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PE20000329A1 - Derivados de indol y composiciones farmaceuticas que los contienen - Google Patents

Derivados de indol y composiciones farmaceuticas que los contienen

Info

Publication number
PE20000329A1
PE20000329A1 PE1999000167A PE00016799A PE20000329A1 PE 20000329 A1 PE20000329 A1 PE 20000329A1 PE 1999000167 A PE1999000167 A PE 1999000167A PE 00016799 A PE00016799 A PE 00016799A PE 20000329 A1 PE20000329 A1 PE 20000329A1
Authority
PE
Peru
Prior art keywords
derivatives
ethyl
indole
pharmaceutical compositions
compositions containing
Prior art date
Application number
PE1999000167A
Other languages
English (en)
Inventor
Makio Kitazawa
Toshiaki Yamaguchi
Hiroshi Miyata
Yukiyoshi Ajisawa
Original Assignee
Kissei Pharmaceutical
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kissei Pharmaceutical filed Critical Kissei Pharmaceutical
Publication of PE20000329A1 publication Critical patent/PE20000329A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)

Abstract

SE REFIERE A DERIVADOS DE INDOL DE FORMULA I; DONDE R ES ETILO, 2,2,2-TRIFLUOROETILO; Y ES HIDROXI, PIVALOILOXI. CUANDO R ES 2,2,2-TRIFLUOROETILO, Y ES PIVALOILOXI. TAMBIEN SE REFIERE A UN PROCEDIMIENTO PARA LA PREPARACION. EL COMPUESTO I ES ALTAMENTE PERMEABLE A LAS MEMBRANAS Y ES CONVERTIDO RAPIDAMENTE EN (R)-1-(3-HIDROXIPROPIL)-5-[2-[[2-[2-(2,2,2-TRIFLUOROETOXI)FENOXI]ETIL]AMINO]PROPIL]-1H-INDOL-7-CARBOXAMIDA o EL CLORHIDRATO DE (R)-5-[2-[[2-(2-ETOXIFENOXI)ETIL]AMINO]PROPIL]-1-(3-HIDROXIPROPIL)-1H-INDOL-7-CARBOXAMIDA QUE SON BLOQUEANTES O1-ADRENOCEPTORES Y PUEDEN SER UTILES EN EL TRATAMIENTO DE GLAUCOMA O DE LA HIPERTENSION OCULAR
PE1999000167A 1998-02-27 1999-02-26 Derivados de indol y composiciones farmaceuticas que los contienen PE20000329A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP9057298 1998-02-27

Publications (1)

Publication Number Publication Date
PE20000329A1 true PE20000329A1 (es) 2000-04-13

Family

ID=14002150

Family Applications (1)

Application Number Title Priority Date Filing Date
PE1999000167A PE20000329A1 (es) 1998-02-27 1999-02-26 Derivados de indol y composiciones farmaceuticas que los contienen

Country Status (23)

Country Link
US (1) US6310086B1 (es)
EP (1) EP1057813B1 (es)
JP (1) JP4342101B2 (es)
KR (1) KR100576207B1 (es)
CN (1) CN1157375C (es)
AR (1) AR014964A1 (es)
AT (1) ATE264841T1 (es)
AU (1) AU766088B2 (es)
BR (1) BR9908301A (es)
CA (1) CA2321547C (es)
DE (1) DE69916586T2 (es)
DK (1) DK1057813T3 (es)
ES (1) ES2220043T3 (es)
HU (1) HUP0100680A3 (es)
NO (1) NO317257B1 (es)
NZ (1) NZ506497A (es)
PE (1) PE20000329A1 (es)
PL (1) PL342477A1 (es)
RU (1) RU2212404C2 (es)
SK (1) SK12722000A3 (es)
TW (2) TWI249525B (es)
WO (1) WO1999043652A1 (es)
ZA (1) ZA991590B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999043652A1 (en) 1998-02-27 1999-09-02 Kissei Pharmaceutical Co., Ltd. Indole derivatives and medicinal compositions containing the same
JP4634560B2 (ja) * 2000-01-14 2011-02-16 キッセイ薬品工業株式会社 光学活性なインドリン誘導体の製造方法およびその製造中間体
EP1293206A4 (en) 2000-05-15 2005-09-21 Kissei Pharmaceutical LIQUID PREPARATION BASED ON WATER
CA2408913A1 (en) * 2000-05-16 2001-11-22 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
JP4921646B2 (ja) * 2001-03-08 2012-04-25 キッセイ薬品工業株式会社 １−（３−ベンジルオキシプロピル）−５−（２−置換プロピル）インドリン誘導体およびその使用方法
US20040235932A1 (en) * 2001-07-13 2004-11-25 Kenji Yamazaki Ophthalmic pharmaceutical compositions
UA78854C2 (en) * 2002-09-06 2007-04-25 Kissei Pharmaceutical Crystal for an oral solid drug and oral solid drug for dysuria treatment containing the same
HU225505B1 (en) * 2002-09-09 2007-01-29 Richter Gedeon Vegyeszet Process for the preparation of r-(-)-tamsulosin hydrochloride and novel intermediates
AR050253A1 (es) 2004-06-24 2006-10-11 Smithkline Beecham Corp Compuesto derivado de indazol carboxamida, composicion que lo comprende y su uso para la preparacion de un medicamento
KR101249865B1 (ko) * 2004-10-27 2013-04-02 깃세이 야쿠힌 고교 가부시키가이샤 인돌린 화합물 및 그 제조방법
WO2006137368A1 (ja) * 2005-06-21 2006-12-28 Kowa Co., Ltd. 緑内障の予防又は治療剤
US8063071B2 (en) 2007-10-31 2011-11-22 GlaxoSmithKline, LLC Chemical compounds
US20100076010A1 (en) * 2007-02-26 2010-03-25 Concert Pharmaceuticals, Inc. Alpha 1a-adrenoceptor antagonists
WO2008106125A2 (en) * 2007-02-26 2008-09-04 Concert Pharmaceuticals, Inc. Deuterated derivatives of silodosin as alpha la-adrenoceptor antagonists
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
WO2010102968A1 (en) 2009-03-10 2010-09-16 Glaxo Group Limited Indole derivatives as ikk2 inhibitors
CN104211631A (zh) * 2013-05-30 2014-12-17 中国科学院上海药物研究所 一类吲哚类化合物、其制备方法、药物组合物及应用
WO2016042441A1 (en) 2014-09-18 2016-03-24 Mankind Research Centre A novel process for the preparation of considerably pure silodosin
ES2607639B1 (es) 2015-09-30 2018-02-28 Urquima, S.A Sal de ácido maleico de un intermedio de silodosina

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5021410A (en) * 1989-05-22 1991-06-04 Allergan, Inc. Combinations of selective alpha-adrenergic agonists and antagonists useful in lowering intraocular pressure
US5068234A (en) * 1990-02-26 1991-11-26 Sterling Drug Inc. 3-arylcarbonyl-1-(c-attached-n-heteryl)-1h-indoles
EP0600675B1 (en) * 1992-12-02 1998-07-08 Kissei Pharmaceutical Co., Ltd. Indoline compounds for the treatment of dysuria
JP3331048B2 (ja) * 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドール誘導体
JP3331047B2 (ja) 1994-06-01 2002-10-07 キッセイ薬品工業株式会社 インドリン誘導体
JPH08143557A (ja) 1994-11-24 1996-06-04 Toyobo Co Ltd 新規なフェニルピペラジン誘導体、その塩及びその溶媒和物
JPH0912563A (ja) 1995-06-30 1997-01-14 Toyobo Co Ltd 新規ベンジルアルコ−ル誘導体、その製造方法およびその用途
AU9095998A (en) * 1997-09-22 1999-04-12 Kissei Pharmaceutical Co. Ltd. Remedies for dysuria resulting from prostatic hypertrophy
WO1999043652A1 (en) 1998-02-27 1999-09-02 Kissei Pharmaceutical Co., Ltd. Indole derivatives and medicinal compositions containing the same

Also Published As

Publication number Publication date
CA2321547A1 (en) 1999-09-02
SK12722000A3 (sk) 2001-03-12
AU2547899A (en) 1999-09-15
HK1036974A1 (en) 2002-01-25
ZA991590B (en) 1999-08-27
HUP0100680A3 (en) 2001-09-28
EP1057813A4 (en) 2001-11-21
NO20004277L (no) 2000-09-11
KR20010041403A (ko) 2001-05-15
JP4342101B2 (ja) 2009-10-14
NO317257B1 (no) 2004-09-27
US6310086B1 (en) 2001-10-30
DE69916586T2 (de) 2004-09-16
HUP0100680A2 (hu) 2001-08-28
AU766088B2 (en) 2003-10-09
ATE264841T1 (de) 2004-05-15
CA2321547C (en) 2010-01-19
RU2212404C2 (ru) 2003-09-20
EP1057813B1 (en) 2004-04-21
TWI241293B (en) 2005-10-11
EP1057813A1 (en) 2000-12-06
BR9908301A (pt) 2000-10-31
CN1157375C (zh) 2004-07-14
AR014964A1 (es) 2001-04-11
DK1057813T3 (da) 2004-08-16
NZ506497A (en) 2004-12-24
KR100576207B1 (ko) 2006-05-03
WO1999043652A1 (en) 1999-09-02
PL342477A1 (en) 2001-06-04
CN1291976A (zh) 2001-04-18
TWI249525B (en) 2006-02-21
DE69916586D1 (de) 2004-05-27
NO20004277D0 (no) 2000-08-25
ES2220043T3 (es) 2004-12-01

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FG Grant, registration
FD Application declared void or lapsed