NO20092476L - Antibakterielle polycykliske ureaforbindelser - Google Patents

Antibakterielle polycykliske ureaforbindelser

Info

Publication number: NO20092476L
Authority: NO; Norway
Prior art keywords: antibacterial; urea compounds; polycyclic; polycyclic urea; compounds
Prior art date: 2006-12-04

Application number

NO20092476A

Other languages

English (en)

Norwegian (no)

Inventor

Brian Sherer

Gregory Steven Basarab

Shanta Bist

John Irvin Manchester

Original Assignee

Astrazeneca Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-12-04

Filing date

2009-06-30

Publication date

2009-09-02

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39110548&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=NO20092476(L) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2009-06-30 Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab

2009-09-02 Publication of NO20092476L publication Critical patent/NO20092476L/no

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/02—Nasal agents, e.g. decongestants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/02—Local antiseptics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/38—Nitrogen atoms
- C07D277/44—Acylated amino or imino radicals
- C07D277/48—Acylated amino or imino radicals by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof, e.g. carbonylguanidines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Pulmonology (AREA)
Urology & Nephrology (AREA)
Hematology (AREA)
Diabetes (AREA)
Cardiology (AREA)
Otolaryngology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)
Pyridine Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

NO20092476A 2006-12-04 2009-06-30 Antibakterielle polycykliske ureaforbindelser NO20092476L (no)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US86850106P	2006-12-04	2006-12-04
PCT/GB2007/004624 WO2008068470A1 (en)	2006-12-04	2007-12-03	Antibacterial polycyclic urea compounds

Publications (1)

Publication Number	Publication Date
NO20092476L true NO20092476L (no)	2009-09-02

Family

ID=39110548

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO20092476A NO20092476L (no)	2006-12-04	2009-06-30	Antibakterielle polycykliske ureaforbindelser

Country Status (26)

Country	Link
US (1)	US7674801B2 (es)
EP (1)	EP2102199B1 (es)
JP (1)	JP2010511682A (es)
KR (1)	KR20090086629A (es)
CN (1)	CN101627038A (es)
AR (1)	AR064130A1 (es)
AT (1)	ATE507225T1 (es)
AU (1)	AU2007330600B2 (es)
BR (1)	BRPI0720057A2 (es)
CA (1)	CA2670870A1 (es)
CL (1)	CL2007003470A1 (es)
CO (1)	CO6190609A2 (es)
DE (1)	DE602007014256D1 (es)
EC (1)	ECSP099451A (es)
ES (1)	ES2363178T3 (es)
IL (1)	IL198865A0 (es)
MX (1)	MX2009005603A (es)
NO (1)	NO20092476L (es)
NZ (1)	NZ578159A (es)
PE (1)	PE20081583A1 (es)
RU (1)	RU2469034C2 (es)
SA (1)	SA07280667B1 (es)
TW (1)	TW200831503A (es)
UA (1)	UA96964C2 (es)
UY (1)	UY30759A1 (es)
WO (1)	WO2008068470A1 (es)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US9453042B2 (en)	2007-10-25	2016-09-27	Cempra Pharmaceuticals, Inc.	Process for the preparation of macrolide antibacterial agents
WO2009094224A1 (en)	2008-01-25	2009-07-30	Millennium Pharmaceuticals, Inc.	Thiophenes and their use as phosphatidylinositol 3-kinase (pi3k) inhibitors
TW200940537A (en) *	2008-02-26	2009-10-01	Astrazeneca Ab	Heterocyclic urea derivatives and methods of use thereof
MX2010013310A (es) *	2008-06-04	2011-03-01	Astrazeneca Ab	Derivados de heterociclil urea para el tratamiento de infecciones bacterianas.
UY31865A (es) *	2008-06-04	2010-01-29	Astrazeneca Ab	Derivados de urea heterocíclicos y métodos para la utilización de los mismos
TW201016676A (en) *	2008-10-03	2010-05-01	Astrazeneca Ab	Heterocyclic derivatives and methods of use thereof
US9139589B2 (en)	2009-01-30	2015-09-22	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
US9090601B2 (en) *	2009-01-30	2015-07-28	Millennium Pharmaceuticals, Inc.	Thiazole derivatives
US8796314B2 (en)	2009-01-30	2014-08-05	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
TW201102065A (en) *	2009-05-29	2011-01-16	Astrazeneca Ab	Heterocyclic urea derivatives and methods of use thereof
US20100317624A1 (en) *	2009-06-08	2010-12-16	Astrazeneca Ab	Heterocyclic urea derivatives and methods of use thereof
CN102573846B (zh)	2009-08-17	2015-10-07	因特利凯公司	杂环化合物及其用途
WO2011024004A1 (en)	2009-08-26	2011-03-03	Astrazeneca Ab	Heterocyclic urea derivatives useful for treatment of bacterial infection
NZ599597A (en)	2009-10-30	2013-05-31	Janssen Pharmaceutica Nv	IMIDAZO[1,2-b]PYRIDAZINE DERIVATIVES AND THEIR USE AS PDE10 INHIBITORS
AR080754A1 (es)	2010-03-09	2012-05-09	Janssen Pharmaceutica Nv	Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10
RU2012146246A (ru)	2010-03-31	2014-05-10	Актелион Фармасьютиклз Лтд	Антибактериальные производные изохинолин-3-илмочевины
WO2012007836A1 (en)	2010-07-16	2012-01-19	Purdue Pharma .Lp.	Pyridine compounds as sodium channel blockers
TW201217365A (en)	2010-08-11	2012-05-01	Millennium Pharm Inc	Heteroaryls and uses thereof
EP2603216A4 (en)	2010-08-11	2013-12-18	Millennium Pharm Inc	HETEROARYLE AND USES THEREOF
WO2012021611A1 (en)	2010-08-11	2012-02-16	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
UY33671A (es)	2010-10-13	2012-04-30	Millenium Pharmaceuticals Inc	Heteroarilos y sus usos
JP6085829B2 (ja)	2011-01-14	2017-03-01	スペロトリネム，インコーポレイテッド	ピリミジンジャイレースおよびトポイソメラーゼｉｖ阻害剤
CA2824519C (en)	2011-01-14	2020-06-16	Vertex Pharmaceuticals Incorporated	Process of making gyrase and topoisomerase inhibitors
EP2663562B1 (en)	2011-01-14	2018-11-07	Spero Trinem, Inc.	Solid forms of gyrase inhibitor (r)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl) pyrimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1h-benzimidazol-2-yl]urea
TW201309676A (zh)	2011-01-14	2013-03-01	Vertex Pharma	旋轉酶抑制劑（ｒ）－１－乙基－３－［５－［２－（１－羥基－１－甲基－乙基）嘧啶－５－基］－７－（四氫呋喃－２－基］－１ｈ－苯并咪唑－２－基］脲之固體形式
AR088729A1 (es)	2011-03-29	2014-07-02	Actelion Pharmaceuticals Ltd	Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica
TWI554515B (zh)	2011-06-20	2016-10-21	維泰克斯製藥公司	旋轉酶（ｇｙｒａｓｅ）及拓樸異構酶抑制劑之磷酸酯
WO2013000924A1 (en)	2011-06-27	2013-01-03	Janssen Pharmaceutica Nv	1-ARYL-4-METHYL-[1,2,4]TRIAZOLO[4,3-a]QUINOXALINE DERIVATIVES
EP2794569B1 (en) *	2011-12-21	2017-05-10	Biota Europe Ltd	Heterocyclic urea compounds
AU2013203824A1 (en)	2012-03-16	2013-10-03	Purdue Pharma L.P.	Substituted pyridines and pryimidines as sodium channel blockers
IN2014DN08939A (es)	2012-03-27	2015-05-22	Cempra Pharmaceuticals Inc
WO2014001314A1 (en)	2012-06-26	2014-01-03	Janssen Pharmaceutica Nv	Combinations comprising pde 2 inhibitors such as 1-aryl-4-methyl- [1,2,4] triazolo [4,3-a] quinoxaline compounds and pde 10 inhibitors for use in the treatment of neurological or metabolic disorders
AU2013289284B2 (en)	2012-07-09	2017-03-30	Janssen Pharmaceutica Nv	Inhibitors of phosphodiesterase 10 enzyme
US9572809B2 (en)	2012-07-18	2017-02-21	Spero Trinem, Inc.	Combination therapy to treat Mycobacterium diseases
WO2014015105A1 (en)	2012-07-18	2014-01-23	Vertex Pharmaceuticals Incorporated	Solid forms of (r)-2-(5-(2-(3-ethylureido)-6-fluoro-7-(tetrahydrofuran-2-yl)-1h-benzo[d]imidazol-5-yl)pyrimidin-2-yl)propan-2-yl dihydrogen phosphate and salts thereof
US9714252B2 (en)	2012-12-20	2017-07-25	Purdue Pharma L.P.	Cyclic sulfonamides as sodium channel blockers
EP2968384A4 (en)	2013-03-15	2017-02-15	Cempra Pharmaceuticals, Inc.	Convergent processes for preparing macrolide antibacterial agents
MX2016009135A (es)	2014-01-14	2016-10-05	Millennium Pharm Inc	Heteroarilos y usos de estos.
US10202373B2 (en)	2014-01-14	2019-02-12	Millennium Pharmaceuticals, Inc.	Heteroaryls and uses thereof
US10730866B2 (en)	2014-04-07	2020-08-04	Purdue Pharma L.P.	Indole derivatives and use thereof
CN105067814A (zh) *	2015-07-24	2015-11-18	中国科学院成都生物研究所	解旋酶水解atp活性测定方法
KR20190133667A (ko)	2017-03-24	2019-12-03	다이쇼 세이야꾸 가부시끼가이샤	2(1h)-퀴놀리논 유도체
WO2018178041A1 (en) *	2017-03-30	2018-10-04	F. Hoffmann-La Roche Ag	Novel pyrido[2,3-b]indole compounds for the treatment and prophylaxis of bacterial infection
CN113194752A (zh)	2018-06-01	2021-07-30	康奈尔大学	Pi3k相关疾病或病症的组合疗法
CN111116559A (zh) *	2018-11-01	2020-05-08	复旦大学	吡啶脲类化合物及其制备方法和制药用途
CN115703738B (zh) *	2021-08-16	2024-06-21	中国科学院上海药物研究所	含2-芳杂环取代的脲类化合物、其制备方法和用途

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1993000342A1 (en) *	1991-06-21	1993-01-07	Boehringer Mannheim Italia S.P.A.	2-amino-4-aryl-thiazoles with antiasthmatic and anti-inflammatory activities on the respiratory tract
US6410533B1 (en) *	2000-02-10	2002-06-25	Genzyme Corporation	Antibacterial compounds
ES2331250T3 (es) *	2000-12-15	2009-12-28	Vertex Pharmaceuticals Incorporated	Inhibidores de la girasa bacteriana y usos de los mismos.
MY130778A (en) *	2001-02-09	2007-07-31	Vertex Pharma	Heterocyclic inhibitiors of erk2 and uses thereof
WO2003089431A1 (en) *	2002-04-19	2003-10-30	Sumitomo Pharmaceuticals Co., Ltd.	Novel carbapenem compounds
JP2007223901A (ja) *	2004-03-24	2007-09-06	Takeda Chem Ind Ltd	複素環化合物およびその用途
CA2582482A1 (en)	2004-10-07	2006-04-13	Warner-Lambert Company Llc	Triazolopyridine derivatives as antibacterial agents
WO2006071940A2 (en) *	2004-12-23	2006-07-06	Deciphera Pharmaceuticals, Llc	Enzyme modulators and treatments
CN101171247A (zh) *	2005-03-04	2008-04-30	阿斯利康(瑞典)有限公司	作为dna促旋酶和拓扑异构酶抑制剂的吡咯衍生物
US7799814B2 (en) *	2005-05-24	2010-09-21	Merck Serono S.A.	Thiazole derivatives and use thereof
FR2889190A1 (fr) *	2005-08-01	2007-02-02	Merck Sante Soc Par Actions Si	Nouveaux derives d'imidazoles carboxamides comme inhibiteurs de fructose -1,6-biphosphatase et compositions pharmaceutiques les contenant
ATE518564T1 (de)	2006-03-23	2011-08-15	Biota Europe Ltd	Benzamide- und pyridylamide-derivate als antibakterielle mittel
WO2007116106A1 (es) *	2006-04-12	2007-10-18	Palobiofarma, S.L.	Nuevos compuestos como antagonistas de los receptores a1 de adenosina
GB0612428D0 (en)	2006-06-22	2006-08-02	Prolysis Ltd	Antibacterial agents

2007
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Also Published As

Publication number	Publication date
NZ578159A (en)	2012-01-12
SA07280667B1 (ar)	2010-12-07
EP2102199B1 (en)	2011-04-27
UA96964C2 (ru)	2011-12-26
KR20090086629A (ko)	2009-08-13
MX2009005603A (es)	2009-06-08
AR064130A1 (es)	2009-03-11
RU2009125441A (ru)	2011-01-27
JP2010511682A (ja)	2010-04-15
RU2469034C2 (ru)	2012-12-10
ATE507225T1 (de)	2011-05-15
AU2007330600A1 (en)	2008-06-12
US20080132546A1 (en)	2008-06-05
DE602007014256D1 (de)	2011-06-09
PE20081583A1 (es)	2008-12-20
TW200831503A (en)	2008-08-01
CA2670870A1 (en)	2008-06-12
HK1136277A1 (en)	2010-06-25
ECSP099451A (es)	2009-07-31
ES2363178T3 (es)	2011-07-26
BRPI0720057A2 (pt)	2013-12-17
US7674801B2 (en)	2010-03-09
AU2007330600B2 (en)	2012-05-10
CL2007003470A1 (es)	2008-08-22
WO2008068470A1 (en)	2008-06-12
IL198865A0 (en)	2010-02-17
CN101627038A (zh)	2010-01-13
UY30759A1 (es)	2008-07-31
CO6190609A2 (es)	2010-08-19
EP2102199A1 (en)	2009-09-23

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