B2 (ja) 2011-11-24
ZA200108364B (en) 2002-10-11
KR100682185B1 (ko) 2007-02-12
DE60028022T2 (de) 2006-09-28
CA2368994C (en) 2010-03-09
EP1169460B1 (en) 2006-05-17
EA006825B1 (ru) 2006-04-28
US7098002B1 (en) 2006-08-29
NO329525B1 (no) 2010-11-01
CN1324140C (zh) 2007-07-04
BR0009782A (pt) 2002-01-08
IL145842A (en) 2008-06-05
ATE326536T1 (de) 2006-06-15
DE60028022D1 (de) 2006-06-22
EE05591B1 (et) 2012-10-15
UA73940C2 (uk) 2005-10-17
DK1169460T3 (da) 2006-09-18
SI1169460T1 (sl) 2006-08-31
NO20014966L (no) 2001-12-11
ES2259287T3 (es) 2006-10-01
AU3985100A (en) 2000-11-14
NO20014966D0 (no) 2001-10-12
MXPA01010487A (es) 2002-05-06
AR023468A1 (es) 2002-09-04
IL145842A0 (en) 2002-07-25
EP1169460A2 (en) 2002-01-09
WO2000061768A3 (en) 2001-02-08
EA200101078A1 (ru) 2002-04-25
KR20020007365A (ko) 2002-01-26
HK1044351A1 (en) 2002-10-18
PT1169460E (pt) 2006-07-31
AU781342B2 (en) 2005-05-19
JP2002541813A (ja) 2002-12-10
IL129427A0 (en) 2000-02-17

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Effective date: 20170413