[go: up one dir, main page]

ES2079068T3 - 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas. - Google Patents

2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.

Info

Publication number
ES2079068T3
ES2079068T3 ES91910593T ES91910593T ES2079068T3 ES 2079068 T3 ES2079068 T3 ES 2079068T3 ES 91910593 T ES91910593 T ES 91910593T ES 91910593 T ES91910593 T ES 91910593T ES 2079068 T3 ES2079068 T3 ES 2079068T3
Authority
ES
Spain
Prior art keywords
antitromboticas
antiateroscleroticas
fenil
piran
onas
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91910593T
Other languages
English (en)
Inventor
Joel Morris
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ES2079068T3 publication Critical patent/ES2079068T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
    • C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A COMPUESTOS DE LA FORMULA (I), QUE SON UTILES COMO AGENTES ANTIATEROSCLEROTICOS Y COMO INHIBIDORES DE LA PROLIFERACION DE CELULAS PARA EL TRATAMIENTO DE ENFERMEDADES PROLIFERATIVAS. ADEMAS, VARIOS COMPUESTOS DE LA FORMULA (I) SON INHIBIDORES UTILES DE LA AGREGACION DE PLAQUETAS.-
ES91910593T 1990-06-29 1991-06-03 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas. Expired - Lifetime ES2079068T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US54593590A 1990-06-29 1990-06-29

Publications (1)

Publication Number Publication Date
ES2079068T3 true ES2079068T3 (es) 1996-01-01

Family

ID=24178137

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91910593T Expired - Lifetime ES2079068T3 (es) 1990-06-29 1991-06-03 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.

Country Status (11)

Country Link
EP (1) EP0489877B1 (es)
JP (1) JPH05501886A (es)
KR (1) KR920702353A (es)
AT (1) ATE128128T1 (es)
AU (1) AU630822B2 (es)
CA (1) CA2064796A1 (es)
DE (1) DE69113221T2 (es)
DK (1) DK0489877T3 (es)
ES (1) ES2079068T3 (es)
GR (1) GR3018304T3 (es)
WO (1) WO1992000290A1 (es)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2687674B1 (fr) * 1992-02-07 1995-05-19 Roussel Uclaf Nouveaux derives de la pyridone, leur procede de preparation, les nouveaux intermediaires obtenus, leur application a titre de medicaments et les compositions pharmaceutiques les renfermant.
US5834024A (en) * 1995-01-05 1998-11-10 Fh Faulding & Co. Limited Controlled absorption diltiazem pharmaceutical formulation
TW587079B (en) * 1998-09-25 2004-05-11 Almirall Prodesfarma Ag 2-phenylpyran-4-one derivatives
US6875791B2 (en) * 2000-04-05 2005-04-05 Pharmacia Corporation Polycyclic aryl and heteroaryl substituted 4-pyrones useful for selective inhibition of the coagulation cascade
GB0119863D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
GB2405870B (en) * 2001-08-14 2005-07-06 Cancer Rec Tech Ltd DNA-PK inhibitors
GB0119865D0 (en) 2001-08-14 2001-10-10 Cancer Res Campaign Tech DNA-PK inhibitors
US7049313B2 (en) 2002-02-25 2006-05-23 Kudos Pharmaceuticals Ltd. ATM inhibitors
WO2003070726A1 (en) * 2002-02-25 2003-08-28 Kudos Pharmaceuticals Ltd Pyranones useful as atm inhibitors
GB0204350D0 (en) * 2002-02-25 2002-04-10 Kudos Pharm Ltd ATM inhibitors
US7429660B2 (en) * 2003-08-13 2008-09-30 Kudos Pharmaceuticals Limited ATM inhibitors
UA88329C2 (en) 2004-09-20 2009-10-12 Кудос Фармасьютикалз Лимитед Dna-pk inhibitors
CN101115747A (zh) 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR053358A1 (es) 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
CL2008000986A1 (es) 2007-04-06 2008-10-17 Neurocrine Biosciences Inc COMPUESTO DERIVADO DE HETEROCICLOS DE NITROGENO, AGONISTAS DEL RECEPTOR GnRH; COMPOSICION FARMACEUTICA QUE COMPRENDE A DICHO COMPUESTO; Y USO PARA TRATAR UNA AFECCION RELACIONADA CON LAS HORMONAS SEXUALES, ENDOMETRIOSIS, DISMENORREA, ENFERMEDAD DE OV
AR065948A1 (es) 2007-04-06 2009-07-15 Neurocrine Biosciences Inc Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
CN102731456B (zh) * 2011-04-01 2014-07-09 华中科技大学 一种抗肿瘤化合物及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2452487A1 (fr) * 1979-03-28 1980-10-24 Rhone Poulenc Agrochimie Nouveaux derives de la phenyl-2-pyrone-4 et leur utilisation comme fongicides
AU634994B2 (en) * 1988-12-21 1993-03-11 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones

Also Published As

Publication number Publication date
WO1992000290A1 (en) 1992-01-09
GR3018304T3 (en) 1996-03-31
EP0489877B1 (en) 1995-09-20
ATE128128T1 (de) 1995-10-15
DK0489877T3 (da) 1996-02-05
AU7955491A (en) 1992-01-23
EP0489877A1 (en) 1992-06-17
KR920702353A (ko) 1992-09-03
JPH05501886A (ja) 1993-04-08
CA2064796A1 (en) 1991-12-30
DE69113221D1 (en) 1995-10-26
DE69113221T2 (de) 1996-03-28
AU630822B2 (en) 1992-11-05

Similar Documents

Publication Publication Date Title
ATE158288T1 (de) Antiatherosklerotische und antithrombotische 1- benzopyran-4-on- und 2-amino-1,3-benzoxazin-4-on- derivate
ES2079068T3 (es) 2-amino-6-fenil-4h-piran-4-onas antiateroscleroticas y antitromboticas.
EA200001223A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
EA200500169A1 (ru) Замещенные производные 1,3-дифенилпроп-2-ен-1-она, получение и применение
TR199901905T2 (xx) 2-(P�rin-9-il)-tetrahidrofuran-3,4-diol t�revleri.
ATE148130T1 (de) Typ-iv-dipeptidyl-aminopeptidase-inhibitoren
IT1209229B (it) Uso di composti perfluorocarburici per il trattamento di lesioni,articoli e composizioni contenenti detti composti
BG98902A (bg) Имидазолови производни и тяхната употреба като инхибитори на цитокин
EA200000759A1 (ru) Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола
TR200200068T2 (tr) Nematisital triflüorobütenler
EA199900559A1 (ru) Замещенные, азотсодержащие гетероциклы в качестве ингибиторов протеинкиназы p38
ATE269290T1 (de) Benzoylderivate
ATE337316T1 (de) Imidazo 1,2-aöpyridin-derivate zur prophylaxe und behandlung von herpes-infektionen
FI831230L (fi) N-glykosylerade karboxylsyraamidderivat, foerfarande foer deras framstaellning samt deras anvaendnifoer att paoverka kroppens eget foersvar
BG100069A (bg) Амидинови производни,съдържащи хетероциклични групи,получаване и приложението им
DE3887151D1 (de) Inhibitoren für zellenzuwachs und methoden für krebsbehandlung.
DE60115466D1 (de) Wirkstoffvorläufer von imidazopyridin-derivaten
ATE173625T1 (de) Zusammensetzungen zur behandlung von hiv- infektionen
FI813912L (fi) I laekemedel anvaendbara tricykliska cytosinderivat och foerfarande foer deras framstaellning
ES491960A0 (es) Procedimiento para la obtencion de derivados de sisomicina
BG98238A (bg) Заместени бензотиазолови производни,получаванетоим и приложението им като хербициди
DK0758312T3 (da) Substituerede fusionerede og broforbundne bicykliske forbindelser som terapeutiske midler
DK398483A (da) Substituerede tert.butanol-derivater, fremgangsmaader til fremstilling deraf samt antimykotiske midler indeholdende disse forbindelser
ATE130304T1 (de) Neue alpha-glukosidaseinhibitoren.
EA200100152A1 (ru) Замещенные пиперазиноны и их терапевтическое применение

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 489877

Country of ref document: ES