MX2009004615A - Derivados de eter como moduladores duales de los receptores de 5-hidroxitriptamina a (5-ht2a) y dopamina (d3). - Google Patents
Derivados de eter como moduladores duales de los receptores de 5-hidroxitriptamina a (5-ht2a) y dopamina (d3).Info
- Publication number
- MX2009004615A MX2009004615A MX2009004615A MX2009004615A MX2009004615A MX 2009004615 A MX2009004615 A MX 2009004615A MX 2009004615 A MX2009004615 A MX 2009004615A MX 2009004615 A MX2009004615 A MX 2009004615A MX 2009004615 A MX2009004615 A MX 2009004615A
- Authority
- MX
- Mexico
- Prior art keywords
- ht2a
- dopamine
- receptors
- hydroxitriptamine
- eter
- Prior art date
Links
- 230000009977 dual effect Effects 0.000 title abstract 2
- VYFYYTLLBUKUHU-UHFFFAOYSA-N dopamine Chemical compound NCCC1=CC=C(O)C(O)=C1 VYFYYTLLBUKUHU-UHFFFAOYSA-N 0.000 title 3
- 229960003638 dopamine Drugs 0.000 title 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 3
- 206010013663 drug dependence Diseases 0.000 abstract 2
- QZAYGJVTTNCVMB-UHFFFAOYSA-N serotonin Chemical compound C1=C(O)C=C2C(CCN)=CNC2=C1 QZAYGJVTTNCVMB-UHFFFAOYSA-N 0.000 abstract 2
- 208000011117 substance-related disease Diseases 0.000 abstract 2
- 102000049773 5-HT2A Serotonin Receptor Human genes 0.000 abstract 1
- 208000019901 Anxiety disease Diseases 0.000 abstract 1
- 208000020925 Bipolar disease Diseases 0.000 abstract 1
- 206010012239 Delusion Diseases 0.000 abstract 1
- 206010012289 Dementia Diseases 0.000 abstract 1
- 102000004073 Dopamine D3 Receptors Human genes 0.000 abstract 1
- 108090000525 Dopamine D3 Receptors Proteins 0.000 abstract 1
- 101150104779 HTR2A gene Proteins 0.000 abstract 1
- 206010026749 Mania Diseases 0.000 abstract 1
- 206010033864 Paranoia Diseases 0.000 abstract 1
- 208000027099 Paranoid disease Diseases 0.000 abstract 1
- 230000036506 anxiety Effects 0.000 abstract 1
- 208000010877 cognitive disease Diseases 0.000 abstract 1
- 231100000868 delusion Toxicity 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 208000024714 major depressive disease Diseases 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 229940076279 serotonin Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/44—Oxygen atoms attached in position 4
- C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurosurgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
La presente invención se refiere a moduladores duales de los receptores de la serotonina 5-HT2A y de la dopamina D3 que se representan mediante la fórmula general I: (ver fórmula (I)) en la que R1, R2 y A tienen los significados definidos en la descripción, a un proceso para su obtención, a sus sales farmacéuticamente aceptables, destinados a la fabricación de medicamentos para el tratamiento o la prevención de trastornos cognitivos, adicción a las drogas, depresión, ansiedad, dependencia de las drogas, demencias, desequilibro de la memoria, trastornos psicóticos, incluida la esquizofrenia, trastornos esquizoafectivos, enfermedad bipolar, manías, depresión psicótica y psicosis que comprenden la paranoia y los delirios.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP06123274 | 2006-10-31 | ||
| PCT/EP2007/061253 WO2008052899A1 (en) | 2006-10-31 | 2007-10-22 | Ether derivatives dual modulators of the 5-ht2a and d3 receptors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2009004615A true MX2009004615A (es) | 2009-05-22 |
Family
ID=38962066
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2009004615A MX2009004615A (es) | 2006-10-31 | 2007-10-22 | Derivados de eter como moduladores duales de los receptores de 5-hidroxitriptamina a (5-ht2a) y dopamina (d3). |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US7795437B2 (es) |
| EP (1) | EP2079693B1 (es) |
| JP (1) | JP5087631B2 (es) |
| KR (1) | KR101114651B1 (es) |
| CN (1) | CN101535258B (es) |
| AR (1) | AR063438A1 (es) |
| AU (1) | AU2007316249B2 (es) |
| BR (1) | BRPI0718127A2 (es) |
| CA (1) | CA2667511A1 (es) |
| CL (1) | CL2007003110A1 (es) |
| ES (1) | ES2401663T3 (es) |
| IL (1) | IL198157A0 (es) |
| MX (1) | MX2009004615A (es) |
| NO (1) | NO20091675L (es) |
| PE (1) | PE20081342A1 (es) |
| RU (1) | RU2009116509A (es) |
| TW (1) | TW200826940A (es) |
| WO (1) | WO2008052899A1 (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2480466C2 (ru) * | 2007-07-26 | 2013-04-27 | Ф.Хоффманн-Ля Рош Аг | Двойные модуляторы 5-ht2a и d3-рецепторов |
| US8273900B2 (en) | 2008-08-07 | 2012-09-25 | Novartis Ag | Organic compounds |
| WO2011060363A2 (en) * | 2009-11-16 | 2011-05-19 | Auspex Pharmaceuticals, Inc. | Cyclohexyl urea modulators of d2 receptors and/or d3 receptors |
| US8877778B2 (en) | 2010-12-15 | 2014-11-04 | Hoffmann-La Roche Inc. | Benzofurane compounds |
| US8722683B2 (en) * | 2011-02-17 | 2014-05-13 | Hoffmann La-Roche Inc. | Benzodioxole piperazine compounds |
| US8921397B2 (en) | 2011-05-04 | 2014-12-30 | Hoffmann-La Roche Inc. | Benzofurane-piperidine compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4024264A (en) * | 1974-08-15 | 1977-05-17 | Ab Ferrosan | Diphenylbutylpiperidines |
| GB1514718A (en) | 1974-08-15 | 1978-06-21 | Ferrosan Ab | Diphenyl-butylpiperidines |
| JP2860689B2 (ja) | 1990-03-14 | 1999-02-24 | 第一製薬株式会社 | ピリミジン誘導体 |
| US5229400A (en) | 1990-10-05 | 1993-07-20 | Ajinomoto Co., Inc. | Piperidine compounds and their use as antiarrhythmic agents |
| SK11822001A3 (sk) | 1999-03-26 | 2002-09-10 | Astrazeneca Ab | Modulátory chemokínovej aktivity, spôsoby ich prípravy, farmaceutické kompozície s ich obsahom a ich použitie v terapii |
| HUP0103986A2 (hu) | 2001-09-28 | 2003-06-28 | Richter Gedeon Vegyészeti Gyár Rt. | Új karbonsavamid szerkezetet tartalmazó piperidinil vegyületek, eljárás az előállításukra és ezeket tartalmazó gyógyszerkészítmények |
| HU227543B1 (en) * | 2001-09-28 | 2011-08-29 | Richter Gedeon Nyrt | N-[4-(2-piperazin- and 2-piperidin-1-yl-ethyl)-cyclohexyl]-sulfon- and sulfamides, process for their preparation, their use and pharmaceutical compositions containing them |
| WO2003048154A1 (en) | 2001-12-04 | 2003-06-12 | Actelion Pharmaceuticals Ltd | 4-(piperidyl- and pyrrolidyl-alkyl-ureido) -quinolines as urotensin ii receptor antagonists |
| EP1348434A1 (en) | 2002-03-27 | 2003-10-01 | Fujisawa Deutschland GmbH | Use of pyridyl amides as inhibitors of angiogenesis |
| AU2003303678A1 (en) | 2003-01-03 | 2004-08-10 | Genzyme Corporation | Urea derivatives and their use as anti-inflammatory agents |
| HU227534B1 (en) | 2003-08-04 | 2011-08-29 | Richter Gedeon Nyrt | (thio)carbamoyl-cyclohexane derivatives, process for producing them and pharmaceutical compositions containing them |
-
2007
- 2007-10-22 ES ES07821617T patent/ES2401663T3/es active Active
- 2007-10-22 CA CA002667511A patent/CA2667511A1/en not_active Abandoned
- 2007-10-22 JP JP2009535053A patent/JP5087631B2/ja not_active Expired - Fee Related
- 2007-10-22 EP EP07821617A patent/EP2079693B1/en not_active Not-in-force
- 2007-10-22 WO PCT/EP2007/061253 patent/WO2008052899A1/en not_active Ceased
- 2007-10-22 US US11/876,007 patent/US7795437B2/en not_active Expired - Fee Related
- 2007-10-22 RU RU2009116509/04A patent/RU2009116509A/ru unknown
- 2007-10-22 KR KR1020097008855A patent/KR101114651B1/ko not_active Expired - Fee Related
- 2007-10-22 AU AU2007316249A patent/AU2007316249B2/en not_active Expired - Fee Related
- 2007-10-22 CN CN2007800408979A patent/CN101535258B/zh not_active Expired - Fee Related
- 2007-10-22 MX MX2009004615A patent/MX2009004615A/es active IP Right Grant
- 2007-10-22 BR BRPI0718127-2A2A patent/BRPI0718127A2/pt not_active IP Right Cessation
- 2007-10-29 TW TW096140627A patent/TW200826940A/zh unknown
- 2007-10-29 CL CL200703110A patent/CL2007003110A1/es unknown
- 2007-10-29 AR ARP070104779A patent/AR063438A1/es unknown
- 2007-10-31 PE PE2007001497A patent/PE20081342A1/es not_active Application Discontinuation
-
2009
- 2009-04-16 IL IL198157A patent/IL198157A0/en unknown
- 2009-04-28 NO NO20091675A patent/NO20091675L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CN101535258B (zh) | 2012-12-05 |
| CL2007003110A1 (es) | 2008-06-13 |
| KR101114651B1 (ko) | 2012-06-12 |
| BRPI0718127A2 (pt) | 2014-02-18 |
| AU2007316249B2 (en) | 2013-01-24 |
| CN101535258A (zh) | 2009-09-16 |
| RU2009116509A (ru) | 2010-12-10 |
| WO2008052899A1 (en) | 2008-05-08 |
| US20080103174A1 (en) | 2008-05-01 |
| ES2401663T3 (es) | 2013-04-23 |
| IL198157A0 (en) | 2009-12-24 |
| NO20091675L (no) | 2009-05-28 |
| AR063438A1 (es) | 2009-01-28 |
| TW200826940A (en) | 2008-07-01 |
| PE20081342A1 (es) | 2008-09-18 |
| AU2007316249A1 (en) | 2008-05-08 |
| JP5087631B2 (ja) | 2012-12-05 |
| US7795437B2 (en) | 2010-09-14 |
| EP2079693A1 (en) | 2009-07-22 |
| CA2667511A1 (en) | 2008-05-08 |
| KR20090075848A (ko) | 2009-07-09 |
| EP2079693B1 (en) | 2013-02-27 |
| JP2010508319A (ja) | 2010-03-18 |
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Legal Events
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| HH | Correction or change in general | ||
| FG | Grant or registration |