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ZA200703079B - DNA-PK Inhibitors - Google Patents

DNA-PK Inhibitors

Info

Publication number
ZA200703079B
ZA200703079B ZA200703079A ZA200703079A ZA200703079B ZA 200703079 B ZA200703079 B ZA 200703079B ZA 200703079 A ZA200703079 A ZA 200703079A ZA 200703079 A ZA200703079 A ZA 200703079A ZA 200703079 B ZA200703079 B ZA 200703079B
Authority
ZA
South Africa
Prior art keywords
inhibitors
dna
Prior art date
Application number
ZA200703079A
Other languages
English (en)
Inventor
Smith Graeme Cameron Murray
Martin Niall Morrison Barr
Menear Keith Allan
Hummersone Marc Geoffrey
Rigoreau Laurent Jean Martin
Griffin Roger John
Golding Bernard Thomas
Newell David Richard
Calvert Hilary Alan
Curtin Nicola Jane
Hardcastle Ian Robert
Saravanan Kappusamy
Original Assignee
Kudos Pharm Ltd
Cancer Rec Tech Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kudos Pharm Ltd, Cancer Rec Tech Ltd filed Critical Kudos Pharm Ltd
Publication of ZA200703079B publication Critical patent/ZA200703079B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA200703079A 2004-09-20 2007-04-16 DNA-PK Inhibitors ZA200703079B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US61151504P 2004-09-20 2004-09-20

Publications (1)

Publication Number Publication Date
ZA200703079B true ZA200703079B (en) 2008-08-27

Family

ID=35610093

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200703079A ZA200703079B (en) 2004-09-20 2007-04-16 DNA-PK Inhibitors

Country Status (16)

Country Link
US (3) US7402607B2 (xx)
EP (1) EP1794151A1 (xx)
JP (1) JP2008513428A (xx)
KR (1) KR20070059156A (xx)
CN (1) CN101061111A (xx)
AU (1) AU2005286329A1 (xx)
BR (1) BRPI0515498A (xx)
CA (1) CA2580229A1 (xx)
IL (1) IL181969A0 (xx)
MX (1) MX2007003116A (xx)
NO (1) NO20071873L (xx)
RU (1) RU2408596C2 (xx)
TW (1) TW200616986A (xx)
UA (1) UA88329C2 (xx)
WO (1) WO2006032869A1 (xx)
ZA (1) ZA200703079B (xx)

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US7815934B2 (en) 2002-09-20 2010-10-19 Alpharma Pharmaceuticals, Llc Sequestering subunit and related compositions and methods
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US7402607B2 (en) 2004-09-20 2008-07-22 Kudos Pharmaceuticals Limited DNA-PK inhibitors
CN101115747A (zh) 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
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US20090035394A1 (en) * 2005-05-26 2009-02-05 Graeme Cameron Murray Smith Use of dna-pk inhibition to sensitise atm deficient cancers to dna-damaging cancer therapies
US20070049588A1 (en) * 2005-08-31 2007-03-01 Kudos Pharmaceuticals Limited Atm inhibitor
ES2600141T3 (es) 2006-06-19 2017-02-07 Alpharma Pharmaceuticals Llc Composiciones farmacéuticas
AU2007322269A1 (en) * 2006-10-11 2008-05-29 Alpharma Pharmaceuticals, Llc Pharmaceutical compositions
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
CA2709905A1 (en) * 2007-12-17 2009-06-25 Alfred Liang Abuse-resistant oxycodone composition
US8623418B2 (en) 2007-12-17 2014-01-07 Alpharma Pharmaceuticals Llc Pharmaceutical composition
WO2009130469A1 (en) * 2008-04-25 2009-10-29 Kudos Pharmaceuticals Limited Dna-pk inhibitors
AU2020297451A1 (en) 2019-06-17 2022-01-06 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
WO2022133246A1 (en) 2020-12-17 2022-06-23 Vertex Pharmaceuticals Incorporated Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
WO2025034702A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Rmc-6291 for use in the treatment of ras protein-related disease or disorder
US20250154171A1 (en) 2023-10-12 2025-05-15 Revolution Medicines, Inc. Ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
WO2025181336A1 (en) 2024-03-01 2025-09-04 Cellectis Sa Compositions and methods for hbb-editing in hspc
WO2025217307A1 (en) 2024-04-09 2025-10-16 Revolution Medicines, Inc. Methods for predicting response to a ras(on) inhibitor and combination therapies
WO2025240847A1 (en) 2024-05-17 2025-11-20 Revolution Medicines, Inc. Ras inhibitors

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US5284856A (en) * 1988-10-28 1994-02-08 Hoechst Aktiengesellschaft Oncogene-encoded kinases inhibition using 4-H-1-benzopyran-4-one derivatives
US5703075A (en) * 1988-12-21 1997-12-30 Pharmacia & Upjohn Company Antiatherosclerotic and antithrombotic 1-benzopyran-4-ones and 2-amino-1,3-benzoxazine-4-ones
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CN101115747A (zh) * 2005-02-09 2008-01-30 库多斯药物有限公司 Atm抑制剂
AR053358A1 (es) * 2005-04-15 2007-05-02 Cancer Rec Tech Ltd Inhibidores de adn - pk
UY31232A1 (es) * 2007-07-19 2009-03-02 Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones

Also Published As

Publication number Publication date
JP2008513428A (ja) 2008-05-01
RU2408596C2 (ru) 2011-01-10
US20080242664A1 (en) 2008-10-02
EP1794151A1 (en) 2007-06-13
IL181969A0 (en) 2007-07-04
NO20071873L (no) 2007-06-15
AU2005286329A1 (en) 2006-03-30
US7402607B2 (en) 2008-07-22
CN101061111A (zh) 2007-10-24
KR20070059156A (ko) 2007-06-11
UA88329C2 (xx) 2009-10-12
US20060106025A1 (en) 2006-05-18
US20070238731A1 (en) 2007-10-11
BRPI0515498A (pt) 2008-07-29
CA2580229A1 (en) 2006-03-30
TW200616986A (en) 2006-06-01
WO2006032869A1 (en) 2006-03-30
US7732483B2 (en) 2010-06-08
MX2007003116A (es) 2007-07-16
RU2007110629A (ru) 2008-10-27

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