[go: up one dir, main page]

NO20071873L - DNA-PK inhibotorer. - Google Patents

DNA-PK inhibotorer.

Info

Publication number
NO20071873L
NO20071873L NO20071873A NO20071873A NO20071873L NO 20071873 L NO20071873 L NO 20071873L NO 20071873 A NO20071873 A NO 20071873A NO 20071873 A NO20071873 A NO 20071873A NO 20071873 L NO20071873 L NO 20071873L
Authority
NO
Norway
Prior art keywords
optionally substituted
alkyl
hydrogen
aryl
group
Prior art date
Application number
NO20071873A
Other languages
English (en)
Norwegian (no)
Inventor
Roger John Griffin
Ian Robert Hardcastle
Keith Allan Menear
Greame Cameron Murray Smith
Niall Morrison Barr Martin
Marc Geoffrey Hummersone
Laurent Jean Martin Rigoreau
Bernard Thomas Golding
David Richard Newell
Hillary Alan Calvert
Nicola Jane Curtin
Kappusamy Saravann
Original Assignee
Kudos Pharm Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd filed Critical Kudos Pharm Ltd
Publication of NO20071873L publication Critical patent/NO20071873L/no

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
NO20071873A 2004-09-20 2007-04-12 DNA-PK inhibotorer. NO20071873L (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US61151504P 2004-09-20 2004-09-20
PCT/GB2005/003621 WO2006032869A1 (fr) 2004-09-20 2005-09-20 Inhibiteurs d'adn-pk

Publications (1)

Publication Number Publication Date
NO20071873L true NO20071873L (no) 2007-06-15

Family

ID=35610093

Family Applications (1)

Application Number Title Priority Date Filing Date
NO20071873A NO20071873L (no) 2004-09-20 2007-04-12 DNA-PK inhibotorer.

Country Status (16)

Country Link
US (3) US7402607B2 (fr)
EP (1) EP1794151A1 (fr)
JP (1) JP2008513428A (fr)
KR (1) KR20070059156A (fr)
CN (1) CN101061111A (fr)
AU (1) AU2005286329A1 (fr)
BR (1) BRPI0515498A (fr)
CA (1) CA2580229A1 (fr)
IL (1) IL181969A0 (fr)
MX (1) MX2007003116A (fr)
NO (1) NO20071873L (fr)
RU (1) RU2408596C2 (fr)
TW (1) TW200616986A (fr)
UA (1) UA88329C2 (fr)
WO (1) WO2006032869A1 (fr)
ZA (1) ZA200703079B (fr)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7815934B2 (en) 2002-09-20 2010-10-19 Alpharma Pharmaceuticals, Llc Sequestering subunit and related compositions and methods
JP2007501836A (ja) 2003-08-13 2007-02-01 クドス ファーマシューティカルズ リミテッド アミノピロン類及びａｔｍ阻害剤としてのその使用
US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
CN101115747A (zh) 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
US20090035394A1 (en) * 2005-05-26 2009-02-05 Graeme Cameron Murray Smith Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
US20070049588A1 (en) * 2005-08-31 2007-03-01 Kudos Pharmaceuticals Limited Atm inhibitor
ES2600141T3 (es) 2006-06-19 2017-02-07 Alpharma Pharmaceuticals Llc Composiciones farmacéuticas
AU2007322269A1 (en) * 2006-10-11 2008-05-29 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
CA2709905A1 (fr) * 2007-12-17 2009-06-25 Alfred Liang Composition d'oxycodone a l'epreuve d'un usage abusif
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009130469A1 (fr) * 2008-04-25 2009-10-29 Kudos Pharmaceuticals Limited Inhibiteurs d'adn-pk
AU2020297451A1 (en) 2019-06-17 2022-01-06 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
WO2022133246A1 (fr) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions et procédés pour l'édition de bêta-globine pour le traitement d'hémoglobinopathies
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (fr) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 destiné à être utilisé dans le traitement d'une maladie ou d'un trouble lié à une protéine ras
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (fr) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Inhibiteurs de ras
WO2025181336A1 (fr) 2024-03-01 2025-09-04 Cellectis Sa Compositions et procédés d'édition de hbb dans hspc
WO2025217307A1 (fr) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Procédés de prédiction de la réponse à un inhibiteur de ras(on) et polythérapies
WO2025240847A1 (fr) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Inhibiteurs de ras

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1303724A (fr) 1969-05-14 1973-01-17
JPH0753725B2 (ja) * 1987-10-08 1995-06-07 富山化学工業株式会社 ４ｈ―１―ベンゾピラン―４―オン誘導体およびその塩、それらの製造法並びにそれらを含有する抗炎症剤
US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5703075A (en) * 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
FI912995A7 (fi) 1988-12-21 1991-06-19 Upjohn Co Antiateroskleroottisia ja antitromboottisia 1-bentsopyran-4-oneja ja 2 -amino-1,3-bentsoksatsin-4-oneja
JPH03215423A (ja) 1990-01-18 1991-09-20 Kyowa Hakko Kogyo Co Ltd 血管拡張剤
WO1991019707A2 (fr) 1990-06-20 1991-12-26 The Upjohn Company 1-benzopyran-4-ones et 2-amino-1,3-benzoxazine-4-ones antiathero sclerotiques et antithrombotiques
US5302613A (en) * 1990-06-29 1994-04-12 The Upjohn Company Antiatheroscleroic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
ES2079068T3 (es) 1990-06-29 1996-01-01 Upjohn Co 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.
US5252735A (en) * 1990-06-29 1993-10-12 The Upjohn Company Antiatherosclerotic and antithrombotic 2-amino-6-phenyl-4H-pyran-4-ones
DE69327153T2 (de) 1992-09-02 2000-05-25 Kyowa Hakko Kogyo Co., Ltd. Anti-hiv-medikament
JP3521145B2 (ja) * 1993-04-09 2004-04-19 富山化学工業株式会社 免疫調節剤，細胞接着阻害剤および自己免疫疾患の治療・予防剤
US5378725A (en) 1993-07-19 1995-01-03 The Arizona Board Of Regents Inhibition of phosphatidylinositol 3-kinase with wortmannin and analogs thereof
US5441947A (en) 1993-08-25 1995-08-15 Eli Lilly And Company Methods of inhibiting vascular restenosis
US5468773A (en) 1993-08-25 1995-11-21 Eli Lilly And Company Methods for inhibiting bone loss and cartilage degradation using wortmannin and its analogs
US5504103A (en) 1993-08-25 1996-04-02 Eli Lilly And Company Inhibition of phosphatidylinositol 3-kinase with 17 β-hydroxywortmannin and analogs thereof
CA2133815A1 (fr) 1993-10-12 1995-04-13 Jeffrey Alan Dodge Inhibition de la phosphatidylinositol 3-kinase au moyen de la viridine, de la demethoxyviridine, du viridiol, du demethoxyviridiol, de la virone et de la wortmannolone et analogues de ces substances.
US6632789B1 (en) 1994-04-29 2003-10-14 The United States Of America As Represented By The Secretary Of The Navy Methods for modulating T cell responses by manipulating intracellular signal transduction
US5480906A (en) 1994-07-01 1996-01-02 Eli Lilly And Company Stereochemical Wortmannin derivatives
GB9521987D0 (en) 1995-10-26 1996-01-03 Ludwig Inst Cancer Res Phosphoinositide 3-kinase modulators
US5733920A (en) * 1995-10-31 1998-03-31 Mitotix, Inc. Inhibitors of cyclin dependent kinases
AU1461197A (en) 1995-11-16 1997-06-05 Icos Corporation Cell cycle checkpoint pik-related kinase materials and methods
GB2302021A (en) 1996-10-16 1997-01-08 Lilly Co Eli Inhibiting bone loss or resorption
CA2292540A1 (fr) 1997-06-06 1998-12-10 Jann N. Sarkaria Criblage d'inhibiteurs de la kinase liee au phosphatidilynositol
AU8068198A (en) 1997-06-13 1998-12-30 President And Fellows Of Harvard College Methods for treating human cancers
FR2776291B1 (fr) 1998-03-18 2000-06-16 Pf Medicament Nouveaux derives bis-benzamides, leur procede de fabrication, les compositions pharmaceutiques les contenant et leur utilisation comme medicament
US6387640B1 (en) * 1999-02-10 2002-05-14 St. Jude Children's Research Hospital ATM kinase modulation for screening and therapies
US6348311B1 (en) * 1999-02-10 2002-02-19 St. Jude Childre's Research Hospital ATM kinase modulation for screening and therapies
US6333180B1 (en) * 1999-12-21 2001-12-25 International Flavors & Fragrances Inc. Bioprocess for the high-yield production of food flavor-acceptable jasmonic acid and methyl jasmonate
AU3042601A (en) 2000-01-24 2001-07-31 Thrombogenix Pty Ltd Therapeutic morpholino-substituted compounds
CA2413702A1 (fr) * 2000-06-28 2002-01-03 Teva Pharmaceuticals Industries Ltd. Carvedilol
US7179912B2 (en) 2000-09-01 2007-02-20 Icos Corporation Materials and methods to potentiate cancer treatment
DE60203260T2 (de) 2001-01-16 2006-02-02 Glaxo Group Ltd., Greenford Pharmazeutische kombination, die ein 4-chinazolinamin und paclitaxel, carboplatin oder vinorelbin enthält, zur behandlung von krebs
GB0119863D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB0119865D0 (en) * 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US6908932B2 (en) 2001-10-24 2005-06-21 Iconix Pharmaceuticals, Inc. Modulators of phosphoinositide 3-kinase
US6894055B2 (en) 2001-10-24 2005-05-17 Iconix Pharmaceuticals Inc. Thieno-2′,3′ -5,6pyrimido[3,4-A]-1,2,4-triazole derivatives as modulators of phoshoinositide 3-kinase
US7049313B2 (en) * 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
ATE451365T1 (de) 2002-02-25 2009-12-15 Kudos Pharm Ltd Als atm-inhibitoren geeignete pyranone
DE60335359D1 (de) * 2002-04-30 2011-01-27 Kudos Pharm Ltd Phthalazinonderivate
JP2007501836A (ja) * 2003-08-13 2007-02-01 クドス ファーマシューティカルズ リミテッド アミノピロン類及びａｔｍ阻害剤としてのその使用
US7402607B2 (en) * 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
CN101115747A (zh) * 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones

Also Published As

Publication number Publication date
JP2008513428A (ja) 2008-05-01
RU2408596C2 (ru) 2011-01-10
US20080242664A1 (en) 2008-10-02
EP1794151A1 (fr) 2007-06-13
IL181969A0 (en) 2007-07-04
AU2005286329A1 (en) 2006-03-30
US7402607B2 (en) 2008-07-22
CN101061111A (zh) 2007-10-24
KR20070059156A (ko) 2007-06-11
UA88329C2 (en) 2009-10-12
US20060106025A1 (en) 2006-05-18
US20070238731A1 (en) 2007-10-11
BRPI0515498A (pt) 2008-07-29
CA2580229A1 (fr) 2006-03-30
TW200616986A (en) 2006-06-01
WO2006032869A1 (fr) 2006-03-30
US7732483B2 (en) 2010-06-08
MX2007003116A (es) 2007-07-16
RU2007110629A (ru) 2008-10-27
ZA200703079B (en) 2008-08-27

Similar Documents

Publication Publication Date Title
NO20071873L (no) DNA-PK inhibotorer.
NO20083408L (no) Korrosjonsinhibitorer som har okt biologisk nedbrytbarhet og redusert giftighet
CY1113687T1 (el) Παραγωγα αμινο νικοτινικου και ισο-νικοτινικου οξεος σαν παραγοντες καταστολης της dhodh
DK1417196T3 (da) DNA-PK inhibitorer
AR067613A1 (es) Inhibidores de adn-pk, uso y sintesis de los mismos
CO6341609A2 (es) 5-heterociclilalquil-3-hidroxi-2-fenilciclopent-2-enonas como herbicidas.
CO6261379A2 (es) Compuestos de ciclopentandiona y derivados utiles como herbicidas
NO20076010L (no) Heterosyklisk forbindelse
NO20074071L (no) Hydrazinometyl, hydrozonometyl og 5-leddete heterocykliske forbindelser som virker som MTOR inhibitorer og anvendelse derav som anti-cancer midler
TW200605883A (en) Condensed heterocycle derivative having HCV inhibitory activity
CR8264A (es) Derivados de malonamida bloqueadores de la actividad gamma-secretase
DE602004026071D1 (de) Aminopyrone und ihre verwendung als atm inhibitoren
TNSN07255A1 (en) Cyclohexylamides as dopamine d3, d2 and 5ht 1a antagonists
MX2010001566A (es) Derivado de aminopirazolamida.
DK2000473T3 (da) Trehalose-forbindelse og lægemiddel omfattende forbindelsen
TW200638938A (en) ATM inhibitors
MX2010010471A (es) Derivado de tetrahidroisoquinolina novedoso.
GB2470170A (en) Dithienothiophene derivatives
ATE528284T1 (de) Metallcarbamate aus tolylendiaminen
IN2012DN01251A (fr)
WO2009130469A8 (fr) Inhibiteurs d'adn-pk
MX2010008740A (es) Derivado de 3,8-diaminotetrahidroquinolina.
ATE525386T1 (de) 3'-ethynylcytidinderivat
MX2007007256A (es) Cetonas de piridina con efecto herbicida.
DK1899331T3 (da) Homomorpholinoxazolidnoner som antibakterielle midler

Legal Events

Date Code Title Description
FC2A Withdrawal, rejection or dismissal of laid open patent application