AR088729A1 - Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica - Google Patents
Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceuticaInfo
- Publication number
- AR088729A1 AR088729A1 ARP120101017A ARP120101017A AR088729A1 AR 088729 A1 AR088729 A1 AR 088729A1 AR P120101017 A ARP120101017 A AR P120101017A AR P120101017 A ARP120101017 A AR P120101017A AR 088729 A1 AR088729 A1 AR 088729A1
- Authority
- AR
- Argentina
- Prior art keywords
- alkyl
- alkoxy
- methyl
- halogen
- carbamoyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Communicable Diseases (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a derivados de 3-ureidoisoquinolin-8-ilo de la fórmula (1) útiles en prevención o tratamiento de enfermedades bacterianas. Reivindicación 1: Un compuesto de la fórmula (1) en donde R¹ es alquilo C₁₋₃, haloalquilo C₂₋₃ o ciclopropilo; R² es H, halógeno, piridazin-4-ilo, pirimidin-5-ilo o un grupo que tiene la fórmula (2), (3) ó (4), en donde Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente H o metilo, o cada uno de Rˣ y Rᶻ es H y Rʸ es halógeno, ciano, alquilo C₂₋₄, alcoxi C₁₋₄, amino, hidroxi, hidroxi-alquilo C₁₋₃, trifluorometilo, carbamoilo, carbamoil-alquilo C₁₋₂, (metilcarbamoil)-alquilo C₁₋₂, (dimetilcarbamoil)-alquilo C₁₋₂, terc-butoxicarbonilmetilo, ciclopropilo, pirrolidin-1-ilo, piperidin-1-ilo, morfolin-1-ilo o 1-morfolinometilo, o Rˣ es H y cada uno de Rʸ y Rᶻ es independientemente halógeno, o Rˣ es metilo, Rʸ es metilo o halógeno y Rᶻ es H, o Rˣ es metilo o halógeno, Rʸ es H y Rᶻ es metilo o halógeno, o Rˣ es metilo o halógeno y cada uno de Rʸ y Rᶻ es H; Rˣ² es H, amino o hidroximetilo; Rˣ³ es hidroxi, carboxi, carbamoilo, hidroximetilo o aminometilo, Rʸ³ es H y Rᶻ³ es H o cada uno de Rˣ³ y Rᶻ³ es H y Rʸ³ es hidroxi, acetamidometilo, (dimetilamino)metilo, carboximetilo, carbamoilo o aminometilo, o cada uno de Rˣ³ y Rʸ³ es H y Rᶻ³ es hidroxi; R³ es alquilo C₁₋₄, alquinilo C₂₋₄, amino-alquilo C₁₋₃, carbamoil-alquilo C₁₋₃, (metilcarbamoil)-alquilo C₁₋₃, alcoxi C₁₋₄, haloalcoxi C₁₋₄, alquiniloxi C₃₋₄, (4-hidroxibut-2-en-1-il)oxi, (4-aminobut-2-en-1-il)oxi, dimetilamino-alcoxi C₂₋₃, carbamoil-alcoxi C₁₋₃, alquilamino C₁₋₃, cicloalquilo C₃₋₆, cicloalquil C₃₋₆-alquilo C₁₋₄, cicloalquil C₃₋₆-alcoxi C₁₋₄, hidroxi-alquilo C₁₋₃, hidroxi-alcoxi C₂₋₃, alcoxi C₁₋₃-alquilo C₁₋₃, alcoxi C₁₋₃-alcoxi C₁₋₃, carboxi-alquilo C₁₋₃, carboxi-alcoxi C₁₋₃, alcoxicarbonil C₁₋₂-alcoxi C₁₋₃, arilo, heteroarilo C₅₋₆, bencilo, benciloxi, 2-cianoetoxi, 2,3-dihidroxipropoxi, 3,4-dihidroxibutoxi, -CH₂Rᵃ, -CH₂CH₂Rᵇ, -(CH₂)ₙ-C(O)O-Rᵈ, (CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -O-(CH₂)ₙ-N(Rᶜ)C(O)O-Rᵈ, -(CH₂)ₙ-Rᵉ o -O-(CH₂)ₙ-Rᵉ; n es 1, 2 ó 3; Rᵃ es ciano, acetilamino, N,N-dimetilamino; y Rᵇ es ciano; Rᶜ es H o metilo; Rᵈ es alquilo C₁₋₄; Rᵉ es pirrolidin-1-ilo, piperidin-1-ilo, piperidin-3-ilo, morfolin-1-ilo, 2-oxopirrolidin-1-ilo, 5-oxopirrolidin-2-ilo, 2,5-dioxopirrolidin-1-ilo, 2-oxoimidazoliden-1-ilo, 4-(terc-butoxicarbonil)piperazin-1-ilo, 4-(aminometil)ciclohexilo o heteroarilo C₅₋₆; R⁴ es H o metilo; o una sal de dicho compuesto.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IB2011051320 | 2011-03-29 | ||
| IB2011054063 | 2011-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR088729A1 true AR088729A1 (es) | 2014-07-02 |
Family
ID=45976978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP120101017A AR088729A1 (es) | 2011-03-29 | 2012-03-27 | Derivados de 3-ureidoisoquinolin-8-ilo y una composicion farmaceutica |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US8889676B2 (es) |
| EP (1) | EP2691373A1 (es) |
| JP (1) | JP2014512352A (es) |
| KR (1) | KR20140019423A (es) |
| CN (1) | CN103476756A (es) |
| AR (1) | AR088729A1 (es) |
| AU (1) | AU2012235706A1 (es) |
| BR (1) | BR112013024899A2 (es) |
| CA (1) | CA2828423A1 (es) |
| IL (1) | IL228486A0 (es) |
| MA (1) | MA35048B1 (es) |
| MX (1) | MX2013011253A (es) |
| PH (1) | PH12013501981A1 (es) |
| RU (1) | RU2013147875A (es) |
| TW (1) | TW201249801A (es) |
| WO (1) | WO2012131588A1 (es) |
| ZA (1) | ZA201308049B (es) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20190133667A (ko) | 2017-03-24 | 2019-12-03 | 다이쇼 세이야꾸 가부시끼가이샤 | 2(1h)-퀴놀리논 유도체 |
| JP7403661B2 (ja) | 2019-12-24 | 2023-12-22 | 杭州中美華東製薬有限公司 | Ｋｈｋ阻害効果を有する化合物 |
| JP2023044027A (ja) * | 2021-09-17 | 2023-03-30 | 三井化学株式会社 | 抗菌剤 |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7928239B2 (en) | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
| US6958333B1 (en) | 1999-07-26 | 2005-10-25 | Banyu Pharmaceutical Co., Ltd. | Biarylurea derivatives |
| ATE285821T1 (de) * | 1999-10-08 | 2005-01-15 | Affinium Pharm Inc | Fab i inhibitoren |
| ES2331250T3 (es) | 2000-12-15 | 2009-12-28 | Vertex Pharmaceuticals Incorporated | Inhibidores de la girasa bacteriana y usos de los mismos. |
| US6831068B2 (en) | 2002-02-13 | 2004-12-14 | Abbott Laboratories | Macrolide antibacterial compounds |
| GB0206876D0 (en) | 2002-03-22 | 2002-05-01 | Merck Sharp & Dohme | Therapeutic agents |
| AU2003245442B2 (en) | 2002-06-13 | 2009-02-05 | Vertex Pharmaceuticals Incorporated | 2-ureido-6-heteroaryl-3h-benzoimidazole-4-carboxylic acid derivatives and related compounds as gyrase and/or topoisomerase IV inhibitors for the treatment of bacterial infections |
| US8193352B2 (en) | 2003-01-31 | 2012-06-05 | Vertex Pharmaceuticals Incorporated | Gyrase inhibitors and uses thereof |
| US7557129B2 (en) | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
| US7615563B2 (en) | 2003-08-08 | 2009-11-10 | Gonzalez Iii Jesus E | Compositions useful as inhibitors of voltage-gated sodium channels |
| BRPI0507653A (pt) | 2004-03-19 | 2007-07-10 | Warner Lambert Co | derivados de imidazopiridina e imidazopiridina formulação farmacêutica compreendendo os mesmos e uso |
| CA2582482A1 (en) | 2004-10-07 | 2006-04-13 | Warner-Lambert Company Llc | Triazolopyridine derivatives as antibacterial agents |
| JP2008518014A (ja) | 2004-10-27 | 2008-05-29 | ニューロゲン コーポレイション | Ｃｂ１拮抗薬としてのジアリール尿素 |
| TW200740820A (en) | 2005-07-05 | 2007-11-01 | Takeda Pharmaceuticals Co | Fused heterocyclic derivatives and use thereof |
| CN1958568B (zh) * | 2005-11-03 | 2011-04-13 | 中国科学院上海药物研究所 | 一类预防或治疗幽门螺杆菌感染化合物、其制法和用途 |
| CN101321744A (zh) | 2005-11-07 | 2008-12-10 | 沃泰克斯药物股份有限公司 | 作为回旋酶抑制剂的苯并咪唑衍生物 |
| US7998978B2 (en) | 2006-05-01 | 2011-08-16 | Pfizer Inc. | Substituted 2-amino-fused heterocyclic compounds |
| WO2007146230A2 (en) * | 2006-06-14 | 2007-12-21 | Merck & Co., Inc. | Non-nucleoside reverse transcriptase inhibitors |
| GB0612428D0 (en) | 2006-06-22 | 2006-08-02 | Prolysis Ltd | Antibacterial agents |
| GB0724349D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Antibacterial agents |
| DE102006029795A1 (de) * | 2006-06-27 | 2008-01-03 | Schebo Biotech Ag | Neue Harnstoff-Derivate und deren Verwendungen |
| JP2010511682A (ja) | 2006-12-04 | 2010-04-15 | アストラゼネカ アクチボラグ | 抗菌性の多環系尿素化合物 |
| US8278337B2 (en) | 2006-12-20 | 2012-10-02 | Merck Sharp & Dohme | Substituted pyridines that are JNK inhibitors |
| CA2686994A1 (en) * | 2007-05-11 | 2008-11-20 | Mpex Pharmaceuticals, Inc. | Polybasic bacterial efflux pump inhibitors and therapeutic uses thereof |
| WO2009027732A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | 5-6-bicyclic heteroaromatic compounds with antibacterial activity |
| WO2009027733A1 (en) | 2007-08-24 | 2009-03-05 | Astrazeneca Ab | (2-pyridin-3-ylimidazo[1,2-b]pyridazin-6-yl) urea derivatives as antibacterial agents |
| GB0724342D0 (en) | 2007-12-13 | 2008-01-30 | Prolysis Ltd | Anitbacterial compositions |
| WO2009089083A1 (en) | 2008-01-04 | 2009-07-16 | Abbott Laboratories | Trpa1 antagonists |
| TW200940537A (en) | 2008-02-26 | 2009-10-01 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| CA2725014C (en) | 2008-05-30 | 2014-06-17 | Amgen Inc. | Inhibitors of pi3 kinase |
| UY31865A (es) | 2008-06-04 | 2010-01-29 | Astrazeneca Ab | Derivados de urea heterocíclicos y métodos para la utilización de los mismos |
| MX2010013310A (es) | 2008-06-04 | 2011-03-01 | Astrazeneca Ab | Derivados de heterociclil urea para el tratamiento de infecciones bacterianas. |
| KR20110031419A (ko) | 2008-06-04 | 2011-03-28 | 아스트라제네카 아베 | 항박테리아제로서의 티아졸로［５,４ｂ］피리딘 및 옥사졸로［５,４ｂ］피리딘 유도체 |
| EP2321309A1 (en) | 2008-06-25 | 2011-05-18 | Ranbaxy Laboratories Limited | Benzothiazoles and aza-analogues thereof use as antibacterial agents |
| TW201102065A (en) | 2009-05-29 | 2011-01-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| US20100317624A1 (en) | 2009-06-08 | 2010-12-16 | Astrazeneca Ab | Heterocyclic urea derivatives and methods of use thereof |
| WO2011024004A1 (en) | 2009-08-26 | 2011-03-03 | Astrazeneca Ab | Heterocyclic urea derivatives useful for treatment of bacterial infection |
| RU2012146246A (ru) * | 2010-03-31 | 2014-05-10 | Актелион Фармасьютиклз Лтд | Антибактериальные производные изохинолин-3-илмочевины |
-
2012
- 2012-03-27 AR ARP120101017A patent/AR088729A1/es not_active Application Discontinuation
- 2012-03-28 JP JP2014501786A patent/JP2014512352A/ja active Pending
- 2012-03-28 RU RU2013147875/04A patent/RU2013147875A/ru not_active Application Discontinuation
- 2012-03-28 BR BR112013024899A patent/BR112013024899A2/pt not_active IP Right Cessation
- 2012-03-28 TW TW101110929A patent/TW201249801A/zh unknown
- 2012-03-28 KR KR1020137028588A patent/KR20140019423A/ko not_active Withdrawn
- 2012-03-28 PH PH1/2013/501981A patent/PH12013501981A1/en unknown
- 2012-03-28 CA CA2828423A patent/CA2828423A1/en not_active Abandoned
- 2012-03-28 MA MA36339A patent/MA35048B1/fr unknown
- 2012-03-28 AU AU2012235706A patent/AU2012235706A1/en not_active Abandoned
- 2012-03-28 WO PCT/IB2012/051473 patent/WO2012131588A1/en not_active Ceased
- 2012-03-28 CN CN2012800151068A patent/CN103476756A/zh active Pending
- 2012-03-28 EP EP12715438.3A patent/EP2691373A1/en not_active Withdrawn
- 2012-03-28 MX MX2013011253A patent/MX2013011253A/es not_active Application Discontinuation
- 2012-03-28 US US14/009,093 patent/US8889676B2/en not_active Expired - Fee Related
-
2013
- 2013-09-17 IL IL228486A patent/IL228486A0/en unknown
- 2013-10-29 ZA ZA2013/08049A patent/ZA201308049B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20140038961A1 (en) | 2014-02-06 |
| IL228486A0 (en) | 2013-12-31 |
| RU2013147875A (ru) | 2015-05-10 |
| KR20140019423A (ko) | 2014-02-14 |
| CN103476756A (zh) | 2013-12-25 |
| BR112013024899A2 (pt) | 2016-12-20 |
| ZA201308049B (en) | 2016-08-31 |
| TW201249801A (en) | 2012-12-16 |
| AU2012235706A1 (en) | 2013-11-14 |
| MX2013011253A (es) | 2013-10-17 |
| NZ617068A (en) | 2015-05-29 |
| US8889676B2 (en) | 2014-11-18 |
| EP2691373A1 (en) | 2014-02-05 |
| WO2012131588A1 (en) | 2012-10-04 |
| JP2014512352A (ja) | 2014-05-22 |
| MA35048B1 (fr) | 2014-04-03 |
| CA2828423A1 (en) | 2012-10-04 |
| PH12013501981A1 (en) | 2013-11-25 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| AR089768A1 (es) | Compuestos terapeuticamente activos y sus metodos de uso | |
| JOP20130256B1 (ar) | مركبات سلفامويل اريل اميدات واستعمالها كمواد علاجية لمعالجة التهاب الكبد نوع بي | |
| EA201491329A1 (ru) | 4,4-дизамещенные 1,4-дигидропиримидины и их применение в качестве лекарственных препаратов для лечения гепатита b | |
| ES2625256T3 (es) | Compuestos de tetrahidroisoquinolina sustituidos como inhibidores del factor XIA | |
| AR085195A1 (es) | Metodo de tratamiento de cancer | |
| AR082101A1 (es) | Acidos de hidroxifenilhexinoico ariloxialquileno-sustituido, procedimiento para su preparacion y su uso como medicamento | |
| NZ607794A (en) | N-acylsulfonamide apoptosis promoters | |
| MY182539A (en) | Methods of treating alzheimer's disease and pharmaceutical compositions thereof | |
| NZ631419A (en) | Inhibitors of hepatitis b virus covalently closed circular dna formation and their method of use | |
| EA201491824A1 (ru) | Производные бензамида для ингибирования активности abl1, abl2 и bcr-abl1 | |
| AR080328A1 (es) | Tienopirimidinas que contienen un grupo alquilo sustituido inhibidoras de quinasas mnk1 y/o mnk2, composiciones farmaceuticas que las contienen y uso de las mismas para el tratamiento de trastornos metabolicos tales como diabetes y obesidad, y trastornos hiperproliferativos, entre otros | |
| PE20150400A1 (es) | Benzamidas n-sustituidas y su uso en el tratamiento del dolor | |
| BR112014029016A8 (pt) | derivados de ácido 7-oxo-tiazolopiridina carbônico e seu uso no tratamento, melhora ou prevenção de uma doença viral | |
| AR094784A1 (es) | Compuestos de tubulisina, métodos para obtenerlos y uso | |
| MD4425B1 (ro) | Alcoxipirazoli în calitate de activatori ai guanilatciclazei solubile | |
| BR112015009850A2 (pt) | compostos de piridila substituídos por heteroarila úteis como moduladores de quinase | |
| RU2017126128A (ru) | Конденсированные бициклические соединения для лечения заболевания | |
| BR112013010552A2 (pt) | derivado de piridina e agente medicinal | |
| EA201490419A1 (ru) | Соединения для лечения и профилактики респираторного синцитиального вирусного заболевания | |
| AR087995A1 (es) | Derivados de n-(4-{[6,7-bis(metiloxi)quinolin-4-il]oxi}fenil)-n-(4-fluorofenil)ciclopropan-1,1-dicarboxamida | |
| MX338114B (es) | Inhibidores de arginasa y sus aplicaciones terapeuticas. | |
| BR112014010420A2 (pt) | inibidores de pak para o tratamento de distúrbios proliferativos celulares | |
| HK1213887A1 (zh) | RORγt的苯基连接的喹啉基调节剂 | |
| AR097082A1 (es) | Compuestos terapéuticamente activos y sus métodos de uso | |
| EA200901573A1 (ru) | Гетероарилзамещенные тиазолы |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA | Abandonment or withdrawal |