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CN1157375C - 吲哚衍生物及其药物组合物 - Google Patents

吲哚衍生物及其药物组合物 Download PDF

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Publication number
CN1157375C
CN1157375C CNB998033219A CN99803321A CN1157375C CN 1157375 C CN1157375 C CN 1157375C CN B998033219 A CNB998033219 A CN B998033219A CN 99803321 A CN99803321 A CN 99803321A CN 1157375 C CN1157375 C CN 1157375C
Authority
CN
China
Prior art keywords
carbon atom
ethyl
general formula
trifluoroethyl
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CNB998033219A
Other languages
English (en)
Chinese (zh)
Other versions
CN1291976A (zh
Inventor
北泽牧雄
山口敏章
־
宫田广志
味泽幸义
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kissei Pharmaceutical Co Ltd
Original Assignee
Kissei Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical Co Ltd filed Critical Kissei Pharmaceutical Co Ltd
Publication of CN1291976A publication Critical patent/CN1291976A/zh
Application granted granted Critical
Publication of CN1157375C publication Critical patent/CN1157375C/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
CNB998033219A 1998-02-27 1999-02-19 吲哚衍生物及其药物组合物 Expired - Lifetime CN1157375C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP9057298 1998-02-27
JP90572/1998 1998-02-27

Publications (2)

Publication Number Publication Date
CN1291976A CN1291976A (zh) 2001-04-18
CN1157375C true CN1157375C (zh) 2004-07-14

Family

ID=14002150

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB998033219A Expired - Lifetime CN1157375C (zh) 1998-02-27 1999-02-19 吲哚衍生物及其药物组合物

Country Status (23)

Country Link
US (1) US6310086B1 (es)
EP (1) EP1057813B1 (es)
JP (1) JP4342101B2 (es)
KR (1) KR100576207B1 (es)
CN (1) CN1157375C (es)
AR (1) AR014964A1 (es)
AT (1) ATE264841T1 (es)
AU (1) AU766088B2 (es)
BR (1) BR9908301A (es)
CA (1) CA2321547C (es)
DE (1) DE69916586T2 (es)
DK (1) DK1057813T3 (es)
ES (1) ES2220043T3 (es)
HU (1) HUP0100680A3 (es)
NO (1) NO317257B1 (es)
NZ (1) NZ506497A (es)
PE (1) PE20000329A1 (es)
PL (1) PL342477A1 (es)
RU (1) RU2212404C2 (es)
SK (1) SK12722000A3 (es)
TW (2) TWI249525B (es)
WO (1) WO1999043652A1 (es)
ZA (1) ZA991590B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2212404C2 (ru) 1998-02-27 2003-09-20 Киссеи Фармасьютикал Ко., Лтд. Производные индола и фармацевтические композиции, включающие их
JP4634560B2 (ja) * 2000-01-14 2011-02-16 キッセイ薬品工業株式会社 光学活性なインドリン誘導体の製造方法およびその製造中間体
WO2001087298A1 (fr) * 2000-05-15 2001-11-22 Rohto Pharmaceutical Co., Ltd. Preparation liquide a base d'eau
US7229986B2 (en) 2000-05-16 2007-06-12 Takeda Pharmaceutical Company Ltd. Melanin-concentrating hormone antagonist
JP4921646B2 (ja) * 2001-03-08 2012-04-25 キッセイ薬品工業株式会社 １−（３−ベンジルオキシプロピル）−５−（２−置換プロピル）インドリン誘導体およびその使用方法
CA2453476A1 (en) * 2001-07-13 2003-01-23 Kissei Pharmaceutical Co., Ltd. Medicinal compositions for opthalmic use
UA78854C2 (en) * 2002-09-06 2007-04-25 Kissei Pharmaceutical Crystal for an oral solid drug and oral solid drug for dysuria treatment containing the same
HU225505B1 (en) * 2002-09-09 2007-01-29 Richter Gedeon Vegyeszet Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates
PE20060373A1 (es) 2004-06-24 2006-04-29 Smithkline Beecham Corp Derivados 3-piperidinil-7-carboxamida-indazol como inhibidores de la actividad cinasa de ikk2
ATE508113T1 (de) * 2004-10-27 2011-05-15 Kissei Pharmaceutical Indolinverbindung und verfahren zu deren herstellung
KR101326425B1 (ko) * 2005-06-21 2013-11-11 코와 가부시키가이샤 녹내장의 예방 또는 치료제
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US20100076010A1 (en) * 2007-02-26 2010-03-25 Concert Pharmaceuticals, Inc. Alpha 1a-adrenoceptor antagonists
US8013007B2 (en) * 2007-02-26 2011-09-06 Concert Pharmaceuticals, Inc. Alpha 1A-adrenoceptor antagonists
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
EP2406249A1 (en) 2009-03-10 2012-01-18 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
CN104211631A (zh) * 2013-05-30 2014-12-17 中国科学院上海药物研究所 一类吲哚类化合物、其制备方法、药物组合物及应用
WO2016042441A1 (en) 2014-09-18 2016-03-24 Mankind Research Centre A novel process for the preparation of considerably pure silodosin
ES2607639B1 (es) 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021410A (en) 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
EP0600675B1 (en) * 1992-12-02 1998-07-08 Kissei Pharmaceutical Co., Ltd. Indoline compounds for the treatment of dysuria
JP3331047B2 (ja) 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドリン誘導体
JP3331048B2 (ja) * 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドール誘導体
JPH08143557A (ja) 1994-11-24 1996-06-04 Toyobo Co Ltd 新規なフェニルピペラジン誘導体、その塩及びその溶媒和物
JPH0912563A (ja) 1995-06-30 1997-01-14 Toyobo Co Ltd 新規ベンジルアルコ−ル誘導体、その製造方法およびその用途
AU9095998A (en) * 1997-09-22 1999-04-12 Kissei Pharmaceutical Co. Ltd. Remedies for dysuria resulting from prostatic hypertrophy
RU2212404C2 (ru) 1998-02-27 2003-09-20 Киссеи Фармасьютикал Ко., Лтд. Производные индола и фармацевтические композиции, включающие их

Also Published As

Publication number Publication date
NO20004277D0 (no) 2000-08-25
ATE264841T1 (de) 2004-05-15
JP4342101B2 (ja) 2009-10-14
SK12722000A3 (sk) 2001-03-12
US6310086B1 (en) 2001-10-30
NZ506497A (en) 2004-12-24
PE20000329A1 (es) 2000-04-13
DE69916586D1 (de) 2004-05-27
AU766088B2 (en) 2003-10-09
BR9908301A (pt) 2000-10-31
PL342477A1 (en) 2001-06-04
ES2220043T3 (es) 2004-12-01
RU2212404C2 (ru) 2003-09-20
CA2321547A1 (en) 1999-09-02
DE69916586T2 (de) 2004-09-16
NO20004277L (no) 2000-09-11
EP1057813A1 (en) 2000-12-06
DK1057813T3 (da) 2004-08-16
EP1057813B1 (en) 2004-04-21
CN1291976A (zh) 2001-04-18
AU2547899A (en) 1999-09-15
HK1036974A1 (en) 2002-01-25
HUP0100680A2 (hu) 2001-08-28
CA2321547C (en) 2010-01-19
AR014964A1 (es) 2001-04-11
ZA991590B (en) 1999-08-27
NO317257B1 (no) 2004-09-27
WO1999043652A1 (en) 1999-09-02
HUP0100680A3 (en) 2001-09-28
TWI241293B (en) 2005-10-11
KR100576207B1 (ko) 2006-05-03
TWI249525B (en) 2006-02-21
EP1057813A4 (en) 2001-11-21
KR20010041403A (ko) 2001-05-15

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