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EA199801000A1 - Производные алкиламинобензотиазола и -бензоксазола - Google Patents

Производные алкиламинобензотиазола и -бензоксазола

Info

Publication number
EA199801000A1
EA199801000A1 EA199801000A EA199801000A EA199801000A1 EA 199801000 A1 EA199801000 A1 EA 199801000A1 EA 199801000 A EA199801000 A EA 199801000A EA 199801000 A EA199801000 A EA 199801000A EA 199801000 A1 EA199801000 A1 EA 199801000A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alkyl
hydrogen
compounds
formula
aminosulfonyl
Prior art date
Application number
EA199801000A
Other languages
English (en)
Other versions
EA001360B1 (ru
Inventor
Людо Эдмон Жозефин Кенни
Йозефус Каролус Мертенс
Серж Мария Алоисиус Питерс
Original Assignee
Жансен Фармасетика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Жансен Фармасетика Н.В. filed Critical Жансен Фармасетика Н.В.
Publication of EA199801000A1 publication Critical patent/EA199801000A1/ru
Publication of EA001360B1 publication Critical patent/EA001360B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
    • C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/002—Heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/60—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings condensed with carbocyclic rings or ring systems
    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D277/82—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Настоящее изобретение относится к соединениям формулы (I), их N-оксидным формам, фармацевтически пригодным солям присоединения кислот и стереохимически изомерным формам, где Х является О или S; n равно 2, 3, 4 или 5; Rявляется водородом, Cалкилом, Cалкилоксигруппой или галогеном; Rявляется водородом, Cалкилом, фенилом, фенил Cалкилом или фенилкарбонилом; Rи Rкаждый независимо выбирают из водорода, галогена, нитрогруппы, Cалкила, Cалкилоксигруппы, галоген Cалкила, аминосульфонила, моно- или ди(Салкил)аминосульфонила; или Rи Rтакже могут вместе образовывать бивалентный радикал формулы -СН=СН-СН=СН-; изобретение относится также к способу получения таких соединений, включающих их композиций, а также их применения в качестве лекарственных препаратов; раскрыты соединения формулы (I), содержащие радиоактивный изотоп; способ маркировки D-рецепторных сайтов допамина и способ получения изображения органов.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199801000A 1996-05-10 1997-05-02 Производные алкиламинобензотиазола и -бензоксазола EA001360B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP96201282 1996-05-10
PCT/EP1997/002505 WO1997043271A1 (en) 1996-05-10 1997-05-02 Alkylaminobenzothiazole and -benzoxazole derivatives

Publications (2)

Publication Number Publication Date
EA199801000A1 true EA199801000A1 (ru) 1999-04-29
EA001360B1 EA001360B1 (ru) 2001-02-26

Family

ID=8223970

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199801000A EA001360B1 (ru) 1996-05-10 1997-05-02 Производные алкиламинобензотиазола и -бензоксазола

Country Status (28)

Country Link
US (2) US6103725A (ru)
EP (2) EP0912533B1 (ru)
JP (1) JP3237759B2 (ru)
KR (1) KR100330699B1 (ru)
CN (1) CN1074766C (ru)
AR (1) AR007079A1 (ru)
AT (2) ATE277917T1 (ru)
AU (1) AU710175B2 (ru)
BG (1) BG64097B1 (ru)
BR (1) BR9709065A (ru)
CA (1) CA2253453C (ru)
CZ (1) CZ295639B6 (ru)
DE (2) DE69730962T2 (ru)
EA (1) EA001360B1 (ru)
EE (1) EE03563B1 (ru)
ES (2) ES2279923T3 (ru)
HU (1) HUP9902993A3 (ru)
ID (1) ID16889A (ru)
IL (1) IL126968A0 (ru)
MY (1) MY117852A (ru)
NO (1) NO311027B1 (ru)
NZ (1) NZ332309A (ru)
PL (1) PL190721B1 (ru)
SK (1) SK282919B6 (ru)
TR (1) TR199802253T2 (ru)
TW (1) TW593290B (ru)
WO (1) WO1997043271A1 (ru)
ZA (1) ZA974053B (ru)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1293804B1 (it) 1997-08-01 1999-03-10 Recordati Chem Pharm Diarilalchilpiperazine attive sulle basse vie urinarie
US6281216B1 (en) * 1998-02-09 2001-08-28 Duphar International Research B.V. 2-aminoquinoline derivatives having d4-agonistic activity
EP0982030A3 (en) 1998-08-17 2000-05-10 Pfizer Products Inc. 2,7-substituted octahydro-pyrrolo 1,2-a]pyrazine derivatives as 5ht 1a ligands
HK1038749A1 (zh) * 1998-09-30 2002-03-28 纽罗根公司 2-哌嗪烷基氨苯并吡咯衍生物:多巴胺受体亚型特异配体
US6284759B1 (en) * 1998-09-30 2001-09-04 Neurogen Corporation 2-piperazinoalkylaminobenzo-azole derivatives: dopamine receptor subtype specific ligands
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
AU5569800A (en) * 1999-06-30 2001-01-31 Santen Pharmaceutical Co. Ltd. Brain sigma-1 receptor-binding ligand
AU2001249679A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Phenyl-substituted imidazopyridines
AU2001251083A1 (en) 2000-03-31 2001-10-15 Ortho-Mcneil Pharmaceutical, Inc. Method for using 2-aryloxyalkylaminobenzoxazoles and 2-aryloxyalkylaminobenzothiazoles as h3 antagonists
GB0203299D0 (en) * 2002-02-12 2002-03-27 Glaxo Group Ltd Novel compounds
PL377087A1 (pl) 2002-09-06 2006-01-23 Janssen Pharmaceutica, N.V. Związki heterocykliczne
US9017724B2 (en) 2004-02-24 2015-04-28 The General Hospital Corporation Catalytic radiofluorination
EP2388017B1 (en) * 2004-02-24 2014-12-24 The General Hospital Corporation Catalytic radiofluorination
US8257680B1 (en) 2004-02-24 2012-09-04 The General Hospital Corporation Catalytic radiofluorination
FR2877005A1 (fr) * 2004-10-22 2006-04-28 Bioprojet Soc Civ Ile Nouveaux derives d'arylpiperazine
US7731940B2 (en) 2006-01-25 2010-06-08 The Regents Of The University Of California Compositions and methods related to serotonin 5-HT1A receptors
EP3231804B1 (en) 2008-03-21 2021-03-03 The General Hospital Corporation Compounds and compositions for the detection and treatment of alzheimer's disease and related disorders
US11337970B2 (en) * 2016-08-26 2022-05-24 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
PT109740B (pt) * 2016-11-14 2020-07-30 Hovione Farmaciencia Sa Processo para a preparação de brometo de umeclidínio
KR102823891B1 (ko) * 2020-01-14 2025-06-20 서울대학교산학협력단 혈관생성 저해 효과를 가지는 n-페닐벤조티아졸-2-아민 화합물 및 그를 포함하는 약제학적 조성물
CN116730948A (zh) * 2022-03-02 2023-09-12 圣奥化学科技有限公司 一种合成n-环己基-2-苯并噻唑的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4687852A (en) * 1984-05-22 1987-08-18 Sumitomo Chemical Company, Limited Radioactive iodospiroperidol
JPS63290858A (ja) * 1987-04-08 1988-11-28 サルター・インコーポレーテツド アミロイド症及びアルツハイマー病の診断分析法及びそのための試薬
US4929618A (en) * 1988-03-25 1990-05-29 Ube Industries, Ltd. Piperdine and piperazine derivatives, and antihistaminic pharmaceutical compositions containing the same
FR2656609B1 (fr) * 1989-12-28 1992-03-27 Synthelabo Derives de 2-aminopyrimidine-4-carboxamide, leur preparation et leur application en therapeutique.
US5731438A (en) * 1996-08-01 1998-03-24 Isis Pharmaceuticals, Inc. N-(aminoalkyl)-and/or N-(amidoalkyl)-dinitrogen heterocycles

Also Published As

Publication number Publication date
TR199802253T2 (xx) 1999-02-22
CN1218461A (zh) 1999-06-02
NO985227D0 (no) 1998-11-09
BG64097B1 (bg) 2003-12-31
TW593290B (en) 2004-06-21
EP1325917A1 (en) 2003-07-09
CZ295639B6 (cs) 2005-09-14
DE69737217D1 (de) 2007-02-15
AR007079A1 (es) 1999-10-13
PL329849A1 (en) 1999-04-12
DE69730962D1 (de) 2004-11-04
HK1018457A1 (en) 1999-12-24
BR9709065A (pt) 1999-08-03
CA2253453C (en) 2007-01-16
ID16889A (id) 1997-11-20
CA2253453A1 (en) 1997-11-20
EE03563B1 (et) 2001-12-17
NO985227L (no) 1999-01-11
BG102819A (en) 1999-08-31
SK153298A3 (en) 1999-03-12
HUP9902993A2 (hu) 2000-05-28
NZ332309A (en) 1999-08-30
ES2230605T3 (es) 2005-05-01
EE9800378A (et) 1999-04-15
DE69737217T2 (de) 2007-11-08
US6103725A (en) 2000-08-15
JP2000503667A (ja) 2000-03-28
WO1997043271A1 (en) 1997-11-20
CN1074766C (zh) 2001-11-14
ATE350373T1 (de) 2007-01-15
JP3237759B2 (ja) 2001-12-10
EA001360B1 (ru) 2001-02-26
SK282919B6 (sk) 2003-01-09
DE69730962T2 (de) 2006-03-30
EP0912533A1 (en) 1999-05-06
AU710175B2 (en) 1999-09-16
US6224849B1 (en) 2001-05-01
KR20000005227A (ko) 2000-01-25
NO311027B1 (no) 2001-10-01
ES2279923T3 (es) 2007-09-01
EP1325917B1 (en) 2007-01-03
CZ355398A3 (cs) 1999-02-17
PL190721B1 (pl) 2005-12-30
AU2956097A (en) 1997-12-05
EP0912533B1 (en) 2004-09-29
ZA974053B (en) 1998-11-09
HUP9902993A3 (en) 2002-01-28
ATE277917T1 (de) 2004-10-15
IL126968A0 (en) 1999-09-22
KR100330699B1 (ko) 2002-08-27
MY117852A (en) 2004-08-30
HK1057044A1 (en) 2004-03-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY KZ MD RU