TN2011000040A1 - Cyclohexyl amide derivatives and their use as crf-1 receptor antagonists - Google Patents
Cyclohexyl amide derivatives and their use as crf-1 receptor antagonistsInfo
- Publication number
- TN2011000040A1 TN2011000040A1 TN2011000040A TN2011000040A TN2011000040A1 TN 2011000040 A1 TN2011000040 A1 TN 2011000040A1 TN 2011000040 A TN2011000040 A TN 2011000040A TN 2011000040 A TN2011000040 A TN 2011000040A TN 2011000040 A1 TN2011000040 A1 TN 2011000040A1
- Authority
- TN
- Tunisia
- Prior art keywords
- receptor antagonists
- crf
- amide derivatives
- cyclohexyl amide
- cyclohexyl
- Prior art date
Links
- PAFZNILMFXTMIY-UHFFFAOYSA-N cyclohexylamine Chemical class NC1CCCCC1 PAFZNILMFXTMIY-UHFFFAOYSA-N 0.000 title abstract 2
- 239000002464 receptor antagonist Substances 0.000 title abstract 2
- 229940044551 receptor antagonist Drugs 0.000 title abstract 2
- 108091005471 CRHR1 Proteins 0.000 title 1
- 102000012289 Corticotropin-Releasing Hormone Human genes 0.000 abstract 2
- 108010022152 Corticotropin-Releasing Hormone Proteins 0.000 abstract 2
- 239000000055 Corticotropin-Releasing Hormone Substances 0.000 abstract 2
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- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
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| WO2011092293A2 (fr) * | 2010-02-01 | 2011-08-04 | Novartis Ag | Dérivés de cyclohexylamide utilisés en tant qu'antagonistes du récepteur du crf |
| CN102753527B (zh) * | 2010-02-02 | 2014-12-24 | 诺华股份有限公司 | 用作crf受体拮抗剂的环己基酰胺衍生物 |
| RU2639876C2 (ru) | 2010-03-30 | 2017-12-25 | Версеон Корпорейшн | Мультизамещенные ароматические соединения в качестве ингибиторов тромбина |
| WO2012088397A2 (fr) | 2010-12-22 | 2012-06-28 | The Salk Institute For Biological Studies | Peptides cycliques antagonistes de la corticolibérine |
| UY34094A (es) | 2011-05-27 | 2013-01-03 | Novartis Ag | Derivados de la piperidina 3-espirocíclica como agonistas de receptores de la ghrelina |
| EP2567959B1 (fr) | 2011-09-12 | 2014-04-16 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxy-phényl)-3-styryl-1h-pyrazolo[3,4-b]pyridine-4-carboxylique en tant qu'inhibiteurs de kinase |
| TW201348235A (zh) | 2012-05-03 | 2013-12-01 | Novartis Ag | 作爲格瑞啉受體促效劑之3-螺環哌啶衍生物 |
| US9814723B2 (en) | 2013-02-23 | 2017-11-14 | Lixin Zhang | Compositions and methods for prophylaxis and therapy for Meniere's disease |
| HK1214252A1 (zh) * | 2013-03-15 | 2016-07-22 | Verseon Corporation | 作為凝血酶抑制劑的鹵代吡唑 |
| NZ711064A (en) | 2013-03-15 | 2019-06-28 | Verseon Corp | Pyridone-substituted pyrazolyl compounds as serine protease inhibitors |
| EP3096756B1 (fr) | 2014-01-21 | 2024-06-12 | Neurocrine Biosciences, Inc. | Antagonistes du récepteur crf1 pour le traitement de l'hyperplasie adrénale congénitale |
| BR112016028255A2 (pt) | 2014-06-06 | 2017-08-22 | Flexus Biosciences Inc | agentes imunorreguladores |
| US10189810B2 (en) | 2014-09-17 | 2019-01-29 | Verseon Corporation | Pyrazolyl-substituted pyridone compounds as serine protease inhibitors |
| UY36390A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen |
| UY36391A (es) | 2014-11-05 | 2016-06-01 | Flexus Biosciences Inc | Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido1), sus métodos de síntesis y composiciones farmacèuticas que las contienen |
| BR112017008809A2 (pt) | 2014-11-05 | 2017-12-19 | Flexus Biosciences Inc | agentes imunorreguladores |
| AU2016224974B2 (en) | 2015-02-27 | 2019-09-26 | Verseon Corporation | Substituted pyrazole compounds as serine protease inhibitors |
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- 2009-08-05 BR BRPI0917574A patent/BRPI0917574A2/pt not_active IP Right Cessation
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- 2009-08-05 PE PE2011000132A patent/PE20110237A1/es not_active Application Discontinuation
- 2009-08-05 US US13/057,015 patent/US8614213B2/en active Active
- 2009-08-05 ES ES09804572.7T patent/ES2582576T3/es active Active
- 2009-08-05 EP EP09804572.7A patent/EP2323970B1/fr active Active
- 2009-08-05 AU AU2009279089A patent/AU2009279089B2/en not_active Ceased
- 2009-08-05 KR KR1020117005153A patent/KR101302796B1/ko not_active Expired - Fee Related
- 2009-08-05 UY UY0001032036A patent/UY32036A/es not_active Application Discontinuation
- 2009-08-05 AR ARP090102998A patent/AR072969A1/es unknown
- 2009-08-05 MY MYPI20110353 patent/MY151568A/en unknown
- 2009-08-05 CN CN200980134704.5A patent/CN102143940B/zh not_active Expired - Fee Related
- 2009-08-05 EA EA201100306A patent/EA020921B1/ru not_active IP Right Cessation
- 2009-08-05 JP JP2011521570A patent/JP5527745B2/ja not_active Expired - Fee Related
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2011
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- 2011-01-24 IL IL210834A patent/IL210834A0/en unknown
- 2011-01-26 TN TN2011000040A patent/TN2011000040A1/fr unknown
- 2011-02-01 MA MA33574A patent/MA32534B1/fr unknown
- 2011-02-01 CO CO11011426A patent/CO6351776A2/es not_active Application Discontinuation
- 2011-02-07 SV SV2011003832A patent/SV2011003832A/es not_active Application Discontinuation
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- 2011-02-07 EC EC2011010814A patent/ECSP11010814A/es unknown
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2013
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