OA10575A - Androstenone derivative - Google Patents

Androstenone derivative Download PDF

Info

Publication number: OA10575A
Authority: OA; OAPI
Prior art keywords: compound; formula; solvaté; bis; aza
Prior art date: 1993-09-17

Application number

OA60795A

Other languages

English (en)

Inventor

Kenneth William Batchelor

Stephen Vernon Frye

Original Assignee

Glaxo Wellcome Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1993-09-17

Filing date

1996-03-13

Publication date

2002-06-25

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22407744&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=OA10575(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

1996-03-13 Application filed by Glaxo Wellcome Inc filed Critical Glaxo Wellcome Inc

2002-06-25 Publication of OA10575A publication Critical patent/OA10575A/en

Links

HFVMLYAGWXSTQI-QYXZOKGRSA-N 5alpha-androst-16-en-3-one Chemical class C1C(=O)CC[C@]2(C)[C@H]3CC[C@](C)(C=CC4)[C@@H]4[C@@H]3CC[C@H]21 HFVMLYAGWXSTQI-QYXZOKGRSA-N 0.000 title description 2
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OAYLNYINCPYISS-UHFFFAOYSA-N ethyl acetate;hexane Chemical compound CCCCCC.CCOC(C)=O OAYLNYINCPYISS-UHFFFAOYSA-N 0.000 description 1
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MKXKFYHWDHIYRV-UHFFFAOYSA-N flutamide Chemical compound CC(C)C(=O)NC1=CC=C([N+]([O-])=O)C(C(F)(F)F)=C1 MKXKFYHWDHIYRV-UHFFFAOYSA-N 0.000 description 1
235000013355 food flavoring agent Nutrition 0.000 description 1
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238000007429 general method Methods 0.000 description 1
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210000002332 leydig cell Anatomy 0.000 description 1
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GSYSFVSGPABNNL-UHFFFAOYSA-N methyl 2-dimethoxyphosphoryl-2-(phenylmethoxycarbonylamino)acetate Chemical group COC(=O)C(P(=O)(OC)OC)NC(=O)OCC1=CC=CC=C1 GSYSFVSGPABNNL-UHFFFAOYSA-N 0.000 description 1
239000007932 molded tablet Substances 0.000 description 1
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PSHKMPUSSFXUIA-UHFFFAOYSA-N n,n-dimethylpyridin-2-amine Chemical compound CN(C)C1=CC=CC=N1 PSHKMPUSSFXUIA-UHFFFAOYSA-N 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
239000007935 oral tablet Substances 0.000 description 1
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239000011118 polyvinyl acetate Substances 0.000 description 1
239000012286 potassium permanganate Substances 0.000 description 1
229940072254 proscar Drugs 0.000 description 1
201000007094 prostatitis Diseases 0.000 description 1
238000011552 rat model Methods 0.000 description 1
230000001172 regenerating effect Effects 0.000 description 1
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239000000377 silicon dioxide Substances 0.000 description 1
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229910000029 sodium carbonate Inorganic materials 0.000 description 1
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235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
WSRBRQQGWDWSON-UHFFFAOYSA-M sodium;3,7-dimethylpurine-2,6-dione;2-hydroxybenzoate Chemical compound [Na+].OC1=CC=CC=C1C([O-])=O.CN1C(=O)NC(=O)C2=C1N=CN2C WSRBRQQGWDWSON-UHFFFAOYSA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
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150000005846 sugar alcohols Polymers 0.000 description 1
239000002511 suppository base Substances 0.000 description 1
239000000375 suspending agent Substances 0.000 description 1
VCKUSRYTPJJLNI-UHFFFAOYSA-N terazosin Chemical compound N=1C(N)=C2C=C(OC)C(OC)=CC2=NC=1N(CC1)CCN1C(=O)C1CCCO1 VCKUSRYTPJJLNI-UHFFFAOYSA-N 0.000 description 1
229960001693 terazosin Drugs 0.000 description 1
210000001550 testis Anatomy 0.000 description 1
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230000000699 topical effect Effects 0.000 description 1
229940100640 transdermal system Drugs 0.000 description 1
241000701447 unidentified baculovirus Species 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J3/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom
- C07J3/005—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by one carbon atom the carbon atom being part of a carboxylic function
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
- A61P5/26—Androgens
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
- C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
- C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/14—Benz[f]indenes; Hydrogenated benz[f]indenes

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Diabetes (AREA)
Endocrinology (AREA)
Steroid Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

OA60795A 1993-09-17 1996-03-13 Androstenone derivative OA10575A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US12328093A	1993-09-17	1993-09-17

Publications (1)

Publication Number	Publication Date
OA10575A true OA10575A (en)	2002-06-25

Family

ID=22407744

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
OA60795A OA10575A (en)	1993-09-17	1996-03-13	Androstenone derivative

Country Status (41)

Country	Link
US (2)	US5565467A (fr)
EP (1)	EP0719278B1 (fr)
JP (1)	JP2904310B2 (fr)
KR (1)	KR100364953B1 (fr)
CN (1)	CN1057771C (fr)
AP (1)	AP494A (fr)
AT (1)	ATE162199T1 (fr)
AU (1)	AU690925B2 (fr)
BG (1)	BG62363B1 (fr)
BR (1)	BR1100329A (fr)
CA (2)	CA2462061A1 (fr)
CY (2)	CY2219B1 (fr)
CZ (1)	CZ286069B6 (fr)
DE (2)	DE69407978T2 (fr)
DK (1)	DK0719278T3 (fr)
EE (1)	EE03241B1 (fr)
ES (1)	ES2113127T3 (fr)
FI (1)	FI115216B (fr)
GR (1)	GR3026144T3 (fr)
HK (1)	HK1004334A1 (fr)
HR (1)	HRP940563B1 (fr)
HU (1)	HU220060B (fr)
IL (1)	IL110978A (fr)
IS (1)	IS1713B (fr)
LU (1)	LU91027I2 (fr)
MY (1)	MY119778A (fr)
NL (1)	NL300122I2 (fr)
NO (2)	NO306117B1 (fr)
NZ (1)	NZ274642A (fr)
OA (1)	OA10575A (fr)
PE (1)	PE15095A1 (fr)
PL (1)	PL180002B1 (fr)
RO (1)	RO117455B1 (fr)
RU (1)	RU2140926C1 (fr)
SA (1)	SA94150231B1 (fr)
SG (1)	SG52650A1 (fr)
SI (1)	SI0719278T1 (fr)
SK (1)	SK281869B6 (fr)
TW (1)	TW369521B (fr)
WO (1)	WO1995007927A1 (fr)
ZA (2)	ZA947118B (fr)

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1994
- 1994-09-03 TW TW083108127A patent/TW369521B/zh active
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- 1994-09-15 PE PE1994250737A patent/PE15095A1/es not_active Application Discontinuation
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- 1994-09-16 IL IL11097894A patent/IL110978A/en active Protection Beyond IP Right Term
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- 1994-09-16 AU AU78751/94A patent/AU690925B2/en not_active Expired
- 1994-09-16 CA CA002462061A patent/CA2462061A1/fr not_active Abandoned
- 1994-09-16 SK SK347-96A patent/SK281869B6/sk unknown
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- 1994-09-16 RU RU96108410A patent/RU2140926C1/ru active
- 1994-09-16 WO PCT/US1994/010530 patent/WO1995007927A1/fr not_active Ceased
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- 1994-09-16 EP EP94929828A patent/EP0719278B1/fr not_active Expired - Lifetime
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1995
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1996
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1997
- 1997-04-23 BR BR1100329-4A patent/BR1100329A/pt active IP Right Grant
1998
- 1998-02-12 GR GR980400317T patent/GR3026144T3/el unknown
2001
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2003
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Also Published As

Publication number	Publication date
DE10399022I2 (de)	2012-09-13
KR100364953B1 (ko)	2003-04-08
PE15095A1 (es)	1995-06-04
CZ74596A3 (en)	1996-09-11
HUT73850A (en)	1996-09-30
CA2170047A1 (fr)	1995-03-23
NL300122I2 (nl)	2003-09-01
CY2004002I2 (el)	2009-11-04
WO1995007927A1 (fr)	1995-03-23
CZ286069B6 (cs)	2000-01-12
ES2113127T3 (es)	1998-04-16
BG100410A (bg)	1996-09-30
US5846976A (en)	1998-12-08
MY119778A (en)	2005-07-29
CA2170047C (fr)	2004-11-09
NO306117B1 (no)	1999-09-20
EP0719278A1 (fr)	1996-07-03
US5565467A (en)	1996-10-15
ZA947119B (en)	1995-05-26
AP9400669A0 (en)	1994-10-31
AU7875194A (en)	1995-04-03
DE69407978T2 (de)	1998-05-07
IL110978A (en)	1999-01-26
CN1131424A (zh)	1996-09-18
BG62363B1 (bg)	1999-09-30
RO117455B1 (ro)	2002-03-29
DE69407978D1 (de)	1998-02-19
IL110978A0 (en)	1994-11-28
HRP940563A2 (en)	1997-02-28
FI961231A0 (fi)	1996-03-15
JP2904310B2 (ja)	1999-06-14
SI0719278T1 (sl)	1998-06-30
LU91027I2 (fr)	2004-04-28
FI115216B (fi)	2005-03-31
EP0719278B1 (fr)	1998-01-14
DK0719278T3 (da)	1998-09-14
GR3026144T3 (en)	1998-05-29
HK1004334A1 (en)	1998-11-20
ATE162199T1 (de)	1998-01-15
FI961231L (fi)	1996-03-15
CN1057771C (zh)	2000-10-25
SK281869B6 (sk)	2001-08-06
AU690925B2 (en)	1998-05-07
HU220060B (hu)	2001-10-28
AP494A (en)	1996-05-15
JPH09502731A (ja)	1997-03-18
TW369521B (en)	1999-09-11
CY2219B1 (en)	2003-04-18
EE03241B1 (et)	1999-12-15
CY2004002I1 (el)	2009-11-04
HRP940563B1 (en)	2000-10-31
ZA947118B (en)	1995-05-26
NO961080D0 (no)	1996-03-15
CA2462061A1 (fr)	1995-03-23
IS4205A (is)	1995-03-18
NO2003003I2 (no)	2007-06-11
IS1713B (is)	1998-12-30
PL313492A1 (en)	1996-07-08
NL300122I1 (nl)	2003-06-02
SA94150231B1 (ar)	2005-05-04
NZ274642A (en)	1997-11-24
RU2140926C1 (ru)	1999-11-10
NO961080L (no)	1996-03-15
BR1100329A (pt)	2000-06-13
PL180002B1 (pl)	2000-11-30
SK34796A3 (en)	1996-07-03
DE10399022I1 (de)	2004-01-15
HU9600656D0 (en)	1996-05-28
SG52650A1 (en)	1998-09-28

Publication	Publication Date	Title
OA10575A (en)	2002-06-25	Androstenone derivative
HK1004334B (en)	1998-11-20	Androstenone derivative
EP0783001B1 (fr)	1999-11-17	Androsténones
US5998427A (en)	1999-12-07	Androstenones
JP3824636B2 (ja)	2006-09-20	アンドロステノン
US5817818A (en)	1998-10-06	Androstenones
WO1996030391A1 (fr)	1996-10-03	6-azacholesten-3-ones substituees