[go: up one dir, main page]

MX2009011997A - Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos. - Google Patents

Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.

Info

Publication number
MX2009011997A
MX2009011997A MX2009011997A MX2009011997A MX2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A MX 2009011997 A MX2009011997 A MX 2009011997A
Authority
MX
Mexico
Prior art keywords
pyrrolopyrimidin
pharmaceuticals
derivatives
compounds
salts
Prior art date
Application number
MX2009011997A
Other languages
English (en)
Inventor
Malken Bayrakdarian
Miroslaw Tomaszewski
Yun-Jin Hu
Louis-David Cantin
Xuehong Luo
Christophe Buon
Vijayaratnam Santhakumar
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=39943763&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009011997(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009011997A publication Critical patent/MX2009011997A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Psychology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Cardiology (AREA)
  • Epidemiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

Se describen compuestos de la fórmula (I) o sales farmacéuticamente aceptables de los mismos (ver fórmula (I)) en donde R1, R2, R3, R4 y R5 son como se define en la descripción, así como sales y composiciones farmacéuticas que incluyen los compuestos. Son útiles en terapia, en particular en el manejo de dolor.
MX2009011997A 2007-05-08 2008-05-07 Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos. MX2009011997A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91658807P 2007-05-08 2007-05-08
PCT/SE2008/050525 WO2008136756A1 (en) 2007-05-08 2008-05-07 Pyrrolopyrimidin-7-one derivatives and their use as pharmaceuticals

Publications (1)

Publication Number Publication Date
MX2009011997A true MX2009011997A (es) 2009-11-19

Family

ID=39943763

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011997A MX2009011997A (es) 2007-05-08 2008-05-07 Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.

Country Status (16)

Country Link
US (1) US20090099195A1 (es)
EP (1) EP2155751A1 (es)
JP (1) JP2010526138A (es)
KR (1) KR20100017688A (es)
CN (1) CN101687875A (es)
AR (1) AR066475A1 (es)
AU (1) AU2008246351A1 (es)
BR (1) BRPI0811436A2 (es)
CA (1) CA2686707A1 (es)
CL (1) CL2008001335A1 (es)
MX (1) MX2009011997A (es)
PE (1) PE20090816A1 (es)
RU (1) RU2009140469A (es)
TW (1) TW200846001A (es)
UY (1) UY31068A1 (es)
WO (1) WO2008136756A1 (es)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102272133A (zh) * 2008-11-06 2011-12-07 阿斯利康(瑞典)有限公司 淀粉样β的调节剂
WO2010066629A2 (en) * 2008-12-09 2010-06-17 F. Hoffmann-La Roche Ag Novel azaindoles
ES2474490T3 (es) 2009-02-13 2014-07-09 Shionogi & Co., Ltd. Derivados de triazina como antagonistas de receptores P2X3 y/o P2X2/3 y composición farmacéutica que los contiene
UY32622A (es) * 2009-05-12 2010-12-31 Astrazeneca Ab Nuevos compuestos para el tratamiento de patologías relacionadas con ab(beta)
TWI468402B (zh) * 2009-07-31 2015-01-11 必治妥美雅史谷比公司 降低β－類澱粉生成之化合物
US8637525B2 (en) 2009-07-31 2014-01-28 Bristol-Myers Squibb Company Compounds for the reduction of beta-amyloid production
BR112012011518B8 (pt) 2009-11-18 2023-01-10 Astrazeneca Ab Compostos, composição farmacêutica, kit e usos de um composto
RU2603008C2 (ru) 2010-04-16 2016-11-20 Ац Иммуне С.А. Новые соединения для лечения заболеваний, связанных с амилоидными или амилоидоподобными белками
US9062072B2 (en) 2010-04-20 2015-06-23 Emory University Inhibitors of HIF and angiogenesis
WO2012020742A1 (ja) * 2010-08-10 2012-02-16 塩野義製薬株式会社 新規複素環誘導体およびそれらを含有する医薬組成物
RU2565073C2 (ru) 2010-08-10 2015-10-20 Сионоги Энд Ко., Лтд. Триазиновое производное и включающая его фармацевтическая композиция, обладающая анальгетической активностью
US9381260B2 (en) 2011-12-27 2016-07-05 Emory University Hypoxia inducible factor-1 pathway inhibitors and uses as anticancer and imaging agents
US9550763B2 (en) 2012-02-09 2017-01-24 Shionogi & Co., Ltd. Heterocyclic ring and carbocyclic derivative
WO2014117274A1 (en) 2013-01-31 2014-08-07 Neomed Institute Imidazopyridine compounds and uses thereof
TWI637949B (zh) 2013-06-14 2018-10-11 塩野義製藥股份有限公司 胺基三衍生物及含有其等之醫藥組合物
JPWO2016088838A1 (ja) * 2014-12-04 2017-09-14 塩野義製薬株式会社 プリン誘導体およびその医薬組成物
CA2969952A1 (en) 2014-12-09 2016-06-16 Adam James Davenport 1,3-thiazol-2-yl substituted benzamides
WO2017158147A1 (en) 2016-03-18 2017-09-21 Savira Pharmaceuticals Gmbh Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease
WO2017209267A1 (ja) * 2016-06-03 2017-12-07 塩野義製薬株式会社 プリン誘導体
JP6856471B2 (ja) * 2017-01-04 2021-04-07 株式会社トクヤマ ラクトン化合物の製造方法、および該ラクトン化合物を使用したビオチンの製造方法
US11365194B2 (en) 2017-09-27 2022-06-21 Kagoshima University Analgesic drug using PAC1 receptor antagonistic drug
CR20200174A (es) * 2017-10-27 2020-06-26 Bayer Ag Novedosos derivados de pirazolo-pirrolo-pirimidina como inhibidores de p2x3
CN107778282B (zh) * 2017-11-03 2020-04-10 中山大学 喹啉-吲哚衍生物及其在制备治疗阿尔茨海默病的药品中的应用
JP2021523092A (ja) * 2018-03-21 2021-09-02 ピラマル・ファーマ・リミテッドＰｉｒａｍａｌ Ｐｈａｒｍａ Ｌｉｍｉｔｅｄ アルファ−（ジアリールメチル）アルキルアミンの改良された不斉合成
CN113727716A (zh) 2019-02-25 2021-11-30 贝卢斯医疗咳嗽病公司 采用p2x3调节剂的治疗
EP3932490B1 (en) 2019-02-27 2025-04-02 Kagoshima University Antipruritic agent using pac1 receptor antagonist
WO2021058018A1 (en) * 2019-09-29 2021-04-01 Beigene, Ltd. Inhibitors of kras g12c
WO2021068698A1 (en) 2019-10-12 2021-04-15 Shanghai Meton Pharmaceutical Co., Ltd Iso-citrate dehydrogenase (idh) inhibitor
KR20220113385A (ko) * 2019-12-10 2022-08-12 상하이 한서 바이오메디컬 컴퍼니 리미티드 피라졸-함유 다환식 유도체 억제제, 그의 제조 방법 및 그의 적용
CN113135924B (zh) * 2020-01-19 2024-04-26 广东东阳光药业股份有限公司 嘧啶衍生物及其在药物中的应用
WO2021173923A1 (en) * 2020-02-28 2021-09-02 Erasca, Inc. Pyrrolidine-fused heterocycles
HUE064037T2 (hu) * 2020-03-13 2024-03-28 Astrazeneca Ab Kondenzált pirimidin vegyületek, mint KCC2 modulátorok
TW202208355A (zh) 2020-05-04 2022-03-01 美商安進公司 作為骨髓細胞觸發受體2促效劑之雜環化合物及使用方法
WO2021225161A1 (ja) 2020-05-08 2021-11-11 国立大学法人鹿児島大学 Ｐａｃ１受容体拮抗薬を用いた抗うつ・抗不安薬
WO2022058344A1 (en) 2020-09-18 2022-03-24 Bayer Aktiengesellschaft Pyrido[2,3-d]pyrimidin-4-amines as sos1 inhibitors
KR20230094198A (ko) 2020-09-23 2023-06-27 에라스카, 아이엔씨. 3환식 피리돈 및 피리미돈
WO2022067462A1 (en) * 2020-09-29 2022-04-07 Beigene (Beijing) Co., Ltd. Process for preparing inhibitors of kras g12c
EP4074317A1 (en) 2021-04-14 2022-10-19 Bayer AG Phosphorus derivatives as novel sos1 inhibitors
CN117843618A (zh) * 2022-08-29 2024-04-09 北京沐华生物科技有限责任公司 一种ep300/cbp调节剂及其制备方法和用途
WO2025188953A1 (en) * 2024-03-06 2025-09-12 Ovid Therapeutics Inc. Fused amino pyrimidine compounds for treatment of neuropathic and neuro-inflammatory pain

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040058914A1 (en) * 2000-12-22 2004-03-25 Takayuki Doi Combination drugs
ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
WO2007035873A1 (en) * 2005-09-21 2007-03-29 Pharmacopeia, Inc. Purinone derivatives for treating neurodegenerative diseases

Also Published As

Publication number Publication date
RU2009140469A (ru) 2011-06-20
UY31068A1 (es) 2009-01-05
WO2008136756A1 (en) 2008-11-13
KR20100017688A (ko) 2010-02-16
AU2008246351A1 (en) 2008-11-13
TW200846001A (en) 2008-12-01
CA2686707A1 (en) 2008-11-13
EP2155751A1 (en) 2010-02-24
BRPI0811436A2 (pt) 2014-12-16
CL2008001335A1 (es) 2008-11-14
CN101687875A (zh) 2010-03-31
JP2010526138A (ja) 2010-07-29
US20090099195A1 (en) 2009-04-16
PE20090816A1 (es) 2009-07-25
AR066475A1 (es) 2009-08-19

Similar Documents

Publication Publication Date Title
MX2009011997A (es) Derivados de pirrolopirimidin-7-ona y su uso como farmaceuticos.
TW200716628A (en) Novel compounds
MX2010002584A (es) Derivados de piperidina como agonistas de receptores muscarinicos.
SE0401342D0 (sv) Therapeutic compounds
MX2010001574A (es) Ligandos del receptor cannabinoide.
GEP20125487B (en) Organic compounds and their use
SE0401971D0 (sv) Piperidne derivatives
UY30316A1 (es) Derivados sustituidos de benzamidas, nicotinamidas, propanamidas, acetamidas y carboxamidas n-(2-(piperidin-1-ilmetil)ciclohexil)sustituidas, procesos de preparacion, composiciones conteniéndolos y aplicaciones
TW200607799A (en) Therapeutic compounds: pyridine as scaffold
MY140630A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
MX2010009395A (es) Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y procesos para preparacion de los mismos.
MX2009013501A (es) Compuestos piperidinicos y sus usos.
SE0402762D0 (sv) Indazole sulphonamide derivatives
TW200504029A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
MX2010013310A (es) Derivados de heterociclil urea para el tratamiento de infecciones bacterianas.
MX2010009756A (es) Agonistas de receptores muscarinicos, composiciones, metodos de tratamiento de los mismos, y proceso para preparacion de los mismos.
UY30363A1 (es) Derivados sustituidos de la n-(3-oxo-2,3-dihidro-1h-isoindol-4-il)-1-naftamida, procesos de preparacion, composiciones farmacéuticas y aplicaciones
TW200504030A (en) Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof
TW200504059A (en) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
TW200626581A (en) Compounds, compositions containing them, preparation thereof and uses thereof
SG155181A1 (en) Diarylmethyl piperazine derivatives, preparations thereof and uses thereof
WO2007145563A8 (en) Benzimidazole derivatives which are to be used as antagonist for the cb1-receptor
TW200510312A (en) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
TW200500356A (en) Diarylmethylidene piperidine derivatives, preparations thereof and uses thereof
SE0400285D0 (sv) Pyrroloquinoline and piperidoquinoline derivatives, preparation thereof, compositions containing them and uses thereof