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CY1120073T1 - Παραγωγα πυραζολο-αμινοπυριμιδινης ως ρυθμιστες της lrrk2 - Google Patents

Παραγωγα πυραζολο-αμινοπυριμιδινης ως ρυθμιστες της lrrk2

Info

Publication number
CY1120073T1
CY1120073T1 CY20171101349T CY171101349T CY1120073T1 CY 1120073 T1 CY1120073 T1 CY 1120073T1 CY 20171101349 T CY20171101349 T CY 20171101349T CY 171101349 T CY171101349 T CY 171101349T CY 1120073 T1 CY1120073 T1 CY 1120073T1
Authority
CY
Cyprus
Prior art keywords
lrrk2
pyrazolo
regulators
aminopyrimidine
compounds
Prior art date
Application number
CY20171101349T
Other languages
English (en)
Inventor
Charles Baker-Glenn
Daniel Jon Burdick
Mark Chambers
Huifen Chen
Anthony Estrada
Zachary Kevin Sweeney
Bryan K. Chan
Original Assignee
Genentech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genentech, Inc. filed Critical Genentech, Inc.
Publication of CY1120073T1 publication Critical patent/CY1120073T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Psychology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Ενώσεις του τύπου (I), ή φαρμακευτικά αποδεκτά άλατα αυτών, όπου τα Χ, R1, R1, R2, R3, R4 και R5 είναι όπως ορίζονται ενταύθα. Κοινολογούνται επίσης μέθοδοι παρασκευής των ενώσεων και χρήσεως των ενώσεων για αγωγή νόσων που σχετίζονται με τον υποδοχέα της LRRK2, όπως είναι η νόσος του Parkinson.
CY20171101349T 2010-11-10 2017-12-27 Παραγωγα πυραζολο-αμινοπυριμιδινης ως ρυθμιστες της lrrk2 CY1120073T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41227310P 2010-11-10 2010-11-10
US201161546613P 2011-10-13 2011-10-13
PCT/EP2011/069696 WO2012062783A1 (en) 2010-11-10 2011-11-09 Pyrazole aminopyrimidine derivatives as lrrk2 modulators

Publications (1)

Publication Number Publication Date
CY1120073T1 true CY1120073T1 (el) 2018-12-12

Family

ID=44983512

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20171101349T CY1120073T1 (el) 2010-11-10 2017-12-27 Παραγωγα πυραζολο-αμινοπυριμιδινης ως ρυθμιστες της lrrk2

Country Status (28)

Country Link
US (1) US8815882B2 (el)
EP (3) EP3590933B1 (el)
JP (3) JP5986094B2 (el)
KR (1) KR101566091B1 (el)
CN (1) CN103313978B (el)
AR (1) AR083813A1 (el)
AU (1) AU2011328139A1 (el)
BR (1) BR112013011600B1 (el)
CA (2) CA3017869C (el)
CY (1) CY1120073T1 (el)
DK (2) DK2638031T3 (el)
EC (1) ECSP13012611A (el)
ES (2) ES2746134T3 (el)
HR (2) HRP20172006T1 (el)
HU (2) HUE046617T2 (el)
IL (1) IL225234A0 (el)
LT (2) LT2638031T (el)
MA (1) MA34644B1 (el)
MX (1) MX2013005199A (el)
NO (1) NO2638031T3 (el)
PH (1) PH12013500880A1 (el)
PL (2) PL2638031T3 (el)
PT (2) PT3124483T (el)
RS (2) RS56583B1 (el)
SG (1) SG189043A1 (el)
SI (2) SI3124483T1 (el)
TW (1) TW201302733A (el)
WO (1) WO2012062783A1 (el)

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