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AR072969A1 - Derivados de ciclohexilamida, composiciones farmaceuticas y usos como antagonistas del receptor del factor de liberacion de corticotropina (crf - 1) - Google Patents

Derivados de ciclohexilamida, composiciones farmaceuticas y usos como antagonistas del receptor del factor de liberacion de corticotropina (crf - 1)

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Publication number
AR072969A1
AR072969A1 ARP090102998A ARP090102998A AR072969A1 AR 072969 A1 AR072969 A1 AR 072969A1 AR P090102998 A ARP090102998 A AR P090102998A AR P090102998 A ARP090102998 A AR P090102998A AR 072969 A1 AR072969 A1 AR 072969A1
Authority
AR
Argentina
Prior art keywords
carbon atoms
alkyl
alkoxy
phenyl
halo
Prior art date
Application number
ARP090102998A
Other languages
English (en)
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of AR072969A1 publication Critical patent/AR072969A1/es

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract

Reivindicacion 1: Un compuesto de la formula 1: en donde R1 es -(CH2)n(SO2)mRx; Rx es fenilo, bifenilo, naftilo o heteroarilo, cada uno de los cuales puede estar opcionalmente sustituido por uno o más sustituyentes seleccionados a partir del grupo que consiste en alquilo de 1 a 10 átomos de carbono, alcoxilo de 1 a 10 átomos de carbono, hidroxi-alquilo de 1 a 10 átomos de carbono, halogeno, halo-alquilo de 1 a 10 átomos de carbono, halo-alcoxilo de 1 a 10 átomos de carbono, nitrilo, -CO2R25, -(CH2)pNR29R30, -SO2NR31R32, alcoxilo (de 1 a 6 átomos de carbono)-alquilo (de 1 a 6 átomos de carbono)-, un heterociclo de 5 o 6 miembros, un heteroarilo de 5 o 6 miembros, fenilo, fenil-alquilo (de 1 a 6 átomos de carbono)- ariloxilo, estando cada uno del heterociclo de 5 o 6 miembros, heteroarilo de 5 o 6 miembros, fenilo, y ariloxilo, opcionalmente sustituido por uno o más sustituyentes seleccionados a partir del grupo que consiste en carboxilo, alquilo de 1 a 6 átomos de carbono, halogeno e hidroxilo; R2 es hidrogeno o alquilo de 1 a 6 átomos de carbono, o R1 y R2, junto con el átomo de nitrogeno con el que están unidos, forman un heteroarilo de 5 o 6 miembros que contiene 2, 3 o 4 heteroátomos, estando el heteroarilo opcionalmente sustituido por uno o más sustituyentes seleccionados a partir del grupo que consiste en alquilo de 1 a 10 átomos de carbono, alcoxilo de 1 a 10 átomos de carbono, halogeno, halo-alquilo de 1 a 10 átomos de carbono, halo-alcoxilo de 1 a 10 átomos de carbono, fenilo, o un heterociclo de 5 o 6 miembros, estando el heterociclo opcionalmente sustituido por carboxilo; R3, R4, R5, R6, R7, R9, R10, R17, R22, R25, R29, R30, R31 y R32, los cuales pueden ser iguales o diferentes, son cada uno hidrogeno o alquilo de 1 a 6 átomos de carbono; R30 es hidrogeno, alquilo de 1 a 6 átomos de carbono, o R33CO-; R33 es alquilo de 1 a 6 átomos de carbono; R8 es fenilo, o un heteroarilo, cada uno de los cuales puede estar opcionalmente sustituido por uno o más sustituyentes seleccionados a partir del grupo que consiste en alquilo de 1 a 6 átomos de carbono, halo-alquilo de 1 a 6 átomos de carbono, halogeno, alcoxilo de 1 a 6 átomos de carbono, nitrilo o dialquil-amino de 1 a 6 átomos de carbono, o dos sustituyentes adyacentes pueden formar juntos un anillo carbocíclico o heterocíclico saturado o insaturado; m es un entero de 0 o 1; n es un entero de 0, 1 o 2; p es un entero de 0 a 6; e isomeros del mismo; en forma libre o en forma de sal.
ARP090102998A 2008-01-14 2009-08-05 Derivados de ciclohexilamida, composiciones farmaceuticas y usos como antagonistas del receptor del factor de liberacion de corticotropina (crf - 1) AR072969A1 (es)

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