DK1417196T3 - DNA-PK inhibitorer - Google Patents

DNA-PK inhibitorer

Info

Publication number: DK1417196T3
Authority: DK; Denmark
Prior art keywords: optionally substituted; dna; ring; activity; compounds
Prior art date: 2001-08-14

Application number

DK02751439T

Other languages

English (en)

Inventor

Roger John Griffin

Bernard Thomas Golding

David Richard Newell

Hilary Alan Calvert

Ian Robert Hardcastle

Niall Morrison Barr Martin

Graeme Cameron Murray Smith

Laurent Jean Martin Rigoreau

Xiao-Ling Fan Cockcroft

Vincent Junior Ming-Lai Loh

Paul Workman

Florence Irene Raynaud

Bernard Paul Nutley

Nicola Jane Curtin

Original Assignee

Cancer Rec Tech Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-08-14

Filing date

2002-08-14

Publication date

2009-03-02

2002-08-14 Application filed by Cancer Rec Tech Ltd filed Critical Cancer Rec Tech Ltd

2009-03-02 Application granted granted Critical

2009-03-02 Publication of DK1417196T3 publication Critical patent/DK1417196T3/da

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/50—Pyridazines; Hydrogenated pyridazines
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/34—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D309/36—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms
- C07D309/38—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with oxygen atoms directly attached to ring carbon atoms one oxygen atom in position 2 or 4, e.g. pyrones
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
- C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
- C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D311/78—Ring systems having three or more relevant rings
- C07D311/92—Naphthopyrans; Hydrogenated naphthopyrans
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Virology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Cardiology (AREA)
Communicable Diseases (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Heart & Thoracic Surgery (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Pyrane Compounds (AREA)

DK02751439T 2001-08-14 2002-08-14 DNA-PK inhibitorer DK1417196T3 (da)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0119865.4A GB0119865D0 (en)	2001-08-14	2001-08-14	DNA-PK inhibitors
PCT/GB2002/003781 WO2003024949A1 (en)	2001-08-14	2002-08-14	Dna-pk inhibitors

Publications (1)

Publication Number	Publication Date
DK1417196T3 true DK1417196T3 (da)	2009-03-02

Family

ID=9920420

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
DK02751439T DK1417196T3 (da)	2001-08-14	2002-08-14	DNA-PK inhibitorer

Country Status (22)

Country	Link
US (2)	US7226918B2 (da)
EP (1)	EP1417196B1 (da)
JP (1)	JP4332032B2 (da)
KR (1)	KR100905457B1 (da)
CN (1)	CN1279034C (da)
AT (1)	ATE411987T1 (da)
AU (1)	AU2002362385B2 (da)
BR (1)	BR0211889A (da)
CA (1)	CA2454023A1 (da)
CY (1)	CY1110269T1 (da)
DE (1)	DE60229531D1 (da)
DK (1)	DK1417196T3 (da)
ES (1)	ES2315377T3 (da)
GB (2)	GB0119865D0 (da)
HU (1)	HUP0401052A3 (da)
MX (1)	MXPA04000804A (da)
NO (1)	NO20040636L (da)
NZ (1)	NZ530909A (da)
PL (1)	PL367081A1 (da)
PT (1)	PT1417196E (da)
WO (1)	WO2003024949A1 (da)
ZA (1)	ZA200400237B (da)

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GB0119863D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
GB0119865D0 (en)	2001-08-14	2001-10-10	Cancer Res Campaign Tech	DNA-PK inhibitors
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BRPI0409063A (pt) *	2003-04-03	2006-03-28	Semafore Pharmaceuticals Inc	pró medicamentos de inibidor de pi-3 cinase
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CN101061111A (zh) *	2004-09-20	2007-10-24	库多斯药物有限公司	Dna－pk抑制剂
TW200638938A (en)	2005-02-09	2006-11-16	Kudos Pharm Ltd	ATM inhibitors
AR053358A1 (es) *	2005-04-15	2007-05-02	Cancer Rec Tech Ltd	Inhibidores de adn - pk
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UY29774A1 (es) *	2005-08-31	2007-03-30	Kudos Pharm Ltd	Inhibidor de atm
WO2008009934A1 (en) *	2006-07-18	2008-01-24	Kudos Pharmaceuticals Limited	Synthesis of 2-amino-substituted 4-oxo-4h-chromen-8.yl-trifluoro-methanesulfonic acid esters
EP2061762B1 (en) *	2006-08-16	2011-07-27	Boehringer Ingelheim International GmbH	Pyrazine compounds, their use and methods of preparation
WO2009008991A2 (en) *	2007-07-06	2009-01-15	Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services National Institutes Of Health	Dna-pkcs modulates energy regulation and brain function
UY31232A1 (es) *	2007-07-19	2009-03-02		Compuestos derivados de dibenzotifenilamino-cromen-4-onas activas sustituidas y sus isomeros y aplicaciones
WO2009130469A1 (en) *	2008-04-25	2009-10-29	Kudos Pharmaceuticals Limited	Dna-pk inhibitors
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FR2947548B1 (fr) *	2009-07-02	2012-05-18	Sanofi Aventis	Nouveaux derives de 1h-pyrimidin-2-one, leur preparation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
SG10201402867TA (en)	2009-07-02	2014-08-28	Sanofi Sa	Novel (6-oxo-1, 6-dihydro-pyrimidin-2-yl)-amide derivatives, preparation thereof, and pharmaceutical use thereof as akt(pkb) phosphorylation inhibitors
AU2010267815B2 (en)	2009-07-02	2015-07-16	Sanofi	Novel 1,2,3,4-tetrahydro-pyrimido(1,2-a)pyrimidin-6-one derivatives, preparation thereof, and pharmaceutical use thereof
WO2011001115A1 (fr)	2009-07-02	2011-01-06	Sanofi-Aventis	Nouveaux derives de 6-morpholin-4-yl-pyrimidin-4- ( 3h ) -one, leur preparation pharmaceutique comme inhibiteurs de phos phorylat i on d ' akt ( pkb )
ES2627428T3 (es)	2009-07-02	2017-07-28	Sanofi	Nuevos derivados de 2,3-dihidro-1H-imidazo{1,2-a}pirimidin-5-ona, su preparación y su utilización farmacéutica
FR2951170B1 (fr) *	2009-10-09	2011-12-02	Sanofi Aventis	Nouveaux derives de 1h-pyrimidin-2-one, leur preparation et leur utilisation pharmaceutique comme inhibiteurs de phosphorylation d'akt(pkb)
WO2011137428A1 (en) *	2010-04-30	2011-11-03	The United States Of America, As Represented By The Secretary, Department Of Health And Human Services	Methods of treating hiv infection: inhibition of dna dependent protein kinase
EP2655375B1 (fr)	2010-12-23	2014-12-03	Sanofi	Derives de pyrimidinone, leur preparation et leur utilisation pharmaceutique
DK2658844T3 (da)	2010-12-28	2017-02-06	Sanofi Sa	Hidtil ukendte pyrimidinderivater, fremstilling deraf og farmaceutisk anvendelse deraf som akt(pkb)-phosphoryleringshæmmere
UY34013A (es) *	2011-04-13	2012-11-30	Astrazeneca Ab	?compuestos de cromenona con actividad anti-tumoral?.
FR2992314B1 (fr)	2012-06-22	2015-10-16	Sanofi Sa	Nouveaux derives de 2,3-dihydro-1h-imidazo{1,2-a}pyrimidin-5-one et 1,2,3,4-tetrahydro-pyrimido{1,2-a}pyrimidin-6-one comportant une morpholine substituee, leur preparation et leur utilisation pharmaceutique
FR2992316A1 (fr)	2012-06-22	2013-12-27	Sanofi Sa	Derives de pyrimidinones, leur preparation et leur application en therapeutique
CN102977063A (zh) *	2012-11-26	2013-03-20	盛世泰科生物医药技术(苏州)有限公司	一种2-吗啡啉-8-苯基-4-苯并吡喃-4-酮的合成方法
SI3527563T1 (sl)	2013-03-12	2022-01-31	Vertex Pharmaceuticals Incorporated	Inhibitorji DNA-PK
EP3042900B1 (en) *	2013-08-29	2020-09-23	Fujifilm Corporation	Novel morpholine derivative or salt thereof
US11433047B2 (en)	2015-10-09	2022-09-06	Neurotheryx Canada Ltd.	Pharmaceutical compositions comprising one or more pyrone compounds, and their use for treating inflammatory and neurodegenerative diseases
WO2018183868A1 (en) *	2017-03-31	2018-10-04	Bioventures, Llc	Inhibitors of dna pk and uses thereof
CA3142521A1 (en)	2019-06-17	2020-12-24	Vertex Pharmaceuticals Incorporated	Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
EP4143304A2 (en)	2020-04-28	2023-03-08	Intellia Therapeutics, Inc.	Methods of in vitro cell delivery
WO2022133246A1 (en)	2020-12-17	2022-06-23	Vertex Pharmaceuticals Incorporated	Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
AU2022258733A1 (en)	2021-04-17	2023-11-30	Intellia Therapeutics, Inc.	Inhibitors of dna-dependent protein kinase and compositions and uses thereof
CN116903577B (zh) *	2023-07-03	2025-07-29	大连华一锂电科技有限公司	一种直接合成碳酸亚乙烯酯的方法
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CN119118977A (zh) *	2024-08-23	2024-12-13	西北工业大学	一种γ-吡喃酮类化合物的制备方法

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JP2007501836A (ja)	2003-08-13	2007-02-01	クドスファーマシューティカルズリミテッド	アミノピロン類及びａｔｍ阻害剤としてのその使用
CN101061111A (zh)	2004-09-20	2007-10-24	库多斯药物有限公司	Dna－pk抑制剂
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AR053358A1 (es)	2005-04-15	2007-05-02	Cancer Rec Tech Ltd	Inhibidores de adn - pk
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2001
- 2001-08-14 GB GBGB0119865.4A patent/GB0119865D0/en not_active Ceased
2002
- 2002-08-14 WO PCT/GB2002/003781 patent/WO2003024949A1/en not_active Ceased
- 2002-08-14 CN CNB028159780A patent/CN1279034C/zh not_active Expired - Fee Related
- 2002-08-14 AT AT02751439T patent/ATE411987T1/de active
- 2002-08-14 PT PT02751439T patent/PT1417196E/pt unknown
- 2002-08-14 US US10/486,816 patent/US7226918B2/en not_active Expired - Lifetime
- 2002-08-14 DK DK02751439T patent/DK1417196T3/da active
- 2002-08-14 HU HU0401052A patent/HUP0401052A3/hu unknown
- 2002-08-14 CA CA002454023A patent/CA2454023A1/en not_active Abandoned
- 2002-08-14 DE DE60229531T patent/DE60229531D1/de not_active Expired - Lifetime
- 2002-08-14 PL PL02367081A patent/PL367081A1/xx not_active Application Discontinuation
- 2002-08-14 KR KR1020047002182A patent/KR100905457B1/ko not_active Expired - Fee Related
- 2002-08-14 EP EP02751439A patent/EP1417196B1/en not_active Expired - Lifetime
- 2002-08-14 GB GB0401411A patent/GB2393653B/en not_active Expired - Fee Related
- 2002-08-14 BR BR0211889-0A patent/BR0211889A/pt not_active IP Right Cessation
- 2002-08-14 MX MXPA04000804A patent/MXPA04000804A/es active IP Right Grant
- 2002-08-14 NZ NZ530909A patent/NZ530909A/en not_active IP Right Cessation
- 2002-08-14 AU AU2002362385A patent/AU2002362385B2/en not_active Ceased
- 2002-08-14 ES ES02751439T patent/ES2315377T3/es not_active Expired - Lifetime
- 2002-08-14 JP JP2003528797A patent/JP4332032B2/ja not_active Expired - Fee Related
2004
- 2004-01-13 ZA ZA200400237A patent/ZA200400237B/xx unknown
- 2004-02-12 NO NO20040636A patent/NO20040636L/no not_active Application Discontinuation
2007
- 2007-06-05 US US11/758,332 patent/US7674823B2/en not_active Expired - Fee Related
2009
- 2009-01-14 CY CY20091100039T patent/CY1110269T1/el unknown

Also Published As

Publication number	Publication date
MXPA04000804A (es)	2004-06-03
BR0211889A (pt)	2004-09-21
WO2003024949A1 (en)	2003-03-27
KR100905457B1 (ko)	2009-07-02
KR20040032152A (ko)	2004-04-14
DE60229531D1 (de)	2008-12-04
EP1417196B1 (en)	2008-10-22
GB0401411D0 (en)	2004-02-25
US7674823B2 (en)	2010-03-09
CN1543457A (zh)	2004-11-03
HUP0401052A2 (hu)	2004-09-28
GB2393653B (en)	2005-02-02
AU2002362385B2 (en)	2008-07-31
GB0119865D0 (en)	2001-10-10
HUP0401052A3 (en)	2007-05-29
US20070238729A1 (en)	2007-10-11
NO20040636L (no)	2004-04-02
US7226918B2 (en)	2007-06-05
ZA200400237B (en)	2004-08-18
EP1417196A1 (en)	2004-05-12
CA2454023A1 (en)	2003-03-27
ATE411987T1 (de)	2008-11-15
PT1417196E (pt)	2009-01-02
JP4332032B2 (ja)	2009-09-16
NZ530909A (en)	2005-10-28
PL367081A1 (en)	2005-02-21
ES2315377T3 (es)	2009-04-01
US20040192687A1 (en)	2004-09-30
CY1110269T1 (el)	2015-01-14
JP2005503414A (ja)	2005-02-03
HK1070368A1 (en)	2005-06-17
GB2393653A (en)	2004-04-07
CN1279034C (zh)	2006-10-11

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