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MA60161B1 - Compositions et méthodes pour moduler l'expression de hbv et de ttr - Google Patents

Compositions et méthodes pour moduler l'expression de hbv et de ttr

Info

Publication number
MA60161B1
MA60161B1 MA60161A MA60161A MA60161B1 MA 60161 B1 MA60161 B1 MA 60161B1 MA 60161 A MA60161 A MA 60161A MA 60161 A MA60161 A MA 60161A MA 60161 B1 MA60161 B1 MA 60161B1
Authority
MA
Morocco
Prior art keywords
compositions
methods
ttr expression
modulating hbv
hbv
Prior art date
Application number
MA60161A
Other languages
English (en)
Other versions
MA60161A1 (fr
Inventor
Punit P. Seth
Eric E. Swayze
Thazha P; PRAKASH
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51843959&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA60161(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Publication of MA60161A1 publication Critical patent/MA60161A1/fr
Publication of MA60161B1 publication Critical patent/MA60161B1/fr

Links

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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Abstract

L'invention concerne des composés oligomères à groupes conjugués. Dans certains modes de réalisation de l'invention, ces composés oligomères sont conjugués à la N-acétylgalactosamine.
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