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AR007079A1 - Derivados de alquilaminobenzotiazol y benzoxazol , un proceso para su preparación, una composición farmacéutica que los contiene, y un proceso para preparar dicha composición - Google Patents

Derivados de alquilaminobenzotiazol y benzoxazol , un proceso para su preparación, una composición farmacéutica que los contiene, y un proceso para preparar dicha composición

Info

Publication number
AR007079A1
AR007079A1 ARP970101955A ARP970101955A AR007079A1 AR 007079 A1 AR007079 A1 AR 007079A1 AR P970101955 A ARP970101955 A AR P970101955A AR P970101955 A ARP970101955 A AR P970101955A AR 007079 A1 AR007079 A1 AR 007079A1
Authority
AR
Argentina
Prior art keywords
alkyl
prepare
hydrogen
formula
preparation
Prior art date
Application number
ARP970101955A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR007079A1 publication Critical patent/AR007079A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Derivados de alquilaminobenzotiazol y -benzoxazol de fórmula (I), las formas N-óxido, las sales de adición de ácido farmacéuticamente aceptables, ylas formas estereoquímicamente isómeras de los mismos, en donde X es O o S; n es 2, 3, 4 o 5;R 1 es hidrógeno, alquilo C1-6, alquiloxi C1-6 o halo; R2es hidrógeno, alquilo C1-6, fenilo, fenilalquilo C1-6, o fenilcarbonilo; R3 y R4 cada uno independientemente es seleccionado de hidrógeno, halo, nitro,alquilo C1-6, alquiloxi C1-6,haloalquil o C1-6, aminosulfonilo, mono- o di (alquilo C1-4)aminosulfonilo; o R3 y R4 tambicn pueden ser tomados juntospara formar un radical bivalente de fórmula -CH=CH-CH=CH-, además se relaciona con un proceso para su preparación, concomposiciones que los comprenden,un proceso para preparar dichas composiciones, se descubren compuestos de fórmula (I) que contienen un isotopo radiactivo; un proceso de marcado delugares receptores D4 de dopamina; y un proceso pararepresentar por i mágenes un órgano.
ARP970101955A 1996-05-10 1997-05-09 Derivados de alquilaminobenzotiazol y benzoxazol , un proceso para su preparación, una composición farmacéutica que los contiene, y un proceso para preparar dicha composición AR007079A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10

Publications (1)

Publication Number Publication Date
AR007079A1 true AR007079A1 (es) 1999-10-13

Family

ID=8223970

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970101955A AR007079A1 (es) 1996-05-10 1997-05-09 Derivados de alquilaminobenzotiazol y benzoxazol , un proceso para su preparación, una composición farmacéutica que los contiene, y un proceso para preparar dicha composición

Country Status (28)

Country Link
US (2) US6103725A (es)
EP (2) EP1325917B1 (es)
JP (1) JP3237759B2 (es)
KR (1) KR100330699B1 (es)
CN (1) CN1074766C (es)
AR (1) AR007079A1 (es)
AT (2) ATE350373T1 (es)
AU (1) AU710175B2 (es)
BG (1) BG64097B1 (es)
BR (1) BR9709065A (es)
CA (1) CA2253453C (es)
CZ (1) CZ295639B6 (es)
DE (2) DE69737217T2 (es)
EA (1) EA001360B1 (es)
EE (1) EE03563B1 (es)
ES (2) ES2230605T3 (es)
HU (1) HUP9902993A3 (es)
ID (1) ID16889A (es)
IL (1) IL126968A0 (es)
MY (1) MY117852A (es)
NO (1) NO311027B1 (es)
NZ (1) NZ332309A (es)
PL (1) PL190721B1 (es)
SK (1) SK282919B6 (es)
TR (1) TR199802253T2 (es)
TW (1) TW593290B (es)
WO (1) WO1997043271A1 (es)
ZA (1) ZA974053B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) * 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
AU6280199A (en) * 1998-09-30 2000-04-17 Neurogen Corporation 2-piperazino alkylamino benzoazole derivatives: dopamine receptor subtype specific ligands
US6284759B1 (en) 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU5569800A (en) * 1999-06-30 2001-01-31 Santen Pharmaceutical Co. Ltd. Brain sigma-1 receptor-binding ligand
ATE361297T1 (de) 2000-03-31 2007-05-15 Ortho Mcneil Pharm Inc Phenyl-substituierte imidazopyridine
US6436939B2 (en) 2000-03-31 2002-08-20 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as H3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
CN1694704A (zh) * 2002-09-06 2005-11-09 詹森药业有限公司 （1h－苯并咪唑－2－基）－（哌嗪基）－甲酮衍生物及其相关化合物作为组胺h4受体拮抗剂用于治疗炎性和过敏性疾病
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
AU2005216949B2 (en) * 2004-02-24 2011-09-22 The General Hospital Corporation Catalytic radiofluorination
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
JP5501339B2 (ja) 2008-03-21 2014-05-21 ザ ジェネラル ホスピタル コーポレイション アルツハイマー病及び関連疾患の検出及び治療のための化合物及び組成物
EP3503891A1 (en) * 2016-08-26 2019-07-03 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
PT109740B (pt) 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR102823891B1 (ko) * 2020-01-14 2025-06-20 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU564702B2 (en) * 1984-05-22 1987-08-20 Sumitomo Chemical Company, Limited Novel radioactive iodospiroperidol and process for its preparation
AU620327B2 (en) * 1987-04-08 1992-02-20 Salutar, Inc. Amyloidosis and alzheimer's disease diagnostic assay and reagents therefor
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
EA199801000A1 (ru) 1999-04-29
SK282919B6 (sk) 2003-01-09
BG102819A (en) 1999-08-31
TR199802253T2 (xx) 1999-02-22
ZA974053B (en) 1998-11-09
EP0912533B1 (en) 2004-09-29
NO985227D0 (no) 1998-11-09
NO985227L (no) 1999-01-11
KR100330699B1 (ko) 2002-08-27
PL329849A1 (en) 1999-04-12
MY117852A (en) 2004-08-30
ATE350373T1 (de) 2007-01-15
DE69730962T2 (de) 2006-03-30
EP1325917B1 (en) 2007-01-03
CZ295639B6 (cs) 2005-09-14
US6224849B1 (en) 2001-05-01
ID16889A (id) 1997-11-20
HK1057044A1 (en) 2004-03-12
AU710175B2 (en) 1999-09-16
DE69737217D1 (de) 2007-02-15
DE69737217T2 (de) 2007-11-08
JP3237759B2 (ja) 2001-12-10
WO1997043271A1 (en) 1997-11-20
HUP9902993A2 (hu) 2000-05-28
EP0912533A1 (en) 1999-05-06
SK153298A3 (en) 1999-03-12
BR9709065A (pt) 1999-08-03
NZ332309A (en) 1999-08-30
DE69730962D1 (de) 2004-11-04
CA2253453C (en) 2007-01-16
KR20000005227A (ko) 2000-01-25
HK1018457A1 (en) 1999-12-24
CA2253453A1 (en) 1997-11-20
NO311027B1 (no) 2001-10-01
ATE277917T1 (de) 2004-10-15
BG64097B1 (bg) 2003-12-31
EE03563B1 (et) 2001-12-17
CN1218461A (zh) 1999-06-02
EA001360B1 (ru) 2001-02-26
EE9800378A (et) 1999-04-15
HUP9902993A3 (en) 2002-01-28
AU2956097A (en) 1997-12-05
IL126968A0 (en) 1999-09-22
CZ355398A3 (cs) 1999-02-17
ES2279923T3 (es) 2007-09-01
US6103725A (en) 2000-08-15
PL190721B1 (pl) 2005-12-30
ES2230605T3 (es) 2005-05-01
EP1325917A1 (en) 2003-07-09
CN1074766C (zh) 2001-11-14
TW593290B (en) 2004-06-21
JP2000503667A (ja) 2000-03-28

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