|
US513030A
(en)
|
|
1894-01-16 |
|
Machine for waxing or coating paper |
|
US2878264A
(en)
|
|
1959-03-17 |
|
Substituted amino alcohols |
|
DE1144279B
(de)
|
1957-09-26 |
1963-02-28 |
Robins Co Inc A H |
Verfahren zur Herstellung von 3-Aryl-3-hydroxypyrrolidinen und deren Salzen
|
|
US3135766A
(en)
|
1961-10-03 |
1964-06-02 |
Mead Johnson & Co |
3-substituted-3-pyrrolidinols
|
|
US3484473A
(en)
|
1967-05-12 |
1969-12-16 |
Buckman Labor Inc |
Methylene bisesters of thiolsulfonic acids
|
|
DE1934150A1
(de)
|
1968-07-10 |
1970-01-15 |
Pennwalt Corp |
Neue 1-Alkanoyloxy-1,2,4,5-tetrahydro-3H,3-benzazepine
|
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US3745162A
(en)
|
1970-08-31 |
1973-07-10 |
Robins Co Inc A H |
1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides
|
|
GB1448437A
(en)
|
1973-02-24 |
1976-09-08 |
Beecham Group Ltd |
Diphenylpropylamines
|
|
US4022791A
(en)
|
1975-06-03 |
1977-05-10 |
Pfizer Inc. |
2-Aminomethyl-3,4-dihydronaphthalenes
|
|
GB1504424A
(en)
|
1975-08-09 |
1978-03-22 |
Beecham Group Ltd |
Isoquinoline-derived aminoethers
|
|
BR7807288A
(pt)
|
1977-11-08 |
1979-06-12 |
Genentech Inc |
Processo para sintese de polinucleotidos
|
|
DD133885B1
(de)
|
1978-01-04 |
1981-02-25 |
Hans Lehmann |
Mittel zur bekaempfung von phytopathogenen bakterien und pilzen
|
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
|
US4542142A
(en)
|
1982-11-22 |
1985-09-17 |
Roussel Uclaf |
Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain
|
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
|
FR2576898B1
(fr)
|
1985-02-01 |
1988-01-08 |
Lafon Labor |
Derives de 3-phenyl-tetrahydropyridine, procede de preparation et utilisation en therapeutique
|
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
|
US4840956A
(en)
|
1986-02-18 |
1989-06-20 |
Warner-Lambert Company |
Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
|
|
US4735949A
(en)
|
1986-02-18 |
1988-04-05 |
Warner-Lambert Company |
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
|
|
IL83663A0
(en)
|
1986-10-27 |
1988-01-31 |
Robins Co Inc A H |
Preparation of 3-pyrrolidinols
|
|
DE3851889T2
(de)
|
1987-06-24 |
1995-04-13 |
Florey Howard Inst |
Nukleosid-derivate.
|
|
EP0302349B1
(en)
|
1987-07-30 |
1993-09-29 |
Bar Ilan University |
Biologically active carboxylic acid esters
|
|
US4923901A
(en)
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
|
US4943629A
(en)
|
1988-08-12 |
1990-07-24 |
American Cyanamid Company |
Antidiabetic alpha-substituted phosphonates
|
|
US4945158A
(en)
|
1988-08-12 |
1990-07-31 |
American Cyanamid Company |
Antidiabetic phosphonates
|
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
|
CA2029273A1
(en)
|
1989-12-04 |
1991-06-05 |
Christine L. Brakel |
Modified nucleotide compounds
|
|
WO1991009594A1
(en)
|
1989-12-28 |
1991-07-11 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5852188A
(en)
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5506212A
(en)
|
1990-01-11 |
1996-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides with substantially chirally pure phosphorothioate linkages
|
|
US5212295A
(en)
|
1990-01-11 |
1993-05-18 |
Isis Pharmaceuticals |
Monomers for preparation of oligonucleotides having chiral phosphorus linkages
|
|
US5635488A
(en)
|
1991-10-15 |
1997-06-03 |
Isis Pharmaceuticals, Inc. |
Compounds having phosphorodithioate linkages of high chiral purity
|
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
AU651569B2
(en)
|
1990-01-11 |
1994-07-28 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for detecting and modulating RNA activity and gene expression
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US5620963A
(en)
|
1991-10-15 |
1997-04-15 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
|
|
US5036964A
(en)
|
1990-03-28 |
1991-08-06 |
Dana Corporation |
Armature assembly for an electromagnetic coupling
|
|
US5292875A
(en)
|
1990-04-20 |
1994-03-08 |
Lynx Therapeutics, Inc. |
Method of synthesizing sulfurized oligonucleotide analogs
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
JPH06500075A
(ja)
|
1990-05-23 |
1994-01-06 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
Ｒｎａの５´キャップ構造の修飾によりｒｎａ活性を変調させるための組成物および方法
|
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
|
WO1994022886A1
(en)
|
1993-03-30 |
1994-10-13 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
|
US5834607A
(en)
|
1990-07-27 |
1998-11-10 |
Isis Pharmaceuticals, Inc. |
Amines and methods of making and using the same
|
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
|
US6121433A
(en)
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US6087482A
(en)
|
1990-07-27 |
2000-07-11 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
|
US5792844A
(en)
|
1990-07-27 |
1998-08-11 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent nitrogen atoms
|
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
|
CA2088258C
(en)
|
1990-07-27 |
2004-09-14 |
Phillip Dan Cook |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
|
US5783682A
(en)
|
1990-07-27 |
1998-07-21 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide mimics having nitrogen-containing linkages
|
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
US5512668A
(en)
|
1991-03-06 |
1996-04-30 |
Polish Academy Of Sciences |
Solid phase oligonucleotide synthesis using phospholane intermediates
|
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
|
US20020183502A1
(en)
|
1991-05-21 |
2002-12-05 |
Mesmaeker Alain De |
Backbone-modified oligonucleotide analogs and methods for using same
|
|
US6414112B1
(en)
|
1991-05-24 |
2002-07-02 |
Ole Buchardt |
Peptide nucleic acids having 2,6-diaminopurine nucleobases
|
|
US6538126B1
(en)
|
1991-06-10 |
2003-03-25 |
Lucky Limited |
Hepatitis C diagnostics and vaccines
|
|
US5646267A
(en)
|
1991-08-05 |
1997-07-08 |
Polish Academy Of Sciences |
Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
|
|
US5359052A
(en)
|
1991-08-05 |
1994-10-25 |
Polish Academy Of Sciences |
Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
|
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
DE69232699T2
(de)
|
1991-10-15 |
2003-02-06 |
Isis Pharmaceutical, Inc. |
Über chirale phosphoratome gebundene oligonukleotide
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
|
US5654284A
(en)
|
1991-10-15 |
1997-08-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
|
|
DE59208572D1
(de)
|
1991-10-17 |
1997-07-10 |
Ciba Geigy Ag |
Bicyclische Nukleoside, Oligonukleotide, Verfahren zu deren Herstellung und Zwischenprodukte
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
DK1695979T3
(da)
|
1991-12-24 |
2011-10-10 |
Isis Pharmaceuticals Inc |
Gappede modificerede oligonukleotider
|
|
GB9213601D0
(en)
|
1992-06-26 |
1992-08-12 |
Mastico Robert A |
Protein based delivery system
|
|
US7067497B2
(en)
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
|
US6005107A
(en)
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
|
US6444656B1
(en)
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
|
NZ262254A
(en)
|
1993-01-25 |
1997-10-24 |
Hybridon Inc |
Oligonucleotide analogue containing a ribonucleotide alkylphosphon(ate or thioate), gene repression
|
|
WO1994022888A1
(en)
|
1993-03-31 |
1994-10-13 |
Sterlingwinthrop Inc. |
Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
|
|
AU6449294A
(en)
|
1993-03-31 |
1994-10-24 |
Sterling Winthrop Inc. |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
|
US5955591A
(en)
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
|
EP0628394B1
(en)
|
1993-06-10 |
1998-08-26 |
Idemitsu Petrochemical Co. Ltd. |
Injection molding die
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
US5643989A
(en)
|
1993-10-29 |
1997-07-01 |
Azdel, Inc. |
Fiber reinforced functionalized polyolefin composites
|
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
|
DE4435728A1
(de)
|
1994-01-19 |
1995-07-20 |
Boehringer Mannheim Gmbh |
Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
|
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
|
WO1995022615A1
(en)
|
1994-02-22 |
1995-08-24 |
Novo Nordisk A/S |
A method of preparing a variant of a lipolytic enzyme
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
RU2215034C2
(ru)
|
1994-05-11 |
2003-10-27 |
Новосимс А/С |
ФЕРМЕНТ С АКТИВНОСТЬЮ ЭНДО-1,3(4)-β-ГЛЮКАНАЗЫ, КОДИРУЮЩАЯ ЕГО ДНК И СПОСОБ ЕГО ПОЛУЧЕНИЯ
|
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
|
ATE175667T1
(de)
|
1994-05-31 |
1999-01-15 |
Bayer Ag |
Aminobenzofuryl- und -thienylderivate
|
|
HRP950288A2
(en)
|
1994-05-31 |
1997-08-31 |
Bayer Ag |
Oxalylamino-benzofuran- and benzothienyl-derivatives
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
EP0772619B2
(en)
|
1994-07-15 |
2010-12-08 |
The University of Iowa Research Foundation |
Immunomodulatory oligonucleotides
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
EP0779893B1
(en)
|
1994-09-07 |
2001-06-27 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
|
CA2208528A1
(en)
|
1994-12-22 |
1996-06-27 |
Hybridon, Inc. |
Synthesis of stereospecific oligonucleotide phosphorothioates
|
|
GB9501465D0
(en)
|
1995-01-25 |
1995-03-15 |
King S College London |
Nucleoside phosphorothioate derivatives,synthesis and use thereof
|
|
EP0813539B1
(en)
|
1995-03-06 |
2006-05-24 |
Isis Pharmaceuticals, Inc. |
Improved process for the synthesis of 2'-o-substituted pyrimidines and oligomeric compounds therefrom
|
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
|
EP0739983B1
(en)
|
1995-04-27 |
2009-12-30 |
Takara Bio Inc. |
Gene encoding lacto-n-biosidase
|
|
JP4173539B2
(ja)
|
1995-05-11 |
2008-10-29 |
ラボラトアール・セローノ・ソシエテ・アノニム |
Ｉｌ−６活性阻害剤
|
|
AU5855296A
(en)
|
1995-05-19 |
1996-11-29 |
Glycomed Incorporated |
Collection of activated glycoside compounds and their biolog ical use
|
|
AU5871196A
(en)
|
1995-05-23 |
1996-12-24 |
Hybridon, Inc. |
Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
|
|
EP0836612B1
(en)
|
1995-05-23 |
2000-07-26 |
Hybridon, Inc. |
Novel synthons for stereoselective oligonucleotide synthesis
|
|
CA2223103A1
(en)
|
1995-06-06 |
1996-12-12 |
Isis Pharmaceuticals Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5932450A
(en)
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
|
US5824503A
(en)
|
1995-06-29 |
1998-10-20 |
Takara Shuzo Co, Ltd. |
Gene encoding endoglycoceramidase activator
|
|
DE69635849T2
(de)
|
1995-06-29 |
2006-10-19 |
Takara Bio Inc., Otsu |
Für Endoglycoceramidase kodierendes Gen
|
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
|
US5936080A
(en)
|
1996-05-24 |
1999-08-10 |
Genta Incorporated |
Compositions and methods for the synthesis of organophosphorus derivatives
|
|
WO1997009443A1
(en)
|
1995-09-05 |
1997-03-13 |
Michigan State University |
PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
|
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
|
JP2000506384A
(ja)
|
1996-02-15 |
2000-05-30 |
ナショナル インスティチューツ オブ ヘルス |
ＲＮａｓｅ Ｌ アクチベーター及びＲＳＶ感染の治療に有効なアンチセンスオリゴヌクレオチド
|
|
US6214805B1
(en)
|
1996-02-15 |
2001-04-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
|
US5824669A
(en)
|
1996-03-22 |
1998-10-20 |
Nitromed, Inc. |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
|
|
AU3025597A
(en)
|
1996-05-10 |
1997-12-05 |
Novo Nordisk A/S |
Method of providing novel dna sequences
|
|
US5856465A
(en)
|
1996-05-24 |
1999-01-05 |
Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych |
Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
DE19622783A1
(de)
|
1996-06-07 |
1997-12-11 |
Hoechst Ag |
Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung
|
|
EP0912767B1
(en)
|
1996-07-16 |
2006-09-13 |
Gen-Probe Incorporated |
Methods for detecting and amplifying nucleic acid sequences using modified oligonucleotides having increased target specific tm
|
|
EP0960121B1
(en)
|
1996-07-24 |
2005-11-30 |
BUCHARDT, Dorte |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
|
AU4156197A
(en)
|
1996-08-21 |
1998-03-06 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
|
GB9621522D0
(en)
|
1996-10-16 |
1996-12-04 |
Biocompatibles Ltd |
Synthesis of phosphorus compounds
|
|
US6639062B2
(en)
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
|
US6369237B1
(en)
|
1997-03-07 |
2002-04-09 |
President And Fellows Of Harvard College |
DNA glycosylase inhibitors, and uses related thereto
|
|
US6015887A
(en)
|
1997-04-11 |
2000-01-18 |
Isis Pharmaceuticals, Inc. |
Chiral peptide nucleic acids and methods for preparing same
|
|
US6468983B2
(en)
|
1997-04-21 |
2002-10-22 |
The Cleveland Clinic Foundation |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
|
|
PL184612B1
(pl)
|
1997-04-25 |
2002-11-29 |
Pan |
Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
|
|
EP1003480A4
(en)
|
1997-05-28 |
2002-04-17 |
Nielsen Peter Eigil |
NUCLEIC ACIDS CONJUGED WITH PEPTIDES WITH INCREASED UPDATE IN CELLS
|
|
JP2002507212A
(ja)
|
1997-06-27 |
2002-03-05 |
ザ、プロクター、エンド、ギャンブル、カンパニー |
プロ芳香性環状アセタール
|
|
WO1999005160A2
(en)
|
1997-07-25 |
1999-02-04 |
Hybridon, Inc. |
Oligonuclotides having 3' terminal stereospecific phosphorothioates
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
US6767739B2
(en)
|
2001-07-30 |
2004-07-27 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microsomal triglyceride transfer protein expression
|
|
GB9717158D0
(en)
|
1997-08-13 |
1997-10-22 |
King S College London |
Solution synthesis of oligonucleotides and their phosphorothioate analogues
|
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
|
DE19741715A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
|
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
|
US6080543A
(en)
|
1997-12-08 |
2000-06-27 |
E. & J. Gallo Winery |
Detection of fungal pathogens
|
|
US6582936B1
(en)
|
1997-12-12 |
2003-06-24 |
The Regents Of The University Of California |
Methods for making nucleic acids
|
|
US6248519B1
(en)
|
1998-03-11 |
2001-06-19 |
E & J Gallo Winery |
Detection of fermentation-related microorganisms
|
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
|
WO1999056755A1
(en)
|
1998-05-06 |
1999-11-11 |
University Of Iowa Research Foundation |
Methods for the prevention and treatment of parasitic infections and related diseases using cpg oligonucleotides
|
|
EP1078053B1
(en)
|
1998-05-14 |
2005-09-28 |
Coley Pharmaceutical GmbH |
METHODS FOR REGULATING HEMATOPOIESIS USING CpG-OLIGONUCLEOTIDES
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
WO2000006588A1
(en)
|
1998-07-27 |
2000-02-10 |
University Of Iowa Research Foundation |
STEREOISOMERS OF CpG OLIGONUCLEOTIDES AND RELATED METHODS
|
|
DK1104306T3
(da)
|
1998-08-10 |
2006-05-22 |
Antigenics Inc |
Præparater af CpG- og saponinadjuvanser og fremgangsmåder til anvendelse deraf
|
|
WO2000023444A1
(en)
|
1998-10-21 |
2000-04-27 |
Abbott Laboratories |
5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
|
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
|
WO2000031110A1
(en)
|
1998-11-25 |
2000-06-02 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
US6451524B1
(en)
|
1998-11-25 |
2002-09-17 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
|
WO2000040749A2
(en)
|
1999-01-06 |
2000-07-13 |
Genenews Inc. |
Method for the detection of gene transcripts in blood and uses thereof
|
|
US6265172B1
(en)
|
1999-02-08 |
2001-07-24 |
University Of Kentucky |
Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
|
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6506594B1
(en)
|
1999-03-19 |
2003-01-14 |
Cornell Res Foundation Inc |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
|
GB9907245D0
(en)
|
1999-03-29 |
1999-05-26 |
Goldsborough Andrew |
Cleavage of nucleic acids from solid supports
|
|
JP3072345B1
(ja)
|
1999-03-31 |
2000-07-31 |
農林水産省家畜衛生試験場長 |
豚丹毒菌の組換えサブユニットワクチン
|
|
US5998148A
(en)
|
1999-04-08 |
1999-12-07 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microtubule-associated protein 4 expression
|
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
|
US6300069B1
(en)
|
1999-05-03 |
2001-10-09 |
Qiagen Gmbh |
Generation and amplification of nucleic acids from ribonucleic acids
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6271004B1
(en)
|
1999-06-25 |
2001-08-07 |
Display Systems Biotech A/S |
Method for improved reverse transcription at high temperatures
|
|
US6066500A
(en)
|
1999-06-25 |
2000-05-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Beta catenin expression
|
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
|
US20030092647A1
(en)
|
2001-08-08 |
2003-05-15 |
Crooke Rosanne M. |
Antisense modulation of cholesteryl ester transfer protein expression
|
|
US6147200A
(en)
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US7264932B2
(en)
|
1999-09-24 |
2007-09-04 |
Applera Corporation |
Nuclease inhibitor cocktail
|
|
UA77152C2
(en)
|
1999-09-25 |
2006-11-15 |
|
Method for stimulation of immune response using nucleic acid-containing immunostimulating compositions, method for treatment of cancer and method for treatment or prophylaxis of allergy or asthma
|
|
JP2003510290A
(ja)
|
1999-09-27 |
2003-03-18 |
コーリー ファーマシューティカル グループ，インコーポレイテッド |
免疫刺激核酸誘導インターフェロンに関する方法
|
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
|
US20020082227A1
(en)
|
1999-09-30 |
2002-06-27 |
Scott Henry |
Use of oligonucleotides for inhibition of complement activation
|
|
US6528262B1
(en)
|
1999-10-06 |
2003-03-04 |
Quark Biotech, Inc. |
Method for enrichment of natural antisense messenger RNA
|
|
GB9924285D0
(en)
|
1999-10-14 |
1999-12-15 |
Avecia Ltd |
Process
|
|
US20010055761A1
(en)
|
1999-10-29 |
2001-12-27 |
Agilent Technologies |
Small scale dna synthesis using polymeric solid support with functionalized regions
|
|
FR2800750B1
(fr)
|
1999-11-05 |
2003-01-31 |
Centre Nat Rech Scient |
Proteines membranaires ctl (choline transporter like) impliquees dans le transport de la choline
|
|
WO2001040515A1
(en)
|
1999-11-12 |
2001-06-07 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6322985B1
(en)
|
1999-12-27 |
2001-11-27 |
Technion Research And Development Foundation Ltd. |
Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
|
|
WO2001050349A1
(en)
|
1999-12-30 |
2001-07-12 |
Rutgers, The State University Of New Jersey |
Electronic document customization and transformation utilizing user feedback
|
|
JP2004510953A
(ja)
|
1999-12-30 |
2004-04-08 |
キャボット コーポレイション |
改良された性質を有するセンサー
|
|
US6649750B1
(en)
|
2000-01-05 |
2003-11-18 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotide compounds
|
|
US6159697A
(en)
|
2000-01-19 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad7 expression
|
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
|
GB0004889D0
(en)
|
2000-03-01 |
2000-04-19 |
Avecia Ltd |
Synthesis of oligonucleotides
|
|
CA2335389A1
(en)
|
2000-03-01 |
2001-09-01 |
Message Pharmaceuticals, Inc. |
Novel bacterial rnase p proteins and their use in identifying antibacterial compounds
|
|
AU2001245823A1
(en)
|
2000-03-17 |
2001-10-03 |
Corixa Corporation |
Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
|
|
KR100501606B1
(ko)
|
2000-04-20 |
2005-07-18 |
에프. 호프만-라 로슈 아게 |
피롤리딘 및 피페리딘 유도체, 및 신경퇴화성 질환의치료를 위한 그의 용도
|
|
DE10019756A1
(de)
|
2000-04-20 |
2001-10-25 |
Bayer Ag |
Verfahren zur Herstellung von superabsorbierenden Polymeren aus Polyacrylnitrilen
|
|
AU2001259706A1
(en)
|
2000-05-09 |
2001-11-20 |
Reliable Biopharmaceutical, Inc. |
Polymeric compounds useful as prodrugs
|
|
US6492171B2
(en)
|
2000-05-16 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of TERT expression
|
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
|
JP4331476B2
(ja)
|
2000-08-03 |
2009-09-16 |
エフ．ホフマン−ラ ロシュ アーゲー |
プリン−２，６−ジアミンのピラゾロ［３，４−ｄ］ピリミジンアナローグを含有する核酸結合性化合物およびそれらの使用
|
|
US6725412B1
(en)
|
2000-08-15 |
2004-04-20 |
Dolby Laboratories Licensing Corporation |
Low latency data encoder
|
|
US6809195B1
(en)
|
2000-08-16 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotides
|
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
|
CA2419894A1
(en)
|
2000-09-15 |
2002-03-21 |
Coley Pharmaceutical Gmbh |
Process for high throughput screening of cpg-based immuno-agonist/antagonist
|
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
|
GB0024752D0
(en)
|
2000-10-10 |
2000-11-22 |
Univ Belfast |
Oxidative halogenation of aromatic compounds
|
|
JP2004511527A
(ja)
|
2000-10-18 |
2004-04-15 |
グラクソスミスクライン バイオロジカルズ ソシエテ アノニム |
ワクチン
|
|
US6372492B1
(en)
|
2000-10-30 |
2002-04-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of talin expression
|
|
US6682889B1
(en)
|
2000-11-08 |
2004-01-27 |
Becton, Dickinson And Company |
Amplification and detection of organisms of the Chlamydiaceae family
|
|
NL1016978C2
(nl)
|
2000-12-22 |
2002-06-25 |
Robert Jan Colenbrander |
Inrichting en werkwijze voor het verpakken en bereiden van voedsel en werkwijze voor het vervaardigen van een dergelijke inrichting.
|
|
HUP0400726A3
(en)
|
2001-01-22 |
2007-05-29 |
Merck & Co Inc |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
|
WO2002059297A2
(en)
|
2001-01-25 |
2002-08-01 |
Evolva Biotech A/S |
A library of a collection of cells
|
|
US8008459B2
(en)
|
2001-01-25 |
2011-08-30 |
Evolva Sa |
Concatemers of differentially expressed multiple genes
|
|
NZ526507A
(en)
|
2001-01-26 |
2005-07-29 |
Commw Scient Ind Res Org |
Methods and means for producing efficient silencing construct using recombinational cloning
|
|
US20050277133A1
(en)
|
2001-05-18 |
2005-12-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US20030207804A1
(en)
|
2001-05-25 |
2003-11-06 |
Muthiah Manoharan |
Modified peptide nucleic acids
|
|
GB0113523D0
(en)
|
2001-06-04 |
2001-07-25 |
Torotrak Dev Ltd |
An Hydraulic control circuit for a continuosly variable transmission
|
|
US20030069410A1
(en)
*
|
2001-06-14 |
2003-04-10 |
Isis Pharmaceuticals, Inc. |
Methods for preparing oligonucleotides having chiral phosphorothioate linkages
|
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
JP4370161B2
(ja)
|
2001-06-29 |
2009-11-25 |
ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド |
Ｈｃｖｅ１ｅ２ワクチン組成物
|
|
CA2452458A1
(en)
|
2001-07-03 |
2003-01-16 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
|
US6440739B1
(en)
|
2001-07-17 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glioma-associated oncogene-2 expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US7888324B2
(en)
|
2001-08-01 |
2011-02-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
US6455308B1
(en)
|
2001-08-01 |
2002-09-24 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of serum amyloid A4 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
|
US7354909B2
(en)
|
2001-08-14 |
2008-04-08 |
The United States Of America As Represented By Secretary Of The Department Of Health And Human Services |
Method for rapid generation of mature dendritic cells
|
|
WO2003017930A2
(en)
|
2001-08-24 |
2003-03-06 |
Massachusetts Institute Of Technology |
Reagents that facilitate the purification of compounds synthesized on a solid support
|
|
US7049122B2
(en)
|
2001-09-21 |
2006-05-23 |
Academia Sinica |
Mutant-type lipases and applications thereof
|
|
US6933288B2
(en)
|
2002-02-04 |
2005-08-23 |
Isis Pharmaceuticals, Inc. |
Pyranosyl cytosines: pharmaceutical formulations and methods
|
|
JP4348044B2
(ja)
|
2002-02-12 |
2009-10-21 |
株式会社キラルジェン |
立体規則性の高いジヌクレオシドホスホロチオエートの製造法
|
|
US20030159938A1
(en)
|
2002-02-15 |
2003-08-28 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US20040149587A1
(en)
|
2002-02-15 |
2004-08-05 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
CA2477795A1
(en)
|
2002-02-28 |
2003-09-12 |
Kandasamy Sakthivel |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
|
AU2003217863B9
(en)
|
2002-02-28 |
2009-10-29 |
Biota Scientific Management Pty Ltd |
Nucleotide mimics and their prodrugs
|
|
US7288376B2
(en)
|
2002-03-22 |
2007-10-30 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis
|
|
US20040102394A1
(en)
|
2002-11-23 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of huntingtin interacting protein 2 expression
|
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
|
AU2003237875A1
(en)
|
2002-05-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
|
US20040014108A1
(en)
|
2002-05-24 |
2004-01-22 |
Eldrup Anne B. |
Oligonucleotides having modified nucleoside units
|
|
WO2003099840A1
(en)
|
2002-05-24 |
2003-12-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
|
WO2003106477A1
(en)
|
2002-06-01 |
2003-12-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
|
ATE489969T1
(de)
|
2002-06-20 |
2010-12-15 |
Cytos Biotechnology Ag |
Verpackte virusartige partikel in kombination mit cpg zur verwendung als adjuvantien mit allergenen. herstellungsverfahren und verwendung
|
|
WO2004003228A1
(en)
|
2002-07-01 |
2004-01-08 |
Unisearch Limited |
Genotyping method
|
|
EP2333062A1
(en)
|
2002-07-10 |
2011-06-15 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA-interference by single-stranded RNA molecules
|
|
US20040023905A1
(en)
|
2002-07-31 |
2004-02-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of LAR expression
|
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
|
US20050255086A1
(en)
|
2002-08-05 |
2005-11-17 |
Davidson Beverly L |
Nucleic acid silencing of Huntington's Disease gene
|
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
|
WO2004014312A2
(en)
|
2002-08-08 |
2004-02-19 |
Sirna Therapeutics, Inc. |
Small-mer compositions and methods of use
|
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
|
AU2003267785C1
(en)
|
2002-09-13 |
2009-12-24 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
|
MXPA05004588A
(es)
|
2002-10-29 |
2005-12-14 |
Coley Pharmaceutical Group Ltd |
Metodos y productos relacionados con el tratamiento y prevencion de infeccion de virus de hepatitis c.
|
|
CA2504694C
(en)
|
2002-11-05 |
2013-10-01 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
|
WO2004044134A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
EP1560840B1
(en)
|
2002-11-05 |
2015-05-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
AU2003295389A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
|
US7381527B2
(en)
|
2002-11-06 |
2008-06-03 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants
|
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
EP1569695B1
(en)
|
2002-11-13 |
2013-05-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein b expression
|
|
DK2284266T3
(da)
|
2002-11-14 |
2014-01-13 |
Thermo Fisher Scient Biosciences Inc |
sIRNA-MOLEKYLE MOD TP53
|
|
EP3450559A1
(en)
|
2003-03-07 |
2019-03-06 |
Alnylam Pharmaceuticals, Inc. |
Therapeutic compositions
|
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
|
GB0306657D0
(en)
|
2003-03-24 |
2003-04-30 |
Avecia Ltd |
Process and compounds
|
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
|
JP5022028B2
(ja)
|
2003-03-26 |
2012-09-12 |
サイトス・バイオテクノロジー・アクチェンゲゼルシャフト |
メラン−ａペプチドアナログ−ウイルス様粒子コンジュゲート
|
|
ITRM20030149A1
(it)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
WO2004096235A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
|
CN101410120A
(zh)
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
抗炎的膦酸酯化合物
|
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
|
AU2004233898B2
(en)
|
2003-04-25 |
2010-12-23 |
Gilead Sciences, Inc. |
Antiviral phosphonate analogs
|
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
|
WO2004096233A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates
|
|
US20090247488A1
(en)
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
|
US7045306B2
(en)
|
2003-04-28 |
2006-05-16 |
The General Hospital Corporation |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
|
|
US7214491B2
(en)
|
2003-05-07 |
2007-05-08 |
E. I. Du Pont De Nemours And Company |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
|
|
AU2004239114B2
(en)
|
2003-05-14 |
2008-03-13 |
Japan Science And Technology Agency |
Inhibition of the expression of huntingtin gene
|
|
US7541344B2
(en)
|
2003-06-03 |
2009-06-02 |
Eli Lilly And Company |
Modulation of survivin expression
|
|
MXPA05013922A
(es)
|
2003-06-20 |
2006-02-24 |
Coley Pharm Group Inc |
Antagonistas de receptor tipo toll de molecula pequena.
|
|
US8969314B2
(en)
|
2003-07-31 |
2015-03-03 |
Regulus Therapeutics, Inc. |
Methods for use in modulating miR-122a
|
|
EP1648914A4
(en)
|
2003-07-31 |
2009-12-16 |
Regulus Therapeutics Inc |
OLIGOMERIC COMPOUNDS AND COMPOSITIONS USEFUL FOR MODULATING SMALL NON-CODING RNA
|
|
JP2005089441A
(ja)
|
2003-08-08 |
2005-04-07 |
Toudai Tlo Ltd |
立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
|
|
JP2011088935A
(ja)
|
2003-08-08 |
2011-05-06 |
Chiralgen Ltd |
リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド３’−ホスホロアミダイト
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
EP1664072A1
(en)
|
2003-08-21 |
2006-06-07 |
Griffith University |
Novel sulfenamides
|
|
RU2006108577A
(ru)
|
2003-08-21 |
2007-09-27 |
Гриффит Юниверсити (Au) |
Новые сульфенамиды
|
|
CA2537114C
(en)
|
2003-08-27 |
2012-10-02 |
Biota, Inc. |
Tricyclic nucleosides or nucleotides as therapeutic agents
|
|
JP4731324B2
(ja)
|
2003-08-28 |
2011-07-20 |
武 今西 |
Ｎ−ｏ結合性架橋構造型新規人工核酸
|
|
WO2005028494A1
(ja)
|
2003-09-02 |
2005-03-31 |
Takeshi Wada |
５'-ホスフィチル化モノマーおよびh-ホスホネートオリゴヌクレオチド誘導体の製造方法
|
|
JP4580870B2
(ja)
|
2003-09-02 |
2010-11-17 |
株式会社キラルジェン |
リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
|
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
|
JP4690324B2
(ja)
|
2003-09-09 |
2011-06-01 |
ジェロン・コーポレーション |
テロメラーゼ阻害のための改変オリゴヌクレオチド
|
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
EP2821085B1
(en)
|
2003-09-12 |
2020-04-29 |
University of Massachusetts |
Rna interference for the treatment of gain-of-function disorders
|
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
|
GB0323968D0
(en)
|
2003-10-13 |
2003-11-19 |
Glaxosmithkline Biolog Sa |
Immunogenic compositions
|
|
BRPI0416079A
(pt)
|
2003-10-30 |
2007-01-02 |
Coley Pharm Gmbh |
análogos de oligonucleotìdeos de classe c com uma potência imunoestimuladora aumentada
|
|
US20050239102A1
(en)
|
2003-10-31 |
2005-10-27 |
Verdine Gregory L |
Nucleic acid binding oligonucleotides
|
|
US7846436B2
(en)
|
2003-11-28 |
2010-12-07 |
Chemgenes Corporation |
Oligonucleotides and related compounds
|
|
WO2005063983A1
(en)
|
2003-12-29 |
2005-07-14 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
|
WO2005070859A1
(ja)
|
2004-01-27 |
2005-08-04 |
Takeshi Wada |
フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
|
WO2005076744A2
(en)
|
2004-02-18 |
2005-08-25 |
Frutarom Ltd. |
Method for the preparation of peptide-oligonucleotide conjugates
|
|
JP3976742B2
(ja)
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
|
|
WO2005085272A1
(ja)
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
|
JP4865544B2
(ja)
|
2004-03-25 |
2012-02-01 |
株式会社キラルジェン |
立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法
|
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
CA2561741C
(en)
|
2004-04-05 |
2016-09-27 |
Alnylam Pharmaceuticals, Inc. |
Processes and reagents for oligonucleotide synthesis and purification
|
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
|
WO2005116268A2
(en)
|
2004-05-27 |
2005-12-08 |
The Government Of The United States Of America As Represented By The Secretary, Department Of Health |
Differential expression of molecules associated with acute stroke
|
|
US7759318B1
(en)
|
2004-05-28 |
2010-07-20 |
Isis Pharmaceuticals, Inc. |
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
|
|
CA2568735A1
(en)
|
2004-06-03 |
2005-12-22 |
Isis Pharmaceuticals, Inc. |
Double strand compositions comprising differentially modified strands for use in gene modulation
|
|
ATE498685T1
(de)
|
2004-06-28 |
2011-03-15 |
Univ Western Australia |
Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon
|
|
AU2005272912A1
(en)
|
2004-08-10 |
2006-02-23 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
|
BRPI0514644A
(pt)
|
2004-08-26 |
2008-06-17 |
Nippon Shinyaku Co Ltd |
composto fosforamidita, composto ácido ribonucléico, e método para produzir oligo-rna
|
|
EP1791557A4
(en)
|
2004-09-07 |
2009-09-23 |
Archemix Corp |
MEDICAL CHEMISTRY USING APTAMERS
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
US20090203132A1
(en)
|
2004-09-09 |
2009-08-13 |
Swayze Eric E |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
|
EP2397563A3
(en)
|
2004-09-17 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
|
EP1807093A2
(en)
|
2004-10-13 |
2007-07-18 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of ptp1b expression
|
|
US8212012B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US8212011B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues
|
|
US9120774B2
(en)
|
2004-11-03 |
2015-09-01 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
|
US7622451B2
(en)
|
2004-11-03 |
2009-11-24 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
US7608594B2
(en)
|
2004-11-03 |
2009-10-27 |
University Of Kansas |
Novobiocin analogues as anticancer agents
|
|
KR100721928B1
(ko)
|
2004-11-05 |
2007-05-28 |
주식회사 바이오씨에스 |
ＣｐＧ 올리고데옥시뉴클레오티드를 함유하는 피부질환의치료 또는 예방용 약학적 조성물
|
|
EP1657307A1
(en)
|
2004-11-16 |
2006-05-17 |
Immunotech S.A. |
Oligonucleotides that induce the secretion of GM-CSF
|
|
AU2005313883B2
(en)
|
2004-12-09 |
2011-03-31 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs
|
|
WO2006065751A2
(en)
|
2004-12-13 |
2006-06-22 |
Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
Cpg oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
|
WO2006066260A2
(en)
|
2004-12-17 |
2006-06-22 |
Thiosense, Inc. |
Compositions of and methods for producing phosphorus-chiral monomers and oligomers
|
|
US20070099851A1
(en)
|
2004-12-30 |
2007-05-03 |
Linn Gregory S |
Stable analogues of ribose-1-phosphate and methods for treating diabetes and other metabolic disorders
|
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
|
JP4836145B2
(ja)
|
2005-01-28 |
2011-12-14 |
クウォン，ヒュン−ジョ |
マイコバクテリアに由来する、免疫機能刺激用、免疫疾患治療用、アトピー性皮膚炎治療用および／または正常免疫細胞保護用オリゴヌクレオチド
|
|
WO2006091915A2
(en)
|
2005-02-24 |
2006-08-31 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory oligonucleotides
|
|
EP1866319B1
(en)
|
2005-04-01 |
2011-11-23 |
The Regents of The University of California |
Phosphono-pent-2-en-1-yl nucleosides and analogs
|
|
AU2006243218B2
(en)
|
2005-05-05 |
2009-09-17 |
Antisense Pharma Gmbh |
Use of low doses of oligonucleotides antisense to TGF-beta, VEGF, interleukin-10, c-jun, c-fos or prostaglandin E2 genes in the treatment of tumors
|
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
|
DK2548560T3
(en)
|
2005-06-23 |
2015-07-13 |
Cold Spring Harbor Lab |
Compositions and Methods for Modulating SMN2 Splicing
|
|
EP2316967A1
(en)
|
2005-06-28 |
2011-05-04 |
Medtronic, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin gene.
|
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
|
EP1948600B1
(en)
|
2005-07-05 |
2014-04-16 |
The President & Fellows Of Harvard College |
Liver targeted conjugates
|
|
JP4984634B2
(ja)
|
2005-07-21 |
2012-07-25 |
ソニー株式会社 |
物理情報取得方法および物理情報取得装置
|
|
US8632963B2
(en)
|
2005-07-28 |
2014-01-21 |
Id-Fish Technology Inc. |
Method for improving cell permeability to foreign particles
|
|
WO2007028065A2
(en)
|
2005-08-30 |
2007-03-08 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
|
US20070077993A1
(en)
|
2005-09-30 |
2007-04-05 |
Midgley Timothy M |
Method and apparatus for collecting user game play data and crediting users in a gaming environment
|
|
ES2542989T3
(es)
|
2005-10-12 |
2015-08-13 |
Idera Pharmaceuticals, Inc. |
Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll
|
|
US9308252B2
(en)
|
2005-10-27 |
2016-04-12 |
Cook Biotech, Inc. |
Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
|
|
CA2627134A1
(en)
|
2005-10-28 |
2007-05-03 |
Tosoh Corporation |
Method of preparing carotenoid synthesizing microorganism and method of producing carotenoids
|
|
US7320965B2
(en)
|
2005-10-28 |
2008-01-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of Huntingtin gene
|
|
RU2008118144A
(ru)
|
2005-11-11 |
2009-11-20 |
Пфайзер Инк. (US) |
Комбинации иммуномодулирующих олигоодезоксинуклеотидов и способы их применения
|
|
WO2007064291A1
(en)
|
2005-11-30 |
2007-06-07 |
Jyoti Chattopadhyaya |
Method and compounds for rna synthesis
|
|
EP1957507B1
(en)
|
2005-12-02 |
2018-10-24 |
Ionis Pharmaceuticals, Inc. |
Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
|
|
US8076303B2
(en)
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
|
US7884117B2
(en)
|
2005-12-21 |
2011-02-08 |
Pfizer Inc. |
Carbonylamino pyrrolopyrazoles, potent kinase inhibitors
|
|
EP2161038B1
(en)
|
2006-01-26 |
2013-12-25 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to Huntingtin
|
|
ES2516815T3
(es)
|
2006-01-27 |
2014-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en la posición 6
|
|
EP1991678B2
(en)
|
2006-02-15 |
2020-07-15 |
Rechtsanwalt Thomas Beck |
Compositions and methods for oligonucleotide formulations
|
|
JP4713514B2
(ja)
|
2006-02-20 |
2011-06-29 |
エフ．ホフマン−ラ ロシュ アーゲー |
改善された標識試薬
|
|
US8383660B2
(en)
|
2006-03-10 |
2013-02-26 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
|
EP2001871B1
(en)
|
2006-03-31 |
2014-07-16 |
Applied Biosystems, LLC |
Rhodamine-labeled oligonucleotides
|
|
US8088582B2
(en)
|
2006-04-06 |
2012-01-03 |
Ibis Biosciences, Inc. |
Compositions for the use in identification of fungi
|
|
WO2007122103A1
(en)
|
2006-04-20 |
2007-11-01 |
F. Hoffmann-La Roche Ag |
Diazepan derivatives modulators of chemokine receptors
|
|
EP2020449B1
(en)
|
2006-04-24 |
2012-09-26 |
Sigma Alimentos, S.A. De C.V. |
Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
|
|
US20100008937A1
(en)
|
2006-04-25 |
2010-01-14 |
Immune Disease Institute, Inc. |
Targeted delivery to leukocytes using non-protein carriers
|
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
|
WO2007136989A2
(en)
|
2006-05-05 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of dgat2
|
|
WO2007131232A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to ptpr alpha
|
|
US20090012120A1
(en)
|
2006-05-10 |
2009-01-08 |
Board Of Trustees Of Michigan State University |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
|
|
CA2651453C
(en)
|
2006-05-11 |
2014-10-14 |
Isis Pharmaceuticals, Inc. |
5'-modified bicyclic nucleic acid analogs
|
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
CA2653939C
(en)
|
2006-05-31 |
2013-01-22 |
Toray Industries, Inc. |
Immunostimulatory oligonucleotides and use thereof in pharmaceuticals
|
|
US8097596B2
(en)
|
2006-06-30 |
2012-01-17 |
Lakewood-Amedex, Inc. |
Compositions and methods for the treatment of muscle wasting
|
|
EP2046993A4
(en)
|
2006-07-07 |
2010-11-17 |
Univ Massachusetts |
RNA SILENCING COMPOSITIONS, AND METHODS OF TREATING HUNTINGTON CHOREA
|
|
WO2008008476A2
(en)
|
2006-07-12 |
2008-01-17 |
The Regents Of The University Of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
|
EP2051977A2
(en)
|
2006-07-20 |
2009-04-29 |
Amgen Inc. |
SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1
|
|
GB0614947D0
(en)
|
2006-07-27 |
2006-09-06 |
Isis Innovation |
Epitope reduction therapy
|
|
WO2008017081A1
(en)
|
2006-08-04 |
2008-02-07 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of jnk proteins
|
|
AT504194B1
(de)
|
2006-09-07 |
2008-07-15 |
Oesterr Rotes Kreuz |
Bakteriennachweis
|
|
US8138330B2
(en)
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
|
MX2009003398A
(es)
|
2006-09-27 |
2009-08-12 |
Coley Pharm Gmbh |
Analogos de oligonucleotidos cpg que contienen analogos t hidrofobos con actividad inmunoestimuladora mejorada.
|
|
JP5665317B2
(ja)
|
2006-10-18 |
2015-02-04 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
アンチセンス化合物
|
|
WO2008051763A1
(en)
|
2006-10-23 |
2008-05-02 |
Irm Llc |
Cathepsin proteases inhibitors
|
|
US20100144846A1
(en)
|
2006-10-26 |
2010-06-10 |
Coley Pharmaceutical Gmbh |
Oligoribonucleotides and uses thereof
|
|
FR2908414B1
(fr)
|
2006-11-13 |
2012-01-20 |
Centre Nat Rech Scient |
Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
|
|
CN101534824A
(zh)
|
2006-11-17 |
2009-09-16 |
艾博特公司 |
作为化学活素受体拮抗剂的氨基吡咯烷
|
|
JP2010510807A
(ja)
|
2006-11-27 |
2010-04-08 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
高コレステロール血症を治療するための方法
|
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
WO2008073959A2
(en)
|
2006-12-12 |
2008-06-19 |
Idera Pharmaceuticals, Inc. |
Synthetic agonists of tlr9
|
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
|
US20100190837A1
(en)
|
2007-02-15 |
2010-07-29 |
Isis Pharmaceuticals, Inc. |
5'-Substituted-2-F' Modified Nucleosides and Oligomeric Compounds Prepared Therefrom
|
|
RU2559536C2
(ru)
|
2007-03-24 |
2015-08-10 |
Джензим Корпорейшн |
Введение антисмысловых олигонуклеотидов, комплементарных человеческому аполипопротеину в
|
|
US7960353B2
(en)
|
2007-05-10 |
2011-06-14 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
|
EP3199635B1
(en)
|
2007-05-11 |
2019-02-06 |
Adynxx, Inc. |
Gene expression and pain
|
|
WO2008143343A1
(ja)
|
2007-05-24 |
2008-11-27 |
Kyorin Pharmaceutical Co., Ltd. |
１４位置換基に複素芳香環カルボン酸構造を有するムチリン誘導体
|
|
GB0710186D0
(en)
|
2007-05-29 |
2007-07-04 |
Texas Instr Denmark |
PWM loop with minimum allasing error property
|
|
WO2008150729A2
(en)
|
2007-05-30 |
2008-12-11 |
Isis Pharmaceuticals, Inc. |
N-substituted-aminomethylene bridged bicyclic nucleic acid analogs
|
|
CN101808987A
(zh)
|
2007-06-05 |
2010-08-18 |
Nsab神经研究瑞典公司分公司 |
作为皮层儿茶酚胺能神经传递调节剂的二取代的苯基吡咯烷
|
|
EP2173760B2
(en)
|
2007-06-08 |
2015-11-04 |
Isis Pharmaceuticals, Inc. |
Carbocyclic bicyclic nucleic acid analogs
|
|
WO2008151833A2
(en)
|
2007-06-13 |
2008-12-18 |
Hochschule Mannheim |
Compounds for the modulation of huntingtin aggregation, methods and means for identifying such compounds
|
|
EP2014769B1
(en)
|
2007-06-18 |
2010-03-31 |
Commissariat à l'Energie Atomique |
Reversible siRNAa-based silencing of mutated and endogenous wild-type huntingtin gene and its application for the treatment of Huntington's disease
|
|
GB0712494D0
(en)
|
2007-06-27 |
2007-08-08 |
Isis Innovation |
Substrate reduction therapy
|
|
AU2008272918B2
(en)
|
2007-07-05 |
2012-09-13 |
Isis Pharmaceuticals, Inc. |
6-disubstituted bicyclic nucleic acid analogs
|
|
CA2692161C
(en)
|
2007-07-09 |
2015-09-29 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory rna (simra) compounds
|
|
TWI413530B
(zh)
|
2007-07-20 |
2013-11-01 |
Kao Corp |
有機聚矽氧
|
|
EP2185723A4
(en)
|
2007-07-31 |
2011-01-12 |
Univ Saskatchewan |
EFFECT OF A GENETIC VARIATION IN THE GENESIS OF PROMELANIN CONCENTRATING HORMONE ON THE MEAT PROPERTIES IN BOVINE ANIMALS
|
|
US7812003B2
(en)
|
2007-08-02 |
2010-10-12 |
Safe Stephen H |
Antisense microRNA and uses therefor
|
|
US8853375B2
(en)
|
2007-08-15 |
2014-10-07 |
Idera Pharmaceuticals, Inc. |
Toll like receptor modulators
|
|
WO2009046141A2
(en)
|
2007-10-01 |
2009-04-09 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
|
KR100886139B1
(ko)
|
2007-11-13 |
2009-02-27 |
주식회사 삼천리제약 |
올리고뉴클레오타이드의 제조방법
|
|
TW200930375A
(en)
|
2007-12-21 |
2009-07-16 |
Exelixis Inc |
Benzofuropyrimidinones
|
|
TWI340765B
(en)
|
2007-12-26 |
2011-04-21 |
Ind Tech Res Inst |
Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof
|
|
CN101911676A
(zh)
|
2008-01-15 |
2010-12-08 |
联发科技股份有限公司 |
用以播放复数个视频信号以及复数个音频信号的多媒体处理装置及其方法以及多媒体播放系统
|
|
WO2009089659A1
(en)
|
2008-01-18 |
2009-07-23 |
Shanghai Targetdrug Co., Ltd. |
Pyrollidine-based compounds
|
|
US20110105587A1
(en)
|
2008-02-04 |
2011-05-05 |
David Frederik Fishcher |
Target sequences and methods to identify the same, useful in treatment of neurodegenerative diseases
|
|
JP2009190983A
(ja)
|
2008-02-12 |
2009-08-27 |
Tokyo Institute Of Technology |
オリゴヌクレオチド誘導体
|
|
WO2009117589A1
(en)
|
2008-03-21 |
2009-09-24 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
WO2009142822A2
(en)
|
2008-03-26 |
2009-11-26 |
Alnylam Pharmaceuticals, Inc. |
2-f modified rna interference agents
|
|
EP2271351A4
(en)
|
2008-04-03 |
2016-08-31 |
Spring Bank Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR TREATING VIRAL INFECTIONS
|
|
WO2009121347A1
(de)
|
2008-04-04 |
2009-10-08 |
Universität Hamburg |
Verfahren zur stereoselektiven synthese von phosphorverbindungen
|
|
EP2285819B1
(en)
|
2008-04-04 |
2013-10-16 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
CA2726866A1
(en)
|
2008-05-09 |
2009-11-12 |
The University Of British Columbia |
Methods and compositions for the treatment of huntington's disease
|
|
US8679750B2
(en)
|
2008-05-09 |
2014-03-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington'S disease
|
|
US8541388B2
(en)
|
2008-05-22 |
2013-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating expression of RBP4
|
|
EP2294181A4
(en)
|
2008-05-22 |
2013-04-24 |
Isis Pharmaceuticals Inc |
MODULATION OF SMRT EXPRESSION
|
|
WO2009143391A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc |
Methods for modulation expression of creb
|
|
WO2009148605A2
(en)
|
2008-06-04 |
2009-12-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
|
EP2320895A2
(en)
|
2008-07-03 |
2011-05-18 |
Exelixis, Inc. |
Cdk modulators
|
|
US8410070B2
(en)
|
2008-09-12 |
2013-04-02 |
University Of Louisville Research Foundation, Inc. |
Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
|
|
WO2010030858A1
(en)
|
2008-09-15 |
2010-03-18 |
Enanta Pharmaceuticals, Inc. |
4'-allene-substituted nucleoside derivatives
|
|
EP2346883B1
(en)
|
2008-09-23 |
2016-03-23 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
|
WO2010036696A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
|
WO2010036698A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
US20110257251A1
(en)
|
2008-10-07 |
2011-10-20 |
Presidents And Fellows Of Harvard College |
Telomerase inhibitors and methods of use thereof
|
|
NZ591391A
(en)
|
2008-10-22 |
2012-10-26 |
Quark Pharmaceuticals Inc |
Non-invasive methods for treating eye disorders using a topical oligonucleotide composition
|
|
US8883752B2
(en)
|
2008-10-24 |
2014-11-11 |
Isis Pharmaceuticals, Inc. |
5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
RU2015151857A
(ru)
|
2008-12-02 |
2019-01-15 |
Уэйв Лайф Сайенсес Джапан, Инк. |
Способ синтеза модифицированных по атому фосфора нуклеиновых кислот
|
|
EP2382227A1
(en)
|
2008-12-23 |
2011-11-02 |
Girindus America, Inc. |
Sulfurizing reagents and their use for oligonucleotides synthesis
|
|
WO2010080953A1
(en)
|
2009-01-08 |
2010-07-15 |
Isis Pharmaceuticals, Inc. |
Transgenic murine model of human lipoprotein metabolism, hypercholesterolemia and cardiovascular disease
|
|
KR20100087540A
(ko)
|
2009-01-28 |
2010-08-05 |
삼성전자주식회사 |
잉크젯 기록용 잉크 조성물
|
|
WO2010091301A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and excipients
|
|
WO2010093705A2
(en)
|
2009-02-10 |
2010-08-19 |
Idera Pharmaceuticals, Inc. |
Synthetic rna-based agonists of tlr7
|
|
JP5766617B2
(ja)
|
2009-02-20 |
2015-08-19 |
ユニバーシティ・オブ・カンザス |
修飾された糖部分を有するノボビオシン類似体
|
|
EP2669290A1
(en)
|
2009-03-02 |
2013-12-04 |
Alnylam Pharmaceuticals Inc. |
Nucleic Acid Chemical Modifications
|
|
US9107933B2
(en)
|
2009-03-16 |
2015-08-18 |
Isis Pharmaceuticals, Inc. |
Compositions and methods of targeting apolipoprotein B for the reduction of apolipoprotein C-III
|
|
EP2415777B1
(en)
|
2009-03-31 |
2015-07-29 |
Takeda Pharmaceutical Company Limited |
Process for producing nucleoside
|
|
WO2010118263A1
(en)
|
2009-04-08 |
2010-10-14 |
University Of Massachusetts |
Single-nucleotide polymorphism (snp) targeting therapies for the treatment of huntington's disease
|
|
CA2759098A1
(en)
|
2009-04-14 |
2010-10-21 |
Smith Holdings, Llc |
Methods and compositions for the treatment of medical conditions involving cellular programming
|
|
WO2010129853A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS USING MODIFIED dsRNA BINDING DOMAINS
|
|
EP2438079A4
(en)
|
2009-06-01 |
2013-05-22 |
Univ California |
NUCLEIC ACID DELIVERY COMPOSITIONS AND METHOD OF USE THEREOF
|
|
LT2437753T
(lt)
|
2009-06-05 |
2016-12-12 |
Infectious Disease Research Institute |
Sintetiniai gliukopiranozillipidų adjuvantai ir juos turinčios vakcinų kompozicijos
|
|
SI3449926T1
(sl)
|
2009-06-17 |
2020-04-30 |
Biogen Ma Inc. |
Sestave in metode za modulacijo združevanja SMN2 pri subjektu
|
|
JP5670097B2
(ja)
|
2009-06-19 |
2015-02-18 |
花王株式会社 |
二層分離型毛髪化粧料
|
|
US20120108800A1
(en)
|
2009-06-23 |
2012-05-03 |
Shumpei Murata |
Method for synthesizing nucleic acid
|
|
US8329024B2
(en)
|
2009-07-06 |
2012-12-11 |
Ada Technologies, Inc. |
Electrochemical device and method for long-term measurement of hypohalites
|
|
MX342945B
(es)
|
2009-07-06 |
2016-10-18 |
Ontorii Inc * |
Profármacos de ácido nucleico novedosos y métodos de uso de los mismos.
|
|
WO2011005860A2
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
5' phosphate mimics
|
|
EP2451974A2
(en)
|
2009-07-08 |
2012-05-16 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
|
WO2011010706A1
(ja)
|
2009-07-23 |
2011-01-27 |
武田薬品工業株式会社 |
Fgf21シスエレメント結合物質
|
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
|
UA107360C2
(en)
|
2009-08-05 |
2014-12-25 |
Biogen Idec Inc |
Bicyclic aryl sphingosine 1-phosphate analogs
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
US8927553B2
(en)
|
2009-08-10 |
2015-01-06 |
Daljit Singh Dhanoa |
Deuterium-enriched alkyl sulfonamides and uses thereof
|
|
RU2562861C2
(ru)
|
2009-09-11 |
2015-09-10 |
Айсис Фармасьютикалс, Инк. |
Модуляция экспрессии гентингтина
|
|
CN102574888A
(zh)
|
2009-09-16 |
2012-07-11 |
株式会社启拉坚 |
用于rna及其衍生物的合成的新型保护基
|
|
US20120270929A1
(en)
|
2009-09-25 |
2012-10-25 |
Isis Pharmaceuticals, Inc. |
Modulation of ttc39 expression to increase hdl
|
|
EP2488524B1
(en)
|
2009-10-15 |
2013-07-03 |
Pfizer Inc. |
Pyrrolo[2,3-d]pyrimidine compounds
|
|
TWI475051B
(zh)
|
2009-11-18 |
2015-03-01 |
Kao Corp |
Organic polysiloxane
|
|
JP5809408B2
(ja)
|
2009-11-25 |
2015-11-10 |
花王株式会社 |
毛髪化粧料
|
|
WO2011075560A1
(en)
|
2009-12-17 |
2011-06-23 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as syk inhibitors
|
|
EP2488869A1
(en)
|
2009-12-28 |
2012-08-22 |
Achira Labs Pvt. Ltd. |
Diagnostic gel composition, method for making a diagnostic gel composition
|
|
CN106146591B
(zh)
|
2010-01-08 |
2020-07-31 |
Ionis制药公司 |
血管生成素样3表达的调节
|
|
US8750507B2
(en)
|
2010-01-25 |
2014-06-10 |
Cisco Technology, Inc. |
Dynamic group creation for managed key servers
|
|
JP6006120B2
(ja)
|
2010-02-08 |
2016-10-12 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
対立遺伝子多様体の選択的低減
|
|
CA2789038A1
(en)
|
2010-02-08 |
2011-08-11 |
Isis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
|
BR112012018904A2
(pt)
|
2010-02-10 |
2020-09-01 |
Glaxosmithkline Llc |
composto, adjuvante de vacina, composições imunogênica, de vacina e farmacêutica, e uso de um composto"
|
|
WO2011108682A1
(ja)
|
2010-03-05 |
2011-09-09 |
国立大学法人 東京大学 |
リボヌクレオシドホスホロチオエートの製造方法
|
|
WO2011127175A1
(en)
|
2010-04-06 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cd130 (gp130) expression
|
|
EP2556159A1
(en)
|
2010-04-07 |
2013-02-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cetp expression
|
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
|
EP3173419A1
(en)
|
2010-04-28 |
2017-05-31 |
Ionis Pharmaceuticals, Inc. |
Modified nucleosides, analogs thereof and oligomeric compounds prepared therefrom
|
|
WO2011139699A2
(en)
|
2010-04-28 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011139911A2
(en)
|
2010-04-29 |
2011-11-10 |
Isis Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
|
US8906607B2
(en)
|
2010-04-30 |
2014-12-09 |
Cellectis |
Method for modulating double-strand break-induced homologous recombination
|
|
GB201008902D0
(en)
|
2010-05-27 |
2010-07-14 |
Imp Innovations Ltd |
Membrane enhanced polymer sythesis
|
|
EP2611927B1
(en)
|
2010-08-31 |
2018-08-01 |
Sirna Therapeutics, Inc. |
Novel single chemical entities and methods for delivery of oligonucleotides
|
|
US10428019B2
(en)
|
2010-09-24 |
2019-10-01 |
Wave Life Sciences Ltd. |
Chiral auxiliaries
|
|
CN103080314B
(zh)
|
2010-09-30 |
2016-04-13 |
Lsip基金运营联合公司 |
显性突变基因表达抑制剂
|
|
KR101381048B1
(ko)
|
2010-10-20 |
2014-04-14 |
씨제이제일제당 (주) |
Ｏ-포스포세린 생산 균주 및 이로부터 생산된 ｏ-포스포세린으로부터 ｌ-시스테인 또는 이의 유도체의 생산방법
|
|
US9260471B2
(en)
|
2010-10-29 |
2016-02-16 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
|
|
DK2638163T3
(en)
|
2010-11-12 |
2017-07-24 |
Massachusetts Gen Hospital |
POLYCOMB-ASSOCIATED NON-CODING RNAs
|
|
JP6093924B2
(ja)
|
2010-11-30 |
2017-03-15 |
株式会社Wave Life Sciences Japan |
２’−ｏ−修飾ｒｎａ
|
|
WO2012092367A1
(en)
|
2010-12-28 |
2012-07-05 |
University Of Rochester |
Nucleic acid binding compounds, methods of making, and use thereof
|
|
EP2673361B1
(en)
|
2011-02-08 |
2016-04-13 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
|
CA2827380C
(en)
|
2011-02-12 |
2020-08-25 |
University Of Iowa Research Foundation |
Therapeutic nucleic acids
|
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
|
FR2975600B1
(fr)
|
2011-05-24 |
2013-07-05 |
Assist Publ Hopitaux De Paris |
Agents pour le traitement de tumeurs
|
|
AU2012283994A1
(en)
|
2011-07-19 |
2014-03-06 |
University Of Idaho |
Embodiments of a probe and method for targeting nucleic acids
|
|
EP3248982A1
(en)
*
|
2011-07-19 |
2017-11-29 |
Wave Life Sciences Ltd. |
Thiosulfonate reagents for the synthesis of functionalized nucleic acids
|
|
WO2013022967A1
(en)
|
2011-08-11 |
2013-02-14 |
Isis Pharmaceuticals, Inc. |
Gapped oligomeric compounds comprising 5'-modified deoxyribonucleosides in the gap and uses thereof
|
|
US9282242B2
(en)
|
2011-08-24 |
2016-03-08 |
Htc Corporation |
Method and electric device for taking panoramic photograph
|
|
US9976138B2
(en)
|
2011-08-29 |
2018-05-22 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
US20140080896A1
(en)
|
2011-08-30 |
2014-03-20 |
The Regents Of The University Of California |
Identification of small molecules that facilitate therapeutic exon skipping
|
|
CA2846307C
(en)
|
2011-08-31 |
2020-03-10 |
Hospital District Of Helsinki And Uusimaa |
Method for diagnosing a neurodegenerative disease
|
|
WO2013036833A1
(en)
|
2011-09-09 |
2013-03-14 |
Mayo Foundation For Medical Education And Research |
Detecting frontotemporal dementia and amyotrophic lateral sclerosis
|
|
US10066228B2
(en)
|
2011-11-30 |
2018-09-04 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
|
CA2895077A1
(en)
|
2011-12-12 |
2013-06-20 |
Beverly Packard |
In vivo delivery of oligonucleotides
|
|
CN102675386B
(zh)
|
2011-12-24 |
2014-07-02 |
河南科技大学 |
一种龙胆苦苷分离提纯方法
|
|
WO2013134558A1
(en)
|
2012-03-07 |
2013-09-12 |
The Texas A & M University System |
Cancer treatment targeting non-coding rna overexpression
|
|
WO2013138236A1
(en)
|
2012-03-13 |
2013-09-19 |
Gilead Sciences , Inc. |
2'- substituted carba-nucleoside analogs for antiviral treatment
|
|
US9809616B2
(en)
|
2012-10-29 |
2017-11-07 |
Emory University |
Pyrimidine nucleosides and their monophosphate prodrugs for the treatment of viral infections and cancer
|
|
KR20130114435A
(ko)
|
2012-04-09 |
2013-10-17 |
삼성전자주식회사 |
다수의 전극을 갖는 생분자 검출 장치
|
|
BR112014026285B1
(pt)
|
2012-04-23 |
2021-08-31 |
Biomarin Technologies B.V |
Oligonucleotídeos moduladores de rna com características melhoradas para o tratamento de distúrbios neuromusculares
|
|
BR112014029115A8
(pt)
|
2012-05-22 |
2018-04-03 |
Idenix Pharmaceuticals Inc |
Composto, composição farmacêutica, e, uso de um composto ou composição
|
|
WO2013179412A1
(ja)
|
2012-05-30 |
2013-12-05 |
北海道システム・サイエンス株式会社 |
高分散性液相支持体を用いたオリゴヌクレオチド合成法
|
|
CA2879023C
(en)
|
2012-07-13 |
2017-03-28 |
Wave Life Sciences Japan |
Asymmetric auxiliary group
|
|
CA2879066C
(en)
|
2012-07-13 |
2019-08-13 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant
|
|
CN104661664B
(zh)
*
|
2012-07-13 |
2020-07-03 |
波涛生命科学有限公司 |
手性控制
|
|
DK2879718T3
(da)
|
2012-08-06 |
2023-06-19 |
Alnylam Pharmaceuticals Inc |
Proces til fremstilling af kulhydratkonjugerede RNA-stoffer
|
|
KR102237882B1
(ko)
|
2012-08-15 |
2021-04-07 |
아이오니스 파마수티컬즈, 인코포레이티드 |
변형된 캡핑 프로토콜을 이용하는 올리고머 화합물 제조 방법
|
|
EP4086347A3
(en)
|
2012-10-12 |
2023-01-11 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
|
BR112015008399A8
(pt)
|
2012-10-15 |
2017-10-03 |
Ionis Pharmaceuticals Inc |
Composto para modular a expressão de c90rf72, seu uso, oligonucleotídeo modificado, composto de fita dupla e composição
|
|
US10577604B2
(en)
|
2012-10-15 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Methods for monitoring C9ORF72 expression
|
|
FI2906696T4
(fi)
|
2012-10-15 |
2023-03-18 |
|
Menetelmiä c9orf72:n ilmentymisen moduloimiseksi
|
|
EP2725029A1
(en)
|
2012-10-29 |
2014-04-30 |
Laboratoire Biodim |
New antibacterial compounds and biological applications thereof
|
|
JP6358955B2
(ja)
|
2012-10-31 |
2018-07-18 |
武田薬品工業株式会社 |
新規修飾核酸
|
|
SG11201503821YA
(en)
|
2012-11-15 |
2015-06-29 |
Roche Innovation Ct Copenhagen As |
Oligonucleotide conjugates
|
|
KR20150088305A
(ko)
|
2012-11-26 |
2015-07-31 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
Fgfr3 발현의 조절을 위한 조성물 및 방법
|
|
WO2014099941A1
(en)
|
2012-12-19 |
2014-06-26 |
Idenix Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
|
RU2649367C2
(ru)
|
2013-01-30 |
2018-04-02 |
Ф. Хоффманн-Ля Рош Аг |
Конъюгаты углевода и lna-олигонуклеотида
|
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
|
ES2817050T3
(es)
|
2013-02-04 |
2021-04-06 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido selectivos y usos de los mismos
|
|
EP2958998B1
(en)
|
2013-02-22 |
2017-12-27 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage
|
|
US20160050930A1
(en)
|
2013-03-28 |
2016-02-25 |
Syngenta Limited |
Methods of controlling neonicotinoid resistant pests
|
|
WO2014154486A1
(en)
|
2013-03-28 |
2014-10-02 |
Syngenta Participations Ag |
Methods of controlling neonicotinoid resistant pests
|
|
KR102482890B1
(ko)
|
2013-05-01 |
2022-12-30 |
아이오니스 파마수티컬즈, 인코포레이티드 |
아포지질단백질 (a) 발현을 조절하는 조성물 및 방법
|
|
CN105228999B
(zh)
|
2013-05-24 |
2021-03-02 |
味之素株式会社 |
吗啉代寡核苷酸的制备方法
|
|
BR112015029327A2
(pt)
|
2013-05-24 |
2017-09-19 |
Roche Innovation Ct Copenhagen As |
Moduladores de oligonucleotídeo de linfoma 11a/cll de célula b (bcl11a) e usos dos mesmos
|
|
AU2014284152B2
(en)
|
2013-06-21 |
2020-01-23 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulation of target nucleic acids
|
|
DK3013959T3
(da)
|
2013-06-27 |
2020-02-17 |
Roche Innovation Ct Copenhagen As |
Antisense-oligomerer og konjugater målrettet pcsk9
|
|
TW202246503A
(zh)
|
2013-07-19 |
2022-12-01 |
美商百健Ｍａ公司 |
用於調節τ蛋白表現之組合物
|
|
WO2015013673A1
(en)
|
2013-07-25 |
2015-01-29 |
Aurasense Therapeutics, Llc |
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
|
|
WO2015017675A2
(en)
|
2013-07-31 |
2015-02-05 |
Isis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
|
BR112016004352A2
(pt)
|
2013-09-06 |
2017-09-12 |
Syngenta Participations Ag |
compostos inseticidas
|
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
|
EA201690675A1
(ru)
|
2013-10-03 |
2016-08-31 |
Модерна Терапьютикс, Инк. |
Полинуклеотиды, кодирующие рецептор липопротеинов низкой плотности
|
|
WO2015051366A2
(en)
|
2013-10-04 |
2015-04-09 |
Novartis Ag |
Novel formats for organic compounds for use in rna interference
|
|
MY192689A
(en)
|
2013-10-11 |
2022-09-01 |
Ionis Pharmaceuticals Inc |
Compositions for modulating c9orf72 expression
|
|
CA2926341A1
(en)
|
2013-10-14 |
2015-04-23 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating expression of c9orf72 antisense transcript
|
|
WO2015057727A1
(en)
|
2013-10-14 |
2015-04-23 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
CN105934524A
(zh)
|
2013-11-11 |
2016-09-07 |
桑格摩生物科学股份有限公司 |
用于治疗亨廷顿氏病的方法和组合物
|
|
JP2017501684A
(ja)
|
2013-11-14 |
2017-01-19 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブＲｏｃｈｅ Ｉｎｎｏｖａｔｉｏｎ Ｃｅｎｔｅｒ Ｃｏｐｅｎｈａｇｅｎ Ａ／Ｓ |
Ａｐｏｂアンチセンスコンジュゲート化合物
|
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
|
US10144933B2
(en)
|
2014-01-15 |
2018-12-04 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
|
US10322173B2
(en)
|
2014-01-15 |
2019-06-18 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having anti-allergic activity, and anti-allergic agent
|
|
MX2016009290A
(es)
|
2014-01-16 |
2017-02-28 |
Wave Life Sciences Ltd |
Diseño quiral.
|
|
DK3119797T3
(da)
|
2014-03-18 |
2021-03-15 |
Univ Massachusetts |
Raav-baserede sammensætninger og fremgangsmåder til behandling af amyotrofisk lateralsklerose
|
|
WO2015168172A1
(en)
|
2014-04-28 |
2015-11-05 |
Isis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
|
SI3137605T1
(sl)
|
2014-05-01 |
2021-02-26 |
Ionis Pharmaceuticals, Inc. |
Sestavki in metode za modulacijo ekspresije angiopoetin 3-podobnega
|
|
RU2691102C2
(ru)
|
2014-05-08 |
2019-06-11 |
Сангамо Байосайенсиз, Инк. |
Способы и композиции для лечения болезни хантингтона
|
|
AU2015264263B2
(en)
|
2014-05-20 |
2021-08-05 |
University Of Iowa Research Foundation |
Huntington's disease therapeutic compounds
|
|
US20160017327A1
(en)
|
2014-07-11 |
2016-01-21 |
The Johns Hopkins University |
Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity
|
|
WO2016011226A1
(en)
|
2014-07-16 |
2016-01-21 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
|
PL3178807T3
(pl)
|
2014-08-07 |
2020-08-24 |
Takeda Pharmaceutical Company Limited |
Lipid kationowy
|
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
|
WO2016037191A1
(en)
|
2014-09-05 |
2016-03-10 |
Health Research, Inc. |
Use of huntingtin-derived plasmids and peptides for active immunization as a huntington's disease (hd) therapeutic
|
|
JP2017536119A
(ja)
|
2014-11-19 |
2017-12-07 |
ロシュ イノベーション センター コペンハーゲン エーエス |
キラルホスホロチオエート連結を含むｌｎａギャップマーオリゴヌクレオチド
|
|
CN107208092B
(zh)
|
2014-12-16 |
2021-09-10 |
罗氏创新中心哥本哈根有限公司 |
手性毒性筛选方法
|
|
ES2732023T3
(es)
|
2014-12-24 |
2019-11-20 |
Uniqure Ip Bv |
Supresión del gen de la huntingtina inducida por ARNi
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
|
WO2016127000A1
(en)
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Methods of selecting therapeutic molecules
|
|
EP3253871A1
(en)
|
2015-02-04 |
2017-12-13 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
|
US10450563B2
(en)
|
2015-02-10 |
2019-10-22 |
Genzyme Corporation |
Variant RNAi
|
|
CA2976445A1
(en)
|
2015-02-13 |
2016-08-18 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
EP3262174A4
(en)
|
2015-02-23 |
2018-10-17 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing antisense activity
|
|
WO2016141236A1
(en)
|
2015-03-03 |
2016-09-09 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
|
WO2016145142A1
(en)
|
2015-03-10 |
2016-09-15 |
Emory University |
Nucleotide and nucleoside therapeutics compositions and uses related thereto
|
|
WO2016154096A1
(en)
|
2015-03-20 |
2016-09-29 |
Ionis Pharmaceuticals, Inc. |
Modulation of smggds expression
|
|
CN116004624A
(zh)
|
2015-04-03 |
2023-04-25 |
马萨诸塞大学 |
用于靶向亨廷汀mRNA的寡核苷酸化合物
|
|
WO2016164896A2
(en)
|
2015-04-10 |
2016-10-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of smn expression
|
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
JP6606557B2
(ja)
|
2015-04-16 |
2019-11-13 |
アイオーニス ファーマシューティカルズ， インコーポレーテッド |
Ｃ９ｏｒｆ７２発現を調節するための組成物
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
CA2990699A1
(en)
|
2015-06-29 |
2017-01-05 |
Ionis Pharmaceuticals, Inc. |
Modified crispr rna and modified single crispr rna and uses thereof
|
|
PE20180800A1
(es)
|
2015-07-10 |
2018-05-09 |
Ionis Pharmaceuticals Inc |
Moduladores de diaciglicerol aciltransferasa 2 (dgat2)
|
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
|
CA3205381A1
(en)
|
2015-07-17 |
2017-01-26 |
Alnylam Pharmaceuticals, Inc. |
Multi-targeted single entity conjugates
|
|
MA43072A
(fr)
|
2015-07-22 |
2018-05-30 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
TW201718620A
(zh)
|
2015-07-27 |
2017-06-01 |
阿尼拉製藥公司 |
黃嘌呤脫氫酶（ＸＤＨ）ｉＲＮＡ組成物及其使用方法
|
|
ES2842300T3
(es)
|
2015-07-31 |
2021-07-13 |
Alnylam Pharmaceuticals Inc |
Composiciones de ARNi de transtiretina (TTR) y métodos para su uso para el tratamiento o la prevención de enfermedades asociadas con TTR
|
|
DK3341479T3
(da)
|
2015-08-24 |
2020-02-24 |
Roche Innovation Ct Copenhagen As |
LNA-G-Proces
|
|
CN108348541A
(zh)
|
2015-08-25 |
2018-07-31 |
阿尔尼拉姆医药品有限公司 |
用于治疗前蛋白转化酶枯草杆菌蛋白酶kexin(pcsk9)基因相关障碍的方法和组合物
|
|
SG10202007937SA
(en)
|
2015-09-02 |
2020-09-29 |
Alnylam Pharmaceuticals Inc |
PROGRAMMED CELL DEATH 1 LIGAND 1 (PD-L1) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
US10874686B2
(en)
|
2015-10-01 |
2020-12-29 |
Memorial Sloan-Kettering Cancer Center |
Anthranilyl-adenosinemonosulfamate analogs and uses thereof
|
|
CA3000709A1
(en)
|
2015-10-01 |
2017-04-06 |
Memorial Sloan-Kettering Cancer Center |
Inhibitors of menaquinone biosynthesis
|
|
EP3355932B1
(en)
|
2015-10-02 |
2023-04-12 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide conjugation process
|
|
SG10201912902TA
(en)
|
2015-10-09 |
2020-02-27 |
Wave Life Sciences Ltd |
Oligonucleotide compositions and methods thereof
|
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
Roche Innovation Center Copenhagen A/S |
Oligonucleotide detection method
|
|
US10955407B2
(en)
|
2015-10-22 |
2021-03-23 |
Roche Innovation Center Copenhagen A/S |
In vitro toxicity screening assay
|
|
US11260073B2
(en)
|
2015-11-02 |
2022-03-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating C90RF72
|
|
UA125963C2
(uk)
|
2015-11-12 |
2022-07-20 |
Ф. Хоффманн-Ля Рош Аг |
Олігонуклеотид для індукції батьківської експресії ube3a
|
|
CN114685589A
(zh)
|
2016-03-13 |
2022-07-01 |
波涛生命科学有限公司 |
用于亚磷酰胺和寡核苷酸合成的组合物和方法
|
|
AR108038A1
(es)
|
2016-03-14 |
2018-07-11 |
Roche Innovation Ct Copenhagen As |
Oligonucleótidos para reducir la expresión de pd-l1 (ligando de muerte programada-1)
|
|
KR102372122B1
(ko)
|
2016-03-18 |
2022-03-07 |
로슈 이노베이션 센터 코펜하겐 에이/에스 |
아실-보호된 l-lna-구아노신 단량체
|
|
WO2017165489A1
(en)
|
2016-03-23 |
2017-09-28 |
Emory University |
Antiviral agents for treating zika and dengue virus infections
|
|
WO2017180835A1
(en)
|
2016-04-13 |
2017-10-19 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing c9orf72 expression
|
|
EP3442983A1
(en)
|
2016-04-14 |
2019-02-20 |
H. Hoffnabb-La Roche Ag |
TRITYL-MONO-Ga1NAc COMPOUNDS AND THEIR USE
|
|
MA45290A
(fr)
|
2016-05-04 |
2019-03-13 |
Wave Life Sciences Ltd |
Procédés et compositions d'agents biologiquement actifs
|
|
MA45270A
(fr)
|
2016-05-04 |
2017-11-09 |
Wave Life Sciences Ltd |
Compositions d'oligonucléotides et procédés associés
|
|
JP7097820B2
(ja)
|
2016-05-12 |
2022-07-08 |
ロシュ イノベーション センター コペンハーゲン エーエス |
ヌクレオシドまたはオリゴヌクレオチドへの、立体的に規定されたオキサザホスホリジンホスホルアミダイト単量体のカップリングの増大法
|
|
CA3023621C
(en)
|
2016-05-13 |
2021-07-27 |
F. Hoffmann-La Roche Ag |
Protein-based sample collection matrices and devices
|
|
EP3458464A1
(en)
|
2016-05-18 |
2019-03-27 |
ETH Zurich |
Stereoselective synthesis of phosphorothioate oligoribonucleotides
|
|
US11013757B2
(en)
|
2016-06-03 |
2021-05-25 |
Wave Life Sciences Ltd. |
Oligonucleotides, compositions and methods thereof
|
|
CN109310765A
(zh)
|
2016-06-20 |
2019-02-05 |
领先基因生物技术股份有限公司 |
抗体-药物偶联物
|
|
US20190264267A1
(en)
|
2016-07-25 |
2019-08-29 |
Wave Life Sciences Ltd. |
Phasing
|
|
WO2018098264A1
(en)
|
2016-11-23 |
2018-05-31 |
Wave Life Sciences Ltd. |
Compositions and methods for phosphoramidite and oligonucleotide synthesis
|
|
WO2018223056A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
WO2018223081A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
WO2018223073A1
(en)
|
2017-06-02 |
2018-12-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
JP7402696B2
(ja)
|
2017-06-21 |
2023-12-21 |
ウェイブ ライフ サイエンシズ リミテッド |
合成のための化合物、組成物、及び方法
|
|
EP3664816A4
(en)
|
2017-08-08 |
2021-05-19 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND RELATED PROCESSES
|
|
AU2018333065B2
(en)
|
2017-09-18 |
2024-04-18 |
Wave Life Sciences Ltd. |
Technologies for oligonucleotide preparation
|
|
WO2019075357A1
(en)
|
2017-10-12 |
2019-04-18 |
Wave Life Sciences Ltd. |
OLIGONUCLEOTIDE COMPOSITIONS AND RELATED METHODS
|
|
AU2019252680B2
(en)
|
2018-04-12 |
2025-11-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
CA3098624A1
(en)
|
2018-05-11 |
2019-11-14 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
JP2022513719A
(ja)
|
2018-12-06 |
2022-02-09 |
ウェイブ ライフ サイエンシズ リミテッド |
オリゴヌクレオチド組成物及びその方法
|
|
CA3126845A1
(en)
|
2019-02-01 |
2020-08-06 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
US20230089442A1
(en)
|
2019-03-20 |
2023-03-23 |
Pachamuthu Kandasamy |
Technologies useful for oligonucleotide preparation
|
|
JPWO2020196662A1
(es)
|
2019-03-25 |
2020-10-01 |
|
|
|
MX2021012981A
(es)
|
2019-04-25 |
2022-01-18 |
Wave Life Sciences Ltd |
Composiciones de oligonucleotido y metodos de uso de las mismas.
|
|
CA3137740A1
(en)
|
2019-04-25 |
2020-10-29 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
CN114502177A
(zh)
|
2019-05-09 |
2022-05-13 |
波涛生命科学有限公司 |
寡核苷酸组合物及其使用方法
|
|
WO2021071788A2
(en)
|
2019-10-06 |
2021-04-15 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
US20230220384A1
(en)
|
2019-10-06 |
2023-07-13 |
Prashant Monian |
Oligonucleotide compositions and methods of use thereof
|
|
CN115210377A
(zh)
|
2020-03-01 |
2022-10-18 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
KR20230016201A
(ko)
|
2020-05-22 |
2023-02-01 |
웨이브 라이프 사이언시스 리미티드 |
이중 가닥 올리고뉴클레오티드 조성물 및 이와 관련된 방법
|
|
US20230203087A1
(en)
|
2020-05-22 |
2023-06-29 |
Pachamuthu Kandasamy |
Oligonucleotide compositions and methods thereof
|
|
US20230329201A1
(en)
|
2020-08-24 |
2023-10-19 |
Wave Life Sciences Ltd. |
Cells and non-human animals engineered to express adar1 and uses thereof
|
|
EP4200616A1
(en)
|
2020-08-24 |
2023-06-28 |
Wave Life Sciences Ltd. |
Immunoassays for detecting wild type huntingtin protein and methods of treatment employing such immunoassays
|
|
WO2022067023A1
(en)
|
2020-09-24 |
2022-03-31 |
Mayo Foundation For Medical Education And Research |
Screening platforms
|
|
KR20230118716A
(ko)
|
2020-11-08 |
2023-08-11 |
웨이브 라이프 사이언시스 리미티드 |
올리고뉴클레오티드 조성물 및 이의 방법
|
|
CN116507724A
(zh)
|
2020-11-08 |
2023-07-28 |
波涛生命科学有限公司 |
寡核苷酸组合物及其方法
|
|
CA3232965A1
(en)
|
2021-09-26 |
2023-03-30 |
Christopher Michael ACKER |
Compositions for editing mecp2 transcripts and methods thereof
|
|
JP2024535388A
(ja)
|
2021-09-26 |
2024-09-30 |
ウェイブ ライフ サイエンシズ リミテッド |
オリゴヌクレオチド組成物及びその方法
|
|
AU2021471586A1
(en)
|
2021-10-27 |
2024-05-09 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods of use thereof
|
|
EP4422645A4
(en)
|
2021-10-27 |
2025-12-03 |
Wave Life Sciences Ltd |
OLIGONUCLEOTID COMPOSITIONS AND THEIR METHODS OF USE
|
|
CN118660876A
(zh)
|
2022-02-11 |
2024-09-17 |
波涛生命科学有限公司 |
手性化合物的立体选择性技术
|
|
US20250197857A1
(en)
|
2022-03-02 |
2025-06-19 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof for exon skipping
|
|
EP4507700A2
(en)
|
2022-04-15 |
2025-02-19 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods relating thereto
|
|
WO2023220440A1
(en)
|
2022-05-12 |
2023-11-16 |
Wave Life Sciences Ltd. |
Oligonucleotide compositions and methods thereof
|
|
KR20250051686A
(ko)
|
2022-08-11 |
2025-04-17 |
웨이브 라이프 사이언시스 리미티드 |
올리고뉴클레오티드 조성물 및 이의 방법
|